Phase Ib/II study on the safety, tolerability, and preliminary efficacy of pegylated irinotecan (JK1201I) as second‐line monotherapy for patients with small‐cell lung cancer by Jieran Long, Xuefei Li, Lin Wu, Guohua Yu, Aimin Zang, Yanqiu Zhao, Jinsheng Shi, Ligong Nie, Xuan Zhao, Jian Fang

“…The mPFS and mOS were 3.4 and 12.1 months, respectively. In the 220 mg/m2 group, one patient had stable disease, and one had progressive disease (PD). …”
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Chia (<i>Salvia hispanica</i>) Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, <i>Labeo roh... by Sanjay Kumar Gupta, Rajan Gupta, Akruti Gupta, Md Javed Foysal, Kishore Kumar Krishnani

“…The responses were observed in a 60-day feeding trial, set up with a total of 180 rohu fingerlings (19.74 ± 0.33 g) randomly allocated to four treatment groups with three replicates each. …”
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Surface quality of planed tangential and radial sections of thermally modified Silver fir wood by Dritan Ajdinaj, Holta Cota, Entela Lato, Doklea Quku

“…This study was carried out to provide information on the surface roughness of Abies alba (silver fir) planed after thermal modification, focusing on the anisotropic behavior of the material, particularly along the radial and tangential sections. Four groups of eight samples without defects were prepared. …”
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Effect of The Duration of The Diagnosis on DNA Methylation Changes in Three Different Diabetic Genes in Type 2 Diabetes Mellitus by Harem Othman Smail

“…Four groups of individuals were created based on their time on the disease: those with T2DM <1 year, those with T2DM 1-3 years, and those with T2DM 3-5 years.  …”
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Organ pedalboard as a rehabilitation tool: A qualitative exploratory study of healthcare providers' perceptions and recommendations. by Mandy M P Kan, Wai Hang Kwok, Eric C Fan, Fadi M Al Zoubi

“…Verbatim transcription and content analysis were performed on qualitative data.<h4>Findings</h4>Seventeen healthcare providers were interviewed in four focus groups. …”
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Two complete chloroplast genomes of Ceratophyllum, an aquatic genus with unresolved phylogenetic position by Shuangyan Ru, Zhigang Wu, Huijun Wang, Qi Li, Tao Li

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Toxicological Effects of Commonly Used Mosquito Coil Smoke on Liver and Lung Function in Rats by Hadiza Abubakar, Yahuza Gimba Muhammed, Alhassan Muhammad Wudil, Dayyabu Shehu, Murtala Yaú

“…A questionnaire was used to make inquiries regarding the prevalent types and brands of mosquito coils employed, the manner in which they are used, the durations for which they are utilized. A total of twenty-four albino rats were categorized into three distinct groups: the control group and two exposed groups. …”
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Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…The Panel also notes the history of multiple safety assessments of phytosterols performed by Member States and EFSA, in addition to the group ADI established by JECFA. …”
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Predictive models for the implementation of targeted reproductive management in multiparous cows on automatic milking systems by Fergus P. Hannon, Martin J. Green, Luke O'Grady, Chris Hudson, Anneke Gouw, Laura V. Randall

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Relationship between Tai Chi and clinical outcomes in elderly patients with COVID-19: a protocol for systematic review and dose–response meta-analysis by Yang Wang, Na Li, Xiao Peng, Chun Wang, Sheng He, Jinfeng Yang, Yuanpeng Liao

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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

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Geo-epidemiology of temporal artery biopsy-positive giant cell arteritis in Australia and New Zealand: is there a seasonal influence? by Matthew A Brown, Tony R Merriman, Paul G Sanfilippo, Alex W Hewitt, Catherine L Hill, Elisabeth De Smit, Linda Clarke

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Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis by Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo

“…Exercise intervention ranged between two to four days per week. Compared to the control group, in the group submitted to aerobic exercise + resistance training, no significant change was noted for HbA1c (subtotal = mean difference − 0.35 [95% CI: −0.85, 0.15], p = .17, and heterogeneity = 0%) (GRADE: very low), nevertheless, HOMA-IR index was significantly improved (subtotal = mean difference −0.52 [95% CI: −0.99, −0.05], p = .03, and heterogeneity = 0%) (GRADE: very low).Conclusion Despite the very low certainty found in the quality of evidences, our analysis showed that aerobic exercise along with strength exercise seems to improve some metabolic diabetes markers in postmenopausal women with T2DM. …”
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Comments on: “Early High-Titer Convalescent Plasma Therapy in Patients with Moderate and Severe COVID-19” [Transfusion and Apheresis Science 61 (2022) 103321] by Seyed Reza Hosseiniara

