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12681
Confirmatory factor analyses of the Mandarin Chinese version of the perceived stressors in intensive care units among healthcare professionals
Published 2025-03-01“…Confirmatory Factor Analysis (CFA) affirmed construct homogeneity, comprising of (1) lack of fit with families and the organizational functioning, (2) emotional load associated with patient and family, (3) difficulties associated with teamwork, (4) issues associated with workload and human resource management, (5) issues associated with complex/at-risk situations and skill, (6) and suboptimal care situations. …”
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12682
Shared and specific competing endogenous RNAs network mining in four digestive system tumors
Published 2024-12-01“…The ceRNA networks were constructed using the miRcode and ENCORI databases. …”
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12683
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12684
Research progress and new thoughts for high-value utilization of low-rank coal according to the future “dual-carbon” policy
Published 2025-04-01“…The authors recommend that future research on the preparation of carbon nanomaterials from low-rank coal should focus on four aspects: (1) accurate analysis of coal structure, and understanding the evolution of coal structure and its derived carbon at the molecular level; (2) efficient depolymerization and transformation mechanism; by utilizing the activity of low-rank coal and the structure of oxygen-containing organic functional groups, we can achieve efficient conversion of low-rank coal and improve yield and economy by developing reasonable processes, increasing in-situ characterization or calculation combinations; (3) analysis of heteroatom occurrence forms and functions, study the genesis characteristics of complex minerals and heteroatoms in low-rank coal and their influences on the structures and properties of coal-based carbon materials, and develop functional carbon-based composite materials with unique structures; (4) expansion of potential application areas, conduct research on the preparation and application of coal-based carbon materials, focus on the development of cost-effective and scalable synthesis technologies, and construct multifunctional, high-performance, coal-based functional carbon materials. …”
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12685
Identification of neutrophil extracellular trap-related biomarkers in ulcerative colitis based on bioinformatics and machine learning
Published 2025-06-01“…Differentially expressed genes (DEGs) related to NETs in UC patients and healthy controls were identified using Limma R package and WGCNA, followed by functional enrichment analysis. To identify potential diagnostic biomarkers, we applied the Least Absolute Shrinkage and Selection Operator (LASSO), Support Vector Machine-Recursive Feature Elimination (SVM-RFE) model, and Random Forest (RF) algorithm, and constructed Receiver Operating Characteristic (ROC) curves to evaluate accuracy. …”
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12686
Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study
Published 2025-01-01“…Purpose: Over the past decade, tele-neurorehabilitation (TNR) has emerged as a vital and effective tool for delivering continuous care to stroke patients, playing a key role in enhancing functional recovery and ensuring consistent access to rehabilitation services. …”
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12687
ALKBH5 Promotes Breast Cancer Stemness Through Regulating Wnt/β-Catenin Signaling
Published 2025-06-01“…The N6-methyladenylate methylation (m6A) demethylase alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) decreases modification of RNA, while its role in regulating breast cancer development remains unclear.Methods: ALKBH5-silenced breast cancer cell-line MCF-7 was constructed to investigate its functional impact. Cell proliferation, migration and invasion ability were evaluated by CCK8 and transwell assays under ALKBH5 inhibition. …”
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12688
Introduction to Volume 29, Issue 3
Published 2020-01-01“…The paper by Martin Hill and Mary Lynn Everson, “Indicators likely to contribute to clinical and functional improvement among survivors of politically-sanctioned torture” is unique in the length of post-treatment follow-up, and provides an innovative approach in the measurement of rehabilitation outcomes through a structured measure of functional aspects with an instrument designed at the Kovler Center in Chicago. …”
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12689
Intelligent collaborative management and control platform for continuous mining equipment in open-pit mines
Published 2025-04-01“…The platform delivers multiple functionalities, including comprehensive multi-machine synchronous monitoring, online fault self-diagnosis, and early warning systems, alongside improved multi-machine cooperative control efficiency. …”
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12690
Development of a three-species gut microbiome diagnostic model for acute pancreatitis and its association with systemic inflammation: a prospective cross-sectional study
Published 2025-07-01“…This study confirms compositional and functional gut microbiome alterations in AP, with specific taxa strongly associated with inflammatory biomarkers. …”
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12691
Molecular and immune landscape of melanoma: a risk stratification model for precision oncology
Published 2025-05-01“…Computational immune deconvolution highlighted CD8+ T cell infiltration as a key prognostic factor. To validate the functional role of candidate genes, KIR2DL4 was silenced in A375 melanoma cells using shRNA. …”
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12692
USING MODERN NONACRYLIC BASIC MATERIAL IN CLINICAL PROSTHETIC DENTISTRY
Published 2018-03-01“…One of the main shortcomings is insufficient functional durability of prostheses, and as a consequence the fragility of acrylic constructions. …”
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12693
Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease
Published 2024-12-01“…Abca4 gene-deletion mouse models of STGD1 accumulate lipofuscin, a hallmark of the disease, but unlike the human disease show no or only moderate structural changes and no functional decline. The human macula is highly enriched in cones, and reasoning that the low cone percentage in mice retinas (< 3%) might compromise faithful modelling of human maculopathies, we performed sub-retinal injections of CRISPR/Cas9-abca4 Adeno-Associated Virus constructs into young Sand Rats (Psammomys obesus), a diurnal rodent containing > 30% cones. …”
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12694
Personal Characteristics and Adaptation Mechanisms of Patients with Arterial Hypertension and Chronic Heart Failure
Published 2021-01-01“…Objective: to study the characteristics of adaptation and mental functioning of patients with hypertension and heart failure with comorbidity (the patient has concomitant diseases). …”
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12695
Validity and reliability of the screening test for Alzheimer's disease with proverbs (STADP) for the elderly Validade e confiabilidade do teste de rastreio de Doença de Alzheimer c...
Published 2009-09-01“…The prevalence Alzheimer's disease with age compromises memory, language, executive functions, constructive praxis and abstraction, requiring early evaluation with standardized tests. …”
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12696
Role of anoikis-related gene RAC3 in prognosis, immune microenvironment, and contribution to malignant behavior in vitro and in vivo of bladder urothelial carcinoma
Published 2024-11-01“…The immune-related functional studies manifested that the two subtypes’ immune cell expressions differed. …”
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12697
A Five-Genes-Based Prognostic Signature for Cervical Cancer Overall Survival Prediction
Published 2020-01-01“…The overlapping DEGs among all datasets were considered the final DEGs. Then, the functional enrichment analysis was performed. Moreover, the Cox proportional hazards regression was performed to establish a prognostic signature of the DEGs. …”
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12698
Bioprinting of GelMA-Based Hydrogels to Aid in Creation of Biomimetic 3D Models for Glioblastoma
Published 2025-05-01“…Biocompatibility testing was performed via live/dead and AlamarBlue analyses using GBM cells (both commercial cell lines and patient-derived cell lines) encapsulated in the constructs, along with immunohistochemistry staining to understand how ECM properties altered the functions of GBM cells. …”
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12699
Analysis of dynamic network reconfiguration in HIV patients with cognitive impairment based multilayer network
Published 2025-06-01“…Brain functional alterations in the PWND and ANI groups were evaluated from both global and nodal perspectives. …”
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12700
Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis
Published 2025-08-01“…Protein–protein interaction (PPI) network analysis revealed key modules involving 394 nodes, highlighting their functional interconnectivity. A prognostic model was constructed using 8 RBPGs (GTPBP4, KPNA2, CTNNA1, RRS1, SLFN11, CDKN2A, CHD3, TRAP1). …”
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