MRPL21-PARP1 axis promotes cisplatin resistance in head and neck squamous cell carcinoma by inhibiting autophagy through the PI3K/AKT/mTOR signaling pathway by Rui Guan, Ce Li, Ruijie Jiao, Jingao Li, Ran Wei, Chen Feng, Shengda Cao, Ye Qian, Jugao Fang, Jun Liu, Wenming Li, Dongmin Wei, Dapeng Lei

“…Abstract Background Head and neck squamous cell carcinoma (HNSCC) constitutes a major clinical challenge that severely affects patient survival. …”
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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms by Qi Wu, Shuai Zhang, Peng Liu, Wei Xie, Guido Kroemer, Oliver Kepp, Bei Li, Pan Hui, Ai-Ling Tian, Marion Leduc, Sabrina Forveille, Peter Hamley, Warren Galloway, Liwei Zhao, Frank Madeo, Yi Tu

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Comparative Analysis of CAZymes from <i>Trichoderma longibrachiatum</i> LMBC 172 Cultured with Three Different Carbon Sources: Sugarcane Bagasse, Tamarind Seeds, and Hemicellulose... by Alex Graça Contato, Tiago Cabral Borelli, Ana Karine Furtado de Carvalho, Heitor Buzetti Simões Bento, Marcos Silveira Buckeridge, Janet Rogers, Steven Hartson, Rolf Alexander Prade, Maria de Lourdes Teixeira de Moraes Polizeli

“…This study presents findings on categorizing the secretome profile of CAZymes by their function and family, derived from the filamentous fungus <i>Trichoderma longibrachiatum</i> LMBC 172. …”
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Formation of CSE-YAP complex drives FOXD3-mediated transition of neurotoxic astrocytes in Parkinson’s disease by Rong-Xin Zhu, Yue-Han Chen, Xian Xia, Ting Liu, Cong Wang, Lei Cao, Yang Liu, Ming Lu

“…Astrocytes, constituting the predominant glial cells in the brain, undergo significant morphological and functional transformations amidst the progression of Parkinson’s disease (PD). …”
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High temperature stress-strain data for SAE 5120 steel under various strain ratesDataverse by Philippe Moreau, Jean-Dominique Guérin, José Grégorio La Barbara Sosa, Eli Puchi Cabrera, André Dubois, Laurent Dubar

“…The processed data, averaged from raw tests, were then used to characterize austenite flow stress as a function of strain rate and temperature using the incremental approach. …”
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Physiological and Transcriptomic Analysis of a Sepal Mutant in <i>Phalaenopsis</i> by Yu Qi, Yenan Wang, Fei Dong, Jiao Zhu, Xiaohui Lv

“…MADS-box transcription factors have undergone in-depth investigations regarding their function in regulating the development of plant floral organs. …”
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Patients with Coronary Artery Disease Have Lower Levels of Antibody to Heat-Stressed Fibroblast Derived Proteins, versus Normal Subjects by Azin Aghamajidi, Hesam Babaei Khameneh, Narges Amirjamshidi, Seyed Farzad Jalali, Haleh Akhavan-Niaki, Soraya Khafri, Seyedeh Narges Mousavi, Monireh Golpour, Maryam Mehri, AmrollahMostafazadeh

“…Inhibition of cellular stress may provide a novel clinical approach regarding the diagnosis and treatment of CAD. Fibroblasts constitute 60-70% of cardiac cells and have a crucial role in cardiovascular function. …”
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Clinical spectrum and uncommon features of McCune-Albright syndrome in children: a cohort study from a National Referral Center by Solène Bergignat, Roland Chapurlat, Roland Chapurlat, Roland Chapurlat, Marc Nicolino, Marc Nicolino, Kevin Perge, Kevin Perge

“…IntroductionMcCune-Albright syndrome (MAS) is a rare disease caused by somatic gain-of-function variants in the GNAS gene that lead to constitutive activation of the G protein alpha subunit (Gsα). …”
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Postzygotic mosaicism in SMC1A and the first reported case of a female with Cornelia de Lange syndrome by Marta Gil-Salvador, Laura Trujillano, Cristina Lucia-Campos, Julia Del Rincón, Pilar Pamplona, María Arnedo, Beatriz Puisac, Íñigo Marcos-Alcalde, Paulino Gómez-Puertas, Feliciano J. Ramos, Juan Pié, Ana Latorre-Pellicer

“…Molecular dynamics simulations suggest that this mutation disrupts the elbow domain of SMC1A, potentially impairing cohesin function. Further delineation of phenotypes and genotypes associated with PZM variants in SMC1A reveals that, similar to constitutive variants, mosaic mutations are predominantly missense and distributed throughout the gene. …”
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Mental health impacts of particulate matter exposure and non-optimal temperature among rural and urban children in eastern China by Yangyang Wu, Jing Wei, Biran Cheng, Hong Sun, Yidong Zhou, Chen Li, Peng Wang, Hao Zhang, Yiyi Wang, Lei Huang, Kai Chen

