Assessment of Functional Status and Mental Health in Post-COVID-19 Patients in a Dedicated COVID-19 Hospital in Maharashtra: A Cross-sectional Study by Gauri Bharadwaj, Lalit Sankhe, Shubhendra Bharadwaj

“…Data analysis was done using Chi-square tests and multiple linear regressions to explore the relationship between functional and mental health metrics. …”
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Association between the levels of urinary cell cycle biomarkers and non-recovery of renal function among critically ill geriatric patients with acute kidney injury by Li Cheng, Hui-Miao Jia, Xi Zheng, Yi-Jia Jiang, Xin Xin, Wen-Xiong Li

“…The lack of early renal function recovery among geriatric patients with acute kidney injury (AKI) in the intensive care unit (ICU) is a commonly observed and acknowledged poor prognostic factor, especially for older adults. …”
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Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection. by Takahiro Asatsuma, Marcela L Moreira, Hyun J Lee, Brooke J Wanrooy, Oliver P Skinner, Shihan Li, Ivana Rea, Taidhgin Harkin, Saba Asad, Cameron G Williams, Lynette Beattie, Ashraful Haque

“…Prr13/Txr1 is reported to transcriptionally regulate sensitivity to anti-cancer drugs. To test for cell-intrinsic gene function, we generated Plasmodium-specific TCR transgenic, PbTII cells harbouring CD4-promoter driven Cre recombinase and target genes with loxP-flanked essential exons. …”
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Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sh... by Yu Zhang, Kaina Zhu, Fengshuo Zhang, Zhenling Wu, Shengzhen Hou, Linsheng Gui

“…The 14% protein diet with RES and HMB improved the hepatic function through modulating the gene and metabolite in Tibetan sheep.…”
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The functional and clinical significance of nucleoporin NUP153 across human cancers: a systematic study based on multi-omics analysis and bench work validation by Youfu He, Youfu He, Qing Wang, Zhaorui Wang, Menghui Duan, Yu Zhou, Jing Huang, Qiang Wu, Feichang Wu, Chen Li

“…Expression differences between tumour and normal tissues were assessed using Wilcoxon signed-rank tests. Gene set enrichment analysis (GSEA) was used to identify the biological functions and pathways related to NUP153. …”
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Serum Osteopontin and Procollagen Type 1 N-Terminal Propeptide Concentrations: Links to Liver Function, Muscle Mass, and Bone Mineral Density in MASLD and Hypertension by Anna F. Sheptulina, Anastasia Yu. Elkina, Elvira M. Mamutova, Yuriy S. Timofeev, Victoria A. Metelskaya, Oxana M. Drapkina

“…Muscle strength was evaluated using grip strength measurements and the Five Times Sit-to-Stand Test (FTSST). SMM and BMD were quantified using dual-energy X-ray absorptiometry (DEXA). …”
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4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells by Frederick L Locke, Yannick Bulliard, Bin Yu, Marco L Davila, Emiliano Roselli, Justin C Boucher, Gongbo Li, Hiroshi Kotani, Kristen Spitler, Kayla Reid, Estelle V Cervantes, Nhan Tu, Sae Bom Lee

“…Background Co-stimulatory signals regulate the expansion, persistence, and function of chimeric antigen receptor (CAR) T cells. …”
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Formation of Orthogonal Components of Input Currents in Microprocessor Protections of Electrical Equipment by F. A. Romaniuk, Yu. V. Rumiantsev, V. Yu. Rumiantsev, I. V. Novash

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An improved Harris hawks optimizer with enhanced logarithmic spiral and dynamic factor and its application for predicting molten iron temperature in the blast furnace by Zhendong Liu, Yiming Fang, Le Liu, Shuidong Ma

“…Based on 23 classical test functions, the influence of the distribution probability, the three improved mechanisms, and the exploration–exploitation ratio in IHHO‐ELSDF are analyzed. …”
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Factors Determining the Efficacy of Guided Intervention-based Management of Shoulder Adhesive Capsulitis Secondary to Breast Cancer Treatment: A Prospective Study by Chandrakant Pilania, Himanshu Agrawal, Pravin Mahadeorao Pisudde, Bhavay Sonik, Ravi Gaur

