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13561
Endoplasmic reticulum-localized circular RNA FAM13B restrains nasopharyngeal carcinoma lymphatic metastasis through downregulating XBP1
Published 2025-07-01“…Stable cell lines with circFAM13B overexpression and knockdown were constructed. Functional experiments, including cell invasion, migration, and metastasis assays, were performed in vitro and in vivo. …”
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13562
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1
Published 2025-06-01“…Abstract Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and proliferation of ovarian granulosa cells has been identified as an important cause for abnormal folliculogenesis. …”
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13563
Graphene coated micro/nano fiber gas sensing mechanism and SF6 decomposition component SO2 detection
Published 2025-03-01“…The optical gas-sensitive response performance of the graphene is analyzed based on the density functional theory. A fiber-loop ring-down (FLRD) gas detection system is constructed,and typical SF6 decomposition component detection experiments are carried out. …”
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13564
Trend analysis of the coupling effect between new urbanization and resources-environment in the Guangdong-Hong Kong-Macao Greater Bay area
Published 2025-06-01“…Achieving sustainable urbanization necessitates the assurance of the stability and functionality of the urbanization-resource-environment system, but extant studies lack adequate methods for dynamic prediction and analysis of new urbanization characteristics. …”
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13565
Structural network topologies are associated with deep brain stimulation outcomes in Meige syndrome
Published 2024-07-01“…Subsequent functional annotation and correlation analyses were also conducted. …”
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13566
Linearity of Structure Kernels in Main-sequence and Subgiant Solar-like Oscillators
Published 2025-01-01“…First, we examine what we call the “kernel errors,” which measure how well the mode sensitivity functions can recover known frequency differences between two models. …”
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13567
Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omic...
Published 2025-07-01“…This study aimed to construct a comprehensive cellular and transcriptional landscape of ccRCC, with emphasis on gene expression dynamics during malignant progression. …”
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13568
Study on mechanism of Miao medicine Xinnao Liantong capsule in treatment of myocardial ischemia diseases based on network pharmacology and molecular docking
Published 2025-06-01“…Functional enrichment analyses were performed using DAVID, and molecular docking was employed to validate core component-target interactions. …”
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13569
Genetically Modified Porcine Mesenchymal Stem Cells by Lentiviral Tbx18 Create a Biological Pacemaker
Published 2019-01-01“…The porcine SAN dysfunction model was constructed by electrocoagulation using a surgical electrotome. …”
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13570
Machine learning developed an immune evasion signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma
Published 2025-06-01“…Low IRS-based risk score indicated higher level of NK cells, CD8+ T cells, and immune activation-related functions. The C-index of IRS was higher than that of many developed signatures for LUAD and clinical stage. …”
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13571
Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production
Published 2025-04-01“…Significantly, further functional analyses revealed that in vitro treatment with CXCL13 could enhance the expression of CXCR5, thereby promoting lymphocyte migration and secretion of antimicrobial proteins. …”
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13572
Assessment of the severity of delayed changes in the state of the neuromuscular system during correction of local cold injury of III-IV degree with pCMV-VEGF165 plasmid preparation...
Published 2025-03-01“…The aim of the study was to study the effectiveness of the use of a genetic construct – pCMV-VEGF165 plasmid in the correction of delayed complications of cold injury in rats. …”
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13573
Layered Soil Moisture Retrieval and Agricultural Application Based on Multi-Source Remote Sensing and Vegetation Suppression Technology: A Case Study of Youyi Farm, China
Published 2025-06-01“…Soil moisture dynamics are a key parameter in regulating agricultural productivity and ecosystem functioning. The accurate monitoring and quantitative retrieval of soil moisture play a crucial role in optimizing agricultural water resource management. …”
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13574
A novel identified epithelial ligand-receptor-associated gene signature highlights POPDC3 as a potential therapy target for non-small cell lung cancer
Published 2025-02-01“…Functional assays revealed that POPDC3 knockdown reduced cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), while its overexpression promoted cancerous activities. …”
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13575
Three-Dimensional Real-Scene-Enhanced GNSS/Intelligent Vision Surface Deformation Monitoring System
Published 2025-04-01“…The system integrates GNSS monitoring terminals and multi-source meteorological sensors to accurately capture minute displacements at monitoring points and multi-source Internet of Things (IoT) data, which are then automatically stored in MySQL databases. To enhance the functionality of the system, the visual sensor data are fused with 3D models through streaming media technology, enabling 3D real-scene augmented reality to support dynamic deformation monitoring and visual analysis. …”
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13576
Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma
Published 2025-04-01“…Moreover, STK11@PPCM was also found to improve the sensitivity of cancer cells to αPD1 by increasing the expression of PD-L1, which was confirmed in STK11-mutated NSCLC cell xenografted mouse models, constructed by CRISPR-Cas9 knockout technology. This work demonstrated for the first time that restoration of functional STK11 can effectively reverse ITME and boost αPD1 efficacy in NSCLC, offering a new therapeutic approach for STK11-mutated lung adenocarcinoma in clinic. …”
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13577
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13578
Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction
Published 2024-12-01“…Additionally, a gene set enrichment analysis (GSEA) was performed to investigate the functions of the key target genes, and the mRNA-miRNA and TF-mRNA regulatory networks were developed to explore the potential regulation of these key genes. …”
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13579
Quality of life and its determinants in women with delayed conception in low-mid socioeconomic neighbourhoods of Northern India: a cross-sectional study
Published 2025-01-01“…Background The inability to conceive or delay in conception has negative and multidimensional effects on health and well-being, daily functioning and societal interactions. This study assesses the impact of delayed conception on quality of life (QoL) among Indian women with delayed conception and evaluates the Fertility Quality of Life (FertiQoL) questionnaire’s reliability and construct validity in this population.Methodology A cross-sectional study of 1530 women aged 18–30, who had not conceived over a period of 18 months, was conducted in low-to-mid-socioeconomic neighbourhoods in Delhi, India. …”
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13580
A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma
Published 2025-02-01“…Enrichment analysis was performed to explore the potential functions of SRmRNAs. Multiple machine learning algorithms were employed to construct a prognostic signature. …”
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