Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes by Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster, Thuy Nguyen, Julie S. Lau, Saurabh Baheti, Tim de Pooter, Peter De Rijk, Mojca Strazisar, Matt Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Cyril Pottier, Marka van Blitterswijk, Yan Asmann, Melissa E. Murray, Leonard Petrucelli, Andrew King, Claire Troakes, Safa Al-Sarraj, Robert A. Rissman, Annie Hiniker, Margaret Flanagan, Bret M. Evers, Charles L. White, Carlos Cruchaga, Rudolph Castellani, Jeroen G.J. van Rooij, Merel O. Mol, Harro Seelaar, John C. van Swieten, Björn Oskarsson, Robert Ross Reichard, Aivi T. Nguyen, Keith A. Josephs, Ronald C. Petersen, Nilüfer Ertekin-Taner, Bradley F. Boeve, Neill R. Graff-Radford, Sarah Weckhuysen, Dennis W. Dickson, Rosa Rademakers

“…Abstract Background In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential expression of key genes involved in aging and neurodegenerative diseases. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Abstract Background Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. …”
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Architecture and the Time of Space by Deborah Hauptman

“…And, subsequently, a practical desire to understand the conditions that constituted experience, and thus perception, sensation and mind. …”
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B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant by Claire Fritz, Daniel Feinberg, Akshaya Radhakrishnan, Kayla Klatt, E. Ricky Chan, Philip Rock, Richard Burack, Reshmi Parameswaran

“…Conversely, in the Bonna-12 cell line, we observed constitutive activation of the nonclassical NF-κB pathway. …”
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Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L by Zhengwei Tan, Dandan Lu, Yongliang Yu, Lei Li, Lanjie Xu, Wei Dong, Qing Yang, Chunming Li, Xiufu Wan, Huizhen Liang

“…Abstract Background WRKY transcription factors constitute one of the largest families of plant transcriptional regulators, playing pivotal roles in plant responses to biotic and abiotic stresses, as well as in hormonal signaling and secondary metabolism regulation. …”
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Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…In the paper, the authors considered the essence, functions, classifications of financial assets and liabilities, applied structural and dynamic data analysis, as well as methods of theoretical research in the form of generalization, comparison and special analytical procedures based on official statistics from Rosstat, the Bank of Russia, the Ministry of Finance and international statistical organizations.Results. …”
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REGIME DE COLABORAÇÃO NA POLÍTICA DE FORMAÇÃO DE PROFESSORES ALFABETIZADORES: limites para a gestão democrática by Cleonara Maria Schwartz, Gildo Lyone Antunes de Oliveira, Fernanda Zanetti Becalli

“…From a bibliographical-documentary research, a corpus of documents was constituted that were analyzed with reference to the dialogical perspective and, theoretically, based on the concepts of utterance, text, dialogue formulated by Bakhtin's circle (2003; 2004). …”
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Solar-thermoelectric mobile storage system integrated with electric vehicles for reducing postharvest and microbial losses in agro produce transportation by Lalith Pankaj Raj Nadimuthu, Kirubakaran Victor, Mohit Bajaj, Vojtech Blazek, Lukas Prokop

“…Abstract Agriculture constitutes a foundational pillar of the Indian economy, contributing nearly 18% to the national Gross Domestic Product (GDP) and ranking second globally in horticultural output. …”
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INTERNATIONAL LEGAL STANDARDS OF HUMAN RIGHTS: TOWARDS THE OBJECTIVITY OF THE ISSUE OF CODIFICATION WORKS by Mykhailo O. Baimuratov, Boris Ya. Kofman, Natalia V. Yefremova

“….), and secondly, establish mandatory obligations of their member states (international legal obligations of states, obligations of states under international treaties signed by them) in relation to a wide range of rights recognized by their legally recognized international catalog (personal, political, economic, social, cultural, environmental), thirdly, in the process of their implementation in various conditions (peacetime, state of martial law or war, environmental and man-made disasters, other extraordinary conditions of existence and functioning of statehood, etc.). It is noted that in the modern world, since the creation of the UN, the protection and observance of the basic rights and freedoms of a person and a citizen have ceased to be the competence of a specific country, but have become the business of the entire international community, since, first of all, it is the "alpha and omega" of international cooperation of states in its boundaries (the teleological factor of the modern international order – author); secondly, it is precisely within its limits that a powerful international legal array of treaty law documents was created regarding such specialized protection and protection of human and citizen rights / thanks to the increased concern and attention of the international community to these issues at various times, authoritative international organizations, including the UN, adopted about 300 declarations, conventions, charters/ (determining source factor of the modern international order – author); thirdly, for a long time, they have been the most important task of many states of the world community in terms of fulfilling their international legal obligations, taken within the framework of the international treaties signed by them and the implementation of their instructions within the limits of national jurisdiction (a mandatory factor of the modern international order – author); fourthly, there are clear international legal mechanisms of protection, protection and control over the fulfillment by member states of the international community of international legal obligations in the field of human and citizen rights and freedoms (the technologically protected factor of international protection, protection and control of modern international order – author); fifthly, the regulatory and technological phenomenon "international legal standards of the rights and freedoms of man and citizen" was used for the first time, which was transformed into an important, modern, effective phenomenology of modern international law, based on the relevant international and national implementation mechanisms of the international treaty law and provides for the mandatory borrowing of the above standards by the national constitutional legislation of the states – respectively, either signatories, or participants, or parties to relevant contractual international legal acts (transformational and implementation factor of international protection, protection and control of the modern international order – author). …”
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Environmental impact assessment of rapeseed production using the LCA method: Part two: Life cycle impact assessment by Kiš Ferenc, Đurišić-Mladenović Nataša, Marjanović-Jeromela Ana

