EVALUATION OF THE EFFECTIVENESS OF BIOFEEDBACK TECHNOLOGY FOR LOCOMOTIVE CREW WORKERS by Ирина Алексеевна Несина, Ольга Андреевна Джафарова, Елена Леонидовна Потеряева, Елена Леонидовна Смирнова, Тамара Викторовна Кулишова

“…Employees of locomotive crews of mainline traffic constitute a professional group directly ensuring the safety of the transportation process. …”
Get full text

Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. by Wei Guo, Shuhong Wu, Li Wang, Xiaoli Wei, Xiaoying Liu, Ji Wang, Zhimin Lu, Melinda Hollingshead, Bingliang Fang

“…Blocking JNK activation or overexpression of constitutively active STAT3 partially blocked NSC-743380-induced antitumor activity.…”
Get full text

Challenges in Exercising the Right to Appeal – The Case of Slovenian Administrative Consultation by Polonca Kovač

“…Findings: Administrative appeal serves multiple functions, from protecting the rights of the parties to ensuring consistent sector-specific legislation implementation. …”
Get full text

Linguistic and translational features of the international vocabulary of military subject by L. R. Vartanova, Yu. V. Ryndina

“…Covering the problems of translation of internationalisms and «translator’s false friends» allow us to reveal the peculiarities of their functioning in the texts on military topics and to determine the ways of their translation.   …”
Get full text

Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron by Yingwei Li, Zhongshao Chen, Huimin Xiao, Yanling Liu, Chen Zhao, Ning Yang, Cunzhong Yuan, Shi Yan, Peng Li

“…Furthermore, our findings indicate that high SNRPB expression is correlated with poor prognosis in patients with endometrial cancer. Functionally, SNRPB inhibition hindered the proliferative and metastatic capacities of endometrial cancer cells. …”
Get full text

COMPETENCE OF LOCAL SELF-GOVERNMENTS: DEBATABLE ISSUES by Y. Blagov

“…Certain transferred state powers should not prevail over the powers related to the solution of issues of local importance and determine the functional purpose of local self-government bodies as such. …”
Get full text

Crossover operators for molecular graphs with an application to virtual drug screening by Nico Domschke, Bruno J. Schmidt, Thomas Gatter, Richard Golnik, Paul Eisenhuth, Fabian Liessmann, Jens Meiler, Peter F. Stadler

“…Abstract Genetic algorithms are a powerful method to solve optimization problems with complex cost functions over vast search spaces that rely in particular on recombining parts of previous solutions. …”
Get full text

A durability- based design approach for structural applications with advanced cement-based materials by Francesco Soave, Liberato Ferrara

“…This material concept, which is based on enhanced durability in the cracked state and self-healing functionalities, can lead to new design paradigms both from the mechanical and durability point of view. …”
Get full text

Research Design and Approach by Alexander Wandl

“…Which morphological and functional structures of dispersed urban areas offer the potential for more sustainable development? …”
Get full text

Genome-Wide Identification and Expression Analysis of <i>UBP</i> Genes in Peppers (<i>Capsicum annuum</i> L.) by Xuerui Chang, Tiantian Wang, Jiaxin Huang, Jia Xu, Yangyang Ruan, Yanping Liang, Jing Wang

“…The ubiquitin-specific protease (<i>UBP</i>) family constitutes the largest group within the deubiquitinating enzymes (DUBs) and plays a crucial role in regulating the cell cycle, growth, and developmental processes in living organisms. …”
Get full text

The Model of Fundamental Chemical Training of Bachelors of Technical and Technological Directions in the Conditions of Blended Learning by N. M. Vostrikova

“…The concept and the structural-functional model of the fundamental chemical training of bachelors in the information-and-activity-based educational environment of blended learning have been proposed. …”
Get full text

FROM STATE TO PUBLIC ADMINISTRATION: AN ANALYSIS OF MANAGERIAL TRAINING IN HIGHER EDUCATION SYSTEM OF UKRAINE by S. Andreiev, S. Geraskov, R. Dymenko, A. Kostrubitska, O. Lukianov

“…Lack of the statist component in training of specialists on specialty «Public Administration» will lead to misunderstanding by future managers of essence of institution in a sovereign state, as well as nature of «State Administration», its social impact, functions and role in regulating social development and economic processes, in particular ensuring safety of population. …”
Get full text

