Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. by Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T F Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J Gilson, Mala K Maini

“…NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. …”
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CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models by Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon, Marco Di Duca, Sara Guerrisi, Francesca Antonini, Yeraldin Chiquinquira Castillo De Spelorzi, Lorenzo A. Cingolani, Federico Zara, Paolo Scudieri

“…The F1491S mutation, which is located in a constitutive domain of the channel and therefore causes a complete loss-of-function, impaired neural induction at very early stages, as demonstrated by changes in single-cell transcriptomic signatures of neural progenitors, and by defective polarization of neurons. …”
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Loss of OprD function is sufficient for carbapenem-resistance-only but insufficient for multidrug resistance in Pseudomonas aeruginosa by Maofeng Wang, Yuxiao Zhang, Fengyan Pei, Ying Liu, Yan Zheng

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Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity by Bilal Tulumcu, Richard Ivell, Waleed Alhujaili, Ravinder Anand-Ivell

“…These undergo proliferation and differentiation during puberty to achieve their final adult status in young adulthood, after which there appears to be no further cell division and only very limited attrition into old age. Leydig-cell functional capacity reflects the total number and differentiation status of the Leydig-cell population within an individual and can be assessed by measuring in blood the constitutive Leydig-cell hormone insulin-like peptide 3 (INSL3). …”
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Inhibition of Macrophage Functions by the C-Terminus of Murine S100A9 Is Dependent on B-1 Cells by Rosana Lima Pagano, Natassja Foizer Moraes, Beatriz Helena De Lorenzo, Sandra Coccuzzo Sampaio, Mario Mariano, Renata Giorgi

“…Murine peritoneal cells are constituted by macrophages and B-1 cells, and the latter exert an inhibitory effect on macrophage functions by secreting interleukin- (IL-) 10. …”
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The spatiotemporal evolution of green development in western China under the main functional planning of national land space by Yubin Ma, Xiaoling Yuan, Haotian Chen, Xing Zhang, Yue Li, Hang Yin, Zhengda Li

“…A comprehensive and precise assessment of green development levels in China’s western region, guided by the main functions of national land space strategy, constitutes a fundamental prerequisite for reliably identifying key determinants of green development and systematically exploring viable pathways for its optimization. …”
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Functional characterization of SIZ1 homologs reveals reduced TSWV susceptibility of mutant Nicotiana benthamiana lines by Jelli Venkatesh, Seo-Young Lee, Ghimire Sunita, Jin-Kyung Kwon, Joung-Ho Lee, Byoung-Cheorl Kang

“…Despite considerable research efforts, the specific function of SIZ1 in plants remains largely unknown. …”
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Soil humus-reducing bacteria in the Xisha islands, South China sea: unveiling diversity and predicting functions by Xiao Deng, Saba Najeeb, Kun Liu, Huadong Tan, Yi Li, Chunyuan Wu, Yi Zhang

“…Tropical reef islands, constituting unique ecosystems, possess distinct soil properties. …”
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Decoding the GRAS code: evolutionary phylogeny and functional diversification of a key gene family in Populus simonii by Junbo Chen, Guowei Yao, Xinru Bi, Yishuang Ren, Luping Jiang, Xiaoyu Xie, Lu Han, Wanying Chen, Yi Hao, Kewei Cai, Dandan Zhang, Xiyang Zhao

“…Abstract Background GRAS proteins constitute a plant-specific family of transcription factors involved in growth, development, and stress responses. …”
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Transcriptional dynamics and functions of WUSCHEL-related homeobox (WOX) genes from Ginkgo biloba in tissue culture by Wei Xu, Ang Xu, Pingjun Xu, Jiaqi Li, Chao Luo, Xiaoming Yang, Meiling Ming, Yuhua Liu, Guibin Wang, Liangjiao Xue, Fuliang Cao, Gaiping Wang, Fangfang Fu

“…However, the specific functions of WOX genes in the regeneration processes of gymnosperms had not been previously elucidated. …”
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Prevalence of renal dysfunction and its influence on functional capacity in elderly patients with stable chronic heart failure by Stanojević Dragana, Apostolović Svetlana, Janković-Tomašević Ružica, Šalinger-Martinović Sonja, Pavlović Milan, Živković Milan, Božinović Nenad, Kutlešić-Kurtović Dušanka

