Regulator of G-Protein Signaling 5 Reduces HeyA8 Ovarian Cancer Cell Proliferation and Extends Survival in a Murine Tumor Model by Molly K. Altman, Duy T. Nguyen, Santosh B. Patel, Jada M. Fambrough, Aaron M. Beedle, William J. Hardman, Mandi M. Murph

“…Its other functional role is to promote apoptosis in hypoxic environments. …”
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Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration by Jiseong Kim, Myung Chul Lee, Jieun Jeon, Alejandra Rodríguez-delaRosa, Yori Endo, Da-Seul Kim, Andrea Donaxi Madrigal-Salazar, Jeong Wook Seo, Hyeseon Lee, Ki-Tae Kim, Jae-I Moon, Seung Gwa Park, Mariana Carolina Lopez-Pacheco, Abdulhameed F. Alkhateeb, Nebras Sobahi, Nicole Bassous, Wenpeng Liu, Jae Seo Lee, Seongsoo Kim, Dilara Yilmaz Aykut, Mahmoud Lotfi Nasr, Mohammad Asif Hussain, Soo-Hong Lee, Woo-Jin Kim, Olivier Pourquié, Indranil Sinha, Su Ryon Shin

“…Later, we confirmed a combinational effect, whereby muscle tissue regeneration and functional restoration were improved, via an in vivo murine volumetric muscle loss model.…”
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Investigation of the Internal Structure of Hard-to-Reach Objects Using a Hybrid Algorithm on the Example of Walls by Rafał Brociek, Józef Szczotka, Mariusz Pleszczyński, Francesca Nanni, Christian Napoli

“…In order to solve the considered inverse problem, a functional measuring the fit of the model to the measurement data is created. …”
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The 3′ region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box by Kathryn F. Ball, Kathryn F. Ball, Stephen Manu, Abbie K. Underhill, Jeanyoung Kim, Jessica C. Britton, Sarah R. Rudd, Madison M. Malone, Japhet Amoah, Allen Cooper, Charmaine Pira, Kerby C. Oberg

“…We hypothesized that the central E-box was required for activity, while the other E-boxes and Hoxd13 sites localize ZRS activity to the distal posterior limb mesoderm.MethodsTo identify the functional role of each subdomain, we generated three ZRS fragments (5′, central, and 3′) and combined fragment constructs to test subdomain collective contributions. …”
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Research on NS1 Proteins of Group 2 Tembusu Virus Inhibiting the Production of Duck Type Ⅰ IFN by Yunzhen HUANG, Junqin ZHANG, Linlin LI, Jiawen DONG, Yong XIANG, Ming LIAO, Minhua SUN

“…By using the reverse genetic system, we constructed NS1 recombinant chimeric TMUV to clarify the inhibitory effect of NS1 on the IFN-β in DEF cells with TMUV infection.…”
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A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing by Fan Zhang, Haijuan Zhang, Shengfu Wang, Mingying Gao, Kaiyi Du, Xinyuan Chen, Yang Lu, Qianqian Hu, Anyu Du, Shenghu Du, Jian Wang, Keqing Shi, Zimiao Chen, Zhuo Li, Zhenglin Li, Jian Xiao

“…Herein, a dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions is constructed to integratedly promote rapid re-epithelization with suppressed scars on chronic infected wounds. …”
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A single donor cassette enables site-specific knock-in at either the αAmy3 or αAmy8 locus in rice cells via CRISPR/Cas9 by Desyanti Saulina Sinaga, Po-Yu Huang, Chun‑Kai Huang, Chung-An Lu, Li-Fen Huang

“…The transgene was inserted downstream of the promoter and first exon of the rice αAmy3 or αAmy8 genes, which are highly expressed under sugar-starved conditions in rice suspension cultures. We constructed a simple vector with the homologous intron sequences of the αAmy3 and αAmy8, along with rice codon-optimized recombinant receptor binding domain (rcRBD) of the SARS-CoV-2 spike protein, a functional domain responsible for binding to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells. …”
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Validation using item response theory, and assessment of sensitivity to change of the Hypoglycemia Awareness Questionnaire in patients with type 2 diabetes treated with insulin by Julieth Patricia García‐Lugo, Ana Julia Carrillo Algarra, Fabio Alexander Sierra‐Matamoros, Sandra Milena Hernández‐Zambrano, Diana Cristina Henao‐Carrillo

“…The person‐item map showed that the scale covers a wide range of the construct and that the scale has items to measure these different levels. …”
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3D Printing in Nasal Reconstruction: Application-Based Evidence on What Works, When, and Why by Raisa Chowdhury, Nisreen Al-Musaileem, Karanvir S. Raman, Dana Al-Majid, Philip Solomon, Richard Rival

