BuDDI: Bulk Deconvolution with Domain Invariance to predict cell-type-specific perturbations from bulk. by Natalie R Davidson, Fan Zhang, Casey S Greene

“…We evaluated BuDDI's performance on simulated and real data with experimental designs of increasing complexity. We first validated that BuDDI could learn domain invariant latent spaces on data with matched samples across each source of variability. …”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“….), and virtual target candidates with varying characteristics (baseline expression, half-life, etc.) to unravel rules for antibody drug candidate selection that achieve favorable drug-target interaction, which is defined by target occupancy (TO) percentage. …”
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Performance Comparison of Different Neuroimaging Methods for Predicting Upper Limb Motor Outcomes in Patients after Stroke by Jingyan Tao, Zhaoqing Li, Yang Liu, Jianhua Li, Ruiliang Bai

“…In this study, we aimed to compare the predicative performance of these methods using different neuroimaging modalities and optimize the prediction protocol for upper limb motor function after stroke in a clinical environment. We assessed 28 first-ever stroke patients with upper limb motor impairment. …”
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SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized con... by Beverley Lim Høeg, Katrine Bjerre Løppenthin, Josée Savard, Christoffer Johansen, Jesper Frank Christensen, Mads Nordahl Svendsen, Niels Holländer, Pernille Envold Bidstrup

“…We assessed feasibility and measured objective and patient-reported outcomes at baseline and 3-months follow-up. Changes in both groups were compared using the Wilcoxon test. …”
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Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case–Control Approach by Neha Sudhir, Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Tajinder Kaur, Anupam Kaur

“…Conclusion: The study is the first of its kind from our region and provides baseline data on the genetics of RM.…”
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Identifying Incident Causal Factors to Improve Aviation Transportation Safety: Proposing a Deep Learning Approach by Tianxi Dong, Qiwei Yang, Nima Ebadi, Xin Robert Luo, Paul Rad

“…Then, we take an open-source natural language model, which is well trained with a large corpus of Wikipedia texts, as the baseline and fine-tune it with the texts in incident reports to make it more suited to our specific research task. …”
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Zoledronic acid as adjuvant therapy in neovascular age-related macular degeneration: a randomised controlled pilot study by Øystein Kalsnes Jørstad, Morten Carstens Moe, Morten Wang Fagerland, Yngvil Solheim Husum, Erik Fink Eriksen

“…Bevacizumab was the first-line anti-VEGF drug, but eyes with refractory nAMD were switched to aflibercept. …”
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Retrospective Analysis of Ultrasound-Guided Infraclavicular Block: Effect of Experience of Anesthesiologists on Volume of Local Anesthetic Administered by Tugce Yeniocak, Nur Canbolat

“…Nine anesthesiologists with the same baseline experience in USG performed the blocks. During the initial period, when anesthesiologists had insufficient experience, local anesthetic (LA) dose, success rate, failed blocks, and complications were investigated. …”
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Oral Hygiene in Children with Autism: Teaching Self-Toothbrushing via Behavioural Intervention Including Parents by Marco Esposito, Carlotta Piersanti, Roberta Fadda, Marco Boitani, Monica Mazza, Giuseppina Marrocco

“…In this study, the efficacy is explored of a behavioral intervention mediated by staff and parents in teaching self-brushing teeth in eight autistic children. First, we wanted to examine whether the intervention improved self-brushing teeth skills in a short-term period. …”
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Long-Term Follow-Up after Prostatectomy for Prostate Cancer and the Need for Active Monitoring by Gregory P. Swanson, Wencong Chen, Sean Trevathan, Michael Hermans

“…We excluded lymph node and seminal vesicle positive patients and an additional 47 patients that did not have baseline prostate-specific antigen (PSA). This left 581 patients for analysis. …”
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The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson’s Disease: A Pilot Study by Agata Wróblewska, Agata Gajos, Urszula Smyczyńska, Andrzej Bogucki

“…The results show, for the first time, that FoG during turning and step initiation, two most common forms of this gait disorder, has been significantly reduced by NW training. …”
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Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure by Ahmet Ozbek, Abdullah Algın, Gokhan Tas, Mehmet Ozgur Erdogan

