Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

“…Methods‍　‍Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT+ circ-Olfm1 knockout group, AD group (transgenic APP/PS1 mice), AD+ circ-Olfm1 knockout group, AD+FOXO3a knockout group, with 3 mice in each group. ① The total RNA of mouse brain was extracted, and the differential expression of circRNAs and mRNAs between the AD mice and WT mice was detected, and the obtained circRNAs and mRNAs were analyzed with gene ontology (GO) analysis. ② RT‐qPCR was used to detect the expression of the top 10 up-regulated and down-regulated circRNAs, as well as the expression of circ-Olfm1 and miR-330-5p. ③ Lentiviral vectors were prepared and stereotaxically injected into the cortex or hippocampus of WT and AD mice to knock out circ-Olfm1 gene. Water maze test was used to evaluate the effect of circ-Olfm1 knockout on cognitive function, and immunofluorescence assay was employed to observe the deposition of amyloid β (Aβ) plaque in the brain. ④ The interaction between circ-Olfm1 and miR-330-5p was verified by double luciferase reporter gene analysis. ⑤ The protein levels of AMPK and FOXO3a were detected by Western blotting. ⑥ Transmission electron microscopy was utilized to observe the mitochondria of the hippocampus. ⑦ The levels of inflammatory factors IL-6, IL-1β and TNF-α were detected by ELISA. …”
Get full text

The impact of tangeretin combined with whey protein on exercise-induced bronchoconstriction in professional athletes: a placebo-controlled trial by Zhi Cao, Can Zhao, Shiwei Mo, Bing-Hong Gao, Meng Liu

“…Additionally, the number of cough symptoms decreased from 9 to 3 and dyspnea from 4 to 2 in the TIG.Conclusion After high-intensity exercise, athletes with EIB achieved significant improvements in lung function and blood inflammatory factors by combining tangeretin and whey protein supplementation. …”
Get full text

Relationships between selected performance parameters and body composition in karate by Kristina Něma, Pavel Ružbarský

“…Introduction: Studying the somatic characteristics of karate athletes can provide specific details on the morphological and functional factors best suited for this combat sport. …”
Get full text

EFFECT OF PUMPKIN (CUCURBITA PEPO L.) AND MARIGOLD (TAGETES PATULA L.) EXTRACTS ON HIPPOCAMPAL MITOCHONDRIA FUNCTIONAL ACTIVITY WITHIN CONDITIONS OF EXPERIMENTAL ACUTE BRAIN HYPOME... by A. V. Voronkov, D. I. Pozdnyakov, S. L. Adzhiakhmetova, N. M. Chervonnaya, K. A. Miroshnichenko, A. V. Sosnovskaya, E. I. Chereshkova

“…The work was performed on 50 male Wistar rats, which reproduced an acute brain hypometabolic state by administration of a 3M sodium azide solution in hippocampus (n = 40 and n = 10 – a group of sham-operated animals). The test extracts and the reference drug – EGb 761 – were prophylactically administered at the dose of 100 mg/kg per os for 10 days. 24 hours after the last administration, sodium azide was injected, the brain was taken, the hippocampus was isolated to obtain a supernatant and determine the parameters of mitochondrial respiration, the intensity of anaerobic processes, the concentration of the apoptosis-inducing factor, endonuclease G, and β-amyloid.Results. …”
Get full text

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone also demonstrated significant improvements in cognitive function, as evidenced by enhanced performance in passive avoidance and elevated plus maze tests. …”
Get full text

Effects of Carnosine Supplementation on Cognitive Outcomes in Prediabetes and Well-Controlled Type 2 Diabetes: A Randomised Placebo-Controlled Clinical Trial by Rohit Hariharan, Aya Mousa, Kirthi Menon, Jack Feehan, Barbara Ukropcová, Jozef Ukropec, Martin Schön, Arshad Majid, Giancarlo Aldini, Maximilian de Courten, James Cameron, Simon M. Bell, Barbora de Courten

“…At baseline and follow-up, cognitive function was assessed as a secondary outcome using the Digit-Symbol Substitution Test, Stroop test, Trail Making Tests A & B, and the Cambridge Automated Neuropsychological Test Battery (CANTAB). …”
Get full text

Omija (Schisandra chinensis) extract and soybean mixture to enhance memory function through the gut-brain axis: network pharmacology and in vivo validation of multi-target mechanis... by Yu Yue, Hye Jeong Yang, Myung-Sunny Kim, Ting Zhang, Chen Li, Min Jung Kim, Dai-Ja Jang, Sunmin Park

Get full text

Relationship of LCL finding after post-op ACLR with anterior tibial translation, femorotibial rotation, knee scores, and functional performance: a retrospective cohort study by Ahmet Serhat Genç, Mirsad Yalçınkaya, Egemen Ermiş, Enes Akdemir, Berna Anıl, Esra Korkmaz Salkılıç, Eren Şahin, Ali Kerim Yılmaz

“…Additionally, the LCL sign was not a distinguishing factor in knee scores or lower extremity functional performance at six months post-op. …”
Get full text

