The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis by Shanshan Wang, Tang Kun, Zhen Tian, Mengqi Huang, Yan Fan, Boyu Li, Hongyan Zheng, Rongman Xu, Meijia Wang, Jianping Zhao, Jungang Xie

“…Milk fat globule-EGF factor 8 (MFGE8) is a soluble glycoprotein functioning in phagocytosis, tissue repair, angiogenesis, and the regulation of neutrophil activity. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Autism, epilepsy, movement disorders, sleep disturbances, and various psychiatric behaviors constituted the core of the disorder’s clinical phenotype. …”
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Cálculo de estructuras para semirremolques de pasajeros de grandes dimensiones // Calculation of structures for semi - trailers of large dimensions using in passengers transportati... by L Otero Pereiro, C. Novo Soto, M. Fernández Salgado

“…</p><p>____________________________________________________________________</p><p>Abstract<br />The Finite Elements Method (FEM) developed until the present time is a powerful computerized calculation system applied in<br />the tensions and deformations analysis of solids and structures and much literature has been published on FEM as calculation<br />method,<br />The need of solving the problems of passengers transportation, mainly in Havana City, in the difficult conditions of Cuban<br />special period, conducted to the development of a semi - trailer with the necessary characteristics to fulfil this function , which<br />by their attributes constitutes the only one in his gender for this purpose.…”
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Concept and Characteristic of Urban Landscape Layering, and Design Approach Towards Urban Regeneration by Jinyu ZHANG, Yuan XU, Yufan ZHU

“…Urban landscape evolves through a nonlinear process of accumulation, with physical structures, functions, and meanings continuously transforming. …”
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DEVELOPMENT OF AN AUTOMATED FLUORESCENCE MICROSCOPY ASSAY FOR QUANTIFYING FACTORS AFFECTING RED BLOOD CELL (RBC) SICKLING IN SICKLE CELL DISEASE (SCD) by ML Arrojo, ACS Pinto, SK Haddad, RA Panepucci

“…However, the lack of straightforward functional assays to quantitate how these factor affect cell sickling, hamper a more profound understanding of SCD physiopathology. …”
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StAGE: Stellar Archaeology-driven Galaxy Evolution by Michele Bosi, Andrea Lapi, Lumen Boco, Carlos A. Alvarez, Marcos M. Cueli, Giovanni Antinozzi, Meriem Behiri, Marika Giulietti, Marcella Massardi, Mario Spera, Alessandro Bressan, Carlo Baccigalupi, Luigi Danese

“…Focusing on the supermassive black holes (BHs) hosted by massive QGs, we exploit StAGE to reconstruct the average BH mass assembly history, the cosmic BH accretion rate density as a function of redshift, and the evolution of the Magorrian-like relationship between the relic stellar and BH masses. …”
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Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease by Romain Castelot, Aline Zarea, David Wallon, Anne Rovelet-Lecrux, Catherine Schramm, Muriel Quillard-Muraine, Anne Beaume, Frédéric Blanc, Olivier Bousiges, Julien Dumurgier, Maïté Formaglio, Gwenael Leguyader, Sylvain Lehmann, Cecilia Marelli, Matthieu Martinet, Leonor Nogueira, Jérémie Pariente, Isabelle Quadrio, Adeline Rollin-Sillaire, Susanna Schraen, Gaël Nicolas, Magalie Lecourtois

“…Recently, we demonstrated that a large proportion (~25%) of rare SORL1 missense variants found in AD patients alter SorLA trafficking along the constitutive secretory pathway, resulting in reduced delivery of SorLA to the plasma membrane and thus a loss of function. …”
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A Golden2-like transcription factor, BnGLK1a, improves chloroplast development, photosynthesis, and seed weight in rapeseed by Qianwei Zhang, Yuanyi Mao, Zikun Zhao, Xin Hu, Ran Hu, Nengwen Yin, Xue Sun, Fujun Sun, Si Chen, Yuxiang Jiang, Liezhao Liu, Kun Lu, Jiana Li, Yu Pan

“…Our results not only provide insights into the mechanisms of BnGLK1a function, but also offer a potential approach for improving the productivity of Brassica species.…”
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Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial by Markus W Büchler, Lukas Baumann, Peter Schirmacher, Christoph W Michalski, Markus K Diener, Dirk Jäger, Pascal Probst, Mohammed Al-Saeedi, Martin Schneider, Alexis Ulrich, Constantin Schwab, Anja Sander, Christina Klose, Christoph Kahlert, Hans-Ulrich Kauczor, Jürgen Debus, Rosa Klotz, Solveig Tenckhoff, Cosima Engerer, Kristin Uzun-Lang, Caroline Wild, Bruno C Köhler

“…Introduction Neoadjuvant (chemo)radiotherapy (n(C)RT) followed by resection with total mesorectal excision (TME) constitutes the standard treatment for patients with locally advanced rectal cancer of the middle and lower third. …”
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PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy by Xufeng Lu, Wenhai Deng, Shuaibin Wang, Shengsheng Zhao, Bingzi Zhu, Binglong Bai, Yiwen Mao, Ji Lin, Yongdong Yi, Zuoliang Xie, Xiang Wang, Yongyong Lu, Xiufeng Huang, Tao You, Xiaolei Chen, Weijian Sun, Xian Shen

