Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy. by Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James P Ennen, Jennifer Bosco, Zhiwei Zhou, Guo-Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura

“…Here, we showed that while constitutive deletion of Flt1 is detrimental to the skeletal muscle function, endothelial cell-specific Flt1 deletion resulted in increased vascular density, increased satellite cell number and improvement in the DMD-associated phenotype in the mdx mice. …”
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The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation by Juliane Lehmann, Hui Lin, Zihao Zhang, Maren Wiermann, Albert M. Ricken, Franziska Brinkmann, Jana Brendler, Christian Ullmann, Luisa Bayer, Sandra Berndt, Anja Penk, Nadine Winkler, Franz Wolfgang Hirsch, Thomas Fuhs, Josef Käs, Peng Xiao, Torsten Schöneberg, Martina Rauner, Jin-Peng Sun, Ines Liebscher

“…In this study, we explore the impact of GPR133/ADGRD1 on osteoblast differentiation and function. Constitutive and osteoblast-specific knockouts of Gpr133/Adgrd1 in mice lead to reduced cortical bone mass and trabecularization in the femurs and vertebrae — features characteristic of osteoporosis. …”
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A metabolically engineered bacterium controls autoimmunity and inflammation by remodeling the pro-inflammatory microenvironment by Jugal Kishore Das, Fengguang Guo, Carrie Hunt, Shelby Steinmeyer, Julia A Plocica, Koichi S. Kobayashi, Yufang Ding, Arul Jayaraman, Thomas A Ficht, Robert C. Alaniz, Paul de Figueiredo, Jianxun Song

“…These findings show how a metabolically engineered bacterium can constitute a powerful vehicle for improving the efficacy of immunotherapy, defeating autoimmunity, and reducing inflammation by remodeling the IME and augmenting Treg cell function.…”
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Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids by Gašper Šolinc, Marija Srnko, Franci Merzel, Ana Crnković, Mirijam Kozorog, Marjetka Podobnik, Gregor Anderluh

“…Abstract The structure and function of membrane proteins depend on their interactions with lipids that constitute membranes. …”
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Affordable Condominium Housing by Rosa Elena Donoso Gomez

“…In Ostrom’s words: Colombia has embedded a collective choice-rule in a constitutional one. This concerns a clear and unambiguous anchoring of the body most important to how a homeowner’s association functions. …”
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A dynamic entanglement model for adaptive networks in amorphous polymers with pH-responsive dual-shape memory effect by Jiabin Shi, Haibao Lu, Tengfei Zheng, Yong-Qing Fu

“…However, there are few constitutive models developed to explore the working principles behind these complex shape memory behaviors. …”
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Diabetic cardiomyopathy: merely a complication or a distinct understudied disease? by B. U. Mardanov, M. N. Mamedov

“…At the same time, ongoing studies increasingly reveal characteristic disorders of heart function with pathophysiological features, suggesting that DCM may constitute a separate condition occurring within the diabetic context. …”
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Der moderne Zuschauer: Genealogie und Kritik by Francesco Fiorentino

“…Yet the stage remains an agent of governmentality even as it seeks to evade this function. This is a paradox that is perhaps constitutive and necessary to theater. …”
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Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke by Johanna Ruhnau, Juliane Schulze, Alexander Dressel, Antje Vogelgesang

“…Furthermore, intact neutrophil function is essential for maintaining immunological defense against bacterial infections. …”
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REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA by Giovanni D'arena, Giovanni Rossi, Barbara Vannata, Silvia Deaglio

“…Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in either cancer and autoimmune disorders. …”
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Analysis of Shear Flexible Layered Isotropic and Composite Shells by ‘EPSA’ by Pawel Woelke, Ka-Kin Chan, Raymond Daddazio, Najib Abboud, George Z. Voyiadjis

“…In the case of isotropic shells, the transverse shear stresses are distributed parabolically, based on the assumption of linear normal strain distribution through the thickness and on application of the quadratic shape function to transverse shear strains. The transverse shear stresses are included in the elastic-perfectly plastic yield function of the Huber-Mises-Hencky type.…”
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Hepatoses in highly productive cows, their treatment and prevention by Smolentsev Sergey, Onuchina Maria, Nikolaeva Zhanna, Goncharov Nikita, Gracheva Olga, Gasanov Alizade, Mukhutdinova Dina, Zukhrabova Zulfiyat, Karpova Natalia, Asrutdinova Rezilya

“…Ketone bodies in the urine of first-born heifers on the first day after calving constitute an indicator within the normal range, but by the 30th day after calving in sick animals, the reaction to ketone bodies is 8 times higher than normal. …”
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Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. by Roel Quintens, Sarvjeet Singh, Katleen Lemaire, Katrien De Bock, Mikaela Granvik, Anica Schraenen, Irene Olga Cornelia Maria Vroegrijk, Veronica Costa, Pieter Van Noten, Dennis Lambrechts, Stefan Lehnert, Leentje Van Lommel, Lieven Thorrez, Geoffroy De Faudeur, Johannes Anthonius Romijn, John Michael Shelton, Luca Scorrano, Henri Roger Lijnen, Peter Jacobus Voshol, Peter Carmeliet, Pradeep Puthenveetil Abraham Mammen, Frans Schuit

“…This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. …”
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Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. by Emily B Cohen, Susan J Jun, Zachary Bears, Francisco N Barrera, Miriam Alonso, Donald M Engelman, Daniel DiMaio

“…Transmembrane proteins constitute a large fraction of cellular proteins, and specific interactions involving membrane-spanning protein segments play an important role in protein oligomerization, folding, and function. …”
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Pangenome-scale annotation of mycobacteriophages for dissecting phage–host interactions based on a sequence clustering and structural homology analysis strategy by Xiao Guo, Zheng-Guo He

“…This study addresses a substantial gap in the current knowledge of the potential function of phage proteins and provides key insights into the interactions between mycobacteriophages and their hosts.IMPORTANCEMycobacteriophages constitute the largest group of phages with sequenced genomes. …”
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Results of the valve-preserving operations in the patients, suffering aortal dissection Type A by V. I. Kravchenko, I. M. Kravchenko, O. O. Lohvinenko, V. V. Lazoryshynets

“…Resuspension of aortal valve constitutes an effective method of its function restoration in patients, suffering aortal dissection Type A and aortal insufficiency from moderate to severe. …”
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Unveiling microbial dynamics: a review of health and immune enhancement in school settings by Philip Asumang, Richard Ntumi, Francis Dwomoh

“…This review focuses on the role of microorganisms in promoting health and immune function within school environments. Microbes, including bacteria, viruses, fungi, and other microorganisms, constitute the human microbiome and play a crucial role in various bodily functions and immune system development. …”
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Cell surface receptors for signal transduction and ligand transport: a design principles study. by Harish Shankaran, Haluk Resat, H Steven Wiley

“…Receptors constitute the interface of cells to their external environment. …”
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Ecolinguistics: A paradigm shift by Alexander V. Kravchenko

“…Confined to the methodologically erroneous and theoretically untenable framework based on the code model of language and communication, linguistics of the mainstream persists in viewing language as a cultural tool in the service of the mind rather than a biologically and ecologically functional feature of humans as a species. Reification of language precludes any productive theorizing about its nature and function, and the biological function of language and its role in the evolution of our species is ignored. …”
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Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson’s Disease by Ahmed Tanvir, Junghyun Jo, Sang Myun Park

“…Glucose metabolism is essential for the maintenance and function of the central nervous system. Although the brain constitutes only 2% of the body weight, it consumes approximately 20% of the body’s total energy, predominantly derived from glucose. …”
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