Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models by Junseong Park, Dokyeong Kim, Hyeon-Chun Park, Minyoung Park, Songzi Zhang, Okcho Na, Youn Soo Lee, Minho Lee, Stephen Ahn, Yeun-Jun Chung

“…Histological, molecular, and functional properties were evaluated using H&E staining, immunohistochemistry, whole-exome sequencing, 3D invasion assays, and single-cell RNA sequencing (scRNA-seq). …”
Get full text

Development and feasibility of a conceptual model for planning individualised physical exercise training (IPET) for older adults: a cross-sectional study by Karen Søgaard, Lars Holm, Sanel Teljigovic, Louise Fleng Sandal, Tina Dalager, Nina Odgaard Nielsen, Gisela Sjøgaard, Mette Bahn Ejvang

“…Objective Older adults constitute a heterogeneous group, and the focus of the individual physical exercise is often subject to the reasoning and experience of health professionals or exercise physiologists who prescribe them. …”
Get full text

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia by Min-Hui He, Xian-Hui Zhang, Ji-Hong Zhang, Jie Pan, Chao Yang

“…BackgroundChildhood acute myeloid leukemia (AML) constitutes a significant proportion of pediatric malignancies, with current treatment options remaining limited. …”
Get full text

Optimized expression of oxazolomycins in engineered Streptomyces longshengensis and their activity evaluation by Huiying Sun, Xiang Liu, Junyue Li, Yang Xu, Yue Li, Yuqing Tian, Huarong Tan, Jihui Zhang

“…So a strategy was designed to replace the native promoter regions between oxaG and oxaH with constitutive promoters P neo and P kasO* following functional module evaluation. …”
Get full text

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data by Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao, Mingmang Pan

“…Results Bulk RNA-seq analysis identified 63 oxidative stress-related genes of DFU (DORGs), and the top 59 genes were screened out for key nodes with close functional associations. Functional enrichment analysis showed significant involvement in oxidative stress response. …”
Get full text

The profile of disability grant applicants in Bishop Lavis, Cape Town by Thirumani Govender, Gubela Mji

“…Most applicants had a chronic medical condition and reported functional restrictions but only received a temporary grant. …”
Get full text

Comprehensive analysis of cinnamoyl-CoA reductase (CCR) gene family in wheat: implications for lignin biosynthesis and stress responses by Weimin Zhan, Lianhua Cui, Ningning Song, Xinye Liu, Guanghui Guo, Yanpei Zhang

“…Cinnamoyl-CoA reductase (CCR) catalyzes the conversion of various hydroxycinnamoyl-CoA esters into their corresponding aldehydes, utilizing NADPH as a cofactor. CCR functions as a regulatory point that controls the overall carbon flux towards lignin and constitutes the initial committed step in the lignin biosynthesis pathway. …”
Get full text

THE PUBLIC’S ROLE IN DEVELOPING STATE CUSTOMS POLICY: ECONOMIC AND LEGAL ASPECTS by Ivan Yaromiy, Viktor Rekun, Yaroslav Stupnyk

“…It has been substantiated that the economic component of state customs policy constitutes an important tool for the country's economic development and security. …”
Get full text

Insights into the Stearoyl-Acyl Carrier Protein Desaturase (SAD) Family in Tigernut (<i>Cyperus esculentus</i> L.), an Oil-Bearing Tuber Plant by Zhi Zou, Xiaowen Fu, Chunqiang Li, Xiaoping Yi, Jiaquan Huang, Yongguo Zhao

“…These findings highlight lineage-specific evolution of the <i>SAD</i> family and putative roles of <i>CeSAD</i> genes in tuber oil accumulation, which facilitate further functional analysis and genetic improvement in tigernut and other species.…”
Get full text

Predictive athlete performance modeling with machine learning and biometric data integration by Qin Jianjun, Haytham F. Isleem, Walaa J. K. Almoghayer, Mohammad Khishe

“…This approach integrates multiple factors and constitutes an important progress in sports analytics by providing a comprehensive perspective on the complex realities which influence elite athletic performance.…”
Get full text

