Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation by Junbin Liu, Junbin Liu, Junbin Liu, Xiaoting Zhang, Xiaoting Zhang, Xiaoting Zhang, Jingpei Guo, Jingpei Guo, Jingpei Guo, Yun Zhang, Yun Zhang, Yun Zhang, Jinming Fan, Jinming Fan, Jinming Fan, Junfeng Liu, Jiawen Chen, Jiawen Chen, Jiawen Chen, Jiawei Jiang, Benshuai Yu, Benshuai Yu, Ke Zhang, Ke Zhang, Ke Zhang, Bin Zhou, Bin Zhou

“…IntroductionNeuroinflammation is a pivotal factor in the pathophysiology process of ischemic stroke. …”
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Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis by Suyin Feng, Suyin Feng, Suyin Feng, Long Zhu, Long Zhu, Long Zhu, Jinyuan Gu, Kun Kou, Yongtai Liu, Guangmin Zhang, Hua Lu, Honglai Zhang, Runfeng Sun, Runfeng Sun

“…Subsequently, the clusterProfiler package was employed to functionally annotate the genes specifically highly expressed in the cells. …”
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The Effect of Piracetam Administration on Cerebral Palsy Prevention in Rat Fetuses Born To Pregnant Rats by Determining Bdnf Levels in Brain Tissue by Dudy Aldiansyah, Sarma Nursani Lumbanraja, Khairul Putra Surbakti, Isti Ilmiati Fujiati, Agus Sulistyono

“…Brain-derived neurotrophic factor (BDNF) is potent modulator of many neuronal functions that protect the newborn or developing brain from ischemic injury. …”
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Targeted Delivery of Bortezomib Using Retinoid-Based Nanoparticle: Modulating Liver Fibrosis through the TGF-β1/Smad3 Pathway by Samaneh Siapoush, Mohammad Rahmati, Morteza Milani, Behzad Hatami, Nosratollah Zarghami, Abbas Ebrahimi-Kalan, Mohammad Reza Zali, Kaveh Baghaei

“…Purpose: Hepatic stellate cells (HSCs) play a crucial role in fibrosis progression. we have developed a targeted delivery approach using A-functionalized nanoparticles for bortezomib (BTZ) specifically for activated HSCs in a mouse model of liver fibrosis. …”
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Comparison of primary and secondary stability of a one-piece compressive conometric implant system in the posterior upper and lower jaws by Thabat R. Al-Hity, Thabat R. Al-Hity, Thabat R. Al-Hity, Bilal El-Dhuwaib, Abdulsalam R. Al-Zahawi, Sarhang Sarwat Gul, Sarhang Sarwat Gul

“…BackgroundImplant stability plays a key role in establishing implant osseointegration and is a crucial factor in determining the appropriate timing for functional loading with a fixed prosthesis. …”
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CD3+ B-1a Cells as a Mediator of Disease Progression in Autoimmune-Prone Mice by Wakako Yamamoto, Hidemi Toyoda, Dong-qing Xu, Ryo Hanaki, Mari Morimoto, Daisuke Nakato, Takahiro Ito, Shotaro Iwamoto, Motoki Bonno, Shigeki Tanaka, Masahiro Hirayama

“…B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. …”
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TWO CASES OF PRIMARY AMYLOIDOSIS PRESENTING WITH VERTEBRAL AMYLOIDOMA by Ebru Kavak Yavuz, Vehbi Demircan, Abdullah Karakus, Orhan Ayyildiz

“…The patient developed a hematoma in the surgical area, factor levels were studied, factor 10 level was found to be 10% low. …”
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Ambiguous results of balloon angioplasty for central vein stenosis in hemodialysis patients with native arteriovenous fistula by Z. B. Kardanakhishvili, A. B. Zulkarnaev, B. V. Baykov, V. A. Stepanov

“…Hazard ratio (HR) 0.5337 [95% CI 0.3381; 0.8427], log-rank test p = 0.0011. No differences in functional primary patency (time interval between the start of using AVF and the first intervention for CVS) were found: 89.7% [95% CI 74.9; 96] and 30.8% [95% CI 17.3; 45.4] at 1 year and 3 years, respectively, in the experimental group, and 80.5% [95% CI 64.8; 89.7] and 24.4% [95% CI 12.7; 38.2] in the control group. …”
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Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children by D. I. Novikov, A. Yu. Zaitsev, K. V. Dubrovin, E. K. Bespalov, A. V. Filin

“…After chemotherapy courses, children aged 0–11 years suffering from hepatoblastoma, maintain normal functional activity of the hemostasis system at all stages of surgical treatment. …”
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How do strategic attributes of electronic commerce impel the perceived value and electronic loyalty of online food delivery applications (OFDAs) by Muhammad Asif Zaheer, Tanveer Muhammad Anwar, Zoia Khan, Muhammad Ali Raza, Hira Hafeez

