A nonlinear creep model of hard structural planes. by Aneng Cui, Yongxin Dai, Chao Jia, Quansheng Mao, Kelin Yu, Pengcheng Wu, Mengsheng Zhao

“…By improving traditional elements, a new piecewise nonlinear constitutive relationship of hard structural planes is established and then the creep equation is obtained with integration method. …”
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Global genetic variations predict brain response to faces. by Erin W Dickie, Amir Tahmasebi, Leon French, Natasa Kovacevic, Tobias Banaschewski, Gareth J Barker, Arun Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Hugh Garavan, Juergen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Claire Lawrence, Karl Mann, Jean-Luc Martinot, Frauke Nees, Thomas Nichols, Mark Lathrop, Eva Loth, Zdenka Pausova, Marcela Rietschel, Michal N Smolka, Andreas Ströhle, Roberto Toro, Gunter Schumann, Tomáš Paus, IMAGEN consortium, IMAGEN consortium, IMAGEN consortium

“…Across the network, the strength of the genotype-phenotype relationship varied as a function of the inter-individual variability in the number of functional connections possessed by a given region (R(2) = 0.38, p<0.001). …”
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Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway by Benhuo Zhao, Jiaojiao Wu, Xiuli Cha, Guangtong Mao, Hengliang Shi, Sujuan Fei, Bei Miao

“…In recent years, the involvement of E3 ubiquitin ligase constitutive photomorphogenesis 1 (COP1) in the tumorigenesis of gastric cancer (GC) has been elucidated. …”
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Serum Presepsin Levels among Patients with COVID-19 by Fatma Nihan Turhan Çağlar, Cennet Yildiz, Ramazan Korkusuz, Kadriye Kart Yasar, Nilgun Isıksacan

“…Patients with mild–moderate illness constituted group 0 and those with severe–critical illness constituted group 1. …”
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Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates by Xin Jin, Yanru Zhou, Diwen Zhang, Xiu Chen, Jianghai Ruan, Dengfu Fang

“…Conclusion The CSVD group demonstrated increased stability in brain functional networks but reduced inter-network interaction capabilities. …”
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Study on the vibration prediction model of step group hole blasting considering non-stationarity by LI Hongchao, ZHANG Qipeng, HUANG Guoquan, SHI Yulian, HUANG Yonghui, HAN Haoxuan, YI Jiaxin, QU Chenliang

“…The necessity of this work lies in the fact that blasting vibration, as the most significant hazard in step blasting, directly threatens the safety of neighboring buildings and personnel, and accurate prediction of its characteristics is crucial for blasting engineering design and risk control.MethodsThis study takes the similarity between natural seismic wave and blasting vibration as the theoretical basis, uses the principle of modulated white noise to construct the frequency equation, processes the white noise through the filter and introduces the time-varying damping ratio and the intrinsic angular frequency, so as to make the frequency present non-stationarity; at the same time, the gamma function is selected as the intensity equation, which expresses the intensity non-stationarity with its ability to regulate the shape of the curve, and the product of the two constitutes the prediction model of single-hole blasting vibration X(t)=x(t)*A(t). …”
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SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β by Chun Liu, Kun Wu, Chuwen Li, Zhen Zhang, Peisong Zhai, Haiyan Guo, Jianjun Zhang

“…This study aimed to identify and validate the role and function of SPP1 + Macs in the malignant progression of HNSCC. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…There is strong evidence that hypoxic training, within the context of diabetes, constitutes a specialized form of exercise performed under conditions of intermittent hypoxia. …”
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The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces by Yasumasa Iwatani, Kazuhiro Matsuoka, Hirotaka Ode, Mai Kubota, Yoshihiro Nakata, Yuka Setoyama, Kanako Kojima, Mayumi Imahashi, Yoshiyuki Yokomaku

“…Additionally, mutations of the highly conserved PPLP-α6 hydrophobic residues severely disrupted Vif function. In the Vif structure, PPLP-α6 is positioned behind α1-α2 that constitutes the A3-binding Vif interfaces. …”
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Superoxide Dismutases in Immune Regulation and Infectious Diseases by Tong Liu, Jiajin Shang, Qijun Chen

