Combination of a therapeutic cancer vaccine targeting the endogenous retroviral envelope protein ERVMER34-1 with immune-oncology agents facilitates expansion of neoepitope-specific... by Renee N Donahue, Jeffrey Schlom, James L Gulley, Claudia Palena, Duane H Hamilton, Masafumi Iida, Maria del Mar Maldonado, Maria Gracia-Hernandez, Loc Huu Le

“…When combined with checkpoint blockade, the vaccine promoted expansion of neoepitope-reactive T cells whose function was further enhanced when combined with N-803. …”
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Prognostic factors associated with achieving minimal disease activity in early psoriatic arthritis patients treated according to “treat-to-target” st rategy within 12 months by E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, S. I. Glukhova

“…It is a combination of features on first visit – oligoarthritis, moderate activity, absent of entesitis, dactylitis, nail psoriasis, significant impact on function and fatigue – that constitutes a clinical prognostic factors for achievement MDA after 12 mo of treatment in pts with early PsA according T2T.…”
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Antithrombotic Therapy in Patients with Malignant Lymphoproliferative Disorders Treated with Ibrutinib by EI Emelina, GE Gendlin, IG Nikitin

“…The use of ibrutinib influencing the platelet function constitutes an additional bleeding risk. A crucial task consists in risk minimization of both hemorrhagic complications and thrombosis while sticking to ibrutinib treatment. …”
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Neural Network-Based Prediction of Amplification Factors for Nonlinear Soil Behaviour: Insights into Site Proxies by Ahmed Boudghene Stambouli, Lotfi Guizani

“…A second neural network, the Radial Basis Function (RBF) network, is used to develop simple and practical prediction equations. …”
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Identification of Factors Affecting Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Risk management is now an important part of project management and has a specific function for improving the efficiency of implementing the project, saving prices, and improving the profitability of projects. …”
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Study of the state of th vascular endothelium in various forms of coronary heart disease by F. A. Shukurov, M. S. Tabarov, Z. M. Toshtemirova, M. Kh. Khodzhaeva

“…Campeau, 1976), VNOC (2004), recommendations of the European Society of Cardiology (2007)), aged from 50 to 75 years (mean age 62.6 ± 3.5 and 65.1 ± 3.6 years, respectively) and 20 practically healthy individuals (without signs of CHD), comparable in age (mean age 62.7 ± 3.7 years), who constituted the control group. For comparative analysis of the results before and after treatment the subjects were divided into three groups: Group I - control group, respondents without CHD; Group II - patients with stable angina II and III functional classes (FC); Group III - patients with postinfarction cardiosclerosis, i.e. those who had undergone Ml.Results and their discussion Several risk factors were identified in the majority of hospitalized patients. …”
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ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy by Caitlin M. Miller, James H. Morrison, Laura Bankers, Rachael Dran, Julia M. Kendrick, Emma Briggs, Virginia L. Ferguson, Eric M. Poeschla

“…Picornavirus RdRptg mice have an unusual constitutive MDA5 activation state, with very high lifelong MDA5-mediated ISG expression that confers robust protection from diverse lethal viruses. …”
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The Pseudomonas aeruginosa T3SS can contribute to traversal of an in situ epithelial multilayer independently of the T3SS needle by Eric Jedel, Daniel Schator, Naren G. Kumar, Aaron B. Sullivan, Arne Rietsch, David J. Evans, Suzanne M. J. Fleiszig

“…Surprisingly, a ΔpscC mutant unable to assemble the T3SS needle traversed as efficiently as wild-type P. aeruginosa, while a ΔexsD mutant “constitutively on” for T3SS expression was traversal defective. …”
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JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors by Yang Li, Taeko Hayakawa, Shinsuke Iida, Toshiaki Yoshikawa, Yusuke Ito, Satoshi Inoue, Yuichi Ishikawa, Takahiro Nakashima, Tetsuya Matsukawa, Hitoshi Kiyoi, Yuki Kagoya, Hitomi Kasuya, Haosong Zhang, Tsunenori Ouchida

“…In addition, ectopic expression of G6/7R improved the effector function of TNF-NTF CAR-T cells through constitutive activation of janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling. …”
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The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis by Liu Teng, Yu Chen Feng, Su Tang Guo, Pei Lin Wang, Teng Fei Qi, Yi Meng Yue, Shi Xing Wang, Sheng Nan Zhang, Cai Xia Tang, Ting La, Yuan Yuan Zhang, Xiao Hong Zhao, Jin Nan Gao, Li Yuan Wei, Didi Zhang, Jenny Y. Wang, Yujie Shi, Xiao Ying Liu, Jin Ming Li, Huixia Cao, Tao Liu, Rick F. Thorne, Lei Jin, Feng-Min Shao, Xu Dong Zhang

