ECT2 peptide sequences outside the YTH domain regulate its m6A-RNA binding by Daphné Seigneurin-Berny, Claire Karczewski, Elise Delaforge, Karen Yaacoub, Celso Gaspar Litholdo, Jean-Jacques Favory, Malene Ringkjøbing Jensen, Cécile Bousquet-Antonelli, André Verdel

“…The main m6A readers constitute a super family of proteins with hundreds of members that share a so-called YTH RNA binding domain. …”
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MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation by Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne

“…In addition, the N‐lobe‐mutated MET variants were found to trigger a common HGF‐stimulation‐dependent transcriptional program, consistent with an observed increase in cell motility and invasion. Altogether, this functional characterization revealed that N‐lobe variants still require ligand stimulation, in contrast to other RTK variants. …”
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System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain—an explorative study by Mika Jönsson, Emmanuel Bäckryd, Stefan Ljunggren, Nina Ottosson, Amaia Jauregi-Miguel, Sara I. Liin, Antonio Checa, Craig E. Wheelock, Bijar Ghafouri

“…These results present a previously unexplored network of integrated alterations of lipoproteins, octadecanoids, and cytokines in patients suffering from NeuP, indicative of deviant immuno-protective functioning across several biological systems including lipid metabolic processes, inflammation, and Kv7.2/7.3 signalling.…”
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CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination by Ke Ma, Qinyu Li, Yi Zhang, Jiuyi Wang, Wei Jia, Jihong Liu, Bo Liu, Qiang Li, Qinzhang Wang, Kai Zeng

“…Clear cell renal cell carcinoma (ccRCC) is strongly aetiologically associated with von Hippel‒Lindau (VHL) tumour suppressor gene mutations, which result in constitutive activation of hypoxia-inducible factors and pathological angiogenesis. …”
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Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction by Shizheng Zhang, Mengmeng Li, Yuan Li, Shike Yang, Jian Wang, Xiaoxiang Ren, Xiuhui Wang, Long Bai, Jianping Huang, Zhen Geng, Guosheng Han, Yibin Fang, Jiacan Su

“…Herein, artificial NVs are loaded with UDCA and then functionalized with triphenylphosphonium (TPP) molecules, denoted as UDCA-NVs-TPP. …”
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Surgical Treatment of Distal Radius Fractures Using Minimally Invasive Plate Osteosynthesis or Open Reduction and Internal Fixation: A Five-Year Comparative Follow-Up Study by Giuseppe Rovere, Pierfrancesco Pirri, Gianmarco Murgante, Vincenzo De Luna, Aurelio Testa, Giovanna Fidone, Francesco Liuzza, Pasquale Farsetti, Fernando De Maio

“…Distal radius fractures (DRFs) constitute one of the most prevalent injuries in adults. …”
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Advances in the mechanism of small extracellular vesicles promoting the development of hepatocellular carcinoma through multi-network fusion by Xiaoying Yuan, Defa Huang, Liang Peng, Yilong Lin, Lijuan Wang, Jiawei Yan, Youming Qiu, Chenggui Song, Qi Wang

“…Currently, elucidating the molecular mechanisms of HCC pathogenesis and identifying effective therapeutic targets constitute major research priorities in this field.Small extracellular vesicles (sEVs) are phospholipid bilayer vesicles (30-150 nm in diameter) carrying functional proteomes and nucleic acids (e.g., miRNAs, lncRNAs) with substantial biological activity. …”
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Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression by Jifang Liu, Zhang Ye, Yi Zhang, Shen You, Siqi Sun, Lin Lu, Wan Su, Jie Liu, Jun Pu, Hui Pan, Huijuan Zhu, Kan Deng, Yong Yao, Xiaomin Hu, Shuyang Zhang

“…Abstract Growth hormone-secreting pituitary neuroendocrine tumors (GH-PitNETs) arise from the anterior pituitary gland and constitute 20–30% of all PitNETs, representing a significant subset of functional pituitary tumors. …”
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Genetic basis of the mucilage secretion ability associated with nitrogen fixation from aerial roots of maize inbred lines under low nitrogen conditions by Bowen Zhao, Xin Hou, Zhongliang Yu, Ronghui Zhang, Huixin Teng, Ziqiong Yang, Jianju He, Huijuan Wang, Zhihao Song, Jiankang Zheng, Bolin Song, Shiwei Ma, Doudou Sun, Xiaowei Fan, Jingyang Gao, Zijian Zhou, Jiafa Chen, Pei Jing, Jianyu Wu

