Toll-like receptor 4-mediated inflammatory stimulation in Kupffer cell enhances arsenite-induced liver fibrosis by triggering hepatic stellate cell activation by Qian Song, Meitong Zhou, Rui He, Heng Diao, Lili Fan, Chenglong Tu, Xiong Chen, Dapeng Wang

“…However, the specific functions of these cells in As-induced LF remain to be elucidated. …”
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Artificial Intelligence and Immersive Technologies in Higher Pedagogical Education by V. A. Starodubtsev, O. R. Neradovskaya

“…It is shown that Generative Pretrained Transformers are able to implement reference and encyclopedic, constructive and creative, analytical, control and training functions in the educational process while observing the ethics of their application. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…This study aimed to utilize single-cell RNA sequencing to investigate the heterogeneity of malignant epithelial cells in ovarian cancer, focusing on their potential functions and the implications for treatment and prognosis. …”
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Integrated multi-omics and machine learning reveals immune-metabolic signatures in osteoarthritis: from bulk RNA-seq to single-cell resolution by Hui He, Xiumei Zhao, Bo Zhang, Shijian Zhao, Yinteng Wu

“…Subsequently, Weighted gene co-expression network analysis (WGCNA) was used to identify gene modules associated with OA and immune-metabolism scores, followed by enrichment analysis to reveal the functional characteristics of these modules. To identify immune-metabolism related differentially expressed genes (DEGs), we utilized seven machine learning methods, including lasso regression, random forest, bagging, gradient boosting machines (GBM), Xgboost-xgbLinear, Xgboost-xgbtree, and decision trees, to construct predictive models and validate their reliability. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…Subsequently, a PPI network was constructed to select the top 10 potential hub genes, and functional analysis was performed by GeneMANIA, resulting in the identification of four immune-related genes. …”
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ALOX15B-based efferocytosis clusters: prognostic implications and immune cell infiltration in breast cancer by Juan Chen, Chang Zheng, Fei Zhang, Shiyao Sun, Guowen Liu, Guo Huang

“…In addition, an immune-related gene risk model was constructed, which was found to be a valid predictor of breast cancer prognosis. …”
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Horizontal Control System for Maglev Ruler Based on Improved Active Disturbance Rejection Controller by Gengyun Tian, Chunlin Tian, Jiyuan Sun, Shusen Diao

“…Subsequently, the active disturbance rejection control algorithm is employed to address the decoupling issue, and a novel differential tracker, SYSTD, is designed. SYSTD is constructed using specific elementary functions. Through rigorous theoretical derivation, its favorable stability is verified. …”
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Analysis of Asymmetric Structures with Triple Modal Reservation by S. R. Morozov, T. R. Gazizov

“…An original approach to electrical circuit reservation, referred to as modal reservation (MR), is developed with the purpose of increasing the reliability and functional safety of radio electronic equipment (REA). …”
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The Impact of Spatial Structure on Economic Efficiency of Beijing-Tianjin-Hebei Megalopolis in China by Xingling Huang, Guoping Li, Jianguo Liu

“…Achieving coordinated and integrated development of the BTH urban agglomeration will require constructing a scientific and regional spatial system, improving the development levels of regional central cities, divesting Beijing of noncapital functions, and reshaping the industrial layout of the BTH megaregion in an orderly manner, while continuously improving the internal hierarchical structure of urban agglomeration and strengthening intercity economic connections.…”
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A comprehensive metric study of distributed PV consumption capacity considering multiple uncertainties by Chengmin Wang, Yangzi Wang, Fulong Song

“…Based on the output uncertainty and load uncertainty of the distributed PV power generation, a mathematical model of the distributed PV power generation uncertainty is constructed. Based on the distributed PV operation data under various uncertain factors, considering the PV capacity and active power loss connected to the distribution network as objective functions, and setting constraints such as power balance, node voltage, line power flow, and distributed PV output, a comprehensive measurement model of the distributed PV absorption capacity is constructed. …”
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Professional self-realization of elementary school teachers: definitive ANALYSIS OF THE CONCEPT by Olha V. Lebid, Liudmyla V. Tsurkan

“…The article makes a definitive analysis of the conceptual construct “professional self-realization of primary school teachers”. …”
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Comparison of Machine Learning and Classic Methods on Aerodynamic Modeling and Control Law Design for a Pitching Airfoil by Lang Yan, Xinghua Chang, Nianhua Wang, Laiping Zhang, Wei Liu, Xiaogang Deng

“…To conduct this, a modified NACA0012 airfoil with a tail functioning as an elevator is employed as the geometry model. …”
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Improving the closing sequences of interaction between human and robot through conversation analysis by Takahisa Uchida, Nahoko Kameo, Hiroshi Ishiguro

“…Further, by analyzing the dialogue between the human and the robot through CA, we propose to build a recursive, reflective model to improve the dialogue model design. A constructive approach urges us to reproduce complicated social phenomena in human-robot interaction so that we can investigate the underlying cognitive mechanisms of humans and create robots that can convey human-like cognition functions and coexist with humans. …”
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Identification and analysis of neutrophil extracellular trap-related genes in periodontitis via bioinformatics and experimental verification by Miao Yu, Zhenqi Ye, Zixin Ye, Yaping Wu, Xiang Wu

“…Differentially expressed NRGs (DE-NRGs) were identified and functionally annotated. Then, machine learning algorithms were exploited to screen hub NRGs, and a predictive model was constructed based on these hub NRGs. …”
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Analysis of the stress-strain state of a radially inhomogeneous transversely isotropic sphere with a fixed side surface by N. K. Akhmedov, S. M. Yusubova

“…It is believed that the elastic moduli are linear functions of the radius of the sphere. It is assumed that the side surface of the sphere is fixed, and arbitrary stresses are given on the conic sections, leaving the sphere in equilibrium. …”
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Transcriptomic Analysis Reveals Candidate Hub Genes and Putative Pathways in <i>Arabidopsis thaliana</i> Roots Responding to <i>Verticillium longisporum</i> Infection by Qiwei Zheng, Yangpujia Zhou, Sui Ni

“…A protein–protein interaction network was constructed using the STRING database. CytoHubba and CytoNCA plugins in Cytoscape v3.10.3 were used to analyze and evaluate this network; six hub genes and four functional gene modules were identified. …”
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Axio-Onto-Epistemology in Systemic Practice by Peace Anumah

“…Ultimately, this exploration underlines the transformative potential of axio-onto-epistemology, showing how it functions as a guiding framework for intentional and informed engagement with the world. …”
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A geminivirus attenuation vector for crop protection using episomal plant gene therapy by Natalie Thompson, Rekha Kandaswamy, Aliya Fathima Anwar, Jane Polston, Garry Sunter, Wayne R. Curtis

“…Abstract Although plant viruses inflict billions of dollars in global crop yield loss, they also encode functions that can be used for crop protection. A viral vector attenuation strategy is developed that enables modulation of a ‘gene therapy’ viral vector designed for protective gene delivery. …”
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Artistic time in D. Keyes’ novel Flowers for Algernon by Antonina V. Samoylova, Olga V. Spachil

“…Time serves as the central construct within the text of the novel, intricately weaving together all plot lines and embodying a conceptual framework.…”
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Human Genome Editing: Managing Technological Risks through Legal Means by A. A. Troitskaya, K. A. Sharlovskiy

“…The next step in comprehending the phenomenon of genetic editing becomes possible.Practical significance: the study results can be used for building further constructive dialog on applying legal mechanisms to human genome editing. …”
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