Pseudogene BNIP3P1 Regulates H. pylori–Induced Apoptosis in Gastric Mucosal by Acting on the miR-411-5p/BNIP3 Axis by Andong Zhang, Xin Yan, Ningzhe Li, Shiying Yan, Shu Li, Hua Yang, Yimeng Liu, Jian Zhang, Jia Wang, Jian Zhao, Mei Cao

“…Our findings suggest that BNIP3P1 functions as a competing endogenous RNA (ceRNA) within the BNIP3/miR-411-5p axis during H. pylori infection, which ultimately hinders cell proliferation and promotes apoptosis in GES-1 cells. …”
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Immunoregulatory Effects of <i>Codonopsis pilosula</i> Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice by Yan Long, Hongfei Ji, Jiajing Yang, Haiyu Ji, Keyao Dai, Wenjie Ding, Guoqiang Zheng, Juan Yu

“…These findings could provide theoretical support and data foundation for further development of CPP-SeNPs as functional food and drug adjuvants.…”
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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via redu... by Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang

“…Therefore, there may be molecule(s) that can negate the deleterious effects of overexpressing C-P4HAs during cancer progression. By constructing a functional protein interaction network of <sc>C-P4HAs</sc> and analyzing molecules whose expressions are correlated significantly with that of C-P4HAs, we identify scribble cell polarity complex component 2 (LLGL2) as a factor that antagonizes the effects of overexpressed <sc>C-P4HAs</sc> on HNSC. …”
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Proteomic analysis identified proteins that are differentially expressed in the flavonoid and carotenoid biosynthetic pathways of Camellia Nitidissima flowers by Xing-Wen Zhou, Xiao-Xia Ye, Bao-Jian Ye, Shi-Hong Yan, Hai-Bin Hu, Qiu-Yuan Xu, Xiong Yao, He-Xia Liu, Bo Li, Yi-Qing Xie, Zhong-Jian Liu

“…Phytoene synthase and chalcone synthase exhibited extensive interactions with numerous other proteins and displayed high connectivity within the PPI networks, suggesting their pivotal biological functions in flavonoid and carotenoid biosynthesis. …”
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Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics by Jingjing Meng, Xiangqi Zhang, Danfeng Xiang, Hanlu Liang, Shuai Zhao, Lingyan Xu, Jiao Yang, JunJun Chen, Jingxian Zhang, Yonglong Han

“…Abstract Aim Huachansu injection (HCSI) shows effective medicinal functions against osteosarcoma. This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology and bioinformatics. …”
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Comprehensive analysis of prognosis and drug sensitivity of programmed cell death pattern-related genes in gastric cancer patients by Huiheng Qu, Peng Zhou, Zhihui Yang, Hao Wang, Kaiyuan Deng, Nan Wang, Yuyang Li, Yupeng Zhao, Yigang Chen, Qian Yang, Jiazeng Xia

“…Subsequently, a CDI model comprising 17 PCD-related prognostic DEGs was constructed, demonstrating superior predictive capability. …”
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Multidimensional analysis of sedentary behaviour and participation in Spanish stroke survivors (Part&Sed-Stroke): a protocol for a longitudinal multicentre study by Pablo Bellosta-Lopez, Victor Domenech-Garcia, Maria Pilar López-Royo, Javier Gueita-Rodriguez, Jorge Alegre-Ayala, Julia Blasco-Abadía, Cristina de Diego-Alonso, Almudena Buesa, Patricia Roldán-Pérez, Rafael Giner-Nicolás, Natalie Ann Fini, Alicia Tornero Navarro, Ana Conte Lamenca, Andrea Yerro Astrain, Beatriz Martín Lamata, Carina Salgueiro, Claudia Marín Marín, Diana Ruiz Ramos, Elena Sanz Sanza, Enrique Villa Berges, Fernando Cuesta Ruiz, Inés Cortés Cabeza, Javier Harguindey, Juan Luis Abeledo Alcón, Laura Ares Barge, Leyre Leceaga Gaztambide, Lilian Le Roux, Lourdes Martín Gros, Lucía Díez Fuentes, María Carmen Grácia Sen, María Pilar Pardo Sanz, Paloma Rodríguez Escudero, Paz Cristina Sánchez Lecina, Rebeca Yebra Vilarchao, Sara Beltrán Roche, Verónica Montoya Murillo

