A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…Methods In this multicenter, confirmatory, randomized-controlled-clinical-trial, MAAP, which consists of multifaceted, evidence-based treatment elements adapted from other sophisticated treatment programs such as Dialectical Behavior Therapy and Mentalization-Based Treatment, is tested for efficacy against a non-specific supportive psychotherapy (NSSP) program focusing on non-specific general factors of psychotherapy at seven different sites in Germany. …”
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Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. by Darren M Lipnicki, John D Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole A Kochan, Gavin Andrews, M Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona E Matthews, Blossom C M Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda C W Lam, Candy H Y Wong, Ada W T Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Perminder S Sachdev, Cohort Studies of Memory in an International Consortium (COSMIC)

“…We analyzed standardized Mini-Mental State Examination (MMSE) and memory, processing speed, language, and executive functioning test scores using linear mixed models, adjusted for sex and education, and meta-analytic techniques. …”
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Reversing cardiac hypertrophy and heart failure using a cardiac targeting peptide linked to miRNA106a by Ming Lu, Siqi Cai, Kyle Korolowicz, Claire Deng, Kaan Taskintuna, Gerard Ahern, Raymond B. Yurko, Kazi R. Islam, Bryn Schoonover, Jack B. Lopuszynski, Hongkun Wang, Maliha Zahid, G. Ian Gallicano

“…Abstract Background One in five adults aged 40 will develop heart failure (HF) during their lifetime. Risk factors (e.g., hypertension, diabetes mellitus, coronary artery disease, etc.) lead to structural and functional changes in cardiomyocytes, resulting in HF. …”
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Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophreniaResearch in context by Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge

“…A better understanding of the factors that influence this heterogeneity is necessary for the development of individualised patient care. …”
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Contingent Analysis of Open Flap Debridement, Leukocyte-Rich Platelet-Rich Fibrin and Titanium Platelet-Rich Fibrin in the Treatment of Three-Walled Intra-Bony Defects in Chronic P... by Gowri Pendyala, Ameet Mani, Vinay Vadvadgi, Esha Thakare, Bharti Gupta

“…Platelet Rich Fibrin is a polymerized fibrin matrix having a simple strategy of enhancing healing capacity of natural blood clot by supplementing the natural blood clot with growth factors. This unique structure acts as a vehicle for growth factor delivery system and also carry cells that are essential for tissue regeneration. …”
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GENERATION OF CD34+ DERIVED HUMAN MACROPHAGE EXPRESSING CHIMERIC ANTIGEN RECEPTORS FOR CANCER TREATMENT by Ian-Costa, Livia-Furquin, Viviane-Jennifer, Théo-Gremen, Samuel-Campanelli, Rafael-Almeida, Vanderson-Rocha, Rodrigo-Nalio

“…Them, MacCD34 were tested formorphology,phenotype characterization and phagocytosis capabilities. …”
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CHANGES IN MORPHODENSITOMETRIC PARAMETERS OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS IN RATS UNDER STRESS OF DIFFERENT DURATIONS by І. Федоряк, Р. Булик

“… Paraventricular nuclei of the hypothalamus play the important role in both endocrine regulation of the tropic function of the adenohypophysis and the organism's neuroendocrine response to stress of various origins, particularly sustained photoperiod disturbances. …”
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Could the Microbial Profiling of Normal Pancreatic Tissue from Healthy Organ Donors Contribute to Understanding the Intratumoral Microbiota Signature in Pancreatic Ductal Adenocarc... by Francesca Tavano, Alessandro Napoli, Domenica Gioffreda, Orazio Palmieri, Tiziana Latiano, Matteo Tardio, Fabio Francesco di Mola, Tommaso Grottola, Markus W. Büchler, Marco Gentile, Anna Latiano, Tommaso Mazza, Francesco Perri

“…Future prospective studies on larger populations, also including patients in advanced tumor stages and considering all potential existing confounding factors, as well as further functional investigations, are needed to prove the role of microbiota-mediated pathogenicity in PDAC.…”
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Social hierarchy modulates drug reinforcement and protein phosphorylation in the nucleus accumbens by Liang Xu, Liang Xu, Liang Xu, Ruiyi Zhou, Ruiyi Zhou, Jiafeng Zhong, Jiafeng Zhong, Yina Huang, Yingjie Zhu, Yingjie Zhu, Yingjie Zhu, Yingjie Zhu, Wei Xu, Wei Xu, Wei Xu

