Mechanistic insights into Circ-MBOAT2-mediated regulation of TLK1 through miR-664b-3p in non-small cell lung cancer by DanTing Zhao, Cong Wang, GuangCheng Zhang, ZhengChang Song, ChunYu Luan

“…Nevertheless, the precise functional role and mechanistic contributions of circ-MBOAT2 in NSCLC remain poorly characterized. …”
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Evaluation of the Relationship between the Pulp and Periapical Lesions with Controlled Type Type 2 Diabetes in Patients Referred to the Dental Clinic: A Radiographic Evaluation by Abbas Mesgarani, Alireza Sedighi, Ozra Akha, Abolfazl Hosseinnataj, Ali Golmohammadi, Maede Salehi

“…Background and Purpose: Diabetes Mellitus is a group of complex, multi-system metabolic disorders that alter many functions of the immune system and are associated with delayed recovery and a reduced immune response. …”
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PENGEMBANGAN LKPD FUNGSI KUADRAT BERBASIS PEMBUKTIAN DENGAN MODEL ARGUMENTASI TOULMIN UNTUK MEMFASILITASI KEMAMPUAN ARGUMEN MATEMATIS by Debi Suci Putri, Cecil Hiltrimartin, Yusuf Hartono, Nyimas Aisyah

“…The data collection techniques used in the following research are questionnaires, interviews and tests. The validity of proof-based student worksheet is examined through 3 factors, namely construct, content and language contained in the validation sheet in the expert review stage and according to suggestions/comments from the results of one to one experiments. …”
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Clinical manifestations of COVID-19 infection and its impact on the outcome in children and adolescents with benign and malignant hematological disease in Egypt: a single-center ex... by Fatma Soliman Elsayed Ebeid, Aya Mostafa, Sondos M. Magdy, Haidy Moahmed Abd El Kader, Amal Abdel Azim Lotfy, Nihal Hussien Aly

“…Baseline laboratory investigation were collected included complete blood count (CBC), liver and kidney functions, C-reactive protein (CRP), serum ferritin, lactate dehydrogenase, and coagulation test. …”
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Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progression by Yuhui Tang, Aiqi Xu, Zhongbiao Xu, Jindong Xie, Wei Huang, Liulu Zhang, Yitian Chen, Lu Yang, Shasha Du, Kun Wang

“…Methods The thorough analyses of different cell types within TME were conducted on the self-tested single-cell RNA sequencing dataset which contained nine TNBC treatment-naïve patients, including subclusters classification, CellChat algorithm, transcription factors (TFs) expression, pseudotime analysis and functional enrichment assay. …”
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Using preprocessed datasets to construct and interpret multiclass identification models by Cong Wang, Yufeng Fu, Ran Wan, Le Zhao, Hongbo Wang, Junwei Guo, Qiang Liu, Shan Li, Shengtao Ma, Zhicai Wang, Wei Huang, Huimin Liu, Song Yang, Cong Nie

“…Feature importance and contribution analyses were conducted using Shapley additive explanations (SHAP).ResultsThe resulting models demonstrated high robustness and accuracy, achieving classification success rates of 97.9 and 97.4% via n-fold cross validation on rice and tobacco datasets, respectively, and 97.7% on an independent test set (tobacco dataset 2). This analysis identified key variables and elucidated their specific contributions to the model predictions.DiscussionThis study expands the applicability of image and NIR spectroscopic data, offering researchers an effective methodology for investigating factors crucial to the quality control and improvement of agricultural products.…”
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Oral administration of antimicrobial peptide MPX can effectively regulate LPS-mediated testicular oxidative stress and blood‒testis barrier damage by Chunling Zhu, Chengshui Liao, Yilin Bai, Rui Yang, Boyang Zhang, Xueqin Zhao, Wei Zhang, Xiaojing Xia, Huihui Zhang, Huarun Sun, Weiyu Luo, Jianhe Hu, Yuliang Wen, Yueyu Bai, Lei Wang, Ke Ding, Xueming Zhang

“…Abstract Oxidative stress and disruption of blood‒testis barrier permeability are considered key factors in the pathogenesis of testicular inflammation, degeneration, and functional impairment, which play crucial roles in male infertility. …”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…The bedside water swallowing test (BWSS), Functional Oral Intake Scale (FOIS) Score, Clinical Swallowing Evaluation, Mini Nutritional Assessment Test (MNAT), Eating Assessment Tool (EAT-10), the Turkish version of the World Health Organisation Quality of Life Scale Elderly Module, and the Swallowing Therapy Programme Protocol were applied. …”
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Four New Patient-Reported Outcome Measures Examining Health-Seeking Behavior in Persons With Type 2 Diabetes Mellitus (REDD-CAT): Instrument Development Study by Suzanne E Mitchell, Michael A Kallen, Jonathan P Troost, Barbara A De La Cruz, Alexa Bragg, Jessica Martin-Howard, Ioana Moldovan, Jennifer A Miner, Brian W Jack, Noelle E Carlozzi

