Divergent altitudinal patterns of arbuscular and ectomycorrhizal fungal communities in a mid-subtropical mountain ecosystem by Taotao Wei, Huiguang Zhang, Shunfen Wang, Chunping Wu, Tieyao Tu, Yonglong Wang, Xin Qian

“…These findings provide critical insights into the ecological functions and environmental adaptations of mycorrhizal fungi, advancing our understanding of their responses to environmental changes in mountain ecosystems and informing evidence-based conservation strategies.…”
Get full text

Conception de l’artefact, conception du collectif : dynamique d’un processus de conception ouvert et continu dans une communauté de développement de logiciels libres by Flore Barcellini

“…Elicitation of needs and valorization of the new functionality take place in the use-oriented mailing-list, refinements of the functionality specifications take place in the design-oriented mailing list, whereas proper specifications take place in parallel in the two mailing-lists. …”
Get full text

MiR-200c synergizes with trastuzumab-loaded gold nanoparticles to overcome resistance in ovarian cancer cells by Tommaso A. Salamone, Sofia Marotta, Stella Mrmić, Salvatore Raffa, Sara Cerra, Beatrice Pennacchi, Martina Mercurio, Vincenzo Visco, Maurizio Alimandi, Maria Rosaria Ricciardi, Maurizio Taurino, Ilaria Fratoddi, Pankaj Trivedi, Eleni Anastasiadou

“…Abstract Background Trastuzumab (TZ) resistance remains a significant challenge in the treatment of human epidermal growth factor receptor 2 (HER2)-positive epithelial ovarian cancer (EOC), necessitating novel therapeutic strategies to improve treatment efficacy. Functionalized gold nanoparticles (AuNPs) constitute a promising platform for drug delivery and the ability to enhance tumor targeting via the enhanced permeability and retention (EPR) effect. miR-200c, a well-established tumor suppressor microRNA (miRNA), plays a crucial role in inhibiting epithelial-mesenchymal transition (EMT). …”
Get full text

Cancer stem cells: landscape, challenges and emerging therapeutic innovations by Haksoo Lee, Byeongsoo Kim, Junhyeong Park, Sujin Park, Gaeun Yoo, Soomin Yum, Wooseok Kang, Jae-Myung Lee, HyeSook Youn, BuHyun Youn

“…Abstract Cancer stem cells (CSCs) constitute a highly plastic and therapy-resistant cell subpopulation within tumors that drives tumor initiation, progression, metastasis, and relapse. …”
Get full text

Microencapsulation of bioactive volatile compounds from MD2 pineapple peel Extract using spray-drying and foam-mat drying by Nur Liyana Nordin, Jamilah Bakar, Noranizan Mohd Adzahan, Ahmad Faizal Abdull Razis, Norsharina Ismail, Rabiha Sulaiman

“…Pineapple peel extracts constitute bioactive compounds that degrade due to light, oxidation, and moisture. …”
Get full text

Surface Integrity of Austenitic Manganese Alloys Hard Layers after Cavitation Erosion by Ion Mitelea, Ilare Bordeașu, Daniel Mutașcu, Corneliu Marius Crăciunescu, Ion Dragoș Uțu

“…Cavitation erosion, as a mechanical effect of destruction, constitutes a complex and critical problem that affects the safety and efficiency of the functioning of engineering components specific to many fields of work, the most well-known being propellers of ships and maritime and river vessels, seawater desalination systems, offshore oil and gas drilling platforms (including drilling and processing equipment), and the rotors and blades of hydraulic machines. …”
Get full text

Anti-Inflammatory Cytokine Interleukin-4 Inhibits Inducible Nitric Oxide Synthase Gene Expression in the Mouse Macrophage Cell Line RAW264.7 through the Repression of Octamer-Depen... by Miki Hiroi, Yoshiichi Sakaeda, Hana Yamaguchi, Yoshihiro Ohmori

“…These results suggest that a coactivator/cofactor that functionally interacts with Oct-1 is a molecular target for the IL-4-mediated inhibition of Nos2 and that IL-4-activated Stat6 represses Oct-1-dependent transcription by competing with this coactivator/cofactor.…”
Get full text

The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Introduction: Acute subdural hematoma (ASDH) due to traumatic brain injury (TBI) constitutes an increasing global health problem, especially in the elderly population. …”
Get full text

ROSA: An Andean Network of Social–Ecological Observatories by Julieta Carilla, Ricardo Grau, Oriana Osinaga Acosta, Agustina Malizia, Sergio Ceballos, Luis Daniel Llambí, María Piquer-Rodríguez, Lucía Zarbá, Saskia Flores, Francisco Cuesta, Tatiana Ojeda Luna, Wanderley Ferreira, Carolina Tovar, Yohana Jimenez, Ana Belén Hurtado-M, László Nagy, Erika Buscardo, Petra Wallem, Patricia Breuer, Vivien Bonnesoeur, Sophie Hebden, Nicolás Cuvi, Ezequiel Aráoz

