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13481
The effect of nursing shared governance educational program on nurse managers' knowledge for sustainable nursing excellence and empowerment.
Published 2025-01-01“…<h4>Background</h4>Nursing governance residues one of the most composite functions in the complex and complicated healthcare arena. …”
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13482
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13483
MS4A7 based metabolic gene signature as a prognostic predictor in lung adenocarcinoma
Published 2025-04-01“…Genes with differential expression linked to metabolic pathways were identified, and 20 genes were included to develop a risk signature. Further functional enrichment analysis was conducted to compare the biological pathways activated in high-risk versus low-risk groups. …”
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13484
Characteristics of glucose-6-phosphate dehydrogenase mutations in newborns with deficiency from 2021 to 2022 in the Heze area of China
Published 2025-04-01“…The genetic mutations in G6PD in these patients were analyzed using Sanger sequencing. Functional studies were conducted by constructing eukaryotic expression vectors, transfecting them into HEK-293T and HELA cells, and measuring the mRNA and protein levels and G6PD enzymatic activity.ResultsThe incidence of G6PD deficiency in the study population was 0.07% (80/114,285). …”
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13485
T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles
Published 2025-07-01“…To address these challenges, we developed a novel DNA-based targeted lipid nanoparticle (LNP) which we termed NCtx.Methods Minicircle DNA (mcDNA) encoding a CAR construct and SB100x transposase mRNA were encapsulated within a novel lipid formulation which was functionalized with T cell-specific anti-CD7 and anti-CD3 binders. …”
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13486
Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy
Published 2025-06-01“…Furthermore, CD155 expression is also significantly increased in granulocytes derived from cancer patients compared to those from healthy donors. Functionally, high CD155 expression significantly inhibits the release of cytotoxic factors from T cells, thereby functioning as an immune checkpoint that mediates tumor immune evasion. …”
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13487
Increasing Vegetation Cover Enhances Ecosystem Services in the Rare Earth Mining Area of China: Threshold Effects and Implications
Published 2025-01-01“…It also underscores the need for the public and managers to recognize the impact of vegetation restoration on ecosystem functions in rare Earth mining areas.…”
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13488
Decellularized Matrix Scaffolds for Vascular Transplantation: Addressing Immunogenicity, Sterilization, and Current Strategies for Long-Term Storage
Published 2024-12-01“…In addition to sterilization, decellularized tissue constructs require long-term preservation methods, including cryopreservation, lyophilization, and the use of antibiotics and antifungals stored at –20 °C to –80 °C. …”
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13489
Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy
Published 2025-07-01“…Here, we, therefore, investigated the differential expression signatures of genes of patients suffering from GBM from publicly available GEO datasets and constructed a connectivity map. Functional annotation and KEGG pathway analysis showed dysregulated molecular activities and pathways. …”
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13490
Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair
Published 2025-01-01“…The current study examines bone augmentation in critical‐sized bone defects, using functionalized scaffolds, with the hypothesized potential to induce skeletal cell differentiation. 3D printed, porous poly(caprolactone) trimethacrylate (PCL‐TMA900) scaffolds are applied within a murine femur defect, stabilized by a polyimide intramedullary (IM) pin. …”
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13491
A microbead-enhanced electrochemical platform for β-amyloid peptide (1–42) detection
Published 2024-12-01“…In this study, we developed an amperometric immunosensor based on magnetic beads as the platform for constructing the immunosensor. Monoclonal antibodies are immobilized on the MBs, enabling selective detection of Aβ1-42. …”
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13492
Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression
Published 2025-06-01“…WGCNA was employed to construct gene co-expression networks and explore associations between modules and depression-like behavioral phenotypes. …”
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13493
Boosting solar-driven metal-free activation of sulfites by biochar-based photocatalyst for organic pollutants degradation: in-situ precise regulation and the enhancement mechanism
Published 2025-05-01“…Characterizations and density functional theory (DFT) calculations revealed that N vacancies could trap electrons, while N doping regulated the electronic structure, forming mid-gap states to enhance the separation of carriers. …”
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13494
Integrated and holistic knowledge map of phase change materials for pavement: A scientometric analysis and bibliometric review
Published 2024-12-01“…Furthermore, there is an emerging interest in investigating the synergy of PCMs with other functional pavement technologies. These results underscore the potential of the PCMIPE field and emphasize the importance of future research endeavors.…”
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13495
Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma
Published 2025-02-01“…In this study, we used the TCGA-STAD database to identify the expression patterns and prognostic relevance of anoikis-related genes (ARGs) in STAD. Functional enrichment analysis was used to explore the potential pathway. …”
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13496
Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI): Validation of Italian Version in Children with Upper Limb Amputation
Published 2025-01-01“…<b>Background:</b> The Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI) is a comprehensive instrument designed to measure satisfaction across functionality, aesthetic, and service domains. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the CAPP-PSI in an Italian pediatric population. …”
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13497
Establishment and optimization of a tobacco rattle virus -based virus-induced gene Silencing in Atriplex canescens
Published 2025-08-01“…However, the absence of a reliable and stable transformation systems has impeded the functional characterization of candidate genes in this species. …”
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13498
Genome-Wide Identification of the <i>Remorin</i> Gene Family in Poplar and Their Responses to Abiotic Stresses
Published 2024-09-01“…A co-expression network centered by <i>PtREMs</i> was constructed to uncover the possible functions of <i>PtREMs</i> in protein modification, microtube-based movement and hormone signaling. …”
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13499
Research Note: Establishment of vector system harboring duck RNA polymerase I promoter for avian influenza virus
Published 2025-01-01“…Notably, the 250-bp duck RNA pol I promoter demonstrated effective functionality in avian cells, exhibiting higher polymerase activity in a minigenome assay. …”
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13500
Development of a multidimensional 1-year mortality prediction model for patients discharged from the geriatric department: a longitudinal cohort study based on comprehensive geriat...
Published 2025-04-01“…Conclusion Our risk stratification model can accurately predict prospective mortality risk among patients discharged from the geriatric ward. The functionality of this tool facilitates objective palliative care.…”
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