“…All items were devoid of differential item functioning for age, sex, education, or socioeconomic status factors. …”
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Steroids combined with anticoagulant in acute/subacute severe cerebral venous thrombosis by Shimin Hu, Yaqin Gu, Tingyu Zhao, Kaiyuan Zhang, Jingkai Li, Chen Zhou, Haiqing Song, Zhi Liu, Xunming Ji, Jiangang Duan, Ting Gao

“…Univariate and multivariate logistic regression were used to evaluat associations between steroid use and favorable outcomes (mRS ≤2) at the 6-month follow-up. Paired tests assessed changes in hs-CRP and other variables before and after treatment, and Spearman’s correlations were used to analyze relationships between these changes and functional improvements. …”
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Immunological landscape of children with Mycoplasma pneumoniae pneumonia in the post-COVID-19 era reveals distinctive severity indicators by Ran Jia, Haiyan Guo, Aizhen Lu, Caiyan Zhang, Yuanyuan Qi, Dingmei Wang, Wen He, Qing Wang, Zimei Cheng, Yajing Gao, Guoping Lu, Libo Wang, Xiaowen Zhai, Jin Xu, Xiaobo Zhang, Yi Wang, Yufeng Zhou

“…However, the key immune factors that contribute to the advancement of the disease remain unknown. …”
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CHARACTERISATION AND STUDY OF 1- [2- (2-BENZOYLPHENOXY) ETHYL] -6-METHYLURACIL MECHANISM OF ACTION by E. A. Jain (Korsakova), D. V. Demchenko, A. A. Ozerov, M. N. Makarova, V. G. Makarov, V. Yu. Balabanyan

“…In the IR spectrum, there are specific bands in the range of 4000-370 cm–1. These factors make it possible to use UV and IR spectra to identify the test compound in the substance. …”
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Development of a prediction model for acute respiratory distress syndrome in ICU patients with acute pancreatitis based on machine learning algorithms by REN Xia*，LIU Luojie，ZHA Junjie，YE Ye，XU Xiaodan，YE Hongwei，ZHANG Yan

“…Demographic characteristics，initial vital signs，laboratory data，functional scores，and complications within the initial 24⁃hour of ICU admission were collected. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Secondary outcomes included patient self-reported measures of BMI and eating psychopathology, visual analogue scale measuring motivation and ability to recover; psychosocial functioning (assessed using the Work and Social Adjustment Scale). …”
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Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…On this basis, the Box-Behnken design is used to construct a four-factor and three-level experimental scheme, and a second-order response surface agent model is established by 25 sets of simulation data, with the dual optimization objectives of minimizing the equivalent force and maximizing the contact pressure, and the relationship between the structural parameters and the equivalent force and the contact pressure as the optimization function, and the range of geometrical parameters as the boundary conditions. …”
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Deep learning-based body composition analysis from whole-body magnetic resonance imaging to predict all-cause mortality in a large western populationResearch in context by Matthias Jung, Vineet K. Raghu, Marco Reisert, Hanna Rieder, Susanne Rospleszcz, Tobias Pischon, Thoralf Niendorf, Hans-Ulrich Kauczor, Henry Völzke, Robin Bülow, Maximilian F. Russe, Christopher L. Schlett, Michael T. Lu, Fabian Bamberg, Jakob Weiss

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Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification by Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang

“…Abstract Background Lysosomal homeostasis and functions are essential for the survival of neural cells. …”
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Elaboración, validez de contenido y fiabilidad del instrumento de observación SOCTOD-BSR para el análi-sis de acciones en baloncesto en silla de ruedas (Development, content validi... by Adrián García-Fresneda, Verónica Muñoz-Arroyave, Xavier Iglesias, Apostolos Theodorou, David Suárez Iglesias, Alba Pardo Fernández

“…Keywords: psychometric properties, observational methodology, functional classification, line-up formations, parasport. …”
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PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1 by Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu, Zhenhai Yu

“…Protein extracts from both ectopic tissues and cells were subjected to Western blot and co-immunoprecipitation (Co-IP) interaction validation. Functional assays (proliferation/migration/invasion) were performed using EESC and 11Z cell lines with triplicate biological replicates. …”
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Intra-arterial selective hypothermia for acute ischemic stroke neuroprotection: A multicenter pilot trial in China. by Zhi-Xin Huang, Miaomiao Hu, Pan Zhang, Xuying He, Xinan Ma, Quanlong Hong, Ping Chen, Huanhuan Luan, Zongyi Wu, Chaolai Liu, Wei Li, Yongkun Li, Yongtao Yu, Min Li, Yajun Li, Dezhi Liu, Zhongkui Han, Weiliang Shi, Jilong Yi, Liang Liu, Guoqiang Xu, Haike Lu, Lizhi Zhou, Xinfeng Liu, Wen Sun, ISOLATION Group

“…The main limitations include the insufficient sample size of this pilot study which limited statistical power to detect differences in the primary outcome, the inability to adjust for potentially important confounders beyond age and ASPECTS due to the small sample size, and the higher incidence of pulmonary infections in the IA-LTH group that may have resulted from hypothermia-induced immune suppression or sedation-related factors.<h4>Conclusions</h4>This pilot study provides preliminary insights suggesting that IA-LTH combined with endovascular therapy may be feasible and safe, with potential to improve functional outcomes in patients with AIS. …”
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