“…Drug reinforcement is affected by genetic and environmental factors. Social hierarchy has been reported to regulate drug reinforcement and drug-seeking behaviors, but the underlying molecular mechanism is almost unknown.MethodsWe take advantage of the tube test to assess the social hierarchy between two co-housed rats. …”
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Childbearing and Family Instability: The Impact of Children on Women's Divorce Probability in Iran by Davoud Shahpari Sani, Mohammad Jalal Abbasi Shavazi

“…Various demographic and social factors contribute to this trend, with childbearing and the number of children in a family playing a crucial role. …”
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The Effect of Heat Stress on the Performance and Genetic Parameters of Milk Production, Reproduction, and Somatic Cell Scores in Iranian Holstein Cows by Reza Seyedsharifi, Fatemeh Ala Noshahr, Jamal Seif Davati, Nemat Hedayat Evrigh

“…Moreover, the superior genetic fathers for heat tolerance were identified and their genetic value in functional traits was investigated under the genetic evaluation for heat stress. …”
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Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization by Yining Zhou, Yining Zhou, Yining Zhou, Yining Zhou, Yining Zhou, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Huiwen Chen, Huiwen Chen, Huiwen Chen, Huiwen Chen, Huiwen Chen, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song

“…A periodontitis model was established in mice with conditional deletion of Stat3 in Th17 cells (Stat3fl/fl; Il17a-CreERT2, cKO) and wild type (Stat3fl/fl, WT) mice via injection of Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) into gingival sulcus. Cognitive function was assessed through behavioral tests. Expression of Th17-related cytokines and microglial pro-inflammatory markers was evaluated by reverse transcription-quantitative PCR (RT-qPCR), ELISA, flow cytometry, and immunohistochemistry. …”
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Multi-modal MRI for objective diagnosis and outcome prediction in depression by Jesper Pilmeyer, Rolf Lamerichs, Sjir Schielen, Faroeq Ramsaransing, Vivianne van Kranen-Mastenbroek, Jacobus F.A. Jansen, Marcel Breeuwer, Svitlana Zinger

“…By addressing these research questions using the same dataset, we eliminate between-study confounding factors.Various structural (T1-weighted, T2-weighted, diffusion tensor imaging (DTI)) and functional (resting-state and task-based functional MRI) scans were acquired from 32 MDD and 31 healthy control (HC) subjects during the first visit at the investigational site (baseline). …”
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A domain-based framework for cognitive profile identification in Parkinson’s disease across diverse samples by Elvira Andújar-Castillo, Carla Carrillo-Molina, Fernando Alonso, Fernando Alonso, Clara Villanueva-Iza, Clara Villanueva-Iza, Gustavo Fernández-Pajarín, Gustavo Fernández-Pajarín, Angel Sesar, Angel Sesar, Isabel Jiménez-Martín, Isabel Jiménez-Martín, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Maria Jesús Lama, Pablo Mir, Pablo Mir, Pablo Mir, Elena Perez-Hernandez, Cristina Nombela Otero

“…Five cognitive domains were constructed, addressing attention/working memory, executive functions, memory, visuospatial abilities, and language, using composite z-scores derived from standardized neuropsychological tests.ResultsLatent Cluster Analysis identified three distinct cognitive profiles: (1) a fronto-striatal profile characterized by mild deficits in executive and attention functions and intact visuospatial abilities, (2) a posterior cortical profile marked by severe memory and visuospatial impairments but strong language performance, and (3) a preserved profile displaying mild deficits across multiple domains. …”
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Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…The aims of our study are to co-design and test the feasibility of FREED-Mobile (FREED-M), an online intervention tool for young people with early-stage EDs. …”
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The preoperative hemoglobin, albumin, lymphocyte, and platelet score (HALP) as a prognostic indicator in patients with non-small cell lung cancer by Qiteng Liu, Qiteng Liu, Qiteng Liu, Qiteng Liu, Hailun Xie, Hailun Xie, Hailun Xie, Wenjuan Cheng, Tong Liu, Tong Liu, Tong Liu, Chenan Liu, Chenan Liu, Chenan Liu, Heyang Zhang, Heyang Zhang, Heyang Zhang, Shiqi Lin, Shiqi Lin, Shiqi Lin, Xiaoyue Liu, Xiaoyue Liu, Xiaoyue Liu, Haiying Tian, Haiying Tian, Haiying Tian, Xiangrui Li, Xiangrui Li, Xiangrui Li, Xin Zheng, Xin Zheng, Xin Zheng, Yue Chen, Yue Chen, Yue Chen, Jinyu Shi, Jinyu Shi, Jinyu Shi, Hong Zhao, Hong Zhao, Hong Zhao, Hanping Shi, Hanping Shi, Hanping Shi

