Epidemiological and clinical analysis, and outcomes of tuberculosis co-infection among people living with HIV in Türkiye (2014-2024) ClinSurv HIV cohort: A large case series. by Ali Mert, Okan Derin, Esra Zerdali, Abdurrahman Kaya, Özlem Gül, Deniz Borcak, Ahmet Furkan Kurt, Meliha Meriç Koç, Bircan Kayaaslan, Ayşe Batırel, Alper Gündüz, İnci Yılmaz Nakir, Gülşen Yörük, Dilek Yıldız Sevgi, Hayat Kumbasar Karaosmanoğlu, Bilgül Mete, Melike Nur Özçelik, Nagehan D Sarı, Yasemin Akkoyunlu, Fehmi Tabak

“…<h4>Objective</h4>In this HIV cohort study, we aimed to evaluate the clinical features, diagnosis, and prognosis of TB among PLHIV in Türkiye.…”
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Designing host-associated microbiomes using the consumer/resource model by Germán Plata, Karthik Srinivasan, Madan Krishnamurthy, Lukas Herron, Purushottam Dixit

“…Moreover, microbiome compositions are heavily context dependent, with characteristics of the host and the abiotic environment leading to distinct patterns in host-microbiome associations. Consequently, off-the-shelf generative modeling has not been successfully applied to microbiomes.To address these challenges, we develop a generative model for host-associated microbiomes derived from the consumer/resource (C/R) framework. …”
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Clinicopathological and molecular characterization of astroblastoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…These tumors showed a growth pattern similar to traditional intracranial astroblastoma, and the histological manifestations of the four patients were all high-grade, showing features of high-density areas of tumor cells or necrosis. …”
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Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan by Zhenjie Ma, Chenhao Li, Wenhao Bai, Wei Xie, Mingjie Zhang, Han Xiao, Cancan Chen, Yang Li, Wenwen Zhang, Deqi Zhai, Yingyuan Liu, Dengfa Zhao, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu

“…Current animal models that predominantly employ passive drug administration fail to recapitulate the hallmark feature of voluntary medication-seeking behaviour observed clinically. …”
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Artificial Intelligence in Primary Malignant Bone Tumor Imaging: A Narrative Review by Platon S. Papageorgiou, Rafail Christodoulou, Panagiotis Korfiatis, Dimitra P. Papagelopoulos, Olympia Papakonstantinou, Nancy Pham, Amanda Woodward, Panayiotis J. Papagelopoulos

“…The integration of radiomics with AI enables the extraction of quantitative features from medical images, allowing for precise tumor characterization and the development of personalized therapeutic strategies. …”
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Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data by Lili Tang, Rui Tang, Junjie Zheng, Pengfei Zhao, Rongxin Zhu, Yanqing Tang, Xizhe Zhang, Xiaohong Gong, Fei Wang

“…We identified three neuroimaging-based MDD subtypes, each characterized by unique ALFF pattern alterations compared to HC. Multi-omics analysis showed a strong genetic predisposition for Subtype 1, primarily enriched in neuronal development and synaptic regulation pathways. …”
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Identification of genes related to fatty acid metabolism in type 2 diabetes mellitus by Ji Yang, Yikun Zhou, Jiarui Zhang, Yongqin Zheng, Jundong He

“…Immune cells, including dendritic cells, eosinophils, and neutrophils, may play a role in the progression of T2DM. ceRNA and drug-target network analysis revealed potential interactions, such as RP11-miR-29a-YTHDF3 and BPA-MSANTD1. The expression patterns of the feature genes, except for YTHDF3, were consistently upregulated in T2DM, aligning with trends observed in the training set. …”
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Driving factors of fragmentation in urban landscapes: Local contributions, spatial relationships, and causal effects by Simin Jiang, Fei Feng, Xinna Zhang, Chengyang Xu, Baoquan Jia, Raffaele Lafortezza

“…Understanding the drivers of fragmentation is crucial for developing sustainable urban planning strategies. This study investigates the spatial patterns and driving mechanisms of landscape fragmentation in Nanchang, China, a rapidly urbanizing city. …”
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Metagenomic analysis revealing links between age, gut microbiota and bone loss in Chinese adults by Yufeng Li, Zhun Shi, Xiuying Zhang, Huahui Ren, Hongyi Ji, Fangming Yang, Zuodi Fu, Xiangshuang Kong, Xiaoguang Cheng, Junhua Li, Kui Wu, Yiyi Zhong, Huanzi Zhong, Linong Ji

“…Moreover, we demonstrated that individuals with enterotype Bacteroides exhibited a more pronounced age-related decline in BMD compared to those with enterotype Prevotella, a pattern we validated in an independent cohort. Our findings offer valuable insights into BMD-related gut microbial features and interactions between aging, gut microbiota, and bone loss, opening potential avenues for microbiota-based prevention and treatment strategies for osteoporosis.…”
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Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets by Myungji Kim, Seungyeun Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang

“…Here, we bioengineer the in vivo-like pancreatic niches by optimizing the combination of pancreatic tissue-specific extracellular matrix and basement membrane proteins and utilizing bioprinting-based geometrical guidance to recreate the spatial pattern of islet peripheries. The bioprinted islet-specific niche promotes coordinated interactions between islets and vasculature, supporting structural and functional features resembling native islets. …”
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Computer-Aided Application in Medicine and Biomedicine by Qi-Ming Liao, Wahab Hussain, Zhong-Xia Liao, Sarfraz Hussain, Zhi-Liang Jiang, Yong-Hao Zhu, Huang-Yin Luo, Xin-Ying Ji, Hong-Wei Wen, Dong-Dong Wu

“…It explores diverse computer applications in medicine, including simulations, modeling, data visualization, and advanced data processing. Pattern classification techniques, decision support systems, and the integration of supercomputers—particularly in drug development—are discussed, alongside natural user interfaces and the application of Computer Methods and Programs in Biomedicine, with attention to human–computer interface integration. …”
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Adaptive malware identification via integrated SimCLR and GRU networks by Faisal S. Alsubaei, Abdulwahab Ali Almazroi, Walid Said Atwa, Abdulaleem Ali Almazroi, Nasir Ayub, N. Z. Jhanjhi

“…To this end, we introduce SimCLR-GRU, a novel ensemble architecture that integrates SimCLR-based contrastive learning for feature extraction and a GRU module to capture sequential behavioural patterns. …”
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Assessing Fire Regimes in the Paraguayan Chaco: Implications for Ecological and Fire Management by Cristina Vidal-Riveros, William Jefferson Watler Reyes, Marie Ange Ngo Bieng, Pablo Souza-Alonso

“…This study analyzed the fire regime in the highly diverse Paraguayan Chaco, focusing on different aspects of fire patterns, including spatial (area burned) and temporal (frequency) aspects and magnitude (severity). …”
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The value of MRI in differentiating ovarian clear cell carcinoma from other adnexal masses with O-RADS MRI scores of 4–5 by Lingling Lin, Le Fu, Huawei Wu, Saiming Cheng, Guangquan Chen, Lei Chen, Jun Zhu, Yu Wang, Jiejun Cheng

“…Abstract Objective To assess the utility of clinical and MRI features in distinguishing ovarian clear cell carcinoma (CCC) from adnexal masses with ovarian-adnexal reporting and data system (O-RADS) MRI scores of 4–5. …”
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On Generalized Overlap and Grouping Indices in n-Dimensional Contexts by Tiago Asmus, Graçaliz Dimuro, Giancarlo Lucca, Cedric Marco-Detchart, Helida Santos, Heloisa Camargo, Humberto Bustince

“…Overlap and grouping indices can be built employing overlap and grouping functions, respectively, which are possibly non-associative aggregation functions with features that provide good results when applied to practical bivariate problems. …”
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Fatty acid filled polyaniline nanofibres with dual electrical conductivity and thermo-regulatory characteristics: Futuristic material for thermal energy storage by Tanwar Surya, Varshney Gunjan, Kaur Raminder

“…Thermogravimetric analysis revealed a multi-step deterioration pattern, demonstrating the developed nano-encapsulated-phase change material’s (PCMs’) exceptional thermal stability. …”
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Chronostructure and circadian rhythms of the parameters of the coagulation system and neurohumoral regulatory systems determining diurnal profile of blood pressure by A.O. Ostapenko, Yu.O. Klitsunova, A.S. Kulbachuk, L.L. Vorontsova

“…Physiological features of hemostasis chronobiological characteristics in patients with coronary heart disease are present. …”
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Tailoring smart hydrogels through manipulation of heterogeneous subdomains by Haoqing Yang, Tengxiao Liu, Lihua Jin, Yu Huang, Xiangfeng Duan, Hongtao Sun

“…However, replicating these multifaceted attributes in synthetic soft materials remains a challenge. In this work, we develop a smart hydrogel system featuring engineered stiff cellular patterns that induce strain-driven heterogeneous subdomains within the hydrogel film. …”
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Leishmania donovani Induced Cutaneous Leishmaniasis: An Insight into Atypical Clinical Variants in Sri Lanka by Yamuna Siriwardana, Bhagya Deepachandi, Chalukya Gunasekara, Wipula Warnasooriya, Nadira D. Karunaweera

“…Patients in other regions when travelled to North developed more ACL than when they travelled to South (60.9%, 42.9%). …”
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Metabolism effector links in diet-induced and genetically-based obesity: A full-transcriptome study of liver tissue in experimental models in rodents by S. A. Apryatin, N. V. Trusov, I. V. Gmoshinski, V. A. Tutelyan

“…Background. When developing methods for personalized diet therapy of obesity, an urgent task is to study the molecular genetics features of the obesity pathogenesis using in vivo experimental models in laboratory animals.The aim. …”
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