“…Introduction Stroke survivors usually experience long-lasting functional, emotional and social consequences that might contribute to sedentary behaviour and participation restrictions, which are important targets to address during rehabilitation. …”
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Lymphocyte activation gene 3 served as a potential prognostic and immunological biomarker across various cancer types: a clinical and pan‐cancer analysis by Yifan Liu, Yuntao Yao, Xinyue Yang, Maodong Wei, Bingnan Lu, Keqing Dong, Donghao Lyu, Yuanan Li, Wenbin Guan, Runzhi Huang, Guofeng Xu, Xiuwu Pan

“…Conclusion High LAG3 gene expression was an independent risk factor in kidney neoplasms. It also functioned as a biomarker for prognosis, TIME and immunotherapy efficacy in the pan‐cancer dimension.…”
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Genome and transcriptome analysis of Chinese wheat powdery mildew isolate 21–2 for discovery of important virulence determinants by Fansong Zeng, Bo Zhang, Bin Yuan, Minfeng Xue, Wenqi Shi, Shuangjun Gong, Tom Hsiang, Dazhao Yu, Lijun Yang

“…This study provides comprehensive genomic and transcriptomic insights into Chinese Bgt isolate 21–2, and reveals virulence determinants and their variants fundamental to pathogenesis. Future functional analysis of such genes will enhance our understanding of pathogenic mechanisms of powdery mildews.…”
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Arginine-Mediated Liver Immune Regulation and Antioxidant Defense in Largemouth Bass (<i>Micropterus salmoides</i>): Multi-Omics Insights into Metabolic Remodeling During <i>Nocard... by Yu-Long Sun, Shuai-Liang Zhang, Feng-Feng Zhou, Yuan-Xin Qian, Yang He, Run-Zhe Zhang, Fen Dong, Qiang Chen, Han-Ying Xu, Ji-Teng Wang, Yu-Ting Deng, Tao Han

“…The liver of fish is an essential metabolic organ that also serves an immune regulatory role. In this study, we constructed a model of largemouth bass (<i>Micropterus salmoides</i>) infected with <i>Nocardia seriolae</i> by injection to explore the immune and antioxidant functions of the liver. …”
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Barriers and facilitators to maternal death surveillance and response at a busy urban National Referral Hospital in Uganda [version 2; peer review: 2 approved] by Jolly Beyeza-Kashesya, Dan K.Kaye, Joseph Rujumba, Noah Kiwanuka, Moses Mukuru, Imelda Namagembe, Annettee Nakimuli, Josaphat Byamugisha, Ashley Moffett

“…Major facilitators were involving all health workers in the MDSR process, eliminate blame, strengthen leadership, implement recommendations from MDSR and functionalize lower health facilities (especially Health Centre -IVs). …”
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N-terminus GTPase domain of the cytoskeleton protein FtsZ plays a critical role in its adaptation to high hydrostatic pressure by Xue-Hua Cui, Xue-Hua Cui, Yu-Chen Wei, Xue-Gong Li, Xue-Gong Li, Xiao-Qing Qi, Xiao-Qing Qi, Long-Fei Wu, Long-Fei Wu, Long-Fei Wu, Wei-Jia Zhang, Wei-Jia Zhang

“…The specific characteristics of FtsZ that allow for functional cell division in the deep-sea environments, especially in obligate piezophiles that grow exclusively under HHP condition, remain enigmatic. …”
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Enhancing neurological disease diagnostics: fusion of deep transfer learning with optimization algorithm for acute brain stroke prediction using facial images by Fadwa Alrowais, Mohammed Alqahtani, Jahangir Khan, Achraf Ben Miled, Da’ad Albalawneh, Abdulwhab Alkharashi, Samah Al Zanin, Radwa Marzouk

“…It contains a nervous illness, which can result from haemorrhage or ischemia of the brain veins, and regular mains to assorted motor and cognitive damages that cooperate with functionality. Screening for stroke comprises physical examination, history taking, and valuation of risk features like age or certain cardiovascular illnesses. …”
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Unveiling intraspecific diversity and evolutionary dynamics of the foodborne pathogen Bacillus paranthracis through high-quality pan-genome analysis by Yuhui Du, Chengqian Qian, Xianxin Li, Xinqian Zheng, Shoucong Huang, Zhiqiu Yin, Tingjian Chen, Li Pan

