Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease by Joshua Pillai, Kijung Sung, Linda Shi, Chengbiao Wu

“…Using the protocol described in our previous work [1], we determined the structural, stability, and potential functional effects of these variants. Our evaluations of the mutations were divided into those (i) implicated in NHD, (ii) located on the transmembrane domain, (iii) surface of the IgV-like domain, (iv) buried in the receptor, and (v) on low confidence predicted local distance difference test residues. …”
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The Problem of the Reliability of Bending Models for Composite Plates of Medium Thickness by Shvabyuk V. I., Rotko S. V., Ribeiro L. F., Kuts N. H., Zakharchuk V. I., Shvabyuk V. V.

“…Therefore, developing a plate-bending model that incorporates all the above factors and is on par with previously applied theories regarding the complexity of the calculation equations remains relevant. …”
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Right hemisphere engagement in language abilities in older adults: indication of compensation rather than decline by Daniel Solomons, Daniel Solomons, Maria Rodriguez-Fernandez, Maria Rodriguez-Fernandez, Francisco Mery-Muñoz, Leonardo Arraño-Carrasco, David Toloza-Ramirez, David Toloza-Ramirez, Francisco Sahli-Costabal, Francisco Sahli-Costabal, Francisco Sahli-Costabal, Carolina Mendez-Orellana, Carolina Mendez-Orellana

“…This study investigates correlations between language performance, gray matter volume (GMV), and neural activity in language regions, adjusted for demographic factors, in healthy older adults.MethodsTwenty-seven right-handed participants aged 60–87 were evaluated for overall linguistic performance using the Spanish version of ScreeLing (SCL) test and phonemic fluency and semantic verbal fluency tasks (PF and SF). …”
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The Effect of Different Levels of CLA and Omega-3 Supplements Along with Essential Oils of Fennel, Peppermint, and Eucalyptus Medicinal Plants on Production Performance, Blood Para... by Yadollah Chashnidel, Matin Movagharnezhad, Mehdi Jafary charati

“…During the experimental period, the chickens had full access to water freely. Functional traits of the egg production rate and the average weight of eggs were measured daily, and feed consumption and conversion factor were measured weekly. …”
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Evaluation of effectiveness of long-term therapy with Russian rituximab biosimilar in Sjogren’s disease in real clinical practice by B. D. Chaltsev, V. I. Vasilyev, A. V. Torgashina, Yu. I. Khvan, E. B. Rodionova, E. I. Selifanova, T. N. Safonova, L. A. Semenova, M. V. Burtseva, S. I. Glukhova

“…When assessing the lacrimal glands function, a significant increase in lacrimation was found according to the stimulated Schirmer’s test (from 6 [3.75; 12] to 8 [5; 15] mm; p=0.005); an increase in lacrimation was noted in 38% of patients, stabilization in 40.6%, and a decrease in 21.4%. …”
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Evaluating the effect of immune checkpoint inhibitor treatment on chronic obstructive pulmonary disease in lung cancer patients by Anet Greib, Songzhu Zhao, Michelle Ploch, Jonathan Henricks, Robert Easterling, Meghana Moodabagil, Gabrielle Lopez, Mingjia Li, Evelyn G. Goodyear, John Sharp, Asrar Alahmadi, Jacob Kaufman, Regan Memmott, Kai He, Peter Shields, David P. Carbone, Gregory A. Otterson, Carolyn J. Presley, Lai Wei, Dwight H. Owen, Kevin Ho

“…For those with COPD, COPD medications were collected at and after ICI initiation. Pulmonary function tests, COPD exacerbations, and COPD-related hospitalizations were compared before and after ICI treatment. …”
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Change in mental health service utilization from pre- to post-COVID-19 period in the United States by Md Rezaul Kader, Mohammod Mahmudur Rahman, Piali Dey Bristi, Foyez Ahmmed

“…Along with the univariate analysis, bivariate analysis was conducted using the Chi-square and Cochran-Armitage trend tests. Stepwise binary logistic regression was implemented to find the best-fitted model and examine the effects of different factors on mental healthcare utilization. …”
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AI-based system for food and beverage selection towards precision nutrition in Indonesian restaurants by Kudang Boro Seminar, Evy Damayanthi, Karlisa Priandana, Harry Imantho, Bonang Waspadadi Ligar, Annisa Utami Seminar, Angga Dwi Krishnajaya, Muhamad Reza Aditya, Muhammad Ilham Hakim Suherman, Ismy Fana Fillah

“…In this study, the structure and chromosome content of the food, its corresponding energy and nutrient contents, and GA operators such as crossover, mutation, and tournament selection for determining the best meal using the defined fitness functions are discussed. The proposed system has been tested at Karimata Restaurant and proved to be highly suitable for the ultimate goal of meal selection for individual diners with different needs, and it can be replicated at other restaurants. …”
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Understanding continued use of smart learning platforms: psychological wellbeing in an extended TAM-ISCM model by Jinlei Li, Meilin Jin, Xiaowei Chen, Xiaowei Chen

