Involvement of circadian clock protein PER2 in controlling sleep deprivation induced HMGB1 up-regulation by targeting p300 in the cortex by Min Zhang, Zhuoyao Ma, Haoran Cui, Yumeng Miao, Yu Yin, Qing Wen, Zhihui Liu, Xin Huang, Chen Xing, Kun Liu, Hui Peng, Lun Song

“…The truncated PER2 mutant without p300 binding ability lost its ability to regulate p300 expression, indicating that PER2 functioned as a co-suppressor of p300 in regulating acetylation and expression of HMGB1. …”
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Historical traces in Southern Grevena during Ottoman occupation by Vasileios D. Spanos

“…Consequently, the southern part of the Prefecture of Grevena and the territory of today’s Prefecture of Trikala, constituted then, the area of northwest Thessaly which already from the era of Byzantium was a single geographical entity. …”
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GLOBAL ENERGY MARKET SUSTAINABILITY: MODERN CHALLENGES IN SCOPE OF UKRAINIAN CONTEXT by Mariya Kuznetsova

“…The natural potential and generating capacities of key energy market actors all over the world constitute an enormous political advantage. The use of innovative technologies, such as 3D printing, could transform cargo transportation by reducing the volume of physical transportation, opening avenues for optimising transport infrastructure and reducing logistics costs. …”
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Regulatory and legal support for the basic military training of students in higher education institutions of Ukraine by O. S. Kuruch, O. V. Batiuk, M. V. Fedorov

“… In the scientific article, the authors note that basic military training, hereinafter referred to as BMT, must be conducted on a mandatory basis in order for Ukrainian citizens to obtain military specialisation, skills and abilities necessary to fulfil their constitutional duty to defend the homeland, independence and territorial integrity of Ukraine. …”
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Tendencias cuánticas en empresas orientadas hacia el conocimiento: Análisis de caso de una experiencia costarricense. Quantic trends in knowledge-based companies: A case analysis o... by César Zúñiga Ramírez, Jennier Solano Cordero, Rolando Bolaños Garita

“…From the information collected from the project managers involved in this firm, we have concluded that their points of view show tendencies that differ from the quantic approaches, and this constitutes an element that diminishes the enterprise’s competitiveness, as well as its capacity to adapt, and the flexibility in the functioning of its operation.…”
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Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict. by Nicholas J Croucher, Rafal Mostowy, Christopher Wymant, Paul Turner, Stephen D Bentley, Christophe Fraser

“…To evaluate the feasibility of the functions suggested by the modelling analysis, we analysed genomic data from longitudinal sampling of individuals carrying Streptococcus pneumoniae. …”
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Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3... by Miao Xiong, Ziqiu He, Liping Wen, Aimin Zhao

“…MicroRNA sequencing revealed that miR-92b-3p were the most significantly upregulated microRNA in trophoblasts treated with URSA-DSC-exos. Further functional experiments demonstrated that URSA-DSC-exos inhibited trophoblast migration and invasion by transferring miR-92b-3p. …”
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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. by Carmela De Marco, Carmelo Laudanna, Nicola Rinaldo, Duarte Mendes Oliveira, Maria Ravo, Alessandro Weisz, Michele Ceccarelli, Elvira Caira, Antonia Rizzuto, Pietro Zoppoli, Donatella Malanga, Giuseppe Viglietto

“…Finally, we made use of Ingenuity Pathway Analysis (IPA) to investigate the relevant BioFunctions enriched by the costitutive activation of AKT1-, PI3K- or PTEN-dependent signalling in lung epithelial cells. …”
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Morphological evaluations in buffaloes (Bubal- us bubalis) in Venezuela by Luis Alfredo Pacheco-Díaz, José Atilio Aranguren-Méndez, Rafael Román-Bravo, Sharon Rivero-Hernández, Luis Edgardo Tovar-Briceño