“…This constitutes the second segment of an environmental life cycle assessment (LCA) study on oilseed rape cultivation in the prevalent conditions of Vojvodina, Serbia. …”
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Educational mediamorphosis and constructivist paradigm by Arūnas Vyšniauskas

“…The same was uttered by the US President Bill Clinton in his 10-point plan on how the Americans must constitute their education. Core role in this plan is devoted to the role of novel technologies, computers, Internet. …”
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Incidence, causes and prognostic outcomes of acute coma: a nationwide population-based retrospective cohort study in Taiwan by Chih-Ching Liu, Chih-Yuan Lin, Yue-Chune Lee, Jen-Feng Liang, Mingche Tsai, Meng-Ling Chang

“…Secondary outcomes assessed were reversible coma, hospitalisation rates, 30-day mortality, 1-year medical utilisation and long-term functional outcomes. Cox regression models identified factors influencing long-term mortality.Results The overall event rate for acute coma was 4.23 per 1000 ED visits, and the incidence rate was 0.93 per 1000 person-years. …”
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Catheter ablation of atrial fibrillation in women with heart failure with preserved ejection fraction by Maura M. Zylla, Maura M. Zylla, Maura M. Zylla, Johannes Leiner, Johannes Leiner, Johannes Leiner, Ann-Kathrin Rahm, Ann-Kathrin Rahm, Ann-Kathrin Rahm, Tobias Hoffmann, Tobias Hoffmann, Tobias Hoffmann, Patrick Lugenbiel, Patrick Lugenbiel, Patrick Lugenbiel, Patrick Schweizer, Patrick Schweizer, Patrick Schweizer, Christine Mages, Christine Mages, Christine Mages, Derliz Mereles, Derliz Mereles, Derliz Mereles, Meinhard Kieser, Eberhard Scholz, Eberhard Scholz, Eberhard Scholz, Hugo A. Katus, Hugo A. Katus, Hugo A. Katus, Norbert Frey, Norbert Frey, Norbert Frey, Dierk Thomas, Dierk Thomas, Dierk Thomas

“…Women with HFpEF still exhibited a lower SF-36 Physical Component Summary Score vs. women without HFpEF (median: 41.2 vs. 52.1, P < 0.001).ConclusionWomen with HFpEF constitute a distinct subgroup with high rates of AF-related events after AF-ablation, and persistence of both symptoms and functional hallmarks of HFpEF. …”
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Identification and Interpretation of Cultural Landscape Field from the Integral Conservation Perspective by Zhitong LIANG, Yan DU, Haiyan XIA

“…ObjectiveThe integrity-based paradigm in cultural heritage conservation and utilization has achieved disciplinary consensus within the professional domain, where systematic documentation of historical − cultural heritage resources (HCHR) constitutes the foundation for resource integration and subsequent spatial specific planning. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…<h4>Summary</h4>In this report we introduce a weak-model approach for examination of the intrinsic time-varying properties of the hemoglobin signal, with the aim of advancing the application of functional near infrared spectroscopy (fNIRS) for the detection of breast cancer, among other potential uses. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Methods: Three novel transgenic mouse models were engineered to investigate the functional contribution of Gpr45 to body weight and appetite regulation: 1) a global Gpr45 knockout, 2) a conditional floxed Gpr45 allele, and 3) a Gpr45-CreERT2 knock-in. …”
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The Effect of Iron Deficiency Stress on the Relative Expression of ZIP3, ZIP6, and ZIP7 Genes in Bread Wheat (Triticum aestivum L.) Cultivars by Saeed Rezaei Musa Dargh, Babak Abdollahi Mandoulakani, Raheleh Ghasemzadeh

“…Extended abstract Background: Bread Wheat is the most extensively cultivated wheat and one of the four major crops in the world that constitutes the principal food of more than 30% of the world population. …”
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The Mission of the Neocatechumenal Way in Times of Covid-19 by Bogumił Gacka

“…A concentration on both kinds of experience which in fact constitute the integral experience of the human person is called for. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…Consequently, prioritizing the advancement of their planning, design, and functional optimization is imperative. Finally, rigorous evaluation of the effectiveness of sleep quality improvement interventions is essential. …”
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Le fromage en Gaule à l’âge du Fer et à l’époque romaine : état des lieux pour sa production et analyse de sa place dans le monde antique by Alain Ferdière, Jean-Marc Séguier

“…It also meant examining the data published or recorded in excavation reports and eliminating the numerous parasitic elements that constitute various other “potsherds pierced with small holes” which have the most diverse functions –and are not always well identified– certainly far removed from the straining of curdled milk. …”
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