“…IntroductionIn response to the growing adoption of digital education technologies, this study explores the factors influencing the continuous use of innovative learning platforms among students in higher vocational education. …”
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An efficient propagation system through stem cuttings of a multipurpose plant—Ficus tikoua Bur by Tinghong Tan, Yu Peng, Biling An, Fan Gao, Yanni Sun, Chuandong Yang, Hong Yang, Zhihong Lu

“…The best substrate-habitat combinations for overall seeding yield were grassland-T4 (loam: light substrate: humus = 2:1:1), sandy-T6 (loam: light substrate: humus = 2:3:1), rocky-T5 (loam: light substrate: humus = 2:2:1), understory-T3 (loam: light substrate: humus = 1:1:1), respectively. Mantel test analyses revealed that the ability of F. tikoua cuttings from different habitats to form adventitious roots (ARs) largely determined the functional traits associated with cutting propagation. …”
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Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restriction by Chen Cheng, Trent Su, Marco Morselli, Siavash K. Kurdistani

“…Ribosome profiling and [35S]-methionine/cysteine or O-propargyl-puromycin (OPP) incorporation assays measured protein synthesis. Functional contributions of SETD8 and MYC were tested through knockdown and overexpression experiments. …”
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When do the symptoms of autonomic nervous system malfunction appear in patients with Parkinson’s disease? by De Luka Silvio R., Svetel Marina, Pekmezović Tatjana, Milovanović Branislav, Kostić Vladimir S.

“…The patients who developed complete autonomic neuropathy (both sympathetic and parasympathetic) were individuals with considerable level of functional failure, more severe clinical presentation and the existing anxiety and depression. …”
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Knockdown of nrf2 Exacerbates TNF-α-Induced Proliferation and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes through Activating JNK Pathway by Yu Du, Qian Wang, Na Tian, Meng Lu, Xian-Long Zhang, Sheng-Ming Dai

“…In this study, we aimed to explore the expression and upstream regulatory factors of nrf2 and revealed its functions in modulating the proliferation and invasion in RA-FLS. …”
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MASP1 in stomach adenocarcinoma: linking diagnosis, prognosis, and tumor immunity by Chuyu Xiao, Fuyang Hong, Guanzi Chen, Wenli Xu, Yusheng Jie

“…The diagnostic performance of MASP1 was evaluated through Receiver Operating Characteristic (ROC) curve analysis using the “pROC” package. Chi-square tests were conducted to examine the association between MASP1 expression and clinicopathological factors. …”
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Effectiveness and cost-effectiveness of a web-based routine assessment with integrated recommendations for action for depression and anxiety (RehaCAT+): protocol for a cluster rand... by Reinhold Kilian, Harald Baumeister, Yannik Terhorst, Johannes Knauer, Paula Philippi, Selina Kallinger, Sandro Eiler, Tamara Waldmann, Morten Moshagen, Martina Bader

“…User behaviour, acceptance, facilitating and hindering factors will be assessed with semistructured qualitative interviews. …”
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Biogenic silver nanoparticles optimization using Plackett–Burman design and its synergistic effect with cefotaxime against multidrug resistant clinical isolates by Hanzala Khan, Anum Gul, Zainab Najam, Taqdees Malik

“…Fourier Transform Infrared Spectroscopy (FTIR) analysis found different functional groups involved in the stabilization and capping of AgNPs, as indicated by the peaks at 2925 cm−1, 1630 cm−1, 1100 cm−1 and 1016 cm−1 revealing –CH stretching aliphatic carbon, the carboxyl group, OH group and C–O–C group, respectively. …”
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Correlation between postprandial hypotension and post-induction hypotension in the elderly: a protocol for a prospective cohort study by Li Xu, Lu Che, Quexuan Cui, Han Zang, Tianchun Li

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STUDY ON THE APPLICATION OF FLY ASH IN ROAD AND AIRPORT CONSTRUCTION by Oleksandr Vasylovych Stepanchuk, Yang Shilin, Valentyna Valentynivna Hrabovchak

“…Incorporation of fly ash into concrete mixtures significantly improves the performance of the concrete, with the main findings including enhanced strength and durability, improved workability, and better resistance to environmental factors such as frost and water; and 2. Fly ash positively affects the physical and mechanical properties of the concrete, making it a functional additive in the production of heavy-duty concrete. …”
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Pyroptosis-Mediator GSDMD in Plasma: A Potent Biomarker Lung Cancer Diagnosis and Prognosis Assessment by Liu X, Yu F, Ding N, Wei C, Cui Y, Huo L

“…This study aimed to evaluate the diagnostic efficacy of Gasdermin D (GSDMD) in lung cancer and explore its biological functions.Methods: A total of 114 lung cancer patients, 87 patients with pulmonary nodules, and 100 healthy controls were enrolled. …”
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A secure and energy-efficient routing using coupled ensemble selection approach and optimal type-2 fuzzy logic in WSN by S. Ambareesh, Pundalik Chavan, S. Supreeth, Rajesh Nandalike, P. Dayananda, S. Rohith

“…Abstract Wireless sensor networks (WSNs) are imperative to a huge range of packages, along with environmental monitoring, healthcare structures, army surveillance, and smart infrastructure, however they’re faced with numerous demanding situations that impede their functionality, including confined strength sources, routing inefficiencies, security vulnerabilities, excessive latency, and the important requirement to keep Quality of Service (QoS). …”
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