“…<b>Background:</b> Nasal reconstruction requires a balance between aesthetic and functional restoration. Recent advances in three-dimensional (3D) printing have introduced new approaches to this field, enabling precise, patient-specific interventions. …”
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The design of paper-based electroanalytical microfluidic device coupled with post-synthesized molecularly imprinted polymers (rGO/Au@Ag2S/PANI/polyacrylamide) for the detection of... by Mina Adampourezare, Karim Asadpour-Zeynali, Miguel de la Guardia, Jafar Ezzati Nazhad Dolatabadi

“…Ag/GQD/chitosan nano ink was used to construct reference and counter electrodes and Au@Ag2S/GQD/chitosan nano ink was used to construct working electrode. rGO/Au@Ag2S/anline nano-sheets were encapsulated with acrylamide as a functional monomer to create novel nano-sized molecular imprinted polymer (MIP) and was used for the modification of electrode working.Paper substrate was modified for forming a hydrophobic region around the hydrophilic region on the filter paper and were suitable for the evaluation of target molecules in aqueous environment. …”
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Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma by Youliang Zhou, Yi Zhou, Jiabin Hu, Yao Xiao, Yan Zhou, Liping Yu

“…Conclusion The present study indicates that AMD1 functions as a potential role in HCC progression and may serve as a therapeutic target in HCC. …”
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Exploration of the role of drug resistance-associated anoikis-related genes in HER2-Negative breast cancer through bioinformatics analysis by Yuanzhao Wu, Cong Chen, Zao Jin, Kesi Zheng

“…Aims: To explore the potential functions and impacts of anoikis-related genes (ARGs) in breast cancer chemotherapy and to construct a prognosis model for HER2-negative breast cancer (HNBC) based on drug resistance-related ARGs. …”
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From genes to drugs: targeting Alzheimer’s with circadian insights by Zekun Li, Xiaohan Li, Lei Su, Zibo Zhang, Hongmin Guo, Yihao Ge, Fang Dong, Feng Zhang

“…Finally, the mRNA–miRNA network was constructed.ResultsNine genes were identified through the DECG analysis between the AD and ND groups. …”
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Flow behavior over well-escape weirs by Hassan I. Mohamed, Gamal Abozeid, Nashat A. Ali, Wagdy M. Saied

“…Weirs play an important role in controlling and managing water in irrigation canal networks through several functions, such as discharge measurements, water distribution, and lowering the water level. …”
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Posttraumatic stress disorder in disaster-exposed youth: examining diagnostic concordance and model fit using ICD-11 and DSM-5 criteria by BreAnne A. Danzi, Ellen A. Knowles, Rachel C. Bock

“…This study evaluates ICD-11 and DSM-5 (both the standard and preschool-age) diagnostic models by identifying diagnostic rates, evaluating diagnostic concordance, investigating the predictive value of constructs associated with PTSD (demographics, disaster threat and exposure, functional impairment), and examining model fit. …”
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Identification of fatty acid metabolism hub genes in endometriosis using integrative bioinformatics analysis by Jiang-Lie Tu, Rui-Xue Fang

“…Protein–protein interaction (PPI) networks were constructed using STRING and visualized using Cytoscape to identify hub genes. …”
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Research on wheelchair form design based on Kansei engineering and GWO-BP neural network by Weilin Cai, Zhengyu Wang, Yi Wang, Meiyu Zhou

“…Abstract With the increasing emphasis on humanistic care in society, consumers are no longer only concerned about the functional needs of products but also about the spiritual, cultural, and emotional needs that products bring to people. …”
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Bibliometric Analysis of Sustainable Food Systems by Maria Claudia Diaconeasa, Alina Zaharia, Georgiana Raluca Lădaru, Steliana Mocanu

“…Therefore, the need for constructing a functioning sustainable food system has emerged. …”
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Validation of “creactability” scale in football: a Rasch modeling approach by Jhinyi Shin, Jongwon Kim, Miyoung Lee, Won Jae Lee

“…The specific aims were (1) each scale measures a unidimensional construct, (2) the scale items investigate the Differential Item Functioning (DIF) base on team group (i.e., the rankings of higher and lower teams), (3) the range of “creactability” item difficulty and personal ability (respondents “creactability” levels) are wide enough to assess the “creactability” changes, and (4) “creactability” differs across subscales (7 points).MethodsFor Rasch analysis, data from a total of 241 football players were used from the K-League (Korean Professional Football League), excluding goalkeepers due to their different abilities and roles from other field players. …”
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Legitimizing incapacity: discursive choices in Norwegian sickness certificates by Egidio Niclas D’Angelo, Ralf Kirchhoff, Kristin Halvorsen

“…This study examines how SC language constructs narratives of work ability, focusing on how it portrays patients’ limitations and prospects for recovery. …”
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