Low rates of patient-reported outcome claims for orphan drugs approved by the us food and drug administration by Szymon Jarosławski, Pascal Auquier, Borislav Borissov, Claude Dussart, Mondher Toumi

“…Background: Claims included in package inserts (PIs) for medicinal products approved by the US Food and Drug Administration (FDA) constitute the regulatory definition of drugs’ benefits and risks. …”
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Difficultés d’intégration d’un quartier spontané dans une ville saharienne : le cas de Bni Ouskout à Adrar by Hadj Mohammed Maachou, Larbi Belouadi, Sidi Mohammed Trache

“…The resistance shown by the inhabitants to the restructuring project is due to the fact that many of them would be forced to modify their practices, such as those related to their occasional residence and their “transit” situation, which would jeopardize the functioning of informal activities.…”
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Combination of the Level-Set Methods with the Contourlet Transform for the Segmentation of the IVUS Images by Hassen Lazrag, Med Saber Naceur

“…The detection of lumen and media-adventitia boundaries in IVUS images constitutes an essential step towards the reliable quantitative diagnosis of atherosclerosis. …”
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ASSESSMENT OF TOURISM EFFECTS ON GEOGRAPHICAL AREA FROM THE PERSPECTIVE OF LOCAL TOURISM ACTORS: BERGAMA CASE (IZMIR/TURKEY) by Emre ATABERK

“…Rich in its cultural attractiveness, tourism in Bergama has brought forth to some visual changes in town’s geographical area. “Functional” changes constitute the primary source of these changes. …”
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SIGNIFICANCE OF THE PORT OF SINGAPORE AGAINST THE COUNTRY’S ECONOMIC GROWTH by Maciej MINDUR

“…This research covers the port’s ownership and organisational structure, and its terminals have been reviewed in terms of their location, infrastructure and functions by taking into account the new generation terminal of the port of Tuas, currently under development. …”
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THE FACTS AND MIRAGE OF INTEGRATING ARTIFICIAL INTELLIGENCE INTO THE JUDICIAL SYSTEM OF NIGERIA by DR ENYINNAYA N. OBOH

“…It is recommended that a formidable legal and regulatory framework be developed in fulfilment of the provision of section 18 (2) of the Constitution of the Federal Republic of Nigeria to achieve a seamless AI integration in the justice system of Nigeria. …”
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JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. by Pier Giorgio Amendola, Nico Zaghet, João J Ramalho, Jens Vilstrup Johansen, Mike Boxem, Anna Elisabetta Salcini

“…The eukaryotic genome is organized in a three-dimensional structure called chromatin, constituted by DNA and associated proteins, the majority of which are histones. …”
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Beneficial Effects of Nutraceuticals, Especially Polyphenols on Canine Health by Domingo Ruiz-Cano, Marino B. Arnao

“…Our focus includes the effects on gastrointestinal functions and its microbiota, as well as aspects such as obesity, diabetes, and fat metabolism. …”
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Couples and parenting dynamics during Covid-19 pandemic: A systematic review of the literature. by Maria Leonor Sentieiro, Luana Cunha Ferreira, Mariana Pires de Miranda, Beatriz Araújo Vitória

“…The COVID-19 pandemic constituted a public health crisis bound to impact couples, parents, and families globally. …”
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High tibial osteotomy in geriatric patients with gonarthrosis by Bedrettin Akar, Yusuf Oztürkmen, Mehmet B. Balioglu, Fatih Ugur, Erhan Sükür

“…Sixty-six patients with grade III-IV gonarthrosis constituted Group I, while 57 patients with grade I-II gonarthrosis formed Group II. …”
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Algorithm reality – intentionality and instrumentality by  V. Е. Kukel

“…The findings of the study suggest that the algorithm functions not only as a technical tool but also as a practice of rationality. …”
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Acute subdural haematoma in the elderly: to operate or not to operate? A systematic review and meta-analysis of outcomes following surgery by John Martin, Susruta Manivannan, Robert Spencer, Malik Zaben, Omar Marei, Isaac Mayo, Omar Elalfy

“…Potential risk factors for poor outcome included age, baseline functional status, preoperative neurological status and imaging parameters.Conclusions Outcomes following surgical evacuation of ASDH in patients aged 60 years and above are poor. …”
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Pulsation Properties of Blazhko and Non-Blazhko RRab Stars by Peng Zong, Jian-Ning Fu, Jie Su, Bing-Kai Zhang, Gao-Chao Liu, Weichao Sun, Jiaxin Wang, Bo Zhang, Xueying Hu, Zhongrui Bai, Weikai Zong

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Quantification of thermo-halotolerant alkaline protease activity derived from Bacillus licheniformis strains isolated from extreme environments in Morocco by Taha Chouati, Ounayssa Ayadi, Mohammed Ajdig, Lahcen Ouchari, Bahia Rached, Jamila El Alami, Elmostafa EL Fahime

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Research on Random Discrete Ordinates Method Based on Quasi-Monte Carlo Integration Technique by DAI Tao, XU Longfei, LI Baiwen, SHEN Huayun, HU Yuan, MA Ruiyao

“…The discrete ordinates (SN) method proposed by Carlson constitutes an angular discretization for neutron transport equation. …”

Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. Subsequently, a protein-protein interaction (PPI) network was constructed in order to screen the core target and confirmed by molecular docking. …”
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The Aporia of Reality/Imagination: Uncertainty in Selected Iranian Monodramas and Surrealist Dramas by Mohammad Bagher Ghahramani, Rahmat Amini, Sahar Meshginghalam

“…This research explores how the aporia of reality and imagination functions as a rhetorical tool that renders drama as self-deconstructive. …”
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Modeling Optical and Electronic Properties of Silica Nano-Clusters in Silicon Rich Oxide Films by N.D. Espinosa-Torres, J.F.J. Flores-Gracia, J.A. Luna-López, A. Morales-Sánchez, J.L. Sosa-Sánchez, J.C. Ramírez-García

“…Quantum effects are very important in nano scale systems such as molecules and clusters constituted of particles from a few to hundreds or a few thousands of atoms. …”
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Cadmium toxicity on communities of ammonia-oxidizing microorganisms by Huan He, Lina Dang, Qian Yang, Ran Chen, Jianmei Yang, Jinshan Li, Qiang Zhu, Jiulan Dai

“…The oxidation of ammonia to nitrite, which constitutes the initial and rate-limiting step in the nitrification process, plays a pivotal role in the transformation of ammonia within soil ecosystems. …”
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Artificial Intelligence for Wireless Communications: The InSecTT Perspective by Ramiro Samano Robles, Gowhar Javanmardi, Christoph Pilz, Przemyslaw Kwapisiewicz, Mateusz Rzymowski, Lukasz Kulas, Luca Davoli, Laura Belli, Gianluigi Ferrari, Bernd-Ludwig Wenning, Bugra Gonca, R. Venkatesha Prasad, Ashutosh Simha, Markku Kiviranta, Ilkka Moilanen, Sean Robinson, Gennaro Cirillo, Mujdat Soyturk, Yavuz Selim Bostanci, Leander B. Hormann

“…These stages include collection, harmonization, refinement, classification, architecture alignment, and functionality modeling of RQs. The most relevant results of these stages are discussed here, with emphasis on the need for a refined granularity of technical components with common functionalities named Sub-Building blocks (SBBs), where collaboration and cross-domain reusability were optimized. …”
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