Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families by Mutaz Amin, Claudia Gragnoli

“…However, the functional relevance of the novel variants and genes reported in our study remains to be explored.…”
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Peripheral arterial pathology and osteoarthritis of the knee: US examination of arterial wall stiffness, thickness, and flow characteristics by Jon Olansen, Minglang Yin, Janine Molino, Thomas Carruthers, Derek Jenkins, George Karniadakis, Roy K. Aaron

“…Shared factors like phenotypic similarities, hypofibrinolysis, and inflammation constitute similarities in pathophysiology and clinical manifestations between OA and peripheral vascular disease (PVD). …”
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Experimental Investigation and Simultaneous Optimisation of Honing Parameters of Dry Cast Iron Cylinder Relining Sleeves of Motor Vehicle Engine Blocks for Surface Finish and Energ... by Nicholas Tayisepi, Lameck Mugwagwa, Albert Mnkandla, Innocent Mapindu, Takudzwa Muhla

“…Machining based manufacturing industries consume significant amounts of electrical energy, to power the several modules constituting the machine tool, with low levels of efficiency. …”
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Comparative analysis of community composition and network structure between phyllosphere endophytic and epiphytic fungal communities of Mussaenda pubescens by Deqiang Chen, Juanjuan Yang, Shunfen Wang, Siren Lan, Yonglong Wang, Zhong-Jian Liu, Xin Qian

“…ABSTRACT The phyllosphere constitutes a critical habitat for microorganisms, exerting profound influences on host vitality, developmental dynamics, reproductive functions, and stress resilience. …”
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The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma by Nour Abu Jayab, Alaa Abed, Iman M. Talaat, Rifat Hamoudi

“…Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. …”
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Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway by Yushan Ye, Fan Wu, Bowen Li, Hanyu Ma, Lianxi Mai, Yu Peng, Xiaodi Feng, Xiao Tan, Min Fu, Yongmei Tan, Tianjun Lan, Ruixin Wang, Siqi Ren, Jinsong Li, Shaohai Chang, Shule Xie

“…PIWI-interacting RNAs (piRNAs) serve as epigenetic effectors in cancer progression and constitute significant compositions of exosomes. Here, we explored the functional mechanism of exosomal piRNAs in OSCC development. …”
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An Open Model of Cultural Dialogue in the Context of Safe Social Interaction by Huseyn G. Zeynalov, Irina B. Vinogradova, Galina A. Shulugina, Alikram Z. Abdullaev, Maxim A. Eliseev

“…The prospects of the study are aimed at revising the basic characteristics and postulates of modern culture in order to determine the constitutive role of dialogue in the formation of a new (mixed) reality and the mechanism of its functioning. …”
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Realist evaluation of the impact and transferability of a greening of school playgrounds program: The APPIE GREEN study protocol by Louise Wallerich, Charlotte Decroix, Lucile Robert, Linda Cambon

“…The aim of the data collection is to characterise the contextual elements (Ce and Ci), the mechanisms (M), and the results (O) of each case and to iteratively validate the CeCiMO configurations, considered as the functions through which greening encourages natural play. …”
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Treatment resistance in schizophrenia and depression as an interactive kind: Mapping the development of a classification through Meta-Narrative review by Leighton Schreyer, Csilla Kalocsai, Oshan Fernando, Melanie Anderson, Vanessa Lockwood, Sophie Soklaridis, Gary Remington, Araba Chintoh, Suze Berkhout

“…We also consider the notion of “pseudoresistance,” a novel concept that functions to manage and contain heterogeneity, defining the boundaries of TR through its exclusions. …”
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Multi-omics analysis identifies LANCL2 as a potential biomarker for the diagnosis and prognosis of gastric cancer by Xidong Fang, Mengxiao Liu, Qian Ren, Renpeng Li, Guozhi Wu, Hao Yuan, Ya Zheng, Xi Gou, Yuping Wang, Yongning Zhou

“…Abstract Gastric cancer (GC) constitutes a significant global public health burden due to its high morbidity rates and poor prognosis, underscoring the critical need for identifying novel therapeutic targets and elucidating their mechanisms. …”
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Enhancing zinc-air battery performance through ph-tuned biopolymeric hydrogels in near-neutral electrolytes by Sara Vaca-Chacón, Vivian Morera Córdova, José Béjar, Lorena Álvarez-Contreras, Juan P. Tafur