A meta-analysis reveals earthworms as mutualists rather than predators of soil microorganisms by Manuel Blouin, Aïssa Robin, Lysandre Amans, Frédérique Reverchon, Isabelle Barois, Patrick Lavelle

“…Microorganisms constitute the largest biomass on Earth after plants, and earthworms are one of the main components of animal biomass. …”
Get full text

Transcriptome combined single-cell sequencing explores molecular mechanisms of ANGPTL4 in sepsis-induced acute lung injury. by Ying Qi, Changqi Zhou, Bing Chen

“…<h4>Objective</h4>Sepsis-induced acute lung injury (ALI) constitutes a critical clinical syndrome associated with high mortality rates, yet its molecular mechanisms remain inadequately elucidated. …”
Get full text

A Peptide Antagonist of the ErbB1 Receptor Inhibits Receptor Activation, Tumor Cell Growth and Migration In Vitro and Xenograft Tumor Growth In Vivo by Ruodan Xu, Gro Klitgaard Povlsen, Vladislav Soroka, Elisabeth Bock, Vladimir Berezin

“…Inherbin3 functions as an antagonist of epidermal growth factor (EGF)-ErbB1 signaling. …”
Get full text

International Protection of Migrant Workers Rights and Migration Legislation by V. P. Kirilenko, G. V. Alekseev, M. Z. Chaava

“…International agreements on the organized recruitment of workers between receiving countries and countries of origin of migrants should ensure the adaptation of migrants to the legal regime of the host country, the participation of migrants in the functioning of civil society institutions, and the monitoring of migration processes.Conclusion. …”
Get full text

MANAGEMENT OF DEVELOPMENTS IN THE AGRICULTURAL SECTOR IN THE QUALITY OF ORGANIZATION by V. Velkovski

“…A necessary tool in this case is the strategic management that gives the specific strategic alternatives for the development and functioning of the agrarian sector. Strategic alternatives, in order to fulfill their important role, must be consistent with changes in the external environment. …”
Get full text

Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter by Peter Buchwald, Peter Buchwald

“…While typically they can be well-described by hyperbolic functions (sigmoid on commonly used semi-log scales) and characterized by half-maximal concentrations values (EC50), their connection to receptor occupancy, characterized in a similar manner by the equilibrium dissociation constant Kd, can be complex due to the intermixing of the effects from occupancy-induced activation with those from partial agonism, constitutive activity, and pathway-specific signal amplification. …”
Get full text

Clinical experience with two etanercept biosimilars in Indian patients with spondyloarthritis by Ashok Kumar, Anshul Goel, Mehul Lapsiwala, Mohit Goyal, Gaurav Dembla

“…BASDAI, Bath Ankylosing Spondylitis Functional Index, and ASDAS and NSAID index were noted at baseline, 12, and 24 weeks. …”
Get full text

Identification of a terpene synthase arsenal using long-read sequencing and genome assembly of Aspergillus wentii by Richard Olumakaiye, Christophe Corre, Fabrizio Alberti

“…In addition, paired-end stranded RNA-seq data from two time points, 7 days and 30 days, was used for functional annotation of the assembled genome. Overall, we assembled a genome of approximately 31.2 Mb and identified 66 biosynthetic gene clusters from the annotated genome. …”
Get full text

Foreign Experience in the Legal Governance of Investment Activities by V. A. Kachalyan

“…The identification of the legal factors contributing to the high efficacy level of these undertakings constitutes the primary objective of the research. To achieve this goal, the following tasks shall be addressed: 1) to examine the legal framework governing the activities of UCITS schemes at various stages of its development, so as to estimate the fundamental rules underpinning their operations; 2) to determine the specifics of the functioning of the collective investment vehicles under consideration in terms of modern legislation.MATERIALS AND METHODS. …”
Get full text

Health Beneficial Effects of Carotenoids Related to Their Interactions with Gut Microbiota by Torsten Bohn, Abdulkerim Eroglu, Ibrahim S. Al’Abri, Rachel E. Kopec, Nathan Crook

“…In summary, though our understanding of the interactions of carotenoids with the gut microbiota is rather limited, these colorful pigments may constitute a promising route to improving gut health and functionality and contributing to systemic health benefits.…”
Get full text