Promoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory by Xiaomei Zheng, Yuting Guo, Meiling Chen, Yudan Lu, Yimou Du, Yu Lei, Ping Zheng, Jibin Sun

“…Results In this study, we identified two functional upstream activation sequences (UAS) located upstream of the core promoters of highly expressed genes in A. niger. …”
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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure. by Tommi A White, Alberto Bartesaghi, Mario J Borgnia, Joel R Meyerson, M Jason V de la Cruz, Julian W Bess, Rachna Nandwani, James A Hoxie, Jeffrey D Lifson, Jacqueline L S Milne, Sriram Subramaniam

“…Our findings suggest a structural explanation for the molecular mechanism of CD4-independent viral entry and further establish that cryo-electron tomography can be used to discover distinct, functionally relevant quaternary structures of Env displayed on intact viruses.…”
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Methodology of Estimating Efficiency of Non-Profit-Making Organization by N. A. Borisova

“…In view of this an important task is to estimate efficiency of NPMO functioning. The author demonstrates three approaches to estimating efficiency of NPMO and provides formulas of calculations and examples of use. …”
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SCARN a Novel Class of SCAR Protein That Is Required for Root-Hair Infection during Legume Nodulation. by Liping Qiu, Jie-Shun Lin, Ji Xu, Shusei Sato, Martin Parniske, Trevor L Wang, J Allan Downie, Fang Xie

“…Surprisingly two of the scarn mutants showed constitutive branching of root hairs in uninoculated plants. …”
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Sympatry and evolution: relationships between the endemic Myrcia guarujana and the widely distributed M. spectabilis by M. A. G. Magenta, L. F. Almeida, L. M. Rocha, C. E. A. Batista, R. H. G. Priolli

“…Among the outlier loci, we have LNG1, which promotes foliar elongation, and MYB82, a transcription activator functionally equivalent to GL1, in which high levels of expression result in decreased trichome abundance. …”
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Genome-Wide Identification of the GPAT Family in <i>Medicago sativa</i> L. and Expression Profiling Under Abiotic Stress by Jianzhi Ma, Mingyang Du, Huiyan Xiong, Ruijun Duan

“…This research can further constitute a fundamental basis for the exploration of the alfalfa GPAT family, the screening of key GPATs, and the investigation of their functionalities.…”
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CSN-CRL Complexes: New Regulators of Adipogenesis by Dawadschargal Dubiel, Michael Naumann, Wolfgang Dubiel

“…Recent discoveries revealed mechanistic insights into the control of adipogenesis by the Constitutive Photomorphogenesis 9 Signalosome (CSN) and its variants, CSN^CSN7A and CSN^CSN7B, which differ in the paralog subunits, CSN7A and CSN7B. …”
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Minimally Invasive Posterior Plating for Comminuted Middle to Distal One-Third Humeral Shaft Fractures: A Case Report by Shlok Patel, Kalp Shah, Stuti Shah, Stuti Dave, Pranav Shah

“…Introduction: Humeral shaft fractures constitute 1–1.5% of all fractures, with most occurring in the middle and distal segments. …”
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Divergent altitudinal patterns of arbuscular and ectomycorrhizal fungal communities in a mid-subtropical mountain ecosystem by Taotao Wei, Huiguang Zhang, Shunfen Wang, Chunping Wu, Tieyao Tu, Yonglong Wang, Xin Qian

“…These findings provide critical insights into the ecological functions and environmental adaptations of mycorrhizal fungi, advancing our understanding of their responses to environmental changes in mountain ecosystems and informing evidence-based conservation strategies.…”
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Conception de l’artefact, conception du collectif : dynamique d’un processus de conception ouvert et continu dans une communauté de développement de logiciels libres by Flore Barcellini

“…Elicitation of needs and valorization of the new functionality take place in the use-oriented mailing-list, refinements of the functionality specifications take place in the design-oriented mailing list, whereas proper specifications take place in parallel in the two mailing-lists. …”
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MiR-200c synergizes with trastuzumab-loaded gold nanoparticles to overcome resistance in ovarian cancer cells by Tommaso A. Salamone, Sofia Marotta, Stella Mrmić, Salvatore Raffa, Sara Cerra, Beatrice Pennacchi, Martina Mercurio, Vincenzo Visco, Maurizio Alimandi, Maria Rosaria Ricciardi, Maurizio Taurino, Ilaria Fratoddi, Pankaj Trivedi, Eleni Anastasiadou

