Engineered transcription-associated Cas9 targeting in eukaryotic cells by Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan, Max A. B. Haase, Larisa Kagermazova, Mauricio A. Arias, Kenenna Onyebeke, Samantha Adams, Daniel K. Beyer, David Fenyö, Marcus B. Noyes, Jef D. Boeke

“…Both interactions are nucleic acid sequence specific but function constitutively; thus, they provide intrinsic spatial control over DNA targeting activities but naturally lack temporal control. …”
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Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction by Yuanling Ye, Fan Shen, Maoli Yan, Conghui Zhan, Jiahua Lv, Mengqin Zou, Zhifeng Wang, Shaokai Ning, Yanfei Gao, Jingxian Wu, Wen Li

“…Intermediate filaments, which constitute a key element of the cytoskeleton, function not only as diagnostic markers but also play a role in malignant processes, including tumor proliferation, apoptosis, and migration. …”
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Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity by Ida Stangerup, Ida Stangerup, Birgitte Georg, Jens Hannibal, Jens Hannibal

“…IntroductionProkineticin 2 (PK2) is believed to function as an output molecule, relaying circadian rhythms of behavior and physiology from the suprachiasmatic nucleus (SCN). …”
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Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis by Sima Besharat, Ali Jafari, Kosar Kordkatuli, Helia Mardani, Fatemeh Mehdipoor, Pardis Bakhtiari Jami, Maryam Abbastabar, Mohammadali Vakili, Alireza Alaghi

“…Introduction Heart diseases constitute a significant global public health concern. …”
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Misinformation or education? A comparative analysis of Instagram posts related to full mouth rehabilitation by Amal Alfaraj, Faris A. Alshahrani, Meshal Albalawi, Naif AlQahtani, Mohammed Alhajji, Ali Sulaiman Alharbi, Sultan Ainoosah, Khalifa S. Al-Khalifa

“…Full Mouth Rehabilitation (FMR), a complex treatment aimed at restoring oral function and aesthetics, remains underrecognized by the general public. …”
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Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells by Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa

“…Abstract Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS. …”
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Dark Ship Detection via Optical and SAR Collaboration: An Improved Multi-Feature Association Method Between Remote Sensing Images and AIS Data by Fan Li, Kun Yu, Chao Yuan, Yichen Tian, Guang Yang, Kai Yin, Youguang Li

“…Secondly, by integrating position, dimensions (length and width), and course characteristics, we devise a joint cost function to evaluate the combined significance of multiple features. …”
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OA-MEN: a fusion deep learning approach for enhanced accuracy in knee osteoarthritis detection and classification using X-Ray imaging by Xiaolu Ren, Xiaolu Ren, Lingxuan Hou, Shan Liu, Peng Wu, Siming Liang, Haitian Fu, Chengquan Li, Ting Li, Yongjing Cheng

“…BackgroundKnee osteoarthritis (KOA) constitutes the prevailing manifestation of arthritis. …”
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Severe Aplastic Anemia Complicated with Fatal Invasive Fungal Infections in a Young Patient Harboring Perforin Gene Polymorphisms by Maria I. Krithinaki, Ioannis Kokkinakis, Styliani Markatzinou, Christos Masaoutis, Elena Solomou, Ioanna Papakitsou, Nektaria Xirouchaki, Ioannis Liapis, Helen A. Papadaki, Charalampos G. Pontikoglou

“…Infections, especially invasive fungal infections such as mucormycosis and aspergillosis, constitute principal causes of morbidity and mortality in patients with SAA. …”
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Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection by Mariya Lobanovska, Ying Feng, Jonathan Zhang, Allison H. Williams, Daniel A. Portnoy

“…We show that the heterogeneity of the stressosome mutants cannot be rescued by constitutive activation of PrfA. These data defined the importance of the stressosome in controlling bacterial homogeneity and characterized the function of the stressosome in robust virulence activation during infection. …”
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Immunohistochemical analysis of microglial changes in the experimental acute hepatic encephalopathy by T. V. Shulyatnikova

