A laminin-based therapy for dogs with chronic spinal cord injury: promising results of a longitudinal trial by Carolina de Miranda Chize, Carolina de Miranda Chize, Diego Gonzales Vivas, Karla Menezes, Max Nascimento Freire, Rodrigo Ferreira Pinto Jiddu, Aurélio Vicente Graça-Souza, Eliel de Souza-Leite, Paulo Roberto Louzada, Tatiana Coelho-Sampaio

“…After owners provided informed consent, dogs were randomly allocated to either treatment group.ResultsNo neurological deterioration, serious clinical events or notable deviations in blood tests were observed. The TSCIS average baseline score increased from 2.2 to 3.2 (95% CI: 0.77–1.2; p < 0.001), while the OFS score increased from 1.5 to 3.1 (95% CI: 1.3–1.9; p < 0.001).DiscussionAlthough the present study could not discriminate between the benefits of the two treatments, our findings suggest that polylaminin, in combination with GDNF or chondroitinase ABC, is a safe and potentially effective treatment, which underscores the relevance of further studies to establish a new approach to improving gait function in dogs with chronic SCI.…”
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Comparative effect of dietary fortification of raw and roasted seeds of pumpkin (Cucurbita pepo L) on fertility biomolecules in cisplatin-induced spermatotoxic rats by Seun Funmilola Akomolafe, Mary Aderonke Bola Ogundare, Ibikunle Akinlua, Oluwadamilare Oluwaseun Ajayi, Elijah Olalekan Odesanmi, Olusola Bolaji Adewale

“…Testes architectures were efficiently restored in cisplatin-intoxicated rats pre-fed with pumpkin seed. …”
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Korelasi Kadar Hemoglobin dengan Kadar Nitric Oxide pada Preeklamsia dan Kehamilan Normal by Siska Helina, Ariadi , Delmi Sulastri

“…Haemoglobin levels were tested in clinical pathology laboratory of Dr. M. …”
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Synergistic effects of human umbilical cord mesenchymal stem cells/neural stem cells and epidural electrical stimulation on spinal cord injury rehabilitation by Zhiping Mu, Jiaodi Qin, Xiaohua Zhou, Kunzheng Wang

“…Abstract Spinal cord injury (SCI) is a severe neurological condition marked by a complex pathology leading to irreversible functional loss, which current treatments fail to improve. …”
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Silencing LINC00663 inhibits inflammation and angiogenesis through downregulation of NR2F1 via EBF1 in bladder cancer by Xiulong Zhong, Lijiang Sun, Junxiang Liu, Xiaokun Yang, Minghui Hou, Xinning Wang, Huifeng Diao

“…After transfection, functional experiments were conducted to test cell proliferation and invasion, tube formation ability, and content of inflammatory factors, Snail, E-cadherin, and VEGFA. …”
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The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian random... by Shasha Hu, Yuling Chen, Mingjie He, Jun Wen, Aimin Zhong, Dandan Zhan, Zhibin Ye

“…Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. …”
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Self-assembled co-delivery nanoplatform for increasing the broad-spectrum susceptibility of fall armyworm toward insecticides by Shuo Yan, Mingjian Li, Qinhong Jiang, Mingshan Li, Mengfan Hu, Xueyan Shi, Pei Liang, Meizhen Yin, Xiwu Gao, Jie Shen, Lei Zhang

“…Herein, a multicomponent nano-pesticide is designed to increase its broad-spectrum susceptibility toward insecticides. Method: Regulatory function of nuclear factor erythroid 2-related factor 2 (Nrf2) in detoxification was confirmed using transcriptome sequencing, quantitative real-time PCR and enzyme activity measurement. …”
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Curcumin alleviates LPS-induced WI-38 cell inflammation injury by regulating PTGS2 expression by Hongli Xiao, Wangsheng Ma, Lin Zha, Yanmin Xiao, Hui Li

“…Inflammation and oxidative stress were examined by measuring interleukins (IL)-6, IL-1β, tumor necrosis factor α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) levels using the corresponding enzyme-linked immunosorbent assay (ELISA) test kits. …”
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Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population by Ankita Mitra, Sangeetha Vishweswaraiah, Tania Ahalya Thimraj, Mahendra Maheswarappa, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Jayaraj Biligere Siddaiah, Koustav Ganguly, Mahesh Padukudru Anand

“…A weak correlation between lung function parameters and cytokine concentrations was detected. …”
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ggClusterNet 2: An R package for microbial co‐occurrence networks and associated indicator correlation patterns by Tao Wen, Yong‐Xin Liu, Lanlan Liu, Guoqing Niu, Zhexu Ding, Xinyang Teng, Jie Ma, Ying Liu, Shengdie Yang, Penghao Xie, Tianjiao Zhang, Lei Wang, Zhanyuan Lu, Qirong Shen, Jun Yuan

“…To address emerging challenges, including multi‐factor experimental designs, multi‐treatment conditions, and multi‐omics data, we present a comprehensive upgrade with four key components: (1) A microbial co‐occurrence network pipeline integrating network computation (Pearson/Spearman/SparCC correlations), visualization, topological characterization of network and node properties, multi‐network comparison with statistical testing, network stability (robustness) analysis, and module identification and analysis; (2) Network mining functions for multi‐factor, multi‐treatment, and spatiotemporal‐scale analysis, including Facet.Network() and module.compare.m.ts(); (3) Transkingdom network construction using microbiota, multi‐omics, and other relevant data, with diverse visualization layouts such as MatCorPlot2() and cor_link3(); and (4) Transkingdom and multi‐omics network analysis, including corBionetwork.st() and visualization algorithms tailored for complex network exploration, including model_maptree2(), model_Gephi.3(), and cir.squ(). …”
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Alte und neue Wege in der Rheometrie der Polymer-Schmelzen by Joachim Meissner

“…The combined influences of deformation and time can be factorized for the shear modulus obtained from stress relaxation tests with large shear strains. …”
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In-situ catalysis of green lubricants into graphitic carbon by iron single atoms to reduce friction and wear by Wei Song, Chongyang Zeng, Xiaoyang Ma, Janet S. S. Wong, Chuke Ouyang, Shouyi Sun, Weiwei Zhang, Jianbin Luo, Xing Chen, Jinjin Li

“…Here, we introduce a series of diesters, typically dioctyl malate (DOM), as green and effective anti-friction and anti-wear additives which reduce wear by factors of 5-7 and friction by over 50% compared to base oil when tested under high pressures. …”
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Prediction of the Quality of Life of Menopausal Women Based on Health Literacy and Self-Efficacy by Sara Jafarigiv, Nooshin Peyman, Habibollah Esmaily, Mohammad Tajfard

“…The research tool was a 4-part questionnaire including demographic characteristics, test of functional health literacy in adults (TOFLA), Sherer general self-efficacy and quality of life in menopause. …”
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Parameter sensitivity analysis for diesel spray penetration prediction based on GA-BP neural network by Yifei Zhang, Gengxin Zhang, Dawei Wu, Qian Wang, Ebrahim Nