Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…A nomogram was subsequently constructed and validated to assess the integrated prognostic impact of ITPRIPL1 expression on glioma patients. …”
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Irony comprehension in first-degree relatives of patients with bipolar affective disorder – a preliminary fMRI study by András Sándor Hajnal, Eszter Varga, Tamás Tényi, Borbála Pethő, Noémi Albert, Márton Herold, Márton Áron Kovács, Tímea Csulak, Dóra Hebling, Róbert Herold

“…Irony comprehension, which involves constructing a coherent narrative from contradictory information, is linked to ToM. …”
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Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion by Hong Li, Hong Li, Yixin Zhou, Wenya Xue, Pan Yin, Luyu Liu, Shaobo Wu, Yahao Zhao, Qi An, Yang Sun

“…Regulatory networks were constructed using transcription factor (TF) predictions. …”
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Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis by Jiamin Gao, Yanjun Li, Jinping Huang, Cailing Wei, Jieling Chen, Aichun Huang, Ningmei Liu, Yibo Lu, Shixiong Yang

“…This study aims to identify markers associated with biological functions to offer new strategies for sepsis diagnosis. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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Characterization and Specific Detection of <i>Lactobacillus paracasei</i>-Derived Extracellular Vesicles Using Anti-p40-Modified Au Thin Film by Kyeongmin Lee, Eun-Gyung Cho, Youngbo Choi, Yunsik Kim, Jin Hee Lee, Surin Hong

“…For functional evaluation, Lp-EVs were applied to an artificial skin membrane mounted on a Franz diffusion cell, followed by SPR-based quantification and fluorescence imaging to assess their skin penetration behavior. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate associated biological functions and signaling pathways. Meanwhile, molecular docking between core targets and SSA was performed using Autodock software. …”
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Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice by Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan, Yu Chen

“…Our previous work showed that CoV nonstuctural protein 14 (nsp14) functions as (guanine-N7)-methyltransferase (N7-MTase), which is involved in RNA cap formation. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Customization of Ethylene Glycol (EG)‐Induced BmoR‐Based Biosensor for the Directed Evolution of PET Degrading Enzymes by Min Li, Zhenya Chen, Wuyuan Zhang, Tong Wu, Qingsheng Qi, Yi‐Xin Huo

“…Herein, we develop a novel fluorescence‐based HTS tool for evolving polyethylene terephthalate (PET) degrading enzymes by constructing an engineered BmoR‐based biosensor targeting the PET breakdown product, ethylene glycol (EG). …”
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Characterization and prognostic of CD8 + TIM3 + CD101 + T cells in glioblastoma multiforme by Hong-Liang Wang, Sai Li, Chun-Chun Ma, Xiang-Hu Zheng, Hao-Yuan Wu, Chen-Xi Chang, Zhi-Hao Yang, Jia-Wei Wang, Fa-Ming Pan, Bing Zhao

“…Functional enrichment analysis was conducted with clusterProfiler, and a prognostic model was developed. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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CRISPR/Cas9-mediated simultaneous targeting of GmP34 and its homologs produces T-DNA-free soybean mutants with reduced allergenic potential by Dongwon Baek, Byung Jun Jin, Mi Suk Park, Ye Jin Cha, Tae Hee Han, Ye Na Jang, Su Bin Kim, Sang In Shim, Jong-Il Chung, Hyun Jin Chun, Min Chul Kim, Min Chul Kim, Min Chul Kim

“…Gene expression profiling revealed similar expression patterns of all three genes during seed maturation, indicating potential functional redundancy. Two multiplex CRISPR/Cas9 constructs were designed to simultaneously target GmP34/GmP34h1 and GmP34/GmP34h1/GmP34h2 genes, respectively. …”
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Immuno-transcriptomic analysis based on machine learning identifies immunity signature genes of chronic rhinosinusitis with nasal polyps by Zhaonan Xu, Qing Hao, Bingrui Yan, Qiuying Li, Xuan Kan, Qin Wu, Hongtian Yi, Xianji Shen, Lingmei Qu, Peng Wang, Yanan Sun

“…Our study identified a total of 660 differentially expressed genes (DEGs) and 81 differentially immune-related genes (DIRGs) in CRSwNP compared to controls. Functional enrichment analysis revealed that the DIRGs were primarily associated with cell chemotaxis and leukocyte migration, and cytokine-cytokine receptor interaction. …”
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Risk for ocular hypertension progression to early glaucoma: A predictive model and key predictors by Shaofen Huang, Man Luo, Guitong Ye, Zhenlan Yang, Lingling Liao, Nina Wu, Yingting Zhu, Xing Liu, Yehong Zhuo, Hui Xiao

“…Methods: Patients with OHT with at least two follow-up visits within 3 years were categorized into non-progressive and progressive groups based on optic nerve morphology and/or functional changes during follow-up. Data were split into training and testing sets (8:2 ratio). …”
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Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease by Jacqueline S. Penaloza, Blythe Moreland, Jeffrey B. Gaither, Benjamin J. Landis, Stephanie M. Ware, Kim L. McBride, Peter White

“…Functional enrichment and network analyses were used to identify lncRNAs that may be involved in heart development and potentially contribute to CHD. …”
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Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis by Siqi Ye, Siqi Ye, Jingwen Wang, Jingwen Wang, Feng Luo, Feng Luo, Jinjing Jia, Jinjing Jia, Xiumei Mo, Xiumei Mo, Dacan Chen, Dacan Chen

“…These findings provide valuable insights into the mechanisms of AD occurrence and progression, microbial community dynamics, metabolic regulation, and functional food innovation.…”
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Novel multi-omics analysis revealing metabolic heterogeneity of breast cancer cell and subsequent development of associated prognostic signature by Peng Zhang, Cuicui Li, Fen Li, Jiezhong Wu, Kunpeng Hu, He Huang

“…Drug sensitivity prediction was performed via the OncoPredict tool. Functional assays investigated the oncogenic role of PDCD1 in breast cancer cell lines. …”
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Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization by Zixian Xu, Xin Fang, Shan Wang, Jiabei Mu, Qixian Gai, Yantong Chen, Zheyi Sun, Jiemei Zhai

“…Further investigation demonstrated a significant association between exosomal miR-21-5p and M2 polarization of tumor-associated macrophages (TAMs). Functionally, TSCC-derived exosomes promoted the polarization of M0 macrophages towards the M2 phenotype. …”
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