Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüpp... by Hiroaki Sunaga, Hiroki Matsui, Saki Anjo, Mas Risky A. A. Syamsunarno, Norimichi Koitabashi, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi

“…Background Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). …”
Get full text

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…However, the frequent occurrence of a non-canonical disulfide bond between complementarity-determining region (CDR) H1 (C35a) and CDRH2 (C50) is often seen as a liability for therapeutic antibody development, despite limited reports of its effect on antibody binding, function, and stability. Here, we describe the discovery and humanization of a human-mouse cross-reactive anti-programmed cell death (PD-1) monoclonal rabbit antibody, termed h1340.CC, which possesses this non-canonical disulfide bond. …”
Get full text

Silicon-Mediated Modulation of Olive Leaf Phytochemistry: Genotype-Specific and Stress-Dependent Responses by Marin Cukrov, Velemir Ninkovic, Luna Maslov Bandić, Šime Marcelić, Igor Palčić, Mario Franić, Paula Žurga, Valerija Majetić Germek, Igor Lukić, Darija Lemić, Igor Pasković

“…Secondary metabolites in olive (<i>Olea europaea</i> L.) leaves constitute a complex framework wherein phenylpropanoids, terpenoids, and secoiridoids in particular, serve as major contributors to olive plant resilience. …”
Get full text

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC by Xin Yue, Zhen Xiang, Yang Yi, Xuecen Wang, Weilin Zhou, Weijian Wu, Wenjing Qin, Yuxuan Zhao, Xianzhang Bu, Zhenwei Peng

“…Abstract Radiation resistance constitutes a formidable impediment in the treatment paradigm for hepatocellular carcinoma (HCC). …”
Get full text

Comprehensive analysis of potential biomarkers for the diagnosis and prognosis of Cervical squamous cell carcinoma - based on GEO and TCGA databases by Yufen Chen, Qinghua Deng, Tengyue Fu, Yuxiang Huang, Houlin Li, Jingmu Xie, Feng Liao, Feimiao Zeng, Xinyi Fang, Ruiman Li, Zhuming Chen

“…BackgroundCervical squamous cell carcinoma (CESC) constitutes a substantial global health burden, especially in resource-limited regions. …”
Get full text

Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development by Chao Yang, Lingxi Zhu, Li Tang, Xiangyu Zhang, Min Lei, Xiaohong Xie, Cuixia Zhang, Dingsheng Yuan, Congyan Li, Ming Zhang

“…Rabbit meat constitutes a high-protein, low-fat nutritional resource demonstrating rising consumption, particularly within the Asia-Pacific region. …”
Get full text

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model by Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt

“…These results constitute a novel therapeutic approach for neurodegenerative diseases, which is applicable to a range of CNS disease targets.…”
Get full text

A SH3b domain-containing peptidoglycan recognition protein from Magallana gigas with broad recognition spectrum by Yinan Li, Hongbo Lu, Chuanyan Yang, Zhuyun Liu, Weilin Wang, Chang Liu, Lingling Wang

“…These results indicated that MgPGRP5 could function as PRR with a broad range of recognition spectrum in the innate immune response of oyster.…”
Get full text

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker by Tomás A. Martins, Deniz Kaymak, Nazanin Tatari, Fiona Gerster, Sabrina Hogan, Marie-Françoise Ritz, Valerio Sabatino, Ronja Wieboldt, Ewelina M. Bartoszek, Marta McDaid, Alexandra Gerber, Alicia Buck, Aisha Beshirova, Anja Heider, Tala Shekarian, Hayget Mohamed, Manina M. Etter, Philip Schmassmann, Ines Abel, Jean-Louis Boulay, Yasuyuki Saito, Luigi Mariani, Raphael Guzman, Berend Snijder, Tobias Weiss, Heinz Läubli, Gregor Hutter

“…Myeloid immune checkpoint therapy targeting the CD47-signal regulatory protein alpha (SIRPα) axis induces GAM phagocytic function, but CD47 blockade monotherapy is associated with toxicity and low bioavailability in solid tumors. …”
Get full text

Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression by A. Saalbach, M. Stein, S. Lee, U. Krügel, M. Haffner-Luntzer, K. Krohn, S. Franz, J.C. Simon, J. Tuckermann, U. Anderegg

