Integrative bioinformatic analysis identifies differentially expressed gene targets as potential biomarkers for anaplastic thyroid cancer by Angel Sebastian Treviño-Juarez, Jose Gerardo Gonzalez-Gonzalez, Rene Rodriguez-Gutierrez, Adriana Sanchez-Garcia, Camilo Daniel Gonzalez-Velazquez

“…Differentially expressed genes (DEGs) were identified using GEO2R, and overlapping genes across datasets were detected through Venn diagram analysis. Functional enrichment was performed using DAVID and Metascape. …”
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Exploring Optimisation Pathways for Underground Space Quality Under the Synergy of Multidimensional Perception and Environmental Parameters by Tianning Yao, Liang Sun, Lin Geng, Yao Xu, Ziqi Xu, Kuntao Hu, Xing Chen, Pan Liao, Jin Wang

“…The results indicated significant differences in user needs across various functional spaces, with commercial-oriented areas emphasising environmental attractiveness and comfort, while transport-oriented spaces prioritised access efficiency and safety. …”
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Mediating effect of risk propensity between impulsivity and psychotic experiences among Lebanese young adults by Lea Kanbar, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Feten Fekih-Romdhane, Souheil Hallit, Sahar Obeid

“…These subclinical symptoms can disrupt daily functioning and are often linked to risk propensity. …”
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Histology image analysis of 13 healthy tissues reveals molecular-histological correlations by Yi Gao, Jianwen Liang, Mu Tian, Wenjiang Deng, Lei Wang, Siyuan Tao, Tian Mou

“…Based on 4306 samples of 13 organs from the largest human healthy tissue database, the Genotype-Tissue Expression (GTEx) project, a deep learning-based automatic analysis framework was constructed to investigate the geno–micro–correlations across tissues. …”
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Identification and Characterization of a Highly Active Hyaluronan Lyase from <em>Enterobacter asburiae</em> by Linjing Zhang, Jiayu Jiang, Wei Liu, Lianlong Wang, Zhiyuan Yao, Heng Li, Jinsong Gong, Chuanli Kang, Lei Liu, Zhenghong Xu, Jinsong Shi

“…Hyaluronic acid (HA) is a well-known functional marine polysaccharide. The utilization and derivative development of HA are of great interest. …”
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GhLPF1 Associated Network Is Involved with Cotton Lint Percentage Regulation Revealed by the Integrative Analysis of Spatial Transcriptome by Hongyu Wu, Luyao Wang, Shengjun Zhao, Mengtao Gao, Junfeng Cao, Yupeng Hao, Li Yu, Ting Zhao, Siyuan Wang, Jin Han, Yumeng Zhu, Yongyan Zhao, Jie Li, Ke Nie, Kening Lu, Linyun Ding, Zhiyuan Zhang, Tianzhen Zhang, Xueying Guan

“…Given these data, it is demonstrated that GhLPF1 mediates a regulation network in LP as a transcriptional repressor, which makes it a valuable functional marker for fiber‐trait improvement application from QTL‐LP‐ChrA06.…”
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Exploring the mechanism of metabolic cell death-related genes AKR1C2 and MAP1LC3A as biomarkers in Parkinson’s disease by Jia Fu, Jing Zhao, Xue Zhao, Na Mi, Chao Zhang, Xueying Li, Lei Wu, Lige Han, Yali Zhang, Lifen Yao

“…Subsequent analyses included functional enrichment, immune profiling, drug prediction, and single-cell RNA sequencing. …”
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Influence of Homogenization Heat Treatments on the Mechanical, Structural, Biodegradation, and Cavitation Behavior of Some Alloys in the ZnMg(Fe) System by Brandușa Ghiban, Ilare Bordeasu, Aurora Antoniac, Iulian Antoniac, Cristina Maria Gheorghe, Dorin Bordeasu, Lavinia Madalina Micu, Cristian Ghera, Laura Cornelia Salcianu, Bogdan Florea, Daniel Ostoia, Anca Maria Fratila

“…The experimental results demonstrate that the new alloys from the ZnMgFe system are a good option for manufacturing biodegradable implants with functional in vitro properties.…”
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Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…Abstract The T7 phage RNA polymerase (RNAP) is a widely used expression platform, but its implementation in non-model microbial hosts poses significant challenges due to cytotoxicity. We constructed an optimized phage phi15-based expression system as alternative to the T7 platform for a wide range of applications in Pseudomonas putida. …”
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A Multi-Objective Gray Consistency Correction Method for Mosaicking Regional SAR Intensity Images with Brightness Anomalies by Jiaying Wang, Xin Shen, Deren Li, Litao Li, Yonghua Jiang, Jun Pan, Zezhong Lu, Wei Yao