“…The study included 300 patients with chronic renal failure who had a sepsis-related organ failure assessment (SOFA) score ≥3. By taking the baseline troponin at the time of emergency presentation as reference and comparing them with the fourth-hour troponin values, troponin clearance was investigated in the evaluation of mortality among hospitalized patients with CKD within the first month after discharge. …”
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The U-Shaped Association between Bilirubin and Diabetic Retinopathy Risk: A Five-Year Cohort Based on 5323 Male Diabetic Patients by Miao Liu, Jianhua Wang, Yao He

“…And the RRs were 0.928 (95% CI: 0.646–1.331), 0.544 (95% CI: 0.365–0.811), 0.913 (95% CI: 0.629–1.324), and 1.035 (95% CI: 0.725–1.479) for the second, third, fourth, and fifth quintiles of baseline TBiL levels, respectively, compared with the first quintile. …”
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Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin–angiotensin system blockade: a UK general practice-based cohort study by Henrik Toft Sørensen, Liam Smeeth, Dorothea Nitsch, Morten Schmidt, Laurie A Tomlinson, Krishnan Bhaskaran, Kathryn E Mansfield

“…Using logistic regression models, we also examined patient characteristics associated with these biochemical changes, and with follow-up monitoring within the guideline recommendation of 2 weeks after treatment initiation.Results 10% of patients had neither baseline nor follow-up monitoring of creatinine within 12 months before and 2 months after initiation of an ACEI/ARB, 28% had monitoring only at baseline, 15% only at follow-up, and 47% both at baseline and follow-up. …”
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Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study by Xin Chen, Jinyou Yang, Dan Wang, Jiali Liu, Hang Jin, Yongqing Zhang, Quanyong Xiang

“…The TyG index was calculated as ln [fasting triglyceride (TG) (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2] and variation degree was calculated as the TyG index at first year follow-up (2011) minus that at baseline (2010). …”
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The Usability and Effect of a Novel Intelligent Rehabilitation Exergame System on Quality of Life in Frail Older Adults: Prospective Cohort Study by Chien-Hsiang Chang, Chun-Chun Wei, Wei-Chih Lien, Tai-Hua Yang, Bo Liu, Yimo Lin, Poh Thong Tan, Yang-Cheng Lin

“…The System Usability Scale (SUS) and Taiwanese version of the EuroQol-5 Dimensions (EQ-5D) were administered after completing the first (week 1, baseline) and last training (week 4, one-month follow-up) to evaluate the usability of the IRES and its effects on the quality of life of participants. …”
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Clinical Characteristics and Prognostic Factors of Posterior Segment Intraocular Foreign Body: Canadian Experience from a Tertiary University Hospital in Quebec by Jean-Philippe Rozon, Guillaume Lavertu, Mélanie Hébert, Eunice You, Serge Bourgault, Mathieu Caissie, Eric Tourville, Ali Dirani

“…Predictive factors for a better visual outcome included first intention intraocular lens (IOL) implantation and the use of air tamponade. …”
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AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

“…Two main versions of this discourse are distinguished. In the first version (e.g. Buddha), "monolithic self" is fragmented into the successive selves; in the second one (e.g. …”
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Clinical Characteristics of Early-Onset and Late-Onset Multiple Sclerosis in Patients from Lithuania by Emilija Šlajūtė, Naglis Vičkačka, Tautvydas Klėgėris, Ingrida Ulozienė, Renata Balnytė

“…Only LOMS patients had an increase in Multiple Sclerosis Severity Score (MSSS) at the last follow-up compared to the baseline (<i>p</i> = 0.028), and MSSS was higher than in EOMS patients both at the baseline (<i>p</i> = 0.004) and the last follow-up (<i>p</i> < 0.001). …”
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Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide by Maria Voukali, Irene Kastrinelli, Sapfo Stragalinou, Dimitra Tasiopoulou, Pinelopi Paraskevopoulou, Nicholas Katsilambros, Alexandros Kokkinos, Nicholas Tentolouris, Ioannis Ioannidis

“…Exenatide and liraglutide both appear to be equally effective in lowering postprandial lipaemia after the first administration and after a two-week treatment. …”
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