Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…In the efficacy study, a randomized, double-blinded, and placebo-controlled crossover trial, the effects of 3-HB at the predicted doses on cognitive function and mood in healthy subjects were assessed by a serial arithmetic test (SAT), the cognitrax, the profile of mood states 2nd edition (POMS2), and fatigue visual analog scale (VAS).ResultsIn the pharmacokinetic study, a one-compartment model that includes saturable and non-saturable absorption pathways, constant biosynthesis, and the linear elimination of 3-HB after oral administration were constructed. …”
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Development of Fuel Product Barrier Monitoring System Based on State Functions in State-Oriented Emergency Operating Procedure by Wang Zhenying, Shi Yanming, Xu Huibo, Zhang Lijun, Zhou Shiqing, Gao Chunyan, Huang Yu

“…For CPR1000 nuclear power plants, state functions defined in state-oriented emergency operating procedure (SOP) are used to characterize postaccident physical conditions; their degradation substantially represents the challenges on fundamental safety functions and then on the integrity of FPBs in like manner, so degradation of these state functions is referred to as determining initial conditions of each FPB, by which the link between SOP and EALs is established. …”
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Developing Machine Learning-based Control Charts for Monitoring Different GLM-type Profiles With Different Link Functions by Patrik Hric, Hamed Sabahno

“…In this paper, we propose an innovative approach that uses different machine-learning (ML) techniques for constructing control charts and monitoring generalized linear model (GLM) profiles with three different GLM-type response distributions of Binomial, Poisson, and Gamma, and by examining different link functions for each response distribution. …”
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Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain. by George A Follows, Rita Ferreira, Mary E Janes, Dominik Spensberger, Francesco Cambuli, Amy F Chaney, Sarah J Kinston, Josette R Landry, Anthony R Green, Berthold Göttgens

“…Our data suggests that the +45 region functions as a boundary element that separates the Scl/Map17 and Cyp transcriptional domains, and raise the possibility that this element may be useful for improving tissue-specific expression of transgenic constructs.…”
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Global Stability with Lyapunov Function and Dynamics of SEIR-Modified Lassa Fever Model in Sight Power Law Kernel by Muhammad Farman, Cicik Alfiniyah, Muhammad Saqib

“…In this study, a fractional-order model is constructed using the Caputo operator for SEIR-type Lassa fever transmission, including the control strategy. …”
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The snakehead retrovirus promoter functions independently of the 3'ORF protein and its products are maternally inherited in transgenic zebrafish. by Rachel Zamostiano, Odelia Pisanty, Japhette Esther Kembou-Ringert, Reem Abu Rass, Avi Eldar, Marcelo Ehrlich, Yoav Gothilf, Eran Bacharach

“…The 3'ORF protein was suggested to function as a transactivator of transcription (Tat). …”
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Green's functions of the fractional Laplacian on a square: Boundary considerations and applications to the Lévy flight narrow capture problem by J. C. Tzou

“…Our approach involves analytically constructing the singular behavior of the Green's function in a neighborhood around the location of the singularity, and then formulating a “smooth” problem for the remainder term. …”
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Analytical and numerical evaluation of the relationship between elongation calibration function and cyber standard tensile tests for ductile materials by N.Y. Kim, N.H. Kim, M.K. Razali, H.M. Lee, M.S. Joun

“…A novel analytical elongation calibration function is presented and numerically validated. This function simply maps an experimental tensile test to the analytical tensile test of the specimen with arbitrary GLPD.…”
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Free Vibration Analysis of 2D Functionally Graded Porous Beams Using Novel Higher-Order Theory by G. Reddy, Nathi Kumar

“…Functionally graded material (FGM) is an in-homogeneous composite, constructed from various phases of material elements, often ceramic and metal. …”
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Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment by Nuo Cheng, Qianqian Zhou, Zongfang Jia, Yang Mu, Sheng Zhang, Lei Wang, Yunna Chen

