Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…The 2, 037 results of biological process(BP), 39 results of cellular components(CC)and 129 results of molecular function(MF)together constituted 2, 205 results of GO enrichment analysis with <italic>P</italic>&lt;0.05. …”
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Evolution of glioma exosome research: emerging trends and global collaborations (2005–2025) by Yijun Zeng, Ting Liu, Shixue Jing, Yongfeng Wang, Jihong He, Hui Cao, Xinlian Liu, Lushun Zhang

“…Leading institutions include Shandong University, Shandong Provincial Key Laboratory of Brain Function Reconstruction, and Capital Medical University, whose productivity metrics reflect substantial influence. …”
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Elections as a means of citizens political education: A comparative study between Indonesia and Malaysia by Sunarso Sunarso, Suyato Suyato, Puji Wulandari Kuncorowati, Toba Sastrawan Manik, Ali Masykur Fathurrahman

“…The purpose of this study is to compare Indonesian and Malaysian elections in terms of (1) legal basis, (2) organizing institution, (3) implementation, (4) political party function, and (5) public participation. It was a library study using a qualitative approach. …”
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Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis by Alexander Evgen'evich Lepetukhin, Nikolay Petrovich Goncharov, Anatoliy Ivanovich Mordik, Natalya Yur'evna Biskaeva

“…Reduction of the TT level in men with DM1 on PHD is a function of age and constitutes an independent risk factor of anemia. …”
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FUNDAMENTALISATION OF EDUCATION IN ITS PROJECTIVITY – A TRANSSPECTIVE FROM THE MICROWORLD TO THE MACROWORLD by Stanislav V. Sapozhnykov, Anatolii P. Samodryn, Alina O. Teplytska

“…The authors predict the future projective function of education in Ukraine in relation to human life (essentially compensatory).…”
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Activation of SIRT3 / PRDX5 signaling inhibits apoptosis after acute spinal cord injury in mice by Hui Ni, Weiping Sha, Tianli Xu, Qiancheng Zhu, Qun Huang, Jin Wang, Qi Gu, Yi Zhu, Liming Wang, Shoujin Tian, Rong Gao, Jianfei Ge, Xiaolong Lin

“…Spinal cord injury (SCI), a traumatic condition affecting the nervous system, constitutes an orthopedic emergency that is closely associated with a significantly elevated disability rate. …”
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Cryopyrin-Associated Periodic Syndromes (CAPS): Pathogenesis, Clinical Manifestations, and IL-1-Targeted Therapeutic Strategies by Joanna Nadaj, Bartosz Czyżewski, Anna Mariankowska, Anna Dróżdż, Weronika Posuniak, Michał Dorota, Karol Kozłowski, Oliwia Kawa, Wojciech Żywiec, Cezary Milczarek

“… Cryopyrin-associated periodic syndromes (CAPS) are a group of rare, genetically determined autoinflammatory diseases resulting from gain-of-function mutations in the NLRP3 gene. These mutations lead to constitutive activation of the inflammasome and overproduction of interleukin-1β and interleukin-18, driving chronic systemic inflammation. …”
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The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS by Nanni Schmitt, Jana-Julia Siegler, Alexandra Beck, Thomas Müller, Izabela Kozlowska, Séverine Sarlang, Uwe Reusch, Stefan Knackmuss, José Medina-Echeverz, Joachim Koch, Thorsten Ross, Ali Darwich, Lea Hoppe, Mohammed Abba, Alexander Streuer, Stefan Klein, Wolf-Karsten Hofmann, Anna Lisa Gündner, Christian Merz, Jan Endell, Jens Pahl, Daniel Nowak

“…AFM28 induces autologous anti-leukemic activity in fresh AML whole blood cultures, demonstrating its potential to enhance NK cell function from AML patients. Responsiveness can be further enhanced by allogeneic NK cell addition. …”
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Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…The difference in aetiology was a significant factor for 28-day adverse outcomes in multivariate analysis even in a high MELD score (≥15), which indicated poor baseline liver function and prognosis (p < 0.001).Conclusion The aetiology of CLD constitutes a pivotal determinant influencing both short- and long-term adverse outcomes of AD in CLD, even among individuals presenting with elevated MELD scores. …”
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ABA-activated subclass III SnRK2s control kernel maturation in maize by Yayun Wang, Tiandan Long, Aying Qin, Qiang Liao, Hao Wang, Junjie Zhang, Hanmei Liu, Yinghong Liu, Yufeng Hu, Yubi Huang, Yangping Li

