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13761
Mitochondria transplanted adipose-derived stem cells/decellularized adipose tissue hydrogel for adipose tissue regeneration
Published 2025-10-01“…Nevertheless, the therapeutic potential is constrained by the suboptimal functionality of ADSCs, due to the donor health status, long-term culture, and the post-transplantation environment in vivo. …”
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13762
Particle Size Inversion Based on <i>L</i><sub>1,∞</sub>-Constrained Regularization Model in Dynamic Light Scattering
Published 2024-11-01“…Dynamic light scattering (DLS) is a highly efficient approach for extracting particle size distributions (PSDs) from autocorrelation functions (ACFs) to measure nanoparticle particles. …”
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13763
Deciphering organic substrate impacts in Anammox systems: A machine learning driven framework for predictive classification and process mechanism analysis
Published 2025-08-01“…Three datasets were constructed based on organic types: biodegradable organic compounds, biorefractory organic compounds and combined two types organic compounds. …”
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13764
Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy
Published 2025-07-01“…In this study, we innovatively designed a multifunctional metal–organic nanosheet (TiZrRu-MON) by hydrothermal coordination of [Ru(bpy)₃]2⁺ photosensitizing units with TiZr-O clusters, while incorporating Fe3⁺ to construct a cascade catalytic system. Experimental results demonstrated that: (1) Fe3⁺ lattice doping significantly enhanced charge carrier mobility and ultrasound-triggered 1O₂ quantum yield via the formation charge transfer channels; (2) The acidic tumor microenvironment activated Fe3⁺-mediated Fenton reactions, establishing a positive feedback loop with SDT to synergistically amplify ROS generation; (3) Hyaluronic acid functionalization improved nanosheet internalization in HepG2 tumor cells through CD44 receptor-mediated endocytosis. …”
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13765
KnowVID-19: A Knowledge-Based System to Extract Targeted COVID-19 Information from Online Medical Repositories
Published 2024-11-01“…In addition, KnowVID-19 leverages the NetworkX Python library to construct networks of the most relevant terms within publications. …”
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13766
Advancements in chondrocyte 3-dimensional embedded culture: Implications for tissue engineering and regenerative medicine
Published 2025-04-01“…However, in 2D culture, chondrocytes tend to lose their distinctive phenotypes and functionalities after serial passage, thereby limiting their efficacy for tissue engineering purposes.The mechanism of dedifferentiation in 2D culture can be attributed to various factors, including abnormal nuclear strength, stress-induced mitochondrial impairment, chromatin remodeling, ERK-1/2 and the p38/mitogen-activated protein kinase (MAPK) signaling pathway. …”
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13767
Resilience assessment of interprovincial crop virtual water flow network in China
Published 2025-05-01“…Finally, we evaluated network resilience through four dimensions (resistance, absorptive, adaptive, and transformative capacities) by simulating structural and functional responses under both intentional and random node failure scenarios for three major crops (rice, wheat, and maize). …”
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13768
Tunable multiple non-volatile resistance states in multiferroic tunnel junctions based on sliding ferroelectric PtTe2
Published 2025-01-01“…This research highlights the potential use of the sliding ferroelectricity in bilayer PtTe _2 in constructing multistate non-volatile memory and spin filter, and can be used for the development of multifunctional electronic devices.…”
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13769
Network toxicology and molecular docking to investigate the mechanism of bisphenol A toxicity in human diabetic cardiomyopathy
Published 2025-07-01“…Venn diagram analysis identified 93 potential targets associated with BPA-induced DCM, and a robust BPA regulatory network was established using Cytoscape. Functional enrichment analyses revealed significant involvement of oxidative stress, insulin signaling, and metabolic pathways in BPA toxicity. …”
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13770
Integrative Multi-Omics Analysis Reveals Critical Molecular Networks Linking Intestinal-System Diseases to Colorectal Cancer Progression
Published 2024-11-01“…Differentially expressed genes (DEGs) were identified using Limma and DESeq2. Functional enrichment analysis was performed using clusterProfiler. …”
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13771
Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma
Published 2025-08-01“…We generated TRAnsgenic of Cancer of the Kidney (TRACK) mice that express a triple-mutant (P402A, P564A, and N803A) human HIF1α construct specifically in their proximal tubule (PT) cells. …”
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13772
CME Velocity Field Calculation Model Based on an Unsupervised Transformer Optical Flow Network
Published 2024-01-01“…Therefore, we apply fluid motion–based loss functions to analyze the motion of high-energy particles more effectively, addressing the problem of CME motion field extraction. …”
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13773
The Problem of the Reliability of Bending Models for Composite Plates of Medium Thickness
Published 2024-02-01“…Therefore, to provide guaranteed accuracy of the results, some researchers of these problems have introduced such a concept as “energy consistency” between the functions of representation of the displacement vector components, their number, the order of equations, and the number of boundary conditions. …”
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13774
Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma
Published 2021-01-01“…When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN. …”
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13775
PXMP2 inhibits tumor stemness and immune infiltration in hepatocellular carcinoma based on stemness risk
Published 2025-06-01“…A stemness risk model was constructed based on data from TCGA, GEO databases, and bioinformatics methods. …”
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13776
Semantic distances of WAIS Similarities word pairs in non-demented adults: An item-level index of semantic memory granularity
Published 2025-09-01“…Six hundred sixty-nine non-demented participants completed a neuropsychological battery inclusive of SIM and consolidated tests of semantic memory and executive functioning. Hierarchical linear regressions were designed to test the association between LCH and semantic memory performance after controlling for major confounders. …”
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13777
Mapping and identification of QTLs for low light tolerance traits in grapevine
Published 2025-07-01“…Results SNP markers were converted into bin markers using the self-developed VCF_to_binMap analysis pipeline, and a genetic map was constructed containing 19 linkage groups with a total length of 1161.95 cM and an average marker distance of 0.71 cM. …”
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13778
Development and internal validation of a multimorbidity index that predicts healthcare utilisation using the Canadian Longitudinal Study on Aging
Published 2020-04-01“…We used logistic regression models to predict overnight hospitalisation in the last 12 months in the development dataset (random two-thirds of the total) and used these to construct 10 multimorbidity indices (5 models, each treated with and without an age interaction term). …”
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13779
Development of CSOARG: a single-cell and multi-omics-based machine learning model for ovarian cancer prognosis and drug response prediction
Published 2025-05-01“…Immunology analysis, functional enrichment, single-cell analysis, and therapeutic responses of ovarian cancer were conducted using the data from public databases. …”
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13780
Fabrication of carbon nanotube neuromorphic thin film transistor arrays and their applications for flexible olfactory-visual multisensory synergy recognition
Published 2024-01-01“…Furthermore, our SWCNT neuromorphic TFT devices with a high I _On / I _Off ratio (up to 10 ^6 ) at a low operating voltage (−2 to 0.5 V) canmimic not only the basic biological synaptic functions of olfaction and vision (such as paired-pulse facilitation, short-term plasticity, and long-term plasticity), but also optical wireless communication by Morse code. …”
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