The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway. by Annarita Fiorillo, Gianni Colotti, Alberto Boffi, Paola Baiocco, Andrea Ilari

“…Structural analyses bring out key structural features to elucidate LmTXN and LmTXNPx function. LmTXN displays an unusual N-terminal α-helix which allows the formation of a stable domain-swapped dimer. …”
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AAV-IKV mediated expression of decorin inhibits EMT and fibrosis in a murine model of Glaucoma and AAV-IKV transduction in Non-Human Primates by Pushpa Rao, Manish Mishra, Siobhan M. Cashman, David S. Walton, Rajendra Kumar-Singh

“…Expression of human decorin from an AAV-IKV vector (AAV-IKV-Decorin) attenuated fibrosis, IOP and RGC death in AAV-IKV-TGFβ2CS injected mice, suggesting that AAV-IKV-Decorin may function as a therapy for POAG and IAG respectively. …”
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Sustainability of Audit Profession in Digital Technology Era: The Role of Competencies and Digital Technology Capabilities to Detect Fraud Risk by Fazlida Mohd Razali, Norhayati Sulaiman, Dewi Izzwi Abdul Manan, Jamaliah Said

“…Fraud constitutes a significant and pervasive risk within the broader landscape of cybercrime, driven by the rapid evolution of digital technologies. …”
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The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Abstract Cancer stem cells (CSCs) constitute a small yet crucial subgroup in tumors, known for their capacity to self-renew, differentiate, and promote tumor growth, metastasis, and resistance to therapy. …”
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Primer extension coupled with fragment analysis for rapid and quantitative evaluation of 5.8S rRNA isoforms. by Giulia Venturi, Federico Zacchini, Cinzia Lucia Vaccari, Davide Trerè, Lorenzo Montanaro

“…The ribosomal RNA 5.8S is one of the four rRNAs that constitute ribosomes. In human cells, like in all eukaryotes, it derives from the extensive processing of a long precursor containing the sequence of 18S, 5.8S and 28S rRNAs. …”
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Deep crypt secretory cells shape region-specific mucin glycosylation patterns in the mouse colon. by Daisuke Sugahara, Hayato Kawakami, Yoshihiro Akimoto

“…Its region-specific glycosylation patterns are indispensable for adapting to distinct physiological and microbial environments along the colon, thus ensuring appropriate mucin layer function. However, the mechanisms underlying this region-specific glycosylation remain unknown. …”
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Resilient electrified freight transport: Disruptions and mitigation strategies by Maria Björklund, Henrik Gillström, Fredrik Stahre

“…Taking an actor perspective, this paper adopts and combines disruption and mitigation frameworks, both of which are lacking in current electrification literature. The results can function as guidelines for actors pursuing H-BEVs regarding what risks need to be handled, and suggestions on how they can be handled, thus constituting an important step in obtaining zero-emission freight systems.…”
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Conservative treatment of older adult patients with shoulder diseases: a narrative review by Kook Jong Kim, Ho-Seung Jeong

“…Management strategies prioritize pain relief, function preservation, and improving mobility. Nonsurgical modalities, including exercise, manual therapy, and activity modification, constitute first-line treatments, especially for older adults. …”
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A new trauma severity scoring system adapted to wearable monitoring: A pilot study. by Alice Lemarquand, Pierre Jannot, Léo Kammerlocher, Gaëlle Lissorgues, Michel Behr, Pierre-Jean Arnoux, Salah Boussen

“…Combined with new data processing methods, it constitutes a promising opportunity for telemonitoring, triage in mass casualty situations, or early diagnosis after a traffic or sport accident. …”
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Akord à rebours. O muzyce i „duchowej inteligencji” w filmie Interstellar Christophera Nolana by Katarzyna Lisiecka

“…Cassirer), responsible for shaping the ambience that constitutes an inherent structural part of the movie in the metaphysical cinema genre. …”
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THE ONTOGENESIS OF SPEECH DEVELOPMENT by T. E. Braudo, M. Yu. Bobylova, M. V. Kazakova

“…Speech is a higher mental function, which integrates many functional systems. …”
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Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance. by Jonathan D Hibshman, Anthony Hung, L Ryan Baugh