“…Abstract Background Trastuzumab (TZ) resistance remains a significant challenge in the treatment of human epidermal growth factor receptor 2 (HER2)-positive epithelial ovarian cancer (EOC), necessitating novel therapeutic strategies to improve treatment efficacy. Functionalized gold nanoparticles (AuNPs) constitute a promising platform for drug delivery and the ability to enhance tumor targeting via the enhanced permeability and retention (EPR) effect. miR-200c, a well-established tumor suppressor microRNA (miRNA), plays a crucial role in inhibiting epithelial-mesenchymal transition (EMT). …”
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Cancer stem cells: landscape, challenges and emerging therapeutic innovations by Haksoo Lee, Byeongsoo Kim, Junhyeong Park, Sujin Park, Gaeun Yoo, Soomin Yum, Wooseok Kang, Jae-Myung Lee, HyeSook Youn, BuHyun Youn

“…Abstract Cancer stem cells (CSCs) constitute a highly plastic and therapy-resistant cell subpopulation within tumors that drives tumor initiation, progression, metastasis, and relapse. …”
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Microencapsulation of bioactive volatile compounds from MD2 pineapple peel Extract using spray-drying and foam-mat drying by Nur Liyana Nordin, Jamilah Bakar, Noranizan Mohd Adzahan, Ahmad Faizal Abdull Razis, Norsharina Ismail, Rabiha Sulaiman

“…Pineapple peel extracts constitute bioactive compounds that degrade due to light, oxidation, and moisture. …”
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Surface Integrity of Austenitic Manganese Alloys Hard Layers after Cavitation Erosion by Ion Mitelea, Ilare Bordeașu, Daniel Mutașcu, Corneliu Marius Crăciunescu, Ion Dragoș Uțu

“…Cavitation erosion, as a mechanical effect of destruction, constitutes a complex and critical problem that affects the safety and efficiency of the functioning of engineering components specific to many fields of work, the most well-known being propellers of ships and maritime and river vessels, seawater desalination systems, offshore oil and gas drilling platforms (including drilling and processing equipment), and the rotors and blades of hydraulic machines. …”
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Anti-Inflammatory Cytokine Interleukin-4 Inhibits Inducible Nitric Oxide Synthase Gene Expression in the Mouse Macrophage Cell Line RAW264.7 through the Repression of Octamer-Depen... by Miki Hiroi, Yoshiichi Sakaeda, Hana Yamaguchi, Yoshihiro Ohmori

“…These results suggest that a coactivator/cofactor that functionally interacts with Oct-1 is a molecular target for the IL-4-mediated inhibition of Nos2 and that IL-4-activated Stat6 represses Oct-1-dependent transcription by competing with this coactivator/cofactor.…”
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The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Introduction: Acute subdural hematoma (ASDH) due to traumatic brain injury (TBI) constitutes an increasing global health problem, especially in the elderly population. …”
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ROSA: An Andean Network of Social–Ecological Observatories by Julieta Carilla, Ricardo Grau, Oriana Osinaga Acosta, Agustina Malizia, Sergio Ceballos, Luis Daniel Llambí, María Piquer-Rodríguez, Lucía Zarbá, Saskia Flores, Francisco Cuesta, Tatiana Ojeda Luna, Wanderley Ferreira, Carolina Tovar, Yohana Jimenez, Ana Belén Hurtado-M, László Nagy, Erika Buscardo, Petra Wallem, Patricia Breuer, Vivien Bonnesoeur, Sophie Hebden, Nicolás Cuvi, Ezequiel Aráoz

“…The main research questions addressed by these social–ecological observatories include understanding how distant and proximate drivers of change interact with local social, cultural, economic, and environmental contexts to influence the functioning of different SES in the Andes at multiple spatial and temporal scales. …”
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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. …”
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The Surface Water and Ocean Topography Mission (SWOT) Prior Lake Database (PLD): Lake Mask and Operational Auxiliaries by Jida Wang, Claire Pottier, Cécile Cazals, Marjorie Battude, Yongwei Sheng, Chunqiao Song, Md Safat Sikder, Xiao Yang, Linghong Ke, Manon Delhoume, Marielle Gosset, Rafael Reis Alencar Oliveira, Manuela Grippa, Félix Girard, George H. Allen, Xiangtao Xu, Xiaolin Zhu, Sylvain Biancamaria, Laurence C. Smith, Jean‐François Crétaux, Tamlin M. Pavelsky

“…About 97% of the lakes, constituting half of the global lake area, are fully observed at least once per orbit cycle. …”
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Breakdown or Personality Disorder? Psychiatric Characterization and Developmental Pathways Towards Young Adulthood in Adolescents with Pathological Personality Structure by Chiara Rogantini, Marika Orlandi, Arianna Vecchio, Diletta Cristina Pratile, Raffaella Fiamma Cabini, Elena Ballante, Valentina De Giorgis, Renato Borgatti, Martina Maria Mensi

“…This study aimed to characterize the profile of high-risk adolescents compared to adolescents with full-blown PDs and adolescents with other psychiatric disorders and to identify clinical markers that constitute a risk profile. <b>Methods</b>: We evaluated 99 adolescents (12–17 years old) through DSM-5-based semi-structured interviews, questionnaires, cognitive tasks, and scales regarding functioning and disorder severity. …”
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