“…A high-quality pan-genome of B. paranthracis was subsequently constructed to analyze the evolutionary dynamics involved in ecological adaptation comprehensively. …”
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Persistence and stability in an SVIR epidemic model with relapse on timescales by Sabbavarapu Nageswara Rao, Mahammad Khuddush, Ahmed H. Msmali, Ali H. Hakami

“…Using the dynamic inequalities: $ \mathsf{S}(\mathtt{r})\le \alpha^\mathsf{U}/(\alpha^\mathsf{L}+ \gamma^\mathsf{L})+\epsilon, $ $ \mathsf{V}(\mathtt{r})\le \gamma^\mathsf{U}\ell_{11}/(\alpha^\mathsf{L} + \delta_1^\mathsf{L})+\epsilon, $ $ \mathsf{I}(\mathtt{r})\le\alpha^\mathsf{U}/\alpha^\mathsf{L}+\epsilon, $ $ \mathsf{R}(\mathtt{r})\le(\delta_1^\mathsf{U}\ell_{12}+\delta^\mathsf{U}\ell_{13})/(\alpha^\mathsf{L}+\mathsf{d}^\mathsf{L})+\epsilon, $ $ \mathsf{S}(\mathtt{r})\ge \alpha^\mathsf{L}/(\alpha^\mathsf{U} +\beta^\mathsf{U}\ell_1+ \gamma^\mathsf{U})+\epsilon, $ $ \mathsf{V}(\mathtt{r})\ge \gamma^\mathsf{L}\ell_0/(\alpha^\mathsf{U}+ \beta_1^\mathsf{U}\ell_1+\delta_1^\mathsf{U})+\epsilon, $ $ \mathsf{I}(\mathtt{r})\ge\mathsf{d}^\mathsf{L}\ell_{03}/(\delta^\mathsf{U}+\alpha^\mathsf{U})+\epsilon, $ $ \mathsf{R}(\mathtt{r})\ge\delta_1^\mathsf{L}\ell_{02}/(\alpha^\mathsf{U}+\mathsf{d}^\mathsf{U})+\epsilon, $ and constructing an appropriate Lyapunov functional, sufficient conditions were determined to guarantee the permanence of the system. …”
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CCL26 as a prognostic biomarker in hepatocellular carcinoma: integrating bioinformatics analysis, clinical validation, and radiomics score by Junjun Yan, Qiangming Liao, Yong Xie, Sihai Chen

“…Gene set variation and immune cell infiltration analyses were conducted to elucidate the biological functions of CCL26. Radiomic models for predicting CCL26 expression were constructed using CT images and genomic data from 34 TCGA patients. …”
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Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome by Timothy A. Fenton, Stela P. Petkova, Anna Adhikari, Jill L. Silverman

“…In addition, lovastatin’s effects were not assessed in younger subjects, since our study focused exclusively on adult functional outcomes. Metrics of gait, as well as motor coordination and motor learning in rotarod, previously observed to be impaired in AS mice, were not improved by lovastatin treatment. …”
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Knockdown of RGMa reduces vascular calcification by inhibiting the AKT signaling pathway by Hongmei Xiao, Guanru Shen, Zijie Wang, Xiaofan Yuan, Yue Ma, Ruiqi Cheng, Xinyue Qin

“…Western blot (WB) and immunofluorescence (IF) analyses revealed a significant upregulation of RGMa expression in calcified VSMCs. We successfully constructed a VSMC-specific RGMa-targeting AAV, and RGMa knockdown effectively attenuated VC. …”
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Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy by Jinju Li, Hao Yang, Yixuan Lin, Zhaohui Fang

“…Subsequent analyses involved constructing protein-protein interaction (PPI) network, cytoHubba screening, enrichment analysis, and immune infiltration analysis. …”
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Exploring program-cell death patterns to predict prognosis and sensitivity of cervical cancer immunotherapy via multi-omics analysis and clinical samples by Chunhong Pang, Xianfeng Long, Yongjin Luo, Ying Luo

“…Real-time quantitative PCR (qRT-PCR) and immunohistochemistry were used to verify the expression of the model genes. Finally, functional analysis of low- and high-risk groups based on the median risk score was performed, including immune infiltration, genomic mutations, tumor mutational burden (TMB), and drug sensitivity. …”
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