“…Nanozymes constitute a promising treatment strategy for antitumor therapy. …”
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Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling by Lian Wang, Ning Luo, Jihui Zhu, Zubaidan Sulaiman, Wenhan Yang, Ke Hu, Guihai Ai, Weihong Yang, Xiaowen Shao, Shengkai Jin, Xue Zhang, Yantao Fan, Dan Deng, Zhongping Cheng, Zhengliang Gao

“…The results show that ADSCs modulate OC cell proliferation and migration at multiple layers, constituting a key mechanism in OC progression.…”
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An Analysis of Influential Factors in the Use of Public Bicycles in Tehran by Ehsan Faghihi, Mojtaba Rafieian

“…So far, many researches have been conducted on the components affecting the functional stability of the shared bicycles system, for example Si et al. in 2020 found that factors of efficiency, economic benefits, environmental awareness, and infrastructure incentives influence the willingness to use the shared bicycle system. …”
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A Quasar-anchored Protocluster at z = 6.6 in the ASPIRE Survey. II. An Environmental Analysis of Galaxy Properties in an Overdense Structure by Jaclyn B. Champagne, Feige Wang, Jinyi Yang, Xiaohui Fan, Joseph F. Hennawi, Fengwu Sun, Eduardo Bañados, Sarah E. I. Bosman, Tiago Costa, Melanie Habouzit, Xiangyu Jin, Hyunsung D. Jun, Mingyu Li, Weizhe Liu, Federica Loiacono, Alessandro Lupi, Chiara Mazzucchelli, Maria Pudoka, Sofía Rojas-Ruiz, Wei Leong Tee, Maxime Trebitsch, Haowen Zhang, Ming-Yang Zhuang, Siwei Zou

“…The F356W grism data reveal 124 [O iii ]+H β emitters at 5.3 <  z  < 7, 53 of which constitute a protocluster spanning (10 cMpc) ^2 across 6.5 <  z  < 6.8. …”
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Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinationsResearch in context by Jérémie Decalf, Evangeline Toy, Dongping He, Radhika Kenkre, Amy M. Berkley, Devon Wong, Mandy Kwong, Yee-Seir Kee, Yue Sun, Srividya Myneni, Xiangdan Wang, Ahmad Ebtikar, Anthony Ancheta, Yanli Yang, Hok Seon Kim, Nga Tang, Debarko Banerji, Elaine Mai, Pranay Dogra, Meredith McLerie, Alan G. Gutierrez, Geraldine Strasser, Gautham K. Rao, Matt Betzenhauser, Wilson Phung, Peter Day, Wendy Sandoval, Ayse Meric Ovacik, Pamela Chan, Shomyseh Sanjabi, Laetitia Comps-Agrar, Sivan Cohen, James A. Ernst, Greg A. Lazar, Christopher C. Kemball, Iraj Hosseini, Yichin Liu, Jill M. Schartner, Travis W. Bainbridge, Christine Moussion

“…To prevent Fc gamma receptor (FcγR) mediated effector function, we engineered an effectorless Fc format called NG2LH, consisting of the aglycosylation substitution N297G, combined with a graft of the lower hinge region of IgG2 onto an otherwise IgG1 Fc. …”
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De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…Despite a fire in the thermal baths in 275-280, the monumental complex still appears to have been occupied, though the space witnessed a shift in function and was primarily used as a recycling site. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…Surveillance for undiagnosed psoriatic arthritis generally detects mild cases as measured by physical function. Patients rate pain and fatigue as the most important outcomes. …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…In this latter case, the BCI functions ethically by creating the very possibility for ethical engagement where none previously existed. …”
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Non-canonical internalization mechanisms of mGlu receptors by Marta Cimadevila, Junke Liu, Damien Maurel, Isabelle Brabet, Marine Hoscar, Julia Drube, Carsten Hoffmann, Asuka Inoue, Philippe Rondard, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin

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Otorita IKN dalam Status Kelembagaan dan Hubungan Pembagian Kekuasaan Pusat dengan Daerah by Denis Kurniawan

“…This paper concludes that the otorita IKN does not carry out the principle of decentralization in its capacity as a local government, but only functions as a functional deconcentration which is an extension of the central government, and the position of head of the Otorita IKN does not take the form of an integrated prefecture, so that logically it only functions as a trustee as representative of the central government in the regions, but without the capacity as head of the regional government.…”
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WŁADZA TRZECIA „NEUTRALNA” by Andrzej Sylwestrzak

“…The aim of the article is to present the arguments for “neutral power” as the creative factor indispensable in the proper functioning of the law-based state. Within Montesquieu tripartite classification, “neutral power” entailes the nessesity to restracture juridical power so thet it will include financial control, constitutional bank control as well as ombudsmen. …”
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