Immunomodulatory Effects Mediated by Serotonin by Rodrigo Arreola, Enrique Becerril-Villanueva, Carlos Cruz-Fuentes, Marco Antonio Velasco-Velázquez, María Eugenia Garcés-Alvarez, Gabriela Hurtado-Alvarado, Saray Quintero-Fabian, Lenin Pavón

“…Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT, such as SERT, 5HTR-GPCR, and the 5HT3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-HT metabolism, such as IDO and MAO, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines. …”
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Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling by Giuliana Giamundo, Daniela Intartaglia, Eugenio Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola, Dario Antonini, Paolo Grumati, Alessandra Eva, Rossella De Cegli, Ivan Conte

“…Our data identify a pivotal mechanism of endo-lysosomal signaling involving Ezrin and its associated EGFR/TSC complex, which are essential for retinal function.…”
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NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes by Mengqi Jiang, Xi Chen, Yuanxiu Song, Mingyu Wei, Jixiang Cao, Wenjing Lu, Feng Lan, Yun Bai, Ming Cui

“…Abstract Background Dilated cardiomyopathy (DCM) constitutes a major cause of heart failure, characterized by high mortality rates and a limited availability of effective therapeutic options. …”
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Signal sequences target enzymes and structural proteins to bacterial microcompartments and are critical for microcompartment formation by Elizabeth R. Johnson, Nolan W. Kennedy, Carolyn E. Mills, Shiqi Liang, Swetha Chandrasekar, Taylor M. Nichols, Grant A. Rybnicky, Danielle Tullman-Ercek

“…We characterized two novel Pdu signal sequences on the structural proteins PduM and PduB, which constitute the first report of metabolosome signal sequences on structural proteins rather than enzymes. …”
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Tracing an Archive: The Mackintosh Archive in Familial and Colonial Context by Onni Gust

“…In form and content, they provide the material evidence for the interconnectedness of social, familial, intellectual and political lives. They function both as fantasies and representations of belonging to a social network—a community—and a constitutive part of the consolidation of that network. …”
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The Greek Vision of America during the Greek War of Independence (1821-1830) by Konstantinos Diogos

“…Moreover, the American Declaration of Independence (1776) and the American Constitution of 1787 influenced the Greek political thought and the formation of the Greek revolutionary constitutions. …”
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Powłoki Wzmocnione Belkami by A. Borcz

“…It was necessary to establish conditions inside the shell on the basis of the stress functions and the elastic interaction of the stiffening beams constituting the boundary conditions. …”
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Reading the Background: The Textual and the Visual in Steve Tomasula’s The Book of Portraiture by Pawel Frelik

“…Instead, they constitute an important layer of the narrative, whose significance can only be glimpsed when the reader has re-focused their attention from the textual foreground to the visual background.…”
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Application of the Bipotential Theory to a Nonassociated Drucker–Prager Model by Yang-Jing Zhou, Zhi-Qiang Feng, Juan Antonio Rojas Quintero, Jian-Bo Zhou, Hui-Jian Chen

“…With a new description of the implicit flow rules, we propose dual constitutive cones as well as five forms of the bipotential function: the elastic stage in rate form, the plastic stage in rate form, the elastic stage in incremental form, the plastic stage in incremental form, and the elastoplastic stage in incremental form. …”
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An Analytical Solution of the Advection Dispersion Equation in a Bounded Domain and Its Application to Laboratory Experiments by M. Massabó, R. Cianci, O. Paladino

“…We study a uniform flow in a parallel plate geometry to model contaminant transport through a saturated porous medium in a semi-infinite domain in order to simulate an experimental apparatus mainly constituted by a chamber filled with a glass beads bed. …”
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Mechanical properties and damage model of alkali activated polymer solidified soil containing coal gangue powder by Yang Yang, Shengsheng Yu, Aiping Hu, Yanbing Cao, Yangfei Bai

“…By integrating Lemaitre’s strain equivalence principle with a composite power function, a damage constitutive model was derived. …”
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On modelling of the one dimensional pseudoelastic effect of shape memory alloys by Zidane Imade, Meddour Belkacem

“…To exploit these properties in engineering, several constitutive models of were developed. The aim of this work is to build a constitutive model that could describe the pseudoelastic behaviour of shape memory alloys in a simpler and more accurate way. …”
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Why should we be concerned by internalised racism in global health? by Ferdinand C Mukumbang, Shiva R Mishra, Bipin Adhikari, Chanaki Amaratunga

“…Internalised racism constitutes an adoption of beliefs about one’s inferiority, weaknesses or shortcomings as a function of racial hierarchy affecting one’s identity and self-worth, thoughts, emotions and behaviours. …”
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Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes. by Thomas B Thornley, Krishna A Agarwal, Periklis Kyriazis, Lingzhi Ma, Vaja Chipashvili, Jonathan E Aker, Sarantis Korniotis, Eva Csizmadia, Terry B Strom, Maria Koulmanda

“…The immunoregulatory phenotype and function of IRMs is compromised by TLR4 activation in vitro. …”
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Application of «wide awake» аnesthesia for improvement of results of a tendon–muscular transposition on the hand by А. А. Bezugliy, М. P. Оberemok, S. V. Tymoshenko, А. S. Lysak

“…High efficacy of a «wide awake» аnesthesia in nonvolume function–creating interventions, performed with addition of sliding and active structures and necessitating close intraoperative cooperation with the patient, was proved.…”
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B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome by Haiyan Xu, Xiaozhou He, Renfang Xu

“…The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. …”
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Case Report: long-term misdiagnosis and follow-up of a patient with HNF4A-MODY carrying a new de novo mutation by Jing Luo, Jing Luo, Ai Li, Ai Li, Xiaoli Wang

“…BackgroundHNF4A-MODY constitutes 5%–10% of MODY cases; however, treatment options remain unclearly recommended, and long-term follow-up of patients with HNF4A-MODY is lacking due to limited research. …”
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Parboiled Rice and Glycemic Control: Effects on Postprandial Glucose, Insulin Sensitivity, and Incretin Response in Healthy and Type 2 Diabetic Individuals, a Pilot Study by Sara Alkandari, Tasleem A. Zafar, Suleiman Al-Sabah, Mohammed Abu Farha, Jehad Abubaker, Fahd Al-Mulla

“…Nevertheless, the impact of PBR consumption on insulin sensitivity, β-cell function, and incretin hormone responses remains poorly understood. …”
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Glycine rich proteins of ticks: more than a cement component by Renata Perotto de Souza, Mariana Vieira Dalla Valentina, Bruna Ferreira Leal, Sílvia Dias Oliveira, Carlos Alexandre Sanchez Ferreira, Ala Tabor

“…Glycine-rich proteins (GRPs) are arbitrarily defined as those containing 20% or more glycine residues and constitute a superfamily divided into subfamilies based on their structure and/or function. …”
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Miniinvasive vascular interventions as an alternative surgical method for treatment of the patients, suffering hepatic cirrhosis and portal hypertension by О. F. Dzygal, І. М. Deykalo

“…The decompression operations for portal system in patients with HC prevent the esophago-gastric hemorrhage occurrence in late period of follow-up and guarantee good survival of the patients, suffering compensated and subcompensated hepatic function.…”
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