“…Knockout of ZmSnRK2s demonstrated that subclass III ZmSnRK2s are required for kernel maturation in maize, and the loss-of-function of subclass III ZmSnRK2s showed a disruption in kernel dehydration and dormancy. …”
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Transitions of deformation mechanisms in new metastable β-titanium Ti-1500G alloy by Yongqiang Ye, Yuanfei Han, Siyuan Zhang, Jianwen Le, Fu Chen, Jiaming Zhang, Chunyu Shen, Guangfa Huang, Shewei Xin, Weijie Lu, Di Zhang

“…A two-dimensional deformation-mechanism map (DMM) as a function of temperature and strain rate was creatively proposed on the basis of energy dissipation efficiency mechanisms. …”
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FORMA CZYNNOŚCI PRAWNEJ W PRAWIE PRYWATNYM MIĘDZYNARODOWYM by Jadwiga Pazdan

“…The aim of conflict rules is to indicate territorial application of different legal systems. That function fixes the approach while determining the way of understanding the notion of a „form” in private international law. …”
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Affordable Condominium Housing by Rosa Elena Donoso Gomez

“…In Ostrom’s words: Colombia has embedded a collective choice-rule in a constitutional one. This concerns a clear and unambiguous anchoring of the body most important to how a homeowner’s association functions. …”
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An Architectural Heritage: The Ganj-Ali Khan Bath by Kambiz Hadji-Ghasemi

“…Although the architectural design of these buildings were based on their function, the tastes of their traditional architects turned them into buildings of artistic value. …”
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Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease by Roberta Marongiu, Roberta Marongiu, Roberta Marongiu, Jimcy Platholi, Jimcy Platholi, Laibak Park, Fangmin Yu, Garrett Sommer, Clara Woods, Teresa A. Milner, Michael J. Glass

“…Further, select increases in glial activation also paralleled Ab pathology in distinct hippocampal subregions. However, cognitive function was not affected by peri-AOF.DiscussionThese findings align with the hypothesis that perimenopause constitutes a period of susceptibility for AD pathogenesis in women.…”
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Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model by Jie Jiao, Weijin Liu, Weijin Liu, Ge Gao, Hui Yang

“…Notably, inhibiting Ser129 phosphorylation improved mitochondrial function, underscoring the role of p-α-syn in mitochondrial damage. …”
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A novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes by Trang Thu Hoang, Huyen Thanh Thi Le, Sang Ngoc Nguyen, Ung Dinh Nguyen, Tuan Ngoc Tran, Cuong Hung Nguyen, Thang Quang Truong, Nam S. Vo, Duc Quang Le, Son Hoang Nguyen, Minh Duc Cao, Thi Minh Ngoc Dao, Thi Huyen Bui, Thu An Nguyen, Thi Lan Anh Pham, Thi Bich Thao Le, Tho Huu Ho

“…Comparative genetic analysis revealed distinct genes in ECV219, indicating a novel Imipenem resistance gene. To assess its function, we conducted transformation experiments in E. coli Rosetta™(DE3)pLysS and performed bioinformatics analyses using BLASTp, InterProScan, and Pfam to characterize the gene’s structure and potential functions.Our study identifies ILR-VIN as a novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes. …”
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Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüpp... by Hiroaki Sunaga, Hiroki Matsui, Saki Anjo, Mas Risky A. A. Syamsunarno, Norimichi Koitabashi, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi

“…Background Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…However, the frequent occurrence of a non-canonical disulfide bond between complementarity-determining region (CDR) H1 (C35a) and CDRH2 (C50) is often seen as a liability for therapeutic antibody development, despite limited reports of its effect on antibody binding, function, and stability. Here, we describe the discovery and humanization of a human-mouse cross-reactive anti-programmed cell death (PD-1) monoclonal rabbit antibody, termed h1340.CC, which possesses this non-canonical disulfide bond. …”
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Silicon-Mediated Modulation of Olive Leaf Phytochemistry: Genotype-Specific and Stress-Dependent Responses by Marin Cukrov, Velemir Ninkovic, Luna Maslov Bandić, Šime Marcelić, Igor Palčić, Mario Franić, Paula Žurga, Valerija Majetić Germek, Igor Lukić, Darija Lemić, Igor Pasković

“…Secondary metabolites in olive (<i>Olea europaea</i> L.) leaves constitute a complex framework wherein phenylpropanoids, terpenoids, and secoiridoids in particular, serve as major contributors to olive plant resilience. …”
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