Prospective development of legal education in the field of health care as a guarantee of medical reform implementation in Ukraine by M. A. Anishchenko

“…Materials and methods: normative-legal base of Ukraine, method of analysis, method of synthesis, comparative-legal and structural-functional methods. Results. The need for further development of legal education for healthcare workers stems from a detailed analysis of the regulatory and legal acts of Ukraine regulating medical and pharmaceutical activities, in particular, the Constitution of Ukraine, the Criminal Code of Ukraine, the Code of Ukraine on Administrative Offenses, the Laws of Ukraine “Fundamentals of the Legislation of Ukraine on Health Care”, “On State Financial Guarantees of Medical Care of the Population”, “On Amendments to Certain Legislative Acts of Ukraine regarding the improvement of legislation on the activities of health care institutions”, “On the prevention of corruption”, the decree of the Cabinet of Ministers of Ukraine “On approval of the competition for the position of head of state, municipal health care institutions”, order of the Ministry of Health of Ukraine from 31.10.2018 № 1977 “On Amendments to the Handbook of qualification characteristics of workers occupations”. …”
Get full text

رجسٹریشن نکاح کی شرعی حیثیت اور متعلقہ عدالتی فیصلے by Shahana Tabassum, Saeed ur Rahman

“…The performing of the “Nikah”, in the presence of  two witnesses by the acceptance of an adult male and its confirmation by an adult female went on functional admittedly  with no dispute in it in all schools of  Fiqah (Islamic jurisprudence). …”
Get full text

Standardizing free-text data exemplified by two fields from the Immune Epitope Database by Sebastian Duesing, Jason Bennett, James A. Overton, Randi Vita, Bjoern Peters

“…Abstract Background While unstructured data, such as free text, constitutes a large amount of publicly available biomedical data, it is underutilized in automated analyses due to the difficulty of extracting meaning from it. …”
Get full text

Agricultural mechanization perspective in Pakistan: present challenges and digital future by Gohar Gulshan Mahmood, Sandro Liberatori, Fabrizio Mazzetto

“… Agriculture constitutes a critical sector within the economic landscape of Pakistan, engaging 37.4% of the labour force and contributing 22.9% to the Gross Domestic Product (GDP), thus functioning as an essential element of the country's economic architecture and the sustenance of its citizens. …”
Get full text

Metastatic Spinal Lesion with Minimal Epidural Compression: Surgical Treatment or Stereotactic Radiotherapy? by O. I. Kit, D. E. Zakondyrin, A. A. Grin, E. E. Rostorguev, Y. V. Przhedetskiy, P. G. Sakun, V. I. Voshedskii, B. V. Matevosian, T. S. Shepelya

“…+Аd.SBRT group showed an improvement in the functional status and a significantly more pronounced regression of the pain syndrome in the patients of the SBRT group, which can be explained by direct decompression of the compressed spinal root and elimination of increasing instability of the spinal column. …”
Get full text

Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target. by Sylvaine You, Lynn Poulton, Steve Cobbold, Chih-Pin Liu, Michael Rosenzweig, Douglas Ringler, Wen-Hui Lee, Berta Segovia, Jean-François Bach, Herman Waldmann, Lucienne Chatenoud

“…This activity was not due to a decline in the numbers or functional capacity of CD4(+)CD25(+)Foxp3(+) Tregs but rather to a major activation of 'diabetogenic' T cells. …”
Get full text

STRATEGIC DIRECTIONS FOR INNOVATIVE DEVELOPMENT OF ENTERPRISE FINANCIAL-ECONOMIC SECURITY SYSTEMS BASED ON DIGITAL TECHNOLOGIES by Олександр Правдивець, Наталія Літвін, Олег Денисов, Олександр Поліщук, Віталій Олійник

“…The intensification of directions for innovative development changes over time and depends on the current conditions of the enterprise's functioning. Digital technologies have transformed the situation, but the problem is whether they remain relevant over a prolonged period. …”
Get full text

IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells by Ameera M. Bukhari, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Katherine L. Knight

“…Functionally, GALT IgM+IgD− cells spontaneously secrete IgM, and class-switch to IgA in response to both T-dependent and T-independent stimulation ex-vivo. …”
Get full text