“…We propose a multi-objective gray consistency correction method designed explicitly for mosaicking regional SAR intensity images with brightness anomalies to address this. We constructed a two-objective optimization model to ensure regional image gray consistency and mitigate brightness information loss. …”
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Potential‐Dependent Kinetics and Reaction Pathways of Low‐Potential Furfural Electrooxidation with Anodic H2 Production by Zhaohui Wu, Guihao Liu, Ziheng Song, Yihang Hu, Tianqi Nie, Yu‐Fei Song

“…Herein, a series of oxide‐derived copper catalysts (OD‐Cu‐x, x represents electroreduction time) with distinct Cu0/Cu+ ratios and residual content of lattice oxygen are successfully constructed by tuning in‐situ electroreduction time. …”
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Regulatory role of LncRNA FMR1-AS1 in the pathogenesis of alzheimer’s disease based on bioinformatics and in vitro experimental validation by Xiang Yu, Hao Cai, Cai He, Zhong Ouyang, Yongchang Li, Liang Chen

“…This study analyzed RNA sequencing data from the brain tissues of 17 AD patients and 19 healthy controls (GEO: GSE138260) to construct a gene co-expression network and identified eight lncRNAs strongly associated with AD. …”
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Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis by Yufeng Jiang, Jingcheng Zhang, Ailiyaer Ainiwaer, Yuchao Liu, Jing Li, Liuliu Zhou, Yang Yan, Haimin Zhang

“…Independent risk factors identified included age, fever, diabetes, hyperuricemia, bilateral calculi, functional solitary kidney, self-medication, and prehospital delay. …”
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Bioinformatics reveal macrophages marker genes signature in breast cancer to predict prognosis by Ying Li, Xin Zhao, Qiang Liu, Yujie Liu

“…As constitutes of immune microenvironment of breast cancer, macrophages exert complicated functions in the tumour development and treatment. …”
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Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs by Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li

“…As proof of principle validation, the enhancer functionality of two newly identified susceptibility eRNAs, CCND1e and SNAPC1e, is confirmed through CRISPR inhibition and shRNA‐mediated knockdown, resulting in a marked decrease in the expression of their respective target genes, consequently suppressing the proliferation of prostate cancer cells. …”
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The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics... by Jianhang Du, Guangyao Wu, Bokai Wu, Chang Liu, Zhouming Mai, Yumeng Liu, Yawei Wang, Pandeng Zhang, Guifu Wu, Jia Liu

“…A 3D endothelial surface of the carotid artery with mild atherosclerotic plaque was constructed from images of magnetic resonance angiography (MRA). …”
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3D printed bone nails loaded with ceftriaxone sodium for localized drug delivery by Liwen Zhang, Jinhong Zhao, Jie Zhang, Bang Lou, Huijie Li, Fangyuan Guo, Gensheng Yang, Weiyong Hong

“…These results validate the dual functionality of antibiotic-loaded dental resin constructs, positioning them as promising candidates for patient-specific orthopedic solutions that simultaneously address mechanical stability, osseointegration, and infection prevention.…”
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PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation by Yidong Zhang, Hang Xu, Xuedan Han, Qiyi Yu, Lufeng Zheng, Hua Xiao

“…Genes with significant prognostic value were identified, and immune infiltration analysis was conducted, and a prognostic model was constructed based on the results of these analyses. …”
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Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy by Manisha Agarwal, Sanjeeb Handique, Sanchaita Rajkhowa, Abhichandan Das, Debashis Panda, Sami A. Al-Hussain, Magdi E.A. Zaki

“…The atpF protein was identified based on its high antigenicity and functional importance in S. pyogenes. Three vaccine constructs (SM1, SM2, and SM3) were designed by integrating antigenic B-cell and T-cell epitopes with immune-modulating adjuvants and linkers. …”
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All-optical modulator with photonic topological insulator made of metallic quantum wells by Wang Haiteng, Niu Junru, Chen Qiaolu, Zhao Sihan, Shao Hua, Yang Yihao, Chen Hongsheng, Li Shilong, Qian Haoliang

“…Such a high-performance optical modulator could enable new functionalities in future optical communication and information processing systems.…”
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