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A Trade‐Off Between Leaf Carbon Economics and Plant Size Among Mangrove Species in Dongzhaigang, China by Dalong Jiang, Tao Nie, Qiuyu He, Jing Yan, Erhui Feng, Qing Ye

“…ABSTRACT Plant size is closely linked to its leaf trait characteristics, which are essential for determining its form and function. These relationships constitute a fundamental component of the global spectrum of plant diversity. …”
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Distribution and Neurochemical Characterization of Dorsal Root Ganglia (DRG) Neurons Containing Phoenixin (PNX) and Supplying the Porcine Urinary Bladder by Paweł Janikiewicz, Urszula Mazur, Piotr Holak, Nastassia Karakina, Kamil Węglarz, Mariusz Krzysztof Majewski, Agnieszka Bossowska

“…The present study reveals the extensive expression of PNX in the DRGs supplying to the urinary bladder, indicating an important regulatory role of this neuropeptide in the control of physiological function(s) of this organ.…”
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Susceptibility to chronic mucus hypersecretion, a genome wide association study. by Akkelies E Dijkstra, Joanna Smolonska, Maarten van den Berge, Ciska Wijmenga, Pieter Zanen, Marjan A Luinge, Mathieu Platteel, Jan-Willem Lammers, Magnus Dahlback, Kerrie Tosh, Pieter S Hiemstra, Peter J Sterk, Avi Spira, Jorgen Vestbo, Borge G Nordestgaard, Marianne Benn, Sune F Nielsen, Morten Dahl, W Monique Verschuren, H Susan J Picavet, Henriette A Smit, Michael Owsijewitsch, Hans U Kauczor, Harry J de Koning, Eva Nizankowska-Mogilnicka, Filip Mejza, Pawel Nastalek, Cleo C van Diemen, Michael H Cho, Edwin K Silverman, James D Crapo, Terri H Beaty, David A Lomas, Per Bakke, Amund Gulsvik, Yohan Bossé, Ma'en Obeidat, Daan W Loth, Lies Lahousse, Fernando Rivadeneira, Andre G Uitterlinden, Andre Hofman, Bruno H Stricker, Guy G Brusselle, Cornelia M van Duijn, Uilke Brouwer, Gerard H Koppelman, Judith M Vonk, Martijn C Nawijn, Harry J M Groen, Wim Timens, H Marike Boezen, Dirkje S Postma, LifeLines Cohort study

“…<h4>Background</h4>Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. …”
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Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations by Wen Yih Aw, Aanya Sawhney, Mitesh Rathod, Chloe P. Whitworth, Elizabeth L. Doherty, Ethan Madden, Jingming Lu, Kaden Westphal, Ryan Stack, William J. Polacheck

“…Here, we investigate the role of hemodynamic forces and the biophysical microenvironment in the pathophysiology of vascular malformations (VMs), and we identify hemodynamic shear stress and defective endothelial cell mechanotransduction as key regulators of lesion progression. We found that constitutive PI3K activation impaired flow-mediated endothelial cell alignment and barrier function. …”
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Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway by Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho

“…In this study, we investigated the function of COX-2 in the osteogenic differentiation of BMSCs. …”
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Good outcomes of bipolar radial head arthroplasty for comminuted radial head fractures: a cohort study of 64 patients with an average 5.2-year follow-up by Saga Byman, Oskari Oikarinen, Mikko Salmela, Ville Haapamäki, Thomas Ibounig, Tuomas Lähdeoja

“…This study aimed to assess the functional and radiological outcomes of elbow injuries involving comminuted radial head fractures treated with bipolar radial head arthroplasty. …”
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Extraction of Optimal Measurements for Drowsy Driving Detection considering Driver Fingerprinting Differences by Yifan Sun, Chaozhong Wu, Hui Zhang, Yijun Zhang, Shaopeng Li, Hongxia Feng

“…Secondly, the genetic algorithms were used to optimize fitness functions to obtain measured IDBCPs. Finally, we selected measurements calculated by IDBCPs that can distinguish drowsy driving to constitute individual drivers’ optimal drowsiness-detection measurement set. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Conclusion The HSF1‐MYCN axis constitutes a transcription‐dependent regulatory mechanism that may function as both a prognostic indicator and a promising therapeutic target in liver cancer. …”
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Inteligência biológica versus inteligência artificial: uma abordagem crítica Biologic intelligence versus artificial intelligence: a critical approach by Wilson Luiz Sanvito

“…In the present paper it is stressed that brain/mind complex constitutes a monolithic system that functions with emergent properties at several levels of hierarchical organization. …”
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Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death by Veronica Singh, Kyle T. Wagner, Laura G. Williams, Justin M. Ryan, Katherine R. Keller, Jonathan D. Mohnkern, Robert S. Gardner, Louis T. Dang, Julie M. Ziobro, Richard J. H. Wojcikiewicz, Nathan R. Tucker, David S. Auerbach

“…Abstract Background Long QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes Kv11.1 that forms a delayed-rectifier potassium channel in the brain and heart. …”
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