“…Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function in parallel to insulin-like signaling and nhr-49/Hnf4. …”
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Development of an acrylic emulsion paint added with cellulosic dispersion treated with an electron beam accelerator by Fernando Codelo Nascimento, Pedro Márcio Munhoz, Luiz Fernando Núbile Nascimento, Wilson Aparecido Parejo Calvo

“…Among other results obtained, improvements in appearance, applicability and functionality were significant.  It was concluded that this research constitutes an incremental improvement to the acrylic emulsion paints segment, and environmental sustainability, through the reuse of cellulosic tissue residues…”
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The NSL complex regulates housekeeping genes in Drosophila. by Kin Chung Lam, Friederike Mühlpfordt, Juan M Vaquerizas, Sunil Jayaramaiah Raja, Herbert Holz, Nicholas M Luscombe, Thomas Manke, Asifa Akhtar

“…Strikingly, the majority (85.5%) of NSL-bound genes are constitutively expressed across different cell types. …”
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Evolutionarily conserved herpesviral protein interaction networks. by Even Fossum, Caroline C Friedel, Seesandra V Rajagopala, Björn Titz, Armin Baiker, Armin Baiker, Tina Schmidt, Theo Kraus, Thorsten Stellberger, Christiane Rutenberg, Silpa Suthram, Sourav Bandyopadhyay, Dietlind Rose, Albrecht von Brunn, Mareike Uhlmann, Christine Zeretzke, Yu-An Dong, Hélène Boulet, Manfred Koegl, Susanne M Bailer, Ulrich Koszinowski, Trey Ideker, Peter Uetz, Ralf Zimmer, Jürgen Haas

“…Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. …”
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Optimal Sequencing Control of Variable-speed Air-source Heat Pumps in Office Building by Liu Zhaohui, Li Zhenyu, Tan Hongwei, Xu Wen, Feng Wenbo, Yi Biyi

“…When aiming to achieve energy efficiency, the vital factor is optimal operation of the chiller plants, which constitute a large percentage of the system energy consumption. …”
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Adipokines as Cardioprotective Factors: BAT Steps Up to the Plate by Keely McLeod, Victoria Datta, Scott Fuller

“…Adipose tissue (AT) has come to be regarded as a bona fide endocrine organ which secretes specific molecular entities constituting part of a complex web of inter-organ crosstalk that functions as a key determinant of whole-body metabolic phenotype. …”
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Evaluation of Thyroid Dysfunction in Type 2 DM in Duhok Governorate by Sefar Mohamad Al Haj, Bayar Ahmed Qasim

“…The patients were interviewed and examined, and their blood samples were taken for lipid profiles, Thyroid function tests, and at least 2 fasting blood sugars were checked. …”
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The concurrent ratcheting and stiffness degradation-based damage variable in SA508 steel samples undergoing stress cycles at room and elevated temperatures by M Karimi, A Varvani-Farahani

“…To address the accumulation of plastic strain at elevated temperatures, the dynamic strain aging phenomenon was introduced through an exponential function into the dynamic recovery term of the A-V model. …”
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From drivers to technology empowerment: Decoding the influencing factors of Yellow River tourists' pro-environmental behaviors by Dai Ruirui, Yue Guiling, Zhu He

“…The study identified six core influencing factors and constructed a theoretical model of “two-wheel drive” co-evolution, and the main findings are as follows: (1) Construct a five-dimensional tourism environmental behavior system (TEBS), in which individual intrinsic (psychological cognition and emotional connection), social context (group norms and cultural guidance), environmental design (spatial function and ecological perception), institutional policy (incentive and constraint and governance effectiveness), and special situation (crisis event and spatio-temporal limitation) constitute the basic dimensions; Special situations are included in the system as an independent dimension, which fully meets the needs of economic and social transformation in the new era. (2) Innovatively reveal the intermediary mechanism of technology empowerment: on the one hand, TEBS provides channels and space for technology empowerment through the construction of digital infrastructure and the expansion of intelligent technology application scenarios (thrust effect); On the other hand, the iterative upgrading of reverse driving technologies such as tourists' environmental behavior data feedback and intelligent management needs (pulling effect) has formed a closed-loop system of dynamic adaptation of “demand-supply”. …”
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