“…RNAseq analysis revealed that MSC from Has-tKO are characterised by decreased expression of genes annotated for bone and organ development, whereas expression of genes associated with chemokine related interactions and cytokine signalling is increased.Taken together, we present a novel mouse model with complete deletion of HA synthases in adult mice which has the potential to study HA function in different organs and during age-related HA reduction. …”
Get full text

Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy by Gregor Sachse, Johanna Tennigkeit, Nikolaos Pagonas, Philipp Hillmeister, Ivo Buschmann, Martin Czolbe, Peter Nordbeck, Joachim Schmitt, Daniel Patschan, Oliver Ritter

“…We now address the question of whether inhibition of calpain function in cardiomyocytes, and thereby prevention of calcineurin truncation, attenuates development of myocardial hypertrophy. …”
Get full text

Profiling Language Skills in Minimally Verbal Autism: Findings From Greek-Speaking Preschoolers by Eleni Peristeri, Maria Andreou

“…Background and Aims Minimally verbal (MV) autistic children constitute a considerable portion of the autism spectrum, representing approximately one-third of the autistic individuals. …”
Get full text

Insulin‐Like Growth Factor 2 mRNA‐Binding Protein 2 (IGF2BP2) Promotes Castration‐Resistant Prostate Cancer Progression by Regulating AR‐V7 mRNA Stability by Taruna Saini, Devesh Srivastava, Rajnikant Raut, Parul Mishra, Ashish Misra

“…ABSTRACT Background The emergence of constitutively active androgen receptor (AR) splice variant AR‐V7 poses a formidable challenge in treating prostate cancer, as it lacks the ligand binding region targeted by androgen‐deprivation therapies such as enzalutamide and abiraterone. …”
Get full text

Nośność Graniczna Niejednorodnych Wirujących Tarcz Kołowych by M. Życzkowski

“…From these equations, it follows that the function 20g- 0, must be non-negative over the entire interval 0 ≤ R. …”
Get full text

Associations between knee pain and knee-loading physical activities at work and leisure – a cross-sectional study based on accelerometer measurements by Margareta Törnblom, Emma Haglund, Ann Bremander, Anna Nilsdotter, Maria LE Andersson, Pasan Hettiarachchi, Peter J Johansson, Magnus Svartengren, Katarina Aili

“…Physical activities (PA) constitute the recommended regime to those affected. …”
Get full text

Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study by Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le

“…The principal aim of this study is to elucidate the causal relationship among gut microbiota (GM), immune cell function, and hypertrophic scarring in a European demographic. …”
Get full text

Transcript profiling of plastid ferrochelatase two mutants reveals that chloroplast singlet oxygen signals lead to global changes in RNA profiles and are mediated by Plant U-Box 4 by Snigdha Rai, Matthew D. Lemke, Anika M. Arias, María F. Gómez Méndez, Katayoon Dehesh, Jesse D. Woodson

“…However, fc2 pub4 plants maintained constitutively elevated levels of SA even in the absence of bulk 1O2 accumulation. …”
Get full text

Reliability and validity of the Mentalization Questionnaire in a potentially depressed group of Chinese college students by Xin Huang, Zemin Zhou, Guang Yang, Jiao Liu, Xuan Li, Xuemei Li

“…PurposeMentalization, as a core psychosocial function, not only encompasses emotional regulation but also involves the perception and comprehension of one’s own and others’ emotional states, constituting a crucial capacity for establishing adaptive interpersonal relationships. …”
Get full text

The effect of motivational interviewing on patients with early post-stroke depression: a quasi-experimental study by Yingjie Fu, Yi Zhang, Qianying Deng, Yuenv Wang, Siyi Su, Zheng Wang, Luyi Xu, Beibei Lin, Yun Li, Jufang Li

“…PSD decreases rehabilitation motivation, delays function recovery, and increases the family and social burden of stroke patients. …”
Get full text

Discursive Strategies of Indirect Apology in English-Language Personal Communication by E. Yu. Ilyinova, O. S. Volkova, V. A. Litvinova

“…In situations of indirect apology, as compared with the direct apology scenario, the replacement of a request for forgiveness by means of one or several speech actions is observed, which confirms the hypothesis of their compensating function in English-speaking interpersonal communication. …”
Get full text