“…Chronic heart failure (CHF) is highly prevalent and constitutes an important public health problem around the world. …”
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IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model by Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Fernanda Degobbi Tenorio Quirino dos Santos Lopes

“…Administration of the IL-17-neutralizing antibody reversed these structural and functional alterations. Additionally, the COPD group exhibited an inflammatory response characterized by increased infiltration of polymorphonuclear and mononuclear cells and elevated numbers of IL-17- and IL-6-positive cells. …”
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Dynamics of characteristics of respiratory function for the development of coronary heart disease in patients with chronic obstructive lung disease by D. A. Vishnyak, M. A. Popova

“…During the five-year period in patients with isolated COPD (n=116) progression of violations of volume and speed indicators of external respiration function was registered. It should be noted that the course of COPD in this sample of patients was associated with a predominant decrease in restrictive indicators, manifested in the form of a decrease in the reserve volume of exhalation (RVE) by 20,6% (p=0,004) in patients with COPD, constituting a risk group for the development of coronary catastrophes, there was no significant dynamics of parameters of respiratory function for five years (p >0,05). …”
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Optimizing uni-compartmental knee arthroplasty: the impact of preoperative planning and arithmetic hip-knee-ankle angle by Changquan Liu, Cheng Huang, Xin Suyalatu, Qidong Zhang, Yiling Zhang, Wei Sun, Wanshou Guo, Weiguo Wang

“…Results The proportion of the constitutional alignment group in the planning group was higher than that in the conventional group (86% vs. 66%) (p = 0.033). …”
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Correlating crystallographic texture with anisotropic properties and sheet metal forming of aluminium alloys by Olaf Engler

“…Rather, the materials parameters needed to calibrate the yield function are derived in a pragmatic and computationally efficient approach with VPSC simulations from texture. …”
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Evaluation of the physical function and quality of life of elderly people with femoral neck fracture one year after the injury by Alireza Memar Bashi, Elaheh Mianehsaz, Babak Haghpanah, Seyed Mohammad Reza Tabatabaei, Mohammad Javad Azadchehr, Khadijeh Kalan Farmanfarma

“…Nearly 60% of patients received the maximum QOL score and function score. According to the results of the multiple linear regression analysis, the average level of physical functions decreased significantly with an increase in patients’ age, and patients who had undergone physiotherapy had a significantly higher average level of function than those who had not undergone physiotherapy. …”
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The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis by Jia X, Li X, Miao L, Bao R, Xiong H, You R, Lu Y, Gui X, Qu C

“…The receiver operating characteristic curve showed that a model based on the absolute lymphocyte count (435 cells/μL) and naïve CD4+ T cell percentage (20.25%) performed best in predicting sepsis prognosis.Conclusion: Monitoring of absolute lymphocyte count and analysis of T cell subtypes in the early phase of sepsis is predictive of outcome and may help identify those patients who would benefit from immunotherapy, improving survival.Keywords: sepsis, absolute lymphocyte count, T cell subpopulations, immune function…”
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Deformation characteristics and damage model of T-shaped fractured rock mass with different inclination angles by Miao Sun, Shaoqing Niu, Jinwen Wu

“…Damage constitutive equations for T-shaped cracked rocks were constructed based on different models in this study. …”
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Structure-based modeling of artificial leather used in sports with non-symmetric fiber distribution by Tonghuan QU, Akihiro MATSUDA

“…Therefore, we propose a novel anisotropic hyperelasticity constitutive model which describes the mechanical behavior of fiber-reinforced material by using a generalized structure tensor in the form of separated in-plane and out-of-plane fiber distribution and by applying the sine-skewed von Mises distribution function as the in-plane fiber distribution function. …”
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Seismic performance of multistory frames with novel self-centering friction SMA dampers by Weihong Li, Zhaoqun Chang, Meng Han, Jinyuan Li, Qinkai Jin, Boquan Liu

“…In this study, an improved SMA multi-linear constitutive model is proposed first, and a new material model based on OpenSees platform is developed. …”
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