“…The main research questions addressed by these social–ecological observatories include understanding how distant and proximate drivers of change interact with local social, cultural, economic, and environmental contexts to influence the functioning of different SES in the Andes at multiple spatial and temporal scales. …”
Get full text

Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. …”
Get full text

The Surface Water and Ocean Topography Mission (SWOT) Prior Lake Database (PLD): Lake Mask and Operational Auxiliaries by Jida Wang, Claire Pottier, Cécile Cazals, Marjorie Battude, Yongwei Sheng, Chunqiao Song, Md Safat Sikder, Xiao Yang, Linghong Ke, Manon Delhoume, Marielle Gosset, Rafael Reis Alencar Oliveira, Manuela Grippa, Félix Girard, George H. Allen, Xiangtao Xu, Xiaolin Zhu, Sylvain Biancamaria, Laurence C. Smith, Jean‐François Crétaux, Tamlin M. Pavelsky

“…About 97% of the lakes, constituting half of the global lake area, are fully observed at least once per orbit cycle. …”
Get full text

Breakdown or Personality Disorder? Psychiatric Characterization and Developmental Pathways Towards Young Adulthood in Adolescents with Pathological Personality Structure by Chiara Rogantini, Marika Orlandi, Arianna Vecchio, Diletta Cristina Pratile, Raffaella Fiamma Cabini, Elena Ballante, Valentina De Giorgis, Renato Borgatti, Martina Maria Mensi

“…This study aimed to characterize the profile of high-risk adolescents compared to adolescents with full-blown PDs and adolescents with other psychiatric disorders and to identify clinical markers that constitute a risk profile. <b>Methods</b>: We evaluated 99 adolescents (12–17 years old) through DSM-5-based semi-structured interviews, questionnaires, cognitive tasks, and scales regarding functioning and disorder severity. …”
Get full text

Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families by Mutaz Amin, Claudia Gragnoli

“…However, the functional relevance of the novel variants and genes reported in our study remains to be explored.…”
Get full text

Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics by Jon Olansen, Minglang Yin, Janine Molino, Thomas Carruthers, Derek Jenkins, George Karniadakis, Roy K. Aaron

“…Shared factors like phenotypic similarities, hypofibrinolysis, and inflammation constitute similarities in pathophysiology and clinical manifestations between OA and peripheral vascular disease (PVD). …”
Get full text

Experimental Investigation and Simultaneous Optimisation of Honing Parameters of Dry Cast Iron Cylinder Relining Sleeves of Motor Vehicle Engine Blocks for Surface Finish and Energ... by Nicholas Tayisepi, Lameck Mugwagwa, Albert Mnkandla, Innocent Mapindu, Takudzwa Muhla

“…Machining based manufacturing industries consume significant amounts of electrical energy, to power the several modules constituting the machine tool, with low levels of efficiency. …”
Get full text

Comparative analysis of community composition and network structure between phyllosphere endophytic and epiphytic fungal communities of Mussaenda pubescens by Deqiang Chen, Juanjuan Yang, Shunfen Wang, Siren Lan, Yonglong Wang, Zhong-Jian Liu, Xin Qian

“…ABSTRACT The phyllosphere constitutes a critical habitat for microorganisms, exerting profound influences on host vitality, developmental dynamics, reproductive functions, and stress resilience. …”
Get full text

The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma by Nour Abu Jayab, Alaa Abed, Iman M. Talaat, Rifat Hamoudi

“…Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. …”
Get full text

Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway by Yushan Ye, Fan Wu, Bowen Li, Hanyu Ma, Lianxi Mai, Yu Peng, Xiaodi Feng, Xiao Tan, Min Fu, Yongmei Tan, Tianjun Lan, Ruixin Wang, Siqi Ren, Jinsong Li, Shaohai Chang, Shule Xie

“…PIWI-interacting RNAs (piRNAs) serve as epigenetic effectors in cancer progression and constitute significant compositions of exosomes. Here, we explored the functional mechanism of exosomal piRNAs in OSCC development. …”
Get full text

An Open Model of Cultural Dialogue in the Context of Safe Social Interaction by Huseyn G. Zeynalov, Irina B. Vinogradova, Galina A. Shulugina, Alikram Z. Abdullaev, Maxim A. Eliseev

“…The prospects of the study are aimed at revising the basic characteristics and postulates of modern culture in order to determine the constitutive role of dialogue in the formation of a new (mixed) reality and the mechanism of its functioning. …”
Get full text

Realist evaluation of the impact and transferability of a greening of school playgrounds program: The APPIE GREEN study protocol by Louise Wallerich, Charlotte Decroix, Lucile Robert, Linda Cambon

“…The aim of the data collection is to characterise the contextual elements (Ce and Ci), the mechanisms (M), and the results (O) of each case and to iteratively validate the CeCiMO configurations, considered as the functions through which greening encourages natural play. …”
Get full text