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  1. 181
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    Constitutive IL-7 signaling promotes CAR-NK cell survival in the solid tumor microenvironment but impairs tumor control by Robin Parihar, Cliona M Rooney, Matthew Dysthe, Ishwar Navin, Corrine Baumgartner, Dayenne van Leeuwen, Josue Pineda

    Published 2025-07-01
    “…Here, we aimed to overcome these limitations by modifying CAR-NK cells to express a constitutively active interleukin (IL)-7 receptor, termed C7R, capable of providing intrinsic CAR-NK cell activation that does not rely on or produce exogenous signals nor activate bystander cells.Methods We examined persistence, antitumor function, and transcriptional profiles of CAR-NK cells coexpressing C7R in a novel tumor immune microenvironment (TiME) co-culture system and against hematologic and solid tumor xenografts in vivo.Results Peripheral blood NK cells expressing a CAR directed against the solid tumor antigen GD2 and modified with C7R demonstrated enhanced tumor killing and persistence in vitro compared with CAR-NK cells without cytokine support and similar functions to CAR-NK cells supplemented with recombinant IL-15. …”
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  3. 183

    REORGANIZATION OF THE TAX COURT WITHIN THE STATE ADMINISTRATIVE COURT POST CONSTITUTIONAL COURT DECISION NO 26/PUU-XXI/2023 by Dharma Setiawan Negara, Husban Husban, Samuel Dharma Putra Nainggolan, Lufsiana Lufsiana

    Published 2023-05-01
    “… Pursuant to Article 24 paragraph (2) of the 1945 Constitution of the Republic of Indonesia (1945 Constitution of the Republic of Indonesia) it is stated that judicial power is exercised by a Supreme Court and judicial bodies under it within the realm of general courts, religious courts, military courts, state administrative courts and by a Constitutional Court. …”
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    INFLUENCE OF THE TYPE OF STATE SYSTEM ON CONSTITUTIONAL LEGISLATION: SOME ISSUES OF THEORY AND PRACTICE (by the example of the Russian Federation and Kazakhstan Republic) by T. Z. Zhunuskanov

    Published 2015-06-01
    “…Objective: to study the basic laws of the constitutional law functioning of Kazakhstan Republic and the Russian Federation and its subjects in the system of law and legislation as an institutional phenomenon; to study the impact of government form on the constitutional law of the state. …”
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    An Improved Subdomain Level Nonconformal Discontinuous Galerkin Time Domain (DGTD) Method for Materials With Full-Tensor Constitutive Parameters by Qiang Ren, Qiwei Zhan, Qing Huo Liu

    Published 2017-01-01
    “…In addition, the total-field/scattered-field technique is further studied to allow a nonconformal mesh, vector basis functions, and half-space situation. This newly improved DGTD method is validated with test cases and applied to the negative reflection in YVO<inline-formula> <tex-math notation="LaTeX">$_{4}$</tex-math></inline-formula> bicrystal.…”
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  8. 188

    THE ROMANIAN OMBUDSMAN - PUBLIC INSTITUTION INVOLVED IN THE PROTECTION HUMAN RIGHTS AND THE OBSERVANCE OF THE SEPARATION AND BALANCE BETWEEN THE STATE POWERS by Simina POPESCU

    Published 2016-06-01
    “…Moreover, the Ombudsman shall formulate, at the request of the Constitutional Court, points of view regarding the exceptions of unconstitutionality, competence established by the law for its organization and functioning. …”
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  9. 189

    Functional constipation by Yu. O. Shulpekova, A. A. Kurbatova, A. V. Sedova

    Published 2018-08-01
    “…The origin of functional bowel diseases is still presented in the context of biopsychosocial model; that develop due to impact of constitutive factors, in particular features of serotoninergic and adrenergic regulation, dietary habit, bile acid metabolism etc. …”
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  10. 190

    ‘E pluribus unum......forum?’ A Marxist approach to the EU’s democratic deficit by Dimitrios Kivotidis

    Published 2025-06-01
    “…To do so, the article outlines the structural function and class character of the EU, as well as its role as a (supra-)state formation in the process of capital accumulation. …”
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  11. 191

    The Moral Equilibrium Between State and Individual: Server Cemal’s Perspective on Political Ethics by Yasin Yılmaz, Mehmet Kiremitci

    Published 2024-12-01
    “…The concept is examined in a wide range, from prehistoric human communities to the modern state, including state forms, government systems, and the functions of municipalities. The transformation of the concept of political ethics from the contexts of political philosophy and constitutional law is touched upon from this article to this perspective.…”
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    Conflict between EU law and national sovereignty: Analysis of decisions by the Constitutional Court of Poland in the light of the rule of law in the European Union by O. Lapka, N. Ivanchuk, Ye. Taranich

    Published 2025-05-01
    “…In the course of the study, it was revealed that the decision of the Constitutional Court of Poland regarding the superiority of the national constitution over the law of the European Union led to a legal conflict that makes it impossible for the rule of Law of the European Union to fully function.It was found that this position created legal difficulties for national courts in the application of decisions of the Court of Justice of the European Union and the implementation of the Unionʼs law. …”
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  14. 194

    Uniaxial compressive damage evolution and constitutive modeling of fissure-like rocks under different loading rates based on acoustic emission by Qinyong Wang, Wei Chen, Wenqing Peng, Yuanzeng Wang, Yu Zhou, Zhili Peng

    Published 2025-01-01
    “…The number of AE rings, energy, and cumulative energy are positively correlated with the loading rate, while the cumulative ringing counts decrease. (4) A damage constitutive model constructed with AE energy and the Logistic function can accurately represent the specimen’s response to different loading rates. …”
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    The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes. by Georgina L Hold, Susan Berry, Karin A Saunders, Janice Drew, Claus Mayer, Heather Brookes, Nick J Gay, Emad M El-Omar, Clare E Bryant

    Published 2014-01-01
    “…We investigated TLR4 functional variants D299G and T399I to assess the impact on LPS-induced responsiveness in comparison to wild-type TLR4. …”
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  19. 199

    Is It Possible to Preserve Statehood Without Protection of National Identity? (Some Lessons from Post-Soviet Constitutionalism Based on the Experience of Ukraine) by Barabash Iurii

    Published 2025-07-01
    “…In addition, components of identity such as language, culture, and religion, in the post-Soviet interpretations, received several more important components, which, perhaps not directly, nevertheless had a significant impact on the formation of the national “genocide” at the constitutional level. We mean the cleansing of the elites from the representatives of the former totalitarian regime and those who ensured its functioning, the definition of a clear geopolitical strategy, different from the desire to restore the Soviet Union in one form or another, as well as the definition of citizenship exclusively for persons for whom national state-hood is not “empty sound”. …”
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  20. 200

    The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity. by David Wifling, Günther Bernhardt, Stefan Dove, Armin Buschauer

    Published 2015-01-01
    “…In contrast to the corresponding mouse and rat orthologs, the human histamine H4 receptor (hH4R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H4R significantly reduced constitutive activity. …”
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