Comparison of different severe obesity definitions in predicting future cardiometabolic risk in a longitudinal cohort of children by Gilles Paradis, Melanie Henderson, Lisa Kakinami, Angelo Tremblay, Anna Smyrnova

“…Whether SO definitions differentially predict cardiometabolic disease risk is critical for proper clinical care and management but is unknown.Design Prospective cohort studySetting SO definitions were applied at baseline (2005–2008, Mage=9.6 years, n=548), and outcomes (fasting lipids, glucose, homoeostatic model assessment (HOMA-IR) and blood pressure) were assessed at first follow-up (F1: 2008–2011, Mage=11.6 years) and second follow-up (2015–2017, Mage=16.8 years) of the Quebec Adipose and Lifestyle Investigation in Youth cohort in Montreal, Quebec.Participants Respondents were youth who had at least one biological parent with obesity.Primary outcome measures Unfavourable cardiometabolic levels of fasting blood glucose (≥6.1 mmol/L), insulin resistance (HOMA-IR index ≥2.0), high-density lipoprotein <1.03 mmol/L, low-density lipoprotein ≥2.6 mmol/L and triglycerides >1.24 mmol/L. …”
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Intermittent Use of Flash Glucose Monitoring Improves Glycemic Control in Chinese Older Patients with Type 2 Diabetes Mellitus by Hu Y, Yan R, Shen Y, Li H, Ma J, Su X

“…Overall findings revealed that compared to baseline, HbA1c decreased from 7.81 ± 1.25% to 7.44± 1.10% after 12 weeks of intermittent wearing of FGM (p < 0.001). …”
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Active versus sham transcranial direct current stimulation (tDCS) as an adjunct to varenicline treatment for smoking cessation: Study protocol for a double-blind single dummy rando... by Laurie Zawertailo, Helena Zhang, Noreen Rahmani, Tarek K Rajji, Peter Selby

“…<h4>Background</h4>Smoking is a chronic and relapsing disease, with up to 60% of quitters relapsing within the first year. Transcranial Direct Current Stimulation (tDCS), targets cortical circuits and acutely reduces craving and withdrawal symptoms among cigarette smokers. …”
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Etiology of Emergency Visit and In-Hospital Outcomes of Patients with COPD by Xueyang Zhang, Qingtao Zhou, Shengfeng Wang, Qingbian Ma, Yongchang Sun

“…Demographics, clinical manifestations, and laboratory studies in the ED were collected as the baseline data. The primary diagnosis at discharge or death was recorded. …”
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Health and Characteristics of Australian Apple Growing Soils by Marcus Hardie, Garth Oliver, William Cotching, Brianna Walker, Rachel Lancaster, Nigel Swarts

“…This study is unique in being the first to report the condition and characteristics of Australia’s apple growing soils; it provides essential baseline data for future monitoring of soil health in apple production systems, as well as soil physical and chemical data required for the development of perennial soil-tree-climate models. …”
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Analysis of Air Pollution Data in India between 2015 and 2019 by Disha Sharma, Denise Mauzerall

“…Our dataset also provides a baseline to evaluate the future success of National Clean Air Programme as well as aids in assessment of existing and future air pollution mitigation policies.…”
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Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

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The Effects of Adverse Events and Associated Costs on Value-Based Care for Metastatic Pancreatic Ductal Adenocarcinoma by Prachi Bhatt, Jared Hirsch, Paul Cockrum, George Kim, Gabriela Dieguez

“…**Objectives:** To compare the incidence of adverse events (AEs), AE-associated excess costs, and total cost of care (TCOC) of 3 cohorts receiving first-line treatment for metastatic pancreatic ductal adenocarcinoma (mPDAC). …”
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Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study by Geke Zhu, Han Zhou, Wanying Wang, Yongbo Ma, Xiangtao Nie, Wenjing Qi, Lei Hao, Xiuming Guo

“…Background: China has a large number of myasthenia gravis (MG) patients, creating an urgent need for rapid and tolerable treatment options. As the first-approved Fc receptor antagonist, efgartigimod has bright prospects for treating MG. …”
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Effect of a Narrative-Based Online Course Aimed at Reducing Stigma Toward Transgender Children and Adolescents: Longitudinal Observational Study by Merlin Greuel, Van Kinh Nguyen, Doron Amsalem, Maya Adam, Till Bärnighausen

“…Stigma levels decreased significantly after taking the course, even among participants whose baseline levels of stigma were low. Future interventions should include participants with more variable baseline levels of stigma, ideally in the setting of a randomized controlled trial. …”
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Renal Damage Frequency in Patients with Solitary Kidney and Factors That Affect Progression by T. Basturk, Y. Koc, Z. Ucar, T. Sakaci, E. Ahbap, E. Kara, F. Bayraktar, M. Sevinc, T. Sahutoglu, A. Kayalar, A. Sinangil, C. Akgol, A. Unsal