“…The morphometry study consists of the search for a functional animal. These traits also contribute to the selection process in identifying the morphologically superior animals and eliminating the unwanted characters. …”
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Prohibition of Discrimination Based on Sexual Orientation: Analysis of CJEU and ECtHR Case Law Concerning Human Rights by Monika Patrycja Bator-Bryła

“…The prohibition of discrimination, including on the grounds of sexual orientation, undoubtedly constitutes one of the main social and economic objectives of the European Union. …”
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Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications by Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai

“…The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate proteoglycan, viral protein assembly in conjunction with the N and E genes, and enhanced glucose transport. …”
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Degradation of agricultural polyethylene film by greater wax moth (Galleria mellonella) larvae and screening of involved gut bacteria by Qing Ma, Yule Qian, Weisi Su, Lanxin Shi, Enjun Wang, Aixian Yu, Junjie Zheng, Yin Lu

“…Three novel strains—Pseudomonas putida ZSA123, Enterobacter hormaechei LBA140, and Lysinibacillus fusiformis LBB122—were isolated, constituting the first documented evidence of these bacterial species functioning as highly efficient plastic-degrading symbionts in wax moths, with Pseudomonas putida and Lysinibacillus fusiformis representing particularly novel discoveries in plastic-consuming insects. …”
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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…Specifically, we worked by combining the RWQWRWQWR sequence derived from bovine lactoferricin with different functional peptides such as anticancer peptides, cervical cancer cell-targeting peptides, and cell-penetrating peptides. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…IntroductionThe HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. …”
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Comparison of Dietary Inorganic and Small-Peptide Chelating Trace Minerals on Growth Performance, Immunity, Meat Quality, and Environmental Release in <i>Litopenaeus vannamei</i> by Jingshen Chen, Nan Liu, Shumeng Wang, Hailong Wang, Kun Ouyang, Yuxuan Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yuping Sun, Yongguo Si, Yongliang Zhang, Ting Chen

“…Therefore, replacing 40–50% ITMs with SPMs can maintain growth performance while enhancing physiological functions. In conclusion, the results of this study demonstrate that the incorporation of 30–50% SPMs into one’s diet constitutes a viable alternative to 100% ITMs.…”
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Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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The bacterial microbiome of symbiotic and menthol-bleached polyps of long-term aquarium-reared Galaxea fascicularis by Puntin, Giulia, Wong, Jane C. Y., Röthig, Till, Baker, David M., Sweet, Michael, Ziegler, Maren

“…While understanding coral functioning is essential to guide conservation efforts, research is challenged by the complex nature of corals. …”
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Comparative Analysis of Rhizosphere Microbiomes in Different Blueberry Cultivars by Lifeng Xiao, Qiuyue Zhao, Jie Deng, Lingyan Cui, Tingting Zhang, Qin Yang, Sifeng Zhao

“…Recent advancements in high-throughput sequencing and multi-omics technologies have enhanced the investigation of variations in rhizosphere microbial communities and their functional roles across different plant cultivars. In this study, high-throughput sequencing was utilized to assess the rhizosphere microbial diversity in highbush and rabbiteye blueberry groups, encompassing a total of eight cultivars. …”
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PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis by Qiang Zheng, Jihong Xing, Xiaozhou Li, Xianming Tang, Dongshan Zhang

“…Acute kidney injury (AKI) constitutes a significant public health issue. Sepsis accounts for over 50 % of AKI cases in the ICU. …”
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EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis by Hsuan-Yu Peng, Kwang-Yu Chang, Wei-Min Chang, Chia-Yu Wu, Hsin-Lun Lee, Yung-Chieh Chang, Ko-Jiunn Liu, Shine-Gwo Shiah, Ching-Chuan Kuo, Jang-Yang Chang

“…Among EGFR mutation, EGFRvIII, an extracellular domain truncated form without exons 2–7, exhibits ligand-independent and constitutive EGFR activation. Although EGFRvIII functions as an oncogene in glioblastoma, its role in OSCC remains unclear. …”
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