Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis by Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren, Ruyi Zou, Hanyi Jiang, Miaomiao Xie, Mei Huang, Jingjing Ding, Yin Liu, Jingyu Chen, Min Cao, Hourong Cai

“…COX regression and LASSO algorithm were used to screen featured characteristics. …”
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National-scale mapping topsoil organic carbon of cropland in China using multitemporal Sentinel-2 images by Jie Xue, Xianglin Zhang, Songchao Chen, Zhongxing Chen, Rui Lu, Feng Liu, Bas van Wesemael, Zhou Shi

“…Finally, bootstrapping random forest models were fitted using the covariates selected through forward recursive feature selection (FRFS), and the spatial prediction SOC map was created. …”
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Topology-aware pathway analysis of spatial transcriptomics by Siras Hakobyan, Maria Schmidt, Hans Binder, Arsen Arakelyan

“…In this study, we address that gap by translating gene expression into pathway-level activity using the Pathway Signal Flow (PSF) algorithm. PSF integrates expression data with curated interaction networks to compute numeric activity scores for each branch of a biological pathway, producing a functionally annotated feature space that captures downstream signaling effects as branch-specific activity values. …”
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Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis. by Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop

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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…The molecular data were analysed using a bioinformatics pipeline specifically designed for identifying differentially abundant metabolites between the two breeds in a robust and statistically significant manner, including the Boruta algorithm, which is a Random Forest wrapper, and sparse Partial Least Squares Discriminant Analysis (sPLS-DA) for feature selection. …”
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Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer by Yumin Ke, Meili Liang, Zhimei Zhou, Yajing Xie, Li Huang, Liying Sheng, Yueli Wang, Xinyan Zhou, Zhuna Wu

“…We further validated key DIRGs’ diagnostic ability via a validation set and immunohistochemistry (IHC). The CIBERSORT algorithm was used to analyze correlations between DIRGs and immune cell types in OCCC.ResultsWe detected 10 DIRGs in OCCC compared to HGSC. …”
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