“…Time-patient survival trends were validated using Kaplan–Meier curves and log-rank tests. The Restricted Cubic Spline function was used to analyze the relationship between the HALP index and overall survival (OS). …”
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Healthcare workers' knowledge and attitudes regarding artificial intelligence adoption in healthcare: A cross-sectional study by Moustaq Karim Khan Rony, Khadiza Akter, Latifun Nesa, Md Tawhidul Islam, Fateha Tuj Johra, Fazila Akter, Muhammad Join Uddin, Jeni Begum, Md. Abdun Noor, Sumon Ahmad, Sabren Mukta Tanha, Most. Tahmina Khatun, Shuvashish Das Bala, Mst. Rina Parvin

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Upstream therapy of reperfusion disorders of hemodynamics, rhythm and conduction in patients with acute myocardial infarction with diabetes mellitus and metabolic syndrome (second... by M.I. Shved, I.O. Yastremska, R.M. Ovsiychuk, L.P. Martyniuk, O.A. Prokopovych, Ya.M. Kitsak

“…In patients with STEMI combined with T2DM and MS, hyperglycemia, insulin resistance and severe abnormalities of morphological and functional parameters of the heart with its systolic-diastolic dysfunction are observed at baseline, which are triggers of the complicated course of this pathology, with the deve­lopment of heart failure syndrome, rhythm and conduction disorders. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…This study presents the first evidence that altered liver functions are associated with pathological behaviors arising from genetic SERT deficiency.…”
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Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study by Joan B Soriano, Juan José Soler-Cataluña, Marc Miravitlles, Julio Ancochea, Elena García Castillo, Miguel Barrueco Ferrero, Begoña Gallego, Ramon Fernandez, Inmaculada Alfageme, Borja G Cosío, Cristina Represas, Pilar de Lucas, Ciro Casanova, Francisco García-Río, José Miguel Rodríguez González-Moro, María Guadalupe Sánchez Herrero, Claudia Valenzuela, Ana Pueyo Bastida, Lourdes Lázaro Asegurado, Luis Rodríguez Pascual, Mª José Mora, Luis Borderias Clau, Lourdes Arizón Mendoza, Sandra García, Juan AR Miranda, Julián Grande Gutiérrez, Jesús Agustín Manzano, Manuel González, Milagros Rosales, José AF Villar, Ana Priegue, Isabel Portela Ferreño, Cecilia Mouronte Roibás, Sara Fernández García, Rocío Cordova Díaz, Nuria Toledo Pons, Margalida Llabrés, José MM Trigo, Marta Forner, Pablo Cubero, Elisabet Vera, Mª BP Albero, Noelia González García, Agustín Valido Morales, Carolina Panadero, Cristina Benito Bernáldez, Maria Velarde, Antonio Santa Cruz Siminiani, Carlos Castillo Quintanilla, Rocío Ibáñez Meléndez, José JM Garcerán, Desirée Lozano Vicente, Pedro García Torres, Maria del Mar Valdivia, Juan PT Tajes, Montserrat Cizur Girones, Carmen Labiano Turrillas, Carlos Ruiz Martínez, Elena Hernando, Elvira Alfaro, José Manuel García, Jorge Lázaro, David Bravo, Laura Hidalgo, Silvia Francisco Terreros, Iñaki Zorrilla, Ainara Alonso Colmenero, Cristina Martínez González, Susana Margon, Rosirys Guzman Taveras, Alicia Álvarez, José RA Balbín, Juan Agüero Calvo, Jaume Ferrer Sancho, Esther Rodríguez González, Eduardo Loeb, José LI Alonso, Mª AR García, Juan Abreu González, Candelaria Martín García, Rebeca Muñoz, Haydée Martín García, Miguel AM Muñiz, Andrés AS Antuña, Jesús Allende González, Jose AG Blanco, Fernando JA Navascues, Manuel AV Montes, María Rodríguez Pericacho, Concepción Rodríguez García, Juan DA Mavárez

“…The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.Methods A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. …”
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