CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…IL-12, secreted by TRUCKs on target contact, was further tested for its chemoattractive and activating potential towards monocytes and natural killer (NK) cells.Results After co-cultivation with EBV target cells, TÜ165 CAR-Ts and TRUCKs showed an increased activation marker expression (CD137, CD25) and release of proinflammatory cytokines (interferon-γ and tumor necrosis factor-α). …”
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Examining the comorbidity network of Internet addiction and depression: the role of effortful control on their bridge symptoms in adolescents by Tomoya Hirota, Tomoya Hirota, Masaki Adachi, Masaki Adachi, Rei Monden, Hiroyuki Mori, Hiroyuki Mori, Michio Takahashi, Michio Takahashi, Kazuhiko Nakamura, Kazuhiko Nakamura

“…EC showed a notable negative association with “Concentration”, suggesting important relationships between the transdiagnostic factor and bridge symptoms in understanding the comorbid conditions. …”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…To explore whether Dendrobium officinale, Polygonatum sibiricum, and Ziziphus jujuba can be used as active pharmaceutical ingredient (APIs), a functional snack that is easy to carry and eat was developed. …”
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Association of D-dimer to albumin ratio with adverse cardiovascular outcomes in ischaemic heart failure patients with diabetes mellitus: a retrospective cohort study by Xiaolong Lin, Jinghua Liu, Siyuan Chen, Qiuyu Li, Xiaowen Bo, Donghui Zhao, Qian Fan

“…The cumulative hazards curve manifested significant differences in MACE, all-cause mortality and any revascularisation (log-rank test: all p<0.001). In adjusted models, DAR was an independent risk factor of MACE (tertile 2: HR 1.82, 95% CI 1.37 to 2.42; tertile 3: HR 1.74, 95% CI 1.28 to 2.36) and all-cause mortality (tertile 2: HR 2.04, 95% CI 1.35 to 3.11; tertile 3: HR 1.89, 95% CI 1.20 to 2.98). …”
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Leukocyte-Rich Platelet-Rich Plasma’s Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials by Peiyuan Tang, Meihui Huang, Wenfeng Xiao, Ting Wen, Pavel Volotovsky, Mikhail Gerasimenko, Shiyao Chu, Shuguang Liu, Kai Zhang, Yusheng Li

“…However, there were no statistical differences regarding the Simple Shoulder Test (MD = 0.08, 95% CI: −0.23, 0.39, <i>p</i> = 0.61, I² = 5%). …”
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T-2 toxin-induced spatial learning and memory impairment in mice via the gut-brain axis and the intervening effects of resveratrol by Sheng-Quan Su, Gui-Yuan Xiong, Chun-Yan Yao, Xiao-Ling Liu, Yin-Yin Xia, Jin-Yun Long, Xiu-Kuan Li, Liang-Mei Wang, Long Yi, Wu-Wei Xu, Wu-Qiang Lu, Qian-Qian Li, Ting Hu, Hao Liu, Ke-Xue Wang, Peng Luo, Tong-Jian Cai

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Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…The differential proteins between the two patient groups were identified and functionally analyzed using bioinformatics methods. Key differential proteins were further screened using machine learning models such as Extreme Gradient Boosting （XGBoost） and Least Absolute Shrinkage and Selection Operator （LASSO） regression to construct a nomogram and evaluate its diagnostic performance. …”
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BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias by Hyojin Son, Sechan Lee, Jaeuk Kim, Haangik Park, Myeong-Ha Hwang, Gwan-Su Yi

“…This suggests that the primary factor driving the consistent binding affinities is protein similarity rather than compound structure. …”
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Synergistic Antibacterial and Antibiofilm Effects of Clindamycin and Zinc Oxide Nanoparticles Against Pathogenic Oral <i>Bacillus</i> Species by Maha A. Khalil, Tahany M. Alzaidi, Mohammed Hussein M. Alsharbaty, Sameh S. Ali, Michael Schagerl, Hesham M. Elhariry, Tamer A. Aboshady

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A ROLE OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES M49-16 IN PROMOTING INFECTION AND INHIBITION OF ENDOTHELIAL CELL PROLIFERATION by E. A. Starikova, A. B. Karaseva, L. A. Burova, A. N. Suvorov, A. V. Sokolov, V. B. Vasilyev, I. S. Freidlin

“…., inhibits proliferation and other endothelial cell functions related to angiogenesis. To confirm a leading role of arginine deiminase, as a factor responsible for the anti-proliferative effect, we have constructed an isogenic S. pyogenes M49-16 mutant unable to express arginine deiminase. …”
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Cognitive-Discursive Study of Migration Discourse (Based on English-Language Media Texts) by N. V. Stepanova