“…Beyond their antioxidant functions, SODs also function as immunomodulatory proteins, regulating the maturation, proliferation, and differentiation of immune cells. …”
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PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis by Yu Zhang, Wei Su, Xiaoyu Ji, Zhou Yang, Qing Guan, Yuanxin Pang, Linkun Zhong, Yu Wang, Jun Xiang

“…Furthermore, the loss of the p53 function, particularly the R248Q mutation, de-repressed PCSK9 expression at the transcriptional level. …”
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Model for the assessment of rectangular reinforced concrete columns with limited confinement details by Franco Benedetti, Jesús-Miguel Bairán

“…Secondly, it presents a scheme for a limited confinement constitutive function, considering premature loss, restricted capacity, and section configuration, by adapting existing models. …”
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Research on the Full Life Cycle Deformation, Stress Response, and Dynamic Fatigue Performance of Concrete Structures in Pump Stations by Min Yuan, Xianhong Zhu, Lei Han, Yongfeng Qi, Zhiqiang Xie, Xi Qin, Yun Dong

“…In response to the current lack of three-dimensional analysis and the exploration of the mechanical behavior and damage evolution processes of concrete structures under variable temperature environmental conditions, this paper relies on the Fenghuangjing Pump Station project involving the Yangtze River and Huaihe River and constructs a concrete thermo-mechanical-fatigue-damage model based on the power exponent function damage constitutive model. By using multiple coupled simulation calculations to predict the performance of concrete structures; analyzing the stress, deformation, and fatigue damage of structures from construction to operation; comparing measured data; dynamically optimizing inversion to obtain concrete thermal parameters; proposing key control parameters; and warning indicators and thresholds, the research results can provide reference for the long-term safe operation of similar projects.…”
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Ecotoxicological evaluation in aquaculture in state park Serra do Mar-SP, Nucleo Itariru by Bruno Galvão de Campos, Denis Moledo de Souza Abessa, Mauro Cornacchioni Lopes, Newton José Rodrigues da Silva

“…Moreover, toxicity tests seem to constitute a tool to evaluate environmental quality in aquaculture.…”
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SURGICAL TREATMENT OF VALVULAR DISEASE IN PATIENTS WITH END STAGE CHRONIC RENAL FAILURE AND RENAL TRANSPLANT RECIPIENTS. DEVELOPMENT OF AN OPERATION PROTOCOL AND POSTOPERATIVE CARE by M. L. Semenovsky, Y. G. Moysyuk, D. A. Belokourov, G. A. Akopov

“…Patients with terminal stage of chronic renal failure (CRF), treated by chronic hemodialysis, constitute severe group of patients whose cardiac valve replacement represents a separate problem. …”
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Peroxisome Proliferator-Activated Receptors in HCV-Related Infection by Sébastien Dharancy, Maud Lemoine, Philippe Mathurin, Lawrence Serfaty, Laurent Dubuquoy

“…Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic management of patients chronically infected with HCV.…”
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GPCRs: The most promiscuous druggable receptor of the mankind by Khaled Alhosaini, Asim Azhar, Asma Alonazi, F Al-Zoghaibi

“…Examples of daily biological functions include neuronal communication and neurotransmission in the process of learning and memory, secretion (hormones, sweat, and saliva), muscle contraction, cellular growth, differentiation and migration during wound healing, and immunity to fight infections. …”
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The Role of Ion Channels in Pulmonary Hypertension: A Review by Han‐Fei Li, Xin‐Yao Li, Yu‐Qing Sun, Ze‐Ying Zhi, Liao‐Fan Song, Meng Li, Yi‐Ming Feng, Zhi‐Hao Zhang, Yan‐Feng Liu, Yu‐Jing Chen, Fan‐Rong Zhao, Tian‐Tian Zhu

“…ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. …”
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Is Inducible Nitric Oxide Synthase (iNOS) Promising as a New Target Against Pulmonary Hypertension? by Piotr Ryszkiewicz, Eberhard Schlicker, Barbara Malinowska

“…Consequently, the effectiveness of pharmacological iNOS inhibition and/or iNOS gene deletion is discussed and compared, also with reference to the activity of constitutive NOS isoforms, particularly endothelial NOS (eNOS). …”
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Deciphering the epigenetic role of long non‐coding RNAs in mood disorders: Focus on human brain studies by Bhaskar Roy, Anuj K. Verma, Yu Funahashi, Yogesh Dwivedi

“…The result is impaired brain function, contributing to the symptoms of MDD.…”
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