“…We categorized mucilage secretion into constitutive and low-nitrogen-inducible types. Through genotype-by-environment interaction studies, 8 QTL, 16 QTN, and 19 candidate genes were identified, revealing the genetic mechanisms underlying mucilage secretion under low-nitrogen conditions. …”
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Vascular endotelial dysfunction is a pathogenetic factor in the development of neurodegenerative diseases and cognitive impairment by N. V. Goncharov, P. I. Popova, A. S. Golovkin, N. M. Zalutskaya, E. I. Palchikova, K. V. Zanin, Р. V. Avdonin

“…The small vessel diseases constitute a whole group of primarily epigenetically caused diseases, the clinical consequence of which is often vascular dementia. …”
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Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection by Frauke Lange, Jonathan Garn, Matthias Bruhn, Thomas Pietschmann, Arnaud Carpentier

“…Background & Aims: Stem cell-derived hepatocyte-like cells (HLCs) are an in vitro model of hepatocytes reproducing mature hepatic functions. However, heterogeneous or imperfect differentiation may limit their biological relevance. …”
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New energy effect in non-cylindrical domains with a thermally insulated moving boundary by E. M. Kartashov

“…A new mathematical apparatus for the equivalence of functional constructions for the originals of the obtained operational solutions, which considers the computational difficulties in finding analytical solutions to boundary value problems for equations of hyperbolic type in the domain with a moving boundary, is developed.Results. …”
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Burnout Levels and Affecting Factors in Nurses Working in a University Hospital by Serkan Özsoylu, Başak Akyıldız, Adem Dursun

“…At the same time, PICU nurses were also better in terms of social functioning than nurses working in other departments (p=0.049). …”
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P. TILLICHO ONTOLOGIJA IR I. KANTO TRANSCENDENTALINĖ FILOSOFIJA by Mindaugas Briedis

“…Though Tillich agrees with Kant that faith being of an existential character involving the whole of human existence, does not constitute a theoretical problem of the sort we encounter in empirical inquiry, but because of this wholeness Tillich sees Kant’s moral solution concerning nature of religion as reductive and suggests that an act of faith is a matter of all mental functions (intellect, will, emotion) of human being. …”
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Comparison of carbon budgets and greenhouse gas fluxes in monoculture ponds with milkfish (Chanos chanos) and Taiwanese hard clams (Meretrix taiwanica) by Zhao-Jun Yong, Wei-Jen Lin, Shu-Chiu Hsieh, Hsing-Juh Lin

“…Phytoplankton production constituted the major carbon input pathways in the clam (72–85 %) and fish (41–48 %) ponds. …”
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Relationships between types of balance performance in 3-to-6-year-old preschoolers: a cross-sectional study by Jiefeng Zhu, Ruiqin Li, Ao yu, Pei Deng, Sikuan Ren, Yulong Nie, Ruiyuan Li

“…Methods Four balance types were assessed in 619 preschoolers (aged 3 to 6 years): static steady-state (one-legged stance, OST), dynamic steady-state (10-meter walk, 10MWT), proactive (functional reach test, FRT), and reactive (push and release test, PRT). …”
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P. TILLICHO ONTOLOGIJA IR I. KANTO TRANSCENDENTALINĖ FILOSOFIJA by Mindaugas Briedis

“…Though Tillich agrees with Kant that faith being of an existential character involving the whole of human existence, does not constitute a theoretical problem of the sort we encounter in empirical inquiry, but because of this wholeness Tillich sees Kant’s moral solution concerning nature of religion as reductive and suggests that an act of faith is a matter of all mental functions (intellect, will, emotion) of human being. …”
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P. TILLICHO ONTOLOGIJA IR I. KANTO TRANSCENDENTALINĖ FILOSOFIJA by Mindaugas Briedis

“…Though Tillich agrees with Kant that faith being of an existential character involving the whole of human existence, does not constitute a theoretical problem of the sort we encounter in empirical inquiry, but because of this wholeness Tillich sees Kant’s moral solution concerning nature of religion as reductive and suggests that an act of faith is a matter of all mental functions (intellect, will, emotion) of human being. …”
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Impacts of Low-Order Stream Connectivity Restoration Projects on Aquatic Habitat and Fish Diversity by Xinfeng Li, Xuan Che, Xiaolong Chen, Changfeng Tian, Jiahua Zhang

“…River barriers constitute a key factor that is degrading river connectivity and represent a critical research focus in riverine ecosystem conservation. …”
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Application of Sulfur-2,4-dinitrophenylhydrazine as Modifier for Producing an Advantageous Concrete by Khayit Turaev, Dilnoza Shavkatova, Nodira Amanova, Mohanad Hatem Shadhar, Elyor Berdimurodov, Nessipkhan Bektenov, Ahmad Hosseini-Bandegharae

“…The IR findings verified the presence of amino functional groups (connected melamine ring) and the establishment of polymer sulfur chains. …”
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