Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria by Stephanie I Studniberg, Lisa J Ioannidis, Retno A S Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie S N Li‐Wai‐Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, Rintis Noviyanti, Wei Shi, Alexandra L Garnham, Diana S Hansen

“…Emerging views suggest that these infections are detrimental and constitute a parasite reservoir that perpetuates transmission. …”
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Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells by Jie Liu, Jun Wang, Min Wu, Ling Mao, Jianjun Li, Xuejia Zhai, Junhan Wang, Langhong Li, Jiangjie Duan, Shuang Lin, Shicang Yu

“…Moreover, mechanistic exploration revealed that the attenuation of autophagy-lysosome function caused by microenvironmental alkalization inhibited the degradation of MSLN. …”
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A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula by Nicolás Vidal-Vázquez, Ismael Hernández-Núñez, Pablo Carballo-Pacoret, Sarah Salisbury, Paula R. Villamayor, Francisca Hervas-Sotomayor, Xuefei Yuan, Francesco Lamanna, Céline Schneider, Julia Schmidt, Sylvie Mazan, Henrik Kaessmann, Fátima Adrio, Diego Robledo, Antón Barreiro-Iglesias, Eva Candal

“…Abstract The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. …”
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Effects of acupuncture on the signs and symptoms of people with rheumatic diseases: A scoping review by Mariane Elivânia Silva, Evelin Beatriz Bezerra de Melo, Maria Améllia Lopes Cabral, Laura Lima Souza, Silmara de Oliveira Silva, Nahadja Tahaynara Barros Leal, Jucielly Ferreira da Fonseca, Rodrigo Assis Neves Dantas, Daniele Vieira Dantas

“…Introduction: Rheumatic diseases constitute a wide range of chronic diseases that mainly affect the musculoskeletal system. …”
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Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology by Shuang Ma, Ying Lu, Shang Sui, Jia-shuo Yang, Bing-bing Fu, Pei-xin Tan, Yicheng Chai, Jiaqi Lv, Lingyu Kong, Xiaolin Wu, Yi-bo Gao, Tao Yan

“…The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Abstract Plant growth behavior is a function of genetic network architecture. The importance of root microbiome variation driving plant functional traits is increasingly recognized, but the genetic mechanisms governing this variation are less studied. …”
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Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Furthermore, PecA exhibits high efficacy against anaplastic large T cell lymphoma in vitro and in vivo, especially those with constitutively activated STAT3 or STAT3Y640F. In summary, our study describes a distinct and effective di-covalent modification for the dimeric compound PecA to disrupt STAT3 function.…”
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Navigating the future landscape of uterine fibroid research: a comprehensive summary of patient-centered outcome measures and implications by Shuhao Yang, Qing Yan, Fei Liu, Wei Yan, Suzhen Yuan, Minli Zhang, Ya Li, Zhangying Wu, Tao Xiang, Wenwen Wang

“…Abstract Background Uterine fibroid constitutes a significant burden for affected women and research in this area has increasingly focused on patient-centered outcomes, with patient-reported outcome measures (PROMs) becoming crucial in related studies. …”
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Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk by Patricia Guevara-Ramírez, Rafael Tamayo-Trujillo, Santiago Cadena-Ullauri, Viviana Ruiz-Pozo, Elius Paz-Cruz, Giuseppe Annunziata, Ludovica Verde, Evelyn Frias-Toral, Daniel Simancas-Racines, Ana Karina Zambrano

“…Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group of neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. …”
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Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system by Martta Peltoniemi, Surachet Imlimthan, Sonja C. Jalonen, Niklas Daniel Åke Persson, Terhi J. Lohela, Tuomas O. Lilius, Mirkka Sarparanta

“…Abstract Background The glymphatic system is a recently discovered brain-wide clearance system that allows the cerebrospinal fluid (CSF) flow to clear metabolic waste, but the tools for the quantitative and non-invasive investigation of its function and activity especially in humans is lacking, hindering studies on glymphatic system physiology and therapeutic potential of glymphatic drug delivery and modulation. …”
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El principio de universalización y la razón práctica (2a. parte) by Osvaldo Guariglia

“…This analysis once completed, I will examine (II) the function of the principle in the field of moral judgements and its main role as ultimate rule of practical reason to which it grants its peculiar form of objectivity. …”
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Use Efficiency, Reduction Potential, and Effects of Fertilizers on Carbon Emissions in China’s Major Citrus Regions by Yueyuan Yang, Chunjie Qi, Yumeng Gu, Guozhu Fang

“…Enhancing the efficiency of fertilizer utilization and advancing fertilizer reduction efforts constitutes a pivotal initiative for augmenting the quality and productivity of the citrus industry; this constitutes an indispensable prerequisite for attaining green and sustainable development. …”
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LL-37 Attenuates Sepsis-Induced Lung Injury by Alleviating Inflammatory Response and Epithelial Cell Oxidative Injury via ZBP1-Mediated Autophagy by Hu Gao, Fajuan Tang, Bin Chen, Xihong Li

“…Inflammation and oxidative stress constitute key pathological mechanisms in ALI caused by sepsis. …”
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Engineered transcription-associated Cas9 targeting in eukaryotic cells by Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan, Max A. B. Haase, Larisa Kagermazova, Mauricio A. Arias, Kenenna Onyebeke, Samantha Adams, Daniel K. Beyer, David Fenyö, Marcus B. Noyes, Jef D. Boeke

“…Both interactions are nucleic acid sequence specific but function constitutively; thus, they provide intrinsic spatial control over DNA targeting activities but naturally lack temporal control. …”
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Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction by Yuanling Ye, Fan Shen, Maoli Yan, Conghui Zhan, Jiahua Lv, Mengqin Zou, Zhifeng Wang, Shaokai Ning, Yanfei Gao, Jingxian Wu, Wen Li

“…Intermediate filaments, which constitute a key element of the cytoskeleton, function not only as diagnostic markers but also play a role in malignant processes, including tumor proliferation, apoptosis, and migration. …”
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Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity by Ida Stangerup, Ida Stangerup, Birgitte Georg, Jens Hannibal, Jens Hannibal

“…IntroductionProkineticin 2 (PK2) is believed to function as an output molecule, relaying circadian rhythms of behavior and physiology from the suprachiasmatic nucleus (SCN). …”
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Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis by Sima Besharat, Ali Jafari, Kosar Kordkatuli, Helia Mardani, Fatemeh Mehdipoor, Pardis Bakhtiari Jami, Maryam Abbastabar, Mohammadali Vakili, Alireza Alaghi

“…Introduction Heart diseases constitute a significant global public health concern. …”
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Misinformation or education? A comparative analysis of Instagram posts related to full mouth rehabilitation by Amal Alfaraj, Faris A. Alshahrani, Meshal Albalawi, Naif AlQahtani, Mohammed Alhajji, Ali Sulaiman Alharbi, Sultan Ainoosah, Khalifa S. Al-Khalifa

“…Full Mouth Rehabilitation (FMR), a complex treatment aimed at restoring oral function and aesthetics, remains underrecognized by the general public. …”
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Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells by Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa

“…Abstract Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS. …”
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Dark Ship Detection via Optical and SAR Collaboration: An Improved Multi-Feature Association Method Between Remote Sensing Images and AIS Data by Fan Li, Kun Yu, Chao Yuan, Yichen Tian, Guang Yang, Kai Yin, Youguang Li

“…Secondly, by integrating position, dimensions (length and width), and course characteristics, we devise a joint cost function to evaluate the combined significance of multiple features. …”
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