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  1. 401
  2. 402

    Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways. by Kirill E Medvedev, Lisa N Kinch, R Dustin Schaeffer, Nick V Grishin

    Published 2019-12-01
    “…Rossmann folds are ancient, frequently diverged domains found in many biological reaction pathways where they have adapted for different functions. Consequently, discernment and classification of their homologous relations and function can be complicated. …”
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  3. 403

    Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro by H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén

    Published 2025-06-01
    “…., gapmers), while SSOs alter transcript splicing to restore or inhibit protein function. RNA interference (RNAi) is another approach to down-regulate gene expression via the RISC complex. …”
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    Article
  4. 404

    Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function by Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend

    Published 2025-05-01
    “…This study, therefore, highlights the potential of identifying functional domains in noncoding RNAs. Delivery, or targeting of RNA domains might constitute next‐generation RNA therapeutics.…”
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    Article
  5. 405
  6. 406

    Exploring the potential effect of electroacupuncture on cardiovascular function and lipid profiles in spontaneously hypertensive rats by Hye-Yoom Kim, Sarah Shin, Jung-Joo Yoon, You-Mee Ahn, Ji-Hye Song, Da-Som Lee, Ji-Yeun Park, Ho-Sub Lee, Jeeyoun Jung

    Published 2024-06-01
    “…Background: Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. …”
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    Article
  7. 407

    Effective least squares approximation method for estimating the rhythm function of cyclic random process by Serhii Lupenko, Małgorzata Wiatr, Andrzej Metelski

    Published 2025-02-01
    “…The general problem of least squares approximation of the rhythm function of a cyclic random process is formulated as a problem of optimal selection of a parametric function derived from a predetermined class of functions that satisfy the necessary and sufficient conditions of the rhythm function of a cyclic random process. …”
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  8. 408

    Functional model of road safety for motor transport enterprise with account of high environmental temperatures by I. N. Yakunin, A. P. Fot, N. N. Yakunin, A. F. Fattakhova

    Published 2022-05-01
    “…In this regard, the study of the features of the functioning of a motor transport enterprise in conditions of high ambient temperatures and the development on this basis of a functional model for ensuring road safety is an urgent task.The purpose of this work is to improve the safety of road transport on the basis of the development of a functional structure of the road safety service of a motor transport enterprise, taking into account the high ambient temperature.Methods. …”
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  9. 409
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    Evaluation of the renal function among sickle cell patients: a cross-sectional study by Talal Qadah, Anwar Refaei

    Published 2025-03-01
    “… This cross-sectional study aimed to explore the implications and effects of hematological and kidney function patterns in individuals with sickle cell disorder (SCD) residing in the Jazan Region of Saudi Arabia. …”
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  11. 411

    Long term effects of physical activity types on executive functions in school aged children by Ye Tao, Yunong Zhang, Haonan Qian, Ziyi Cao

    Published 2025-08-01
    “…Executive functions were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB), including measures of working memory, cognitive flexibility, and inhibitory control; motor competence was evaluated through a comprehensive assessment using Movement ABC-2 (assessing fine motor control), Bruininks-Oseretsky Test-2 (assessing gross motor skills), and KTK test (assessing coordination abilities), constituting a comprehensive motor development index system. …”
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  12. 412

    Functional analysis of NtPDX2 in Nicotiana tabacum L. associated with stem development by Li Xu, Yuxin Cui, Jiaxin Xing, Qili Mi, Zhixing Wang, Xujing Wang, Wanli Zeng, Haiying Xiang, Jiarui Jiang, Lele Deng, Kunmiao Wang, Jiangtao Yang, Qian Gao

    Published 2025-04-01
    “…To date, although the molecular functions of genes involved in vitamin B6 biosynthesis, including Pdx1, Pdx2, Pdx3, and Sos4, have been reported in various plants, no studies have yet explored the functions of NtPDX1 and NtPDX2 in tobacco. …”
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    Study on the Damage Behavior of Engineered Cementitious Composites: Experiment, Theory, and Numerical Implementation by Tingting Ding, Zhuo Wang, Yang Liu, Xinlong Wang, Tingxin Sun, Shengyou Yang

    Published 2024-12-01
    “…This study rigorously addresses this gap by initially investigating the uniaxial tensile and compressive behavior of ECCs through experiments and establishing a one-dimensional constitutive relationship of ECCs. It then introduces the concepts of damage energy release rate and energy equivalent strain, and constructs a three-dimensional constitutive model of ECCs by introducing the damage variable function. …”
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  16. 416

    CAR: Discovery and development by the pharmacogenetics laboratory at NIEHS, NIH by Tatsuya Sueyoshi, Masahiko Negishi

    Published 2025-09-01
    “…Within a few years, we revealed that the nuclear receptor CAR, constitutive active/androstane receptor, is the key molecule in these mechanisms. …”
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  17. 417

    Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. by Christoph Schell, Oliver Kretz, Andreas Bregenzer, Manuel Rogg, Martin Helmstädter, Ulrike Lisewski, Michael Gotthardt, Pierre-Louis Tharaux, Tobias B Huber, Florian Grahammer

    Published 2015-01-01
    “…The coxsackie- and adenovirus receptor (CXADR) is a member of the immunoglobulin protein superfamily, present in various epithelial cells including glomerular epithelial cells. Beside its known function as a virus receptor, it also constitutes an integral part of cell-junctions. …”
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  18. 418

    Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function by Patricia Castro-Sánchez, Rocio Ramirez-Munoz, Pedro Roda-Navarro

    Published 2017-01-01
    “…Phosphotyrosine phosphatases (PTPs) constitute a complex family of enzymes that control the balance of intracellular phosphorylation levels to allow cell responses while avoiding the development of diseases. …”
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  19. 419

    The Effect of Temperature Dependency on the Thermo-Electro-Elastic Analysis of Functionally Graded Piezoelectric Spherical Shell by Mohammad Arefi, Masoud Takhayor Ardestani

    Published 2019-04-01
    “…Results of electro-thermo-elastic analysis of a functionally graded thick-walled spherical shell made of temperature dependent materials are presented in this article. …”
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  20. 420

    A Hermeneutic Approach to Necip Fazıl’s “Mirrors Cut My Way” and Functions of Poetry Language by Hilal Akça

    Published 2021-06-01
    “…The functions of the language of poetry will be made visible by illustrating how Necip Fazıl’s “quest” metaphor, which constitutes the main axis of the art of poetry, supports a structure that is suitable for multiple meanings with its religious, philosophical, psychological, historical, mystical, and metaphysical layers.…”
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