Effects of VR task-oriented training combined with rTMS on balance function and brain plasticity in stroke patients: a randomized controlled trial study protocol by Yuanyuan Liu, Ruizhu Lin, Xinbao Tian, Junyi Wang, Ying Tao, Ning Zhu

“…Assessments were conducted at baseline, 2 weeks, and 4 weeks post-treatment, using the Berg Balance Scale (BBS) as the primary measure, and secondary measures including the Timed Up-and-Go Test (TUGT), Fugl-Meyer Assessment-Lower Extremity (FMA-LE), and 6-m walking test (6MWT), as well as assessments for brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VGEF), tyrosine receptor kinase (TrκB), motor-evoked potential latency (PL), central motor conduction time (CMCT), and amplitude. …”
Get full text

The impact of a short-term high-fat diet on coagulation function in a mouse model and its role in exacerbating concanavalin A-induced liver injury by Eri Nanizawa, Yuki Tamaki, Tomiko Yakura, Shun Otsuka, Naoyuki Hatayama, Munekazu Naito

“…These conditions are presumed to be a risk factor that exacerbates Con A-induced liver injury. …”
Get full text

First-phase insulin response (FPIR) to intravenous glucose tolerance test (IVGTT), insulin sensitivity and long-term follow-up in ?- transfusion-dependent thalassemia (TDT) normog... by Vincenzo De Sanctis

“…Objective: To  study the function of the endocrine pancreas in transfusion-dependent ?…”
Get full text

Study on Distributed Ultrasonic Detection Method of Two-dimensional Gas Temperature Field by LI Shaozhuang, SHI Youan, LU Xiaokang, CHEN Yu, WEI Dong

“…The core idea of this algorithm was to fit the distribution of the reciprocal of sound speed using a linear combination of LQ functions to establish an inversion model. SVD was then employed to address the ill-posedness in the inversion process, which enabled the model to be solved. …”
Get full text

DEVELOPMENT OF THE «RISKS - OPPORTUNITIES* MATRIX FOR ASSESSING STRATEGIC RISKS AND OPPORTUNITIES OF THE CHEMICAL INDUSTRY by N. Solovyova

“…The article proposes and tests the «risk-opportunity» matrix for the purpose of assessing the strategic risks and opportunities of chemical companies as dichotomous categories reflecting the probabilistic nature of the environment for the functioning of objects. …”
Get full text

Association Between Obstetric Risk Level and Psychomotor Development Impairments in Children Under Five Years by AdrianaEdit MinietCastillo, Jorge Luis Anaya-González, Jonathan E Muñoz Zambrano, Erlen Carmona Álvarez-Builla

“…Psychomotor development in early childhood is a key indicator of health and neurodevelopmental status. Perinatal risk factors can compromise this process, influencing the child's functional prognosis.  …”
Get full text

Osteosarcopenia in women with rheumatoid arthritis: association with nutritional status and physical condition by O. V. Dobrovolskaya, A. Yu. Feklistov, N. V. Demin, M. V. Kozyreva, N. V. Toroptsova

“…A clinical and laboratory examination as well as tests to assess muscle strength and functional status were performed. …”
Get full text

Characteristics and drivers of carbon emissions intensity vary across countries and time: evidence from 210 countries worldwide by Xu Pengfei, Chen Xiaotong, Chen Jingling

“…Carbon emission intensity (CEI) functions as a pivotal metric for evaluating carbon efficiency, thereby playing a critical role in the promotion of sustainable development and the mitigation of climate change. …”
Get full text

Applying machine learning algorithms to explore the impact of combined noise and dust on hearing loss in occupationally exposed populations by Yong Li, Xin Sun, Yongtao Qu, Shuling Yang, Yueyi Zhai, Yan Qu

“…Abstract This study aimed to explore the combined impacts of occupational noise and dust on hearing and extra-auditory functions and identify associated risk factors via machine learning techniques. …”
Get full text

Relationships between vegetation indices and surface reflectance: Implications for detecting and monitoring sandification in arid regions by Yifan Yue, Wenzhi Zhao, Rentao Liu

“…Soil factors functioned as key mediating variables by integrating climate and human influences, while geographical factors exhibited minimal contribution to the overall model (direct effects < 0.1). …”
Get full text

Scale‐dependence in elk habitat selection for a reintroduced population in Wisconsin, USA by Jennifer L. Merems, Anna L. Brose, Jennifer Price Tack, Shawn Crimmins, Timothy R. Van Deelen

“…As habitat selection can vary by geographic location, available cover, season, and diel period, it is important to understand how a non‐migratory, reintroduced population in northern Wisconsin, USA, is limited by the lack of variation in topography, elevation, and vegetation. We tested scale‐dependent habitat selection on 79 adult elk from 2017 to 2020 using resource selection functions across temporal (i.e., seasonal) and spatial scales (i.e., landscape and home range). …”
Get full text

Degradation of Tetracycline in Wastewater by Persulfate Activated by Sulfidated Nanometer Zero-valent Iron by Qiuyue YE, Zhengchun HU, Ziyi WANG, Wen XU, Shiyi ZHAO, Xuying DENG, Minghao GUO, Na GUO, Bing LIAO

Get full text