“…Statistical analysis involved descriptive statistics, χ2 tests, Fisher’s exact tests and multivariate logistic regression. …”
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Small Intestinal Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular Tachycardia in Chronic Heart Failure with Left Ventricular Systolic Dysfunction by M. V. Fadeeva, M. R. Skhirtladze, V. T. Ivashkin

“…Conventional biochemical and hematological tests , ECG and echocardiography were performed. …”
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Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection. by Xin Yin, Yuan Pu, Shuofeng Yuan, Lars Pache, Christopher Churas, Stuart Weston, Laura Riva, Lacy M Simons, William J Cisneros, Thomas Clausen, Grace Biddle, Simon Doss-Gollin, Meagan Deming, Paul D De Jesus, Ha Na Kim, Daniel Fuentes, John M Whitelock, Jeffrey D Esko, Megan S Lord, Ignacio Mena, Adolfo García-Sastre, Judd F Hultquist, Matthew B Frieman, Trey Ideker, Dexter Pratt, Laura Martin-Sancho, Sumit K Chanda

“…Additionally, a subset of proteins was tested across other coronaviruses revealing a subset of proviral factors that were conserved across pandemic SARS-CoV-2, epidemic SARS-CoV-1 and MERS-CoV, and the seasonal coronavirus OC43-CoV. …”
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The members of zinc finger-homeodomain (ZF-HD) transcription factors are associated with abiotic stresses in soybean: insights from genomics and expression analysis by Hafiz Muhammad Rizwan, Jiayi He, Muhammad Nawaz, Keyu Lu, Mingfu Wang

“…Abstract Background Zinc finger homeodomain (ZF-HD) belongs to the plant-specific transcription factor (TF) family and is widely involved in plant growth, development and stress responses. …”
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Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration. by Ying Gu, Christopher Runyan, Amanda Shoemaker, M Azim Surani, Christopher Wylie

“…Here we show that these functions are distributed between the alternatively spliced membrane-bound and soluble forms of Steel factor. …”
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Exploring the Discriminant Validity of the Modified Arm Care Screen (MACS), Designed for Overhead Athletes, in Detecting Musculoskeletal Risk Factors in the General Population by Eleftherios Paraskevopoulos, Styliani Pentheroudaki, Maria Papandreou

“…Background: Shoulder pain is the third most common musculoskeletal issue in primary care, affecting up to 50% of patients six months post-consultation, leading to significant functional impairments and societal costs, especially due to sick leave. …”
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Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro. by Daniel Koch, Ay Lin Kho, Atsushi Fukuzawa, Alexander Alexandrovich, Kutti J Vanaanen, Andrew Beavil, Mark Pfuhl, Martin Rees, Mathias Gautel

“…Despite extensive testing of multiple GEF domain fragments, we did not detect any nucleotide exchange activity in vitro against 9 representative small GTPases. …”
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Changes in the ocular surface condition during the transition to preservative-free hypotensive combination therapy in the long-term observation of patients with advanced stages of... by Dmitry A. Dorofeev, Aleksandr A. Vitkov, Elena V. Kirilik, Ksenia O. Lukyanova, Olga G. Pozdeeva

“…All patients underwent a standard ophthalmological examination and assessment of structural and functional parameters, as well as examination of their ocular surface condition via the Norn test, Schirmer test, lissamine green vital staining, the Ocular Surface Disease Index (OSDI) questionnaire, and meniscometry 1 month and 1 year after the onset of the study. …”
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ASSESSMENT OF AVIATION SECURITY SCREENERS PROFFICIENCY BY MEANS OF APPLYING THE A. BIRNBAUM TWO-PARAMETER MODEL by B. V. Zubkov, A. K. Volkov

“…There have been presented and tested A. Birnbaum two-parameter model, which is used to assess the screeners’ proficiency competence by means of testing. …”
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Influence of agricultural machinery on the potential realization of winter hard wheat yield by A. G. Galayan, S. N. Medvedko, A. V. Bondarev, V. Y. Chundyshko

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Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies by Frank R. Brennan, J. Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J. Peters, Curtis C. Maier, Changhua Ji, David L. Wensel, Derrick Witcher, Patricia C. Ryan, T. Scott Manetz, Adriano Flora, Brian Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P. Humphreys

“…Using a variety of industry case studies, we highlight key aspects of nonclinical pharmacology and toxicology testing strategies, factors that influence choice of nonclinical models, translatability of findings, input from health authorities and suggest best practice approaches for nonclinical testing of Fc modified mAbs.…”
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