“…Hepatic encephalopathy (HE) is a syndrome of impaired brain function in patients with advanced liver failure and it manifests in form of psychometric tests alterations up to decreased consciousness and coma. …”
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Comportamento morfofisiológico da mamoneira BRS Energia submetida à irrigação com água salina Morphophysiological behavior of castor bean BRS Energia submitted to irrigation with s... by João B. dos Santos, Delfran B. dos Santos, Carlos A. V. de Azevedo, Alex M. Rebequi, Lourival F. Cavalcante, Ítalo H. L. Cavalcante

“…<br>An experiment was conducted at the experimental station of Irrigation and Drainage of the Instituto Federal Baiano, to evaluate the growth variables of the castor bean BRS Energia as a function of salinity of irrigation water in lysimeters. …”
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Surgical treatment of the ischemic heart disease with lowered contractility of left ventricle and mitral valve insufficiency by S. A. Rudenko, A. V. Rudenko, Yu. V. Kaschenko, V. P. Zakharova

“…The patients’ age have constituted 29 - 83 yrs old, (61.1 ± 8.9) yrs old at average. …”
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The implications of frailty in older adults with epilepsy by Syeda Amrah Hashmi, Seerat Sachdeva, Udeept Sindhu, Carolyn Tsai, Kalyanchakradhar Bonda, Mark Keezer, Ifrah Zawar, Vineet Punia

“…Abstract Older adults constitute a large proportion of people with epilepsy (PWE) due to the changing demographics worldwide and epilepsy's natural history. …”
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Extraction of individual tree attributes using ultra-high-density point clouds acquired by low-cost UAV-LiDAR in Eucalyptus plantations by Mei Zhou, Chungan Li, Zhen Li

“…Context Eucalyptus plantation forests constitute the largest expanse of planted broad-leaved forests worldwide. …”
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Features of postconcussion symptoms recovery after traumatic brain injury among military personnel by A. V. Shvets, A. Yu. Kikh, I. A. Lukianchuk

“…Among individuals with postconcussion syndrome, the functioning of non-specific brain systems was found to be impaired making dysregulation changes in the electrical activity of the brain stable and long-lasting. …”
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Stimuli Selection Criteria for the Experiment “Visual Perception of Imitative Words in Native and Non-Native Language by the Method Lexical Decision” by M. A. Flaksman, Yu. V. Lavitskaya, Yu. G. Sedelkina, L. O. Tkacheva

“…The group of real words is constituted of two sub-groups: 32 imitative words and 32 non-imitative words. …”
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Online Occupational Therapy as a Rehabilitation Intervention for Parkinson’s Disease: A Systematized Review by Antigoni Kountoura, Thomas Tegos, Marianthi Arnaoutoglou, Magdalini Tsolaki

“…This review aimed to evaluate the effects of online OT interventions on functional outcomes and QoL of patients with PD. <b>Methods</b>: This review employed a systematized approach, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, though it did not constitute a full systematic review or meta-analysis. …”
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Inferring Mechanical Properties of Wire Rods via Transfer Learning Using Pre-Trained Neural Networks by Adriany A. F. Eduardo, Gustavo A. S. Martinez, Ted W. Grant, Lucas B. S. Da Silva, Wei-Liang Qian

“…The neural network’s input constitutes combined numerical and visual data, and its architecture primarily consists of seven dense layers and eight convolutional layers. …”
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Essential service accessibility and contribution to quality of life: a systematic review by Sarah M Wood, Kira Page, Emma Baker, Hannah Beks, Marley J Binder, Marcus Blake, Vincent L Versace, Neil T Coffee

“…However, there is currently a lack of consensus on what constitutes an essential service in Australia. This gap hinders a detailed spatial understanding of essential service provision, access, and influence on populations. …”
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