“…Design/methodology/approach – The study was quantitative and data were collected from 509 consumers of the district of Rawalpindi, Punjab Pakistan by using a convenience sampling technique who was the users of OFDAs to evaluate the proposed research model. Confirmatory factor analysis was applied to evaluate the validity of the constructs, and structural equation modeling was employed to test the model through Smart-PLS. …”
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Socioeconomic inequalities in meeting the needs of the elderly in western Iran by Sediqheh Mafakheri, Fatemeh Mansouri-Shad, Parvin Cheraghi, Qhadir Nouri, Zahra Cheraghi

“…The data collection process consisted of four sections, including: A demographic information questionnaire, the Abbreviated Mental Test (AMT) questionnaire to determine the absence of dementia, cognitive impairment and the Barthel Index questionnaire to measure functional independence status and 4) Camberwell Assessment of Need for the Elderly. …”
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Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics by Yue Li, Keru Ma, Hao Wang, Zongying Liu, Zhuying Li

“…Sensitivity analysis, including heterogeneity tests for dependent instruments, were conducted to validate the findings. …”
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Neuropeptide S pathway in PTSD and neuropsychiatric disorders: A review by Zhi-cheng Zhu, Xue-jing Han, Zhen He, Meng-yang Liu, Ning Wu, Xiang-min Tong, Fei Li

“…This narrative review surveys studies published 2000–2024 in PubMed, Embase and Web of Science that examine NPS/NPSR involvement in core PTSD features and typical comorbidities. The functional rs324981 A/T polymorphism, which boosts NPSR surface expression and signalling, consistently associates with greater PTSD risk and symptom severity. …”
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Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats by Rasha Z. Alshahawy, Sally M. Safwat, Sanad S. El-Kholy, Soheir F. El-basiony, Sara El-Desouky, Soheir M. Helmi

“…At the end of the study, five behavioral tests were conducted to assess cognitive functions, motor activity, and anxiety-related behaviors, and hippocampal tissues were analyzed for tau pathology, neuroinflammation, expression of VDR, and neurodegeneration-related markers. …”
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COMPARATIVE ANALYSIS OF CYTOKINE PRODUCTION BY BLOOD IMMUNOCOMPETENT CELLS AND TUMOR IN DIFFERENT AGE GROUPS OF PATIENTS WITH INVASIVE DUCTAL CARCINOMA by T. A. Kunts, E. S. Mikhaylova, I. O. Marinkin, N. A. Varaksin, A. I. Autenshlyus

“…In summary, these findings suggest that circulating immunocompetent cells may serve as an additional factor providing tumor progression, due to their high ability to secrete cytokines.…”
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Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. by Fanggeng Zou, Olivia Belbin, Olivia Belbin, Minerva M Carrasquillo, Oliver J Culley, Talisha A Hunter, Li Ma, Gina D Bisceglio, Mariet Allen, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Kevin Morgan, Steven G Younkin

“…We next measured GAB2 mRNA levels in 249 brains and found that decreased neurofibrillary tangle (r = -0.34, p = 0.0006) and senile plaque counts (r = -0.32, p = 0.001) were both good predictors of increased GAB2 mRNA levels albeit that sex (r = -0.28, p = 0.005) may have been a contributing factor. In summary, we hypothesise that GAB2 variants that are protective against LOAD in some populations may act functionally to increase GAB2 mRNA levels (in lymphoblastoid cells) and that increased GAB2 mRNA levels are associated with significantly decreased LOAD pathology. …”
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CGF with Bio-Oss collagen as grafting materials for simultaneous implant placement after osteotome sinus floor elevation: a prospective study by Bashar Shahood, Seba Harphoush, Belal O. M. Muhaisen, Jing Qiu

“…The purpose of this study was to radiologically evaluate the efficacy of using Bio-Oss Collagen with Concentrated Growth Factor (CGF) as grafting materials for OSFE with simultaneous implant placement in the atrophic maxilla after one year of functional loading. …”
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PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report

“… Background: Lipoprotein(a) (Lp(a)) is a well-established, genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). …”
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Study protocol for the validation of a new patient-reported outcome measure (PROM) of listening effort in cochlear implantation: the Listening Effort Questionnaire-Cochlear Implant... by Frances Rapport, Alan Watkins, Sarah E Hughes, Isabelle Boisvert, Catherine M McMahon, Hayley A Hutchings

“…In phase 1, 250 CI patients from four National Health Service CI centres will self-complete a paper version of the LEQ-CI. Factor analysis will establish unidimensionality and Rasch analysis will evaluate item fit, differential item functioning, response scale ordering, targeting of persons and items, and reliability. …”
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On the Control of the Technical Condition of Elevator Ropes Based on Artificial Intelligence and Computer Vision Technology by A. V. Panfilov, A. R. Yusupov, A. A. Korotkiy, B. F. Ivanov

“…The role of elevator rope defects as a factor of dangerous incidents is indicated from the point of view of statistics. …”
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