Ferroptosis triggers mitochondrial fragmentation via Drp1 activation by Lohans Pedrera, Laura Prieto Clemente, Alina Dahlhaus, Sara Lotfipour Nasudivar, Sofya Tishina, Daniel Olmo González, Jenny Stroh, Fatma Isil Yapici, Randhwaj Pratap Singh, Nils Grotehans, Thomas Langer, Ana J. García-Sáez, Silvia von Karstedt

“…Abstract Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases. …”
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Health Status of Hemodialysis Patients with End Stage Kidney Disease in Kirkuk City by Mujda Najim Taha, Abid Salih Kumait

“… Background: Hemodialysis is a treatment for end-stage renal disease (ESRD) in which a machine filters waste and excess fluids from the blood for patients whose kidneys can no longer perform this function on their own. The health status of a hemodialysis patient can vary depending on several factors, including the underlying cause of their kidney disease, their overall health and medical history, the effectiveness of their dialysis treatments, and their adherence to their treatment plan. …”
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Comparison of Outcomes of Live and Deceased Donor Renal Transplantation-A Retrospective Study from a single center in South India by Bharathi Kasinaboina, Swarnalatha Guditi, Gangadhar Taduri

“…Background: Renal transplantation is the treatment modality of choice for patients with end-stage renal disease(ESRD). Living donors constitute the majority of the organ donor pool in India. …”
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Reducing Wave Overtopping on Rubble Mound Breakwaters Using Floating Kelp Farms by Filipe Miranda, Tomás Calheiros-Cabral, Diogo Mendes, Paulo Rosa-Santos, Francisco Taveira-Pinto, Tiago Fazeres-Ferradosa

“…This reduction is mainly a function of the ratio between floating kelp farm length and incident wavelength. …”
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Cpx-signalling in Yersinia pseudotuberculosis modulates Lipid-A remodelling and resistance to last-resort antimicrobials by Dharmender K. Gahlot, Jonasz B. Patkowski, Jaime Fernández de Santaella, Luke P. Allsopp, Zhiqiao Pan, Alain Filloux, Gerald Larrouy-Maumus, Matthew S. Francis, Tiago R. D. Costa

“…The permeability barrier conferred by the Gram-negative bacteria cell envelope constitutes a first line of defence against the action of antibiotics. …”
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Distinct roles for the thioredoxin and glutathione antioxidant systems in Nrf2-Mediated lung tumor initiation and progression by Amanda M. Sherwood, Basma A. Yasseen, Janine M. DeBlasi, Samantha Caldwell, Gina M. DeNicola

“…NRF2 and its negative regulator KEAP1 are commonly mutated in human lung cancers, leading to NRF2 accumulation and constitutive expression of NRF2 target genes, many of which are at the interface between antioxidant function and anabolic processes that support cellular proliferation. …”
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Meta-analysis of the clinical efficacy of liraglutide in treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease by Yuan-Yuan Xu, Xu Wang, Yu-Qing She, Jie Liu, Qing Zhang

“…., insulin), liraglutide may improve glucose metabolism, lipid and liver function parameters, and visceral and subcutaneous fat in patients with T2DM and NAFLD, thus constituting an effective treatment for these patients.…”
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Mediating effect of kinesiophobia between self-efficacy and physical activity levels in post-CABG patients: protocol for a prospective, multicentre, cross-sectional study in China by Yu Chen, Rong Wang, Yanmei Gu, Jing Jing Piao, Yunpeng Ling, Liqun Chi

“…Introduction Physical activity (PA) can improve cardiac function, exercise capacity, and quality of life, in addition to reducing mortality by 20%–30% and preventing the recurrence of adverse cardiovascular events in patients following coronary artery bypass graft (CABG). …”
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Hydrochemical Characteristics and Control Factors of Strontium Enrichment of Groundwater in the Eastern Sanjiang Plain, China by Jingjie Li, Mingguo Wang, Tao Yang, Sheng Lian, Huaisheng Zhang, Chao Bian, Xuqing Wang, Shixiong Tian

“…Groundwater with a Sr content over 0.40 mg/L constituted 7.32% of the total samples. The siliceous rocks and basalts present in this region supply the foundational material for Sr2+ enrichment. …”
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The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome by Molly B. Sheridan, Elizabeth Wohler, Denise A. S. Batista, Carolyn Applegate, Julie Hoover-Fong