“…Obviously, the migration issue is a key factor, a test task, which Biden will have to work on immediately after coming to power.…”
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Inter-protomer opening cooperativity of envelope trimers positively correlates with HIV-1 entry stoichiometry by Revansiddha H. Katte, Wang Xu, Yang Han, Xinyu Hong, Maolin Lu

“…The estimates for all tested Env strains were prevalently higher (T ≥ 7 for BG505 or JR-FL, T ≥ 13 for NL4-3) than reported. …”
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Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing by Tomoki Yanagi, Shean Fu Phen, Jonah Ayala, Deniz Ece Aydin, Susanna Jaramillo, David M. Truong

“…The inclusion of an SV40 poly-A sequence provides a practical solution and genomic architecture to improve the functionality of A2UCOE-based circuits. It also suggests investigating how termination of transcription modulates gene silencing as a novel design parameter. …”
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AIRWAY ASSESSMENT IN OUTPATIENT DENTAL PRACTICE by I. А. Khrypachenko, T. V. Diomina, O. А. Udod

“…Large neck circumference, which often associates with obstructive sleep apnea, is the risk factor of difficult intubation in obese patients. …”
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s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight by K. V. Zhdanov, A. V. Semenov, S. S. Karyakin, K. V. Kozlov, V. S. Sukachev, Yu. V. Ostankova, D. E. Valutite, E. B. Zueva, R. S. Sidorov, A. V. Saulevich, Yu. I. Bulan’kov, Yu. I. Lyashenko, K. S. Ivanov

“…Conclusion: Progressing of fibrosis and functional disturbances in intestines are interconnected with increase in concentration of MadCAM-1 in blood that allows to consider pathological changes in intestines of various genesis as the accessory factor promoting progressing of СHC at patients with excess body weight. …”
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Investigating the Relationship between Air Pollutants and Meteorological Parameters in the Agricultural Sector of Mazandaran Province Using Logistic Regression by Majid Ghorbani, Abolfazl Mahmoodi, Mohammad Khaledi

“…Moreover, the findings from the test phase as well as the prediction error in the network test phase and the correlation between the actual data and the predicted data indicate that the coefficient of determination R2 between the actual data and the predicted data is equal to 0.62. …”
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Chicken liver meal as an effective fishmeal replacement for Litopenaeus vannamei diets: A comprehensive evaluation of growth, non-specific immunity and gut health by Huaxing Lin, Wanting Huang, Xuehe Li, Jiahua Wu, Beiping Tan, Shuyan Chi, Qihui Yang

“…This experiment was conducted to evaluate the effect of chicken liver meal (CLM) on growth, protein synthesis, antioxidative functions, non-specific immunity, and gut microbiota community for juvenile Litopenaeus vannamei. …”
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Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis by Jingfang Liu, Beier Wu, Shihan Wan, Yanlu Jin, Li Yang, Meijuan Wu, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu

“…Abstract Objective Tricho-rhino-phalangeal syndrome-1 (TRPS1), an atypical GATA transcription factor, plays a critical role in diverse physiological and pathological processes and holds potential as a biomarker for diseases and targeted tumor therapies. …”
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FI-Lab predicts all-cause mortality, but not successful rehabilitation, among patients aged 65 and older after hip or pelvic fracture by Evgeniya Zikrin, Evgeniya Zikrin, Abdu El Karim Hilali, Abdu El Karim Hilali, David Shacham, David Shacham, Reut Frenkel, Reut Frenkel, Olga Abel, Olga Abel, Muhammad Abo Abed, Muhammad Abo Abed, Ahmed Abu-Ajaj, Ahmed Abu-Ajaj, Natalia Velikiy, Natalia Velikiy, Tamar Freud, Tamar Freud, Tamar Freud, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press

“…The FI-Lab was calculated based on 26 available blood tests, as well as blood pressure and heart rate measurements. …”
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ZEB1 stratifies the response to Sorafenib and Mdivi-1 combination therapy in hepatocellular carcinoma by H. Freudenstein, M. Strecker, S. Gylstorff, W. Shi, M. Boettcher, S. Medunjanin, C. Catapano, C. Siba, C. Wex, T. Wartmann, A. Y. Sanin, M. Franz, J. Arend, D. Mougiakakos, M. Pech, R. S. Croner, U. D. Kahlert, F. Stelter

“…Zinc finger E-box binding homeobox 1 (ZEB1) is negative prognostic factor in liver cancer by promoting therapy resistance and tumorigenesis. …”
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