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Schiff Base-Functionalized Melamine Sponge with Hierarchical Porous Architecture for High-Efficiency Removal of Organic Dyes in Wastewater by Xiaoyu Du, Hailiang Nie, Yanqing Qu, Jingyu Xu, Hongge Jia, Yong Zhang, Wenhui Ma, Boyu Du

“…In this study, a stable linear polymer network structure was constructed on the surface of melamine sponges via an in situ polymerization strategy based on the Schiff base reaction mechanism. …”
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Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants by Dries Hendrikx, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, Sabine Van Huffel, Alexander Caicedo

“…In the present analysis, we use graphs to study the interaction between cerebral function, brain hemodynamics, and systemic variables in premature neonates. …”
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Structure–Function Relationship of Novel Tetrakis (Mercapto-Terphenyl)Benzene Cobalt (II) Phthalocyanines: Synthesis and Computational Evaluation by Sevil Sener, Nursel Acar-Selcuki

“…Additionally, density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations were employed to elucidate the electronic structure and geometrical features of Co-Pc <b>4</b>, providing theoretical support for the experimental findings. …”
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Dynamic Analysis of Isotropic Homogeneous Beams Using the Method of Initial Functions and Comparison with Classical Beam Theories and FEM by Jitendra Namdeo, S. K. Dubey, Lobzang Dorji

“…A mathematical model for the dynamic response of beams is constructed using the method of initial functions. The novelty of this study lies in its approach to dynamic analysis, where isotropic homogeneous beams are explored without making assumptions, thus ensuring increased precision using the method of initial functions. …”
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Functional safeguards for conservation: Identifying climate change refugia for frugivorous and nectarivorous birds in a degraded area of Colombia. by Fausto Sáenz-Jiménez, María Alejandra Parrado-Vargas, José F González-Maya, Juan Emiro Carvajal-Cogollo

“…We constructed the functional groups based on a dissimilarity matrix with 16 anatomical and ecological traits. …”
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Function of B8N6S4 in Regulating the Growth and Aflatoxin B1 Biosynthesis of Aspergillus flavus by Xinze ZHANG, Ruisi PU, Jinlu NIU, Wenjie HUANG, Shijuan YAN, Wenyang ZHANG, Shaowen WU

“…【Objective】The objective of this study is to examine the function of Zn(Ⅱ)2Cys6 transcription factor B8N6S4 in Aspergillus flavus, and to analyze the role of B8N6S4 in the growth, development, and Aflatoxin B1 (AFB1) biosynthesis of A. flavus.…”
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Molecular function validation and prognostic value analysis of the cuproptosis-related gene ferredoxin 1 in papillary thyroid carcinoma by Shiyue He, Wenzhong Peng, Xinyue Hu, Yong Chen

“…In this study, comprehensive bioinformatics analyses with six independent cohorts and in vitro experiments were performed to explore the expression, prognostic significance, and molecular function of the cuproptosis key regulator FDX1 in papillary thyroid carcinoma (PTC). …”
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Structural succession and functional changes in the river ecosystem of the Yellow River estuary under the influence of ecological restoration measures by Wang Yiping, Yuan Longhu, Lu Yongjun, Zeng Yuhong, Liu Huaixiang

“…Concurrently, functional groups became more interconnected, resulting in a more complex food web structure. …”
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Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment by Yi Ouyang, Yan Chen, Ting Xu, Yihao Sun, Sheng Zhao, Chunmei Chen, Yixin Tan, Liang He, Hui Liu

“…Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites. …”
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SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of SAF-B2 by Xiangjun Wang, Chuanxin Yang, Yangming Liu, Jian Wang

“…SUMOylation, a reversible post-translational modification, plays a critical role in tumor progression, yet its prognostic significance in PDAC remains unclear.MethodsWe assessed SUMOylation expression patterns and function in PDAC using Western blot and the SUMOylation inhibitor TAK-981. …”
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