“…Hence, the proposed system constitutes a promising avenue for sustainable energy storage solutions.…”
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7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits by Dominik Nießen, Ravichandran Rajkumar, Dilsa Cemre Akkoc Altinok, Gereon Johannes Schnellbächer, Shukti Ramkiran, Jana Hagen, Nadim Jon Shah, Tanja Veselinović, Irene Neuner

“…Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. …”
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Removal of Microplastics from Laundry Wastewater Using Coagulation and Membrane Combination: A Laboratory-Scale Study by Thi Trang Luu, Dai Quyet Truong, Van Nam Nguyen, Sanghyun Jeong, Thi Thu Trang Nguyen, Van Manh Do, Saravanamuthu Vigneswaran, Tien Vinh Nguyen

“…Fourier transform infrared spectroscopy further demonstrated the formation of new functional groups, substituted benzene rings, and the presence of Fe-O and Al-O bonds, indicating the interaction between MPs and coagulants. …”
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Technological Evolvement in AAC Modalities to Foster Communications of Verbally Challenged ASD Children: A Systematic Review by Walia Farzana, Farhana Sarker, Tom Chau, Khondaker A. Mamun

“…Augmentative and Alternative Communication (AAC) emerged as a combination of methods or strategies that constitute any device, such as Speech Generating Device (SGD), Program (mobile applications), Procedure (PECS, Picture Exchange Communication System), which enhances individual’s communication ability. …”
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Genome-wide identification and characterization of soybean GH9 endo-1,4-β-glucanases by Weimin Zhan, Huijuan Huang, Zaipan Cai, Zhenwei Zhao, Xuefu Lin, Yize Peng, Zhicheng Dong, Di Qin, Di Qin, Li Jiang

“…Furthermore, we identified 13 distinct types of functional motifs, with light-responsive elements being predominant. …”
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Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design by Rezart Zhubi, Apirat Chaikuad, Christian J. Muñoz Sosa, Andreas C. Joerger, Stefan Knapp

“…Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway. …”
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Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation by Yunhui Si, Xiaorong Li, Shuao Dong, Xueqin Gao, Yuetong Zhu, Linzhen Mo, Zhiwei Wang, Shuhan Wang, Chao Zhang

“…The limited bone regeneration and suboptimal immune responses constitute the major challenges in repairing critical-sized bone defects. …”
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Integrated Transcriptomic and Metabolomic Analyses Reveal the Importance of the Terpenoid, Fatty Acid, and Flavonoid Pathways in Rice Cell Death and Defense by Pengfei Bai, Yanfang Liu, Laisa Gomes-Dias, Rachel Combs-Giroir, Shaoxing Dai, Naeyeoung Choi, Yun Lin, Matthew Bernier, Emmanuel Hatzakis, Guo-Liang Wang, Joshua J. Blakeslee

“…This study provides an overall landscape of the transcriptomic and metabolomic alterations in a lesion mimic mutant, identifying candidate defense-related genes and metabolites for functional analysis in rice.…”
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Deletion of succinic semialdehyde dehydrogenase sad and chromosomal expression of phosphoenolpyruvate carboxylase as metabolic requirements for improved production of 2,4-dihydroxy... by T. A. Stefanie Nguyen, Ceren Alkim, Nadine Ihle, Thomas Walther, Cláudio J. R. Frazão

“…The fermentative production of the functional precursor 2,4-dihydroxybutyrate (DHB) enables sustainable synthesis of the methionine analogue hydroxy-4-(methylthio) butyrate, which is currently still produced from fossil fuels. …”
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Differential coping capacities underlie the overall resistance of temperate seagrasses to herbivory by J. Boada, T. M. Smith, A. M. Ricart, T. Alcoverro, M. Pérez, J. Romero, N. Sanmartí, Y. Ontoria, M. Pierrejen, R. Arthur, D. Alonso, M. P. Adams, F. Rossi

“…The overall ecosystem functioning and associated biodiversity depend on these responses but there is still little understanding on how the intensity and duration of herbivory interact and impact vegetated ecosystems. …”
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