“…These results uncover the function and regulation of PLANE and suggest that PLANE may constitute a therapeutic target in the pan-cancer context.…”
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Spatial pattern of Trees in the Riparian Forests (Case Study: Wildlife Refuge of Karkhe) by Shaieste Gholami

“…Typically these structures constitute one source of the nugget variance of the variograms (Rossi, 2003). …”
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Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check by Mengyao Gong, Mengyao Gong, Junqi Luo, Junqi Luo, Qiankun Liang, Qiankun Liang, Yi Liu, Yi Liu, Yuejuan Zheng, Yuejuan Zheng, Xiao-Dong Yang, Xiao-Dong Yang

“…SOCS1 is the first identified SOCS-box member that functions in ECSSOCS1 to target chromatin-bound RelA for ubiquitination. …”
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Several groups of LysM-RLKs are involved in symbiotic signal perception and arbuscular mycorrhiza establishment by Yi Ding, Zélie Lesterps, Virginie Gasciolli, Anne-Laure Fuchs, Mégane Gaston, Lauréna Medioni, Annélie de-Regibus, Céline Remblière, Céline Vicédo, Sandra Bensmihen, Jean Jacques Bono, Julie Cullimore, Guilhem Reyt, Marion Dalmais, Christine Saffray, Solène Mazeau, Abdelhafid Bendahmane, Richard Sibout, Michiel Vandenbussche, Jacques Rouster, Tongming Wang, Guanghua He, Arnaud Masselin, Sylvain Cottaz, Sébastien Fort, Benoit Lefebvre

“…While LYR-IB knock out mutants had a reduced AMF colonization in several species, constitutive/ectopic expression in wheat increased AMF colonization. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…</em></p><p><em>2)     </em><em>Unconstrained decision problems that consist of minimizing or maximizing a function. The main concern is the finding of the solution value that corresponds to the global optimum. …”
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Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction by Vivek P. Jani, Edwin J. Yoo, Aleksandra Binek, Alina Guo, Julie S. Kim, Jennifer Aguilan, Mohammad Keykhaei, Sydney R. Jenkin, Simone Sidoli, Kavita Sharma, Jennifer E Van Eyk, David A. Kass, Virginia S. Hahn

“…Background Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells. …”
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Study on the mechanical traits, failure mechanisms, energy responses, and influencing factors of columnar jointed basalts under direct and indirect tensile conditions by Dan Liang, Dan Liang, Dan Liang, Haiqing Yang, Haiqing Yang, Zekang Ping, Zekang Ping, Yongyi Wang, Yongyi Wang, Kanglei Song, Kanglei Song, Chiwei Chen, Chiwei Chen, Hao Li, Hao Li, Xingyue Li, Xingyue Li, Lixin Peng, Lixin Peng, Anhua Ju, Anhua Ju

“…However, under the BSC, the sensitivity of the MCEI to joint constitutive behavior is higher than that to the secondary joint set. …”
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From Qibla Deviation to Social Cohesion: The Construction of Minority Fiqh at the Great Mosque of Makale, Tana Toraja by ABD Karim Faiz, Wahidin, Zulfahmi AR, M. Qahar Awaka

“…The article argues that Islamic law in minority contexts does not function as a rigid, normative system, but rather as an adaptive and responsive social construction grounded in the maqāṣid al-sharīʿah (objectives of Islamic law). …”
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Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accur... by Verónica Pulito-Cueto, Belén Atienza-Mateo, Joao C. Batista-Liz, María Sebastián Mora-Gil, Víctor M. Mora-Cuesta, David Iturbe-Fernández, Sheila Izquierdo Cuervo, Carolina Aguirre Portilla, Ricardo Blanco, Raquel López-Mejías

“…Finally, in RA-ILD+ patients, higher MMP-10 levels were associated with worse pulmonary function, increased MMP-2 levels were related to the treatment with conventional synthetic disease-modifying anti-rheumatic drugs, and decreased TIMP-1 levels were linked with positivity rheumatoid factor status. …”
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Assessing the effects of Turkey berry (Solanum torvum) tea consumption on cardiometabolic indices in people living with hypertension by Hamdia Ibrahim Seidu, Marina Aferiba Tandoh, Isaac Amoah, Judith Odei Owusu-Asante, Redeemer Kofi Agbolegbe

“…The use of Turkey berry (Solanum torvum) tea as a natural remedy and functional food high in flavonoids and other phytochemicals may improve bodily function, as well as help attain blood pressure control. …”
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