A Dominant-Negative PPARγ Mutant Promotes Cell Cycle Progression and Cell Growth in Vascular Smooth Muscle Cells by Joey Z. Liu, Christopher J. Lyon, Willa A. Hsueh, Ronald E. Law

“…We herein report that a synthetic dominant-negative (DN) PPARγ mutant functions like a growth factor to promote cell cycle progression and cell proliferation in human coronary artery smooth muscle cells (CASMCs). …”
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HIV infection of hepatocytes results in a modest increase in hepatitis C virus expression in vitro. by Ling Kong, Jeffrey A Welge, Eleanor A Powell, Jason T Blackard

“…Previous studies demonstrate that soluble HIV proteins impact both hepatocyte function and HCV replication in vitro. It has also been reported that HIV can productively infect hepatocytes. …”
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Cited1 deficiency suppresses intestinal tumorigenesis. by Valérie Méniel, Fei Song, Toby Phesse, Madeleine Young, Oliver Poetz, Lee Parry, John R Jenkins, Geraint T Williams, Sally L Dunwoodie, Alastair Watson, Alan R Clarke

“…Conditional deletion of Apc in the murine intestine alters crypt-villus architecture and function. This process is accompanied by multiple changes in gene expression, including upregulation of Cited1, whose role in colorectal carcinogenesis is unknown. …”
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Quality of Life related to health in the morbidity of periodic hemodialysis patient by Eliseo Capote Leyva, Milagros Ortiz González, Raydel Argudín Selier, Carmen Elena Viada González, Lázaro Capote Pereira, Idrissa Leonard Rupalé

“…<p><strong>Foundation</strong>: chronic renal failure has a negative impact in the quality of life and constitutes a morbidity predictor in patients with periodic hemodialysis.…”
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Military experience predicts military multitasking better than laboratory measures in officer cadets by Yannik Hilla, Maximilian Stefani, Elisabeth V. C. Friedrich, Wolfgang Mack

“…Abstract Whether or not it is possible to predict military performance using laboratory measures constitutes an important question. There are indications that humans possess a common multitasking ability enabling them to perform complex behaviors irrespective of task requirements. …”
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The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER. by Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Anne E Willis, Rachel E Simmonds

“…Several lines of evidence support this transformative explanation of mycolactone function. First, cellular TNF and Cox-2 can be once more detected if the action of the 26S proteasome is inhibited concurrently. …”
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G-continuous mappings and G-quotient mappings(G连续映射与G商映射) by 刘丽(LIU Li), 周先耕(ZHOU Xiangeng)

“…As a generalization of the usual convergence in topological spaces, a method G on a set X is a function G:cGX→X defined on a subset cGX which is constituted by some sequences in X. …”
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Habitual physical activity in mitochondrial disease. by Shehnaz Apabhai, Grainne S Gorman, Laura Sutton, Joanna L Elson, Thomas Plötz, Douglass M Turnbull, Michael I Trenell

“…Exercise therapy has been shown to improve mitochondrial function in patients with mitochondrial disease. However, no information exists about the level of habitual physical activity of people with mitochondrial disease and its relationship with clinical phenotype.…”
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Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment. by Yajia Chen, Jingxian Zhang, Weiqian Zheng, Hongwu Xu

“…Cuproptosis, caused by intracellular copper, is a novel RCD process that affects chemotherapy efficacy and glioma progression; however, the precise function of cuproptosis-related lncRNAs (CRLs) and cuproptosis-related genes (CRGs) in GBM remains uncertain. …”
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Lysosomal ion channels and pain by Wanxue Liu, Yiming Li, Yuhan Bao, Zhi-Yong Tan

“…In dorsal root ganglion neurons, lysosomal TRPM8 functions as a constitutive supply from lysosomal to plasma membrane, whereas lysosomal TRPA1 may mediate vehicle exocytosis of neurotransmitters. …”
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Development of Pogo Pin-Based Holding and Release Mechanism for Deployable Solar Panel of CubeSat by Shankar Bhattarai, Hongrae Kim, Sung-Hoon Jung, Hyun-Ung Oh