“…Patients in group 1 were older than those in group 2 (p=0.001). 34 patients who comprise group 1a had smaller kidney size (p=0.002) and higher uric acid levels (p=0.028) than those in group 1b at presentation. Uric acid levels at first and last visit were associated with renal damage progression (p=0.004, 0.019). 18 patients who comprise group 2a were compared with those in group 2b in terms of presence of DM (p=0.038), HT (p=0.003), baseline proteinuria (p=0.014), and uric acid (p=0.032) levels and group 2a showed higher rates for each. …”
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Extensive Use of Interventional Therapies Improves Survival in Unresectable or Recurrent Intrahepatic Cholangiocarcinoma by Ricarda Seidensticker, Max Seidensticker, Kathleen Doegen, Konrad Mohnike, Kerstin Schütte, Patrick Stübs, Erika Kettner, Maciej Pech, Holger Amthauer, Jens Ricke

“…Only the number of lesions, baseline serum CEA and serum CA19-9, and objective response (RECIST) were independently associated with survival. …”
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Halal or Not: Knowledge Graph Completion for Predicting Cultural Appropriateness of Daily Products by Van Thuy Hoang, Tien-Bach-Thanh do, Jinho Seo, Seung Charlie Kim, Luong Vuong Nguyen, Duong Nguyen Minh Huy, Hyeon-Ju Jeon, O-Joun Lee

“…Extensive experiments on the cosmetic dataset over halal prediction tasks demonstrate the superiority of our model over state-of-the-art baselines.…”
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StrideHD: A Binary Hyperdimensional Computing System Utilizing Window Striding for Image Classification by Dehua Liang, Jun Shiomi, Noriyuki Miura, Hiromitsu Awano

“…Under the same inference memory cost, our single-pass mode StrideHD averagely achieves 13.56% accuracy improvement in comparison with the single-pass baseline HD, which is a similar performance even in comparison with the costly iterative baseline HD models. …”
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Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria by Hidetoshi Takahashi, Atsushi Fukunaga, Koremasa Hayama, Takayoshi Sasajima, Ayako Fujishige, Ryohei Ichishita, Naoko Tomimatsu, Eva Hua, Vineeth Varanasi, Alis Burciu, Michihiro Hide, Thomas Severin

“…A sizable proportion of patients achieved DLQI 0–1 with the first dose of ligelizumab (38.5%), and improvements observed throughout the study until Week 52 (68.8%). …”
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Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study by Qing-jun Guo, Jing Shan, Yi-feng Xu, Yan-yan Hu, Cui-lan Huo, Jing-yun Song, Chao-qun Wang, Hui Zhou, Chao-qin Yu, Qin Huang

“…The primary efficacy measure was the change from baseline to week 12 on the Symptom Checklist 90-R (SCL-90-R) scores. …”
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Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent by Xin Gu, Tao Huang, Ding Xu, Liujian Duan, Yang Jiao, Jian Kang, S. Lilly Zheng, Jianfeng Xu, Jielin Sun, Jun Qi

“…No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (All P>0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment.…”
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JiuZhou: open foundation language models and effective pre-training framework for geoscience by Zhou Chen, Ming Lin, Mingrun Zang, Zimeng Wang, Juanzi Li, Yuqi Bai

“…In this study, we introduce JiuZhou, a powerful open foundational language model used in geoscience. First, we construct the large-scale, diverse, and high-quality JiuZhou-Corpus and the JiuZhou-Framework specifically designed for training geoscience large language models (LLMs). …”
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Impact of Moderate to Severe Renal Impairment on Mortality and Appropriate Shocks in Patients with Implantable Cardioverter Defibrillators by Venkata M. Alla, Kishlay Anand, Mandeep Hundal, Aimin Chen, Showri Karnam, Tom Hee, Claire Hunter, Aryan N. Mooss, Dennis Esterbrooks, Syed M. Mohiuddin

“…Severe but not moderate CKD is an independent predictor for time to first appropriate shock.…”
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The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate by Laetitia Clotaire, Isabelle Rubera, Christophe Duranton, Jocelyn Gal, Emmanuel Chamorey, Hélène Humeau, Samir Yamani, Christine Chiaverini, Serge Willoteaux, Bernard Padovani, Laurie Mourozeau, Adam Mainguy, Stéphanie Baillif, Ludovic Martin, Georges Leftheriotis

“…The primary endpoint is the change in arterial calcification volume quantified by non-contrast CT scan between baseline and 12 months of treatment. Secondary endpoints include the safety and efficacy of daily oral PPi administration on ocular and skin lesions and the evaluation of patients’ quality of life. …”
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