“…Our patients shared multiple homozygous genomic regions; ten shared regions were >1 Mb in length and constituted 0.99% of the genome. DCAF17, encoding a transmembrane nuclear protein of uncertain function, was the only gene identified in a homozygous region known to cause hypogonadotropic hypogonadism. …”
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Energy dissipation properties of backfill materials under compaction in solid waste backfill mining by Bangyong Yu, Bangyong Yu, Xu He, Ying Zhang, Jinglin Jiang, Ang Li, Zhen Li

“…The relationship between particle crushing energy and axial strain is approximated by a linear function. The energy consumed by particle breakage constitutes a small proportion (0.7%∼7.8%) of the total energy consumption for specimen deformation, while the majority of energy consumption is attributed to inter-particle friction, especially in the later compaction stage. …”
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Bio-Composite Nanogels Based on Chitosan and Hyaluronic Acid for the Treatment of Lung Infections by Francesca Della Sala, Marco Barretta, Mario di Gennaro, Rubina Paradiso, Giorgia Borriello, Assunta Borzacchiello

“…Pathogen infections constitute a serious problem in the field of lung diseases, especially in severe conditions such as chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS). …”
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Advances in immune microenvironment and immunotherapy strategy for colorectal cancer by Yang Changjiang, Zhao Long, Lin Yilin, Ye Yingjiang, Wang Shan, Shen Zhanlong

“…T cells, B cells, macrophages, and other immune cells together constitute a complex immune microenvironment and participate in the development and progression of colorectal cancer. …”
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Legal Pluralism: Interactions Between Official and Unofficial Laws: The Case Study of a Multi-ethnic Community Farm by Gabriela Ribeiro Farinha

“…However, its creation process and daily practice also exposes the relevance of the official law in its constitution, shape and function. En 2011 se creó en California una granja multiétnica comunal, para que fuera explotada en comunidad por refugiados y emigrantes de diferentes países. …”
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Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance. by Shabeesh Balan, Sumitha Prameela Bharathan, Neetha Nanoth Vellichiramal, Sanish Sathyan, Vijai Joseph, Kurupath Radhakrishnan, Moinak Banerjee

“…Epilepsy constitutes a heterogeneous group of disorders that is characterized by recurrent unprovoked seizures due to widely different etiologies. …”
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LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling by Pasano Bojang, Yingshan Wang, Kenneth S. Ramos

“…Silencing of NACC2 in TP53 wildtype NCI-H460 or TP53-null NCI-1299 cell lines replicated many of these changes, with profiles varying as a function of p53 status. Stable overexpression of HDM2 increased LINE-1 ORF1p in cancer cell lines. …”
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The Role of Protein Kinase C During the Differentiation of Stem and Precursor Cells into Tissue Cells by Oliver Pieles, Christian Morsczeck

“…Furthermore, PKC is capable of directly phosphorylating transcription factors with pivotal function for a certain developmental process. Ultimately, profound knowledge about the role of distinct PKC isoforms and the involved signaling pathways during differentiation constitutes a promising tool to improve the use of stem cells in regenerative therapies by precisely manipulating the activity of PKC or downstream effectors.…”
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Samfundssikkerhed i Arktis – en ny dagsorden for Arktisk Råd? by Rasmus Dahlberg, Jens Heine Grauen Larsen

“…This article discusses how societal security may be interpreted in an Arctic context and investigates how preparedness is organized in the region with a special emphasis on the function and meaning of the Arctic Council and other collaborative organizations in a future perspective. …”
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Structure of the EphB6 receptor ectodomain. by Emilia O Mason, Yehuda Goldgur, Dorothea Robev, Andrew Freywald, Dimitar B Nikolov, Juha P Himanen

“…To further our understanding of Eph receptor function, we crystallized the EphB6-ECD and determined its three-dimensional structure using X-ray crystallography. …”
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Extreme genetic fragility of the HIV-1 capsid. by Suzannah J Rihn, Sam J Wilson, Nick J Loman, Mudathir Alim, Saskia E Bakker, David Bhella, Robert J Gifford, Frazer J Rixon, Paul D Bieniasz

“…The capsid (CA) domain of the HIV-1 Gag protein is under strong pressure to conserve functional roles in viral assembly, maturation, uncoating, and nuclear import. …”
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