“…In this study, for the improvement of the conventional cable cutting mechanism, a spring-loaded pogo pin-based nichrome burn wire holding and release mechanism (HRM) was proposed and fabricated. The pogo pin constitutes an immensely attractive function for the holding and release mechanism of solar panels because it works as an electrical interface to provide power, a separation spring to initiate the reaction force to deploy the panels, and a status switch to determine deployments. …”
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Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Deciphering the “vimentin posttranslational modification code”, that is, the structure-function relationships of vimentin proteoforms, constitutes a major challenge to understand the regulation of vimentin behavior and its multiple personalities. …”
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Enhancing Neural Network Interpretability Through Deep Prior-Guided Expected Gradients by Su-Ying Guo, Xiu-Jun Gong

“…However, traditional DNNs often function as “black boxes,” delivering accurate predictions without providing insight into the factors driving their outputs. …”
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STAT signaling pathways in immune cells and their associated mechanisms in cancer pathogenesis by Sepideh Sohrabi, Shiva Alipour, Zahra Ghahramanipour, Javad Masoumi, Behzad Baradaran

“…Methods: In the current study, we review recent studies on the contribution of individual STAT proteins to cytokine signaling, development, and activity of diverse immune cells that constitute the whole immune system and help its performance against endogenous or exogenous agents with a particular focus on meaningful STAT factor in each of innate and adaptive immune cells’ subsets to clarify their function in favor of the tumor or against it. …”
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Efficacy of Routine Fecal Microbiota Transplantation for Treatment of Recurrent Clostridium difficile Infection: A Retrospective Cohort Study by Alexandra Nowak, Magnus Hedenstierna, Johan Ursing, Christer Lidman, Piotr Nowak

“…Patients with recurrent Clostridium difficile infections (CDIs) constitute an increasing treatment problem. Fecal microbiota transplantation (FMT) has shown promising results of treating recurrent CDI, where treatment with antibiotics fails repeatedly. …”
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Networked Language Communities: From Constructed Languages to Natural Languages by Marat N. Chistanov

“…The situation with the functioning of regional languages will change either with the revitalization of old language communities, or with the formation of new language communities in which the language can function as a real means of communication and will gain a new lease on life. …”

A Case of Calcific Myonecrosis: A Rare Clinical Presentation by Dhanasegaran Arunachalam, Balasubramaniam Ramasamy, Lalithambigai Chellamuthu

“…Routine blood tests, including liver function test, serum calcium, phosphorus, and alkaline phosphatase levels, were all normal. …”
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A Multi-Objective PSO-GWO Approach for Smart Grid Reconfiguration with Renewable Energy and Electric Vehicles by Tung Linh Nguyen, Quynh Anh Nguyen

“…Distribution network reconfiguration emerges as a pivotal strategy to mitigate power losses, facilitate the seamless assimilation of renewable generation, and regulate the charging and discharging dynamics of EVs, thereby constituting a critical endeavor in modern electrical engineering. …”
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Interaction between two timing microRNAs controls trichome distribution in Arabidopsis. by Xue-Yi Xue, Bo Zhao, Lu-Men Chao, Dian-Yang Chen, Wen-Rui Cui, Ying-Bo Mao, Ling-Jian Wang, Xiao-Ya Chen

“…The miR156-targeted squamosa promoter binding protein like (SPL) transcription factors function as an endogenous age cue in regulating plant phase transition and phase-dependent morphogenesis, but the control of SPL output remains poorly understood. …”
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Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes. by Michael D Hall, Caroline A Murray, Michael J Valdez, Alan O Perantoni

“…To date, mutations within the coding region and translocations around the SOX9 gene both constitute the majority of genetic lesions underpinning human campomelic dysplasia (CD). …”
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