“…Specifically, the mortality rates were reported as 13.7% for the moderate group and a staggering 86.3% for the severe group, culminating in an overall death rate of 29.7%.1 In contrast, a previous study by the same research group in 2020 reported a mortality rate of 24.3% in a control group that did not receive convalescent plasma but was treated with standard care.2 The similarities in the study settings for both investigations suggest that convalescent plasma therapy may have had no significant impact on mortality rates, potentially even contributing to higher mortality among Iranian patients.The lack of a control group receiving standard treatment in Fazeli et al.'…”
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Long-term observation of the in vivo safety of a new design of phakic refractive lens by Yinjie Jiang, Xun Chen, Mingrui Cheng, I-Chun Lin, Boliang Li, Xinjie Zhu, Guanghan Xu, Huamao Miao, Xiaoying Wang, Xingtao Zhou

“…An IOP elevation was noted on the first postoperative day (18.8 to 37.9 mmHg). …”
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Attitude to tattooing in modern Russian society: Regional aspect by V. V. Levchenko

“…Certain limitations of these studies and their fragmentation have been noted. The integral variant of this phenomenon analysis, including four components of the attitude to tattoo (cognitive, emotional, behavioral, and motivational) and considering peculiarities of social attitudes of the three main subjects occupying different positions in relation to tattoo (tattoo masters, their clients and a control group without tattoos) has been offered. …”
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Circulating Th1 and Th2 Subset Accumulation Kinetics in Septic Patients with Distinct Infection Sites: Pulmonary versus Nonpulmonary by Ming Xue, Yuying Tang, Xu Liu, Mingyuan Gu, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Yi Yang, Haibo Qiu

“…Persistent peripheral CD4+T cell differentiation towards T helper (Th)2 rather than Th1 has been proved to be related to immunosuppression and poor prognosis in sepsis. …”
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Clonality and the Phenotype–Genotype Correlation of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> Isolates: A Multicenter Study of Clinical Isolates from Romania by Adrian-Gabriel Pană, Pavel Șchiopu, Dan Alexandru Țoc, Vlad Sever Neculicioiu, Anca Butiuc-Keul, Anca Farkas, Matei-Ștefan Dobrescu, Mirela Flonta, Carmen Costache, Izabella Éva Szász, Lia-Monica Junie

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"They gave us the right to choose." A qualitative study of preferences for differentiated service delivery location among recipients of antiretroviral therapy at Lighthouse Trust i... by Lisa Orii, Kate S Wilson, Jacqueline Huwa, Christine Kiruthu-Kamamia, Odala Sande, Agness Thawani, Astrid Berner-Rodoreda, Evelyn Viola, Hannock Tweya, Petros Tembo, Wapu Masambuka, Richard Anderson, Caryl Feldacker

“…In this qualitative study, we explore reasons why RoC enrolled in LT clinics and eligible for DSD chose clinic-based ART services or a Nurse-led Community-based ART Program (NCAP) that reaches clients in established community peer support groups. We conducted eight focus group discussions (FGDs) among LT RoC: four FGDs among NCAP groups and four clinic-based FGDs (2 per setting) to explore opinions, preferences, and perceptions about ART service delivery. …”
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Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of Levodopa by Cindy Zadikoff, Werner Poewe, James T. Boyd, Lars Bergmann, Horia Ijacu, Pavnit Kukreja, Weining Z. Robieson, Janet Benesh, Angelo Antonini

“…Baseline demographics and disease severity were similar between dosage groups with more men in the high-dosage group. Compared with the <2000 mg/day dosage group, patients requiring ≥2000 mg/day LCIG had higher rates of AEs/ADRs including polyneuropathy; improvements in “Off” time and discontinuations due to AEs were similar between dosage groups and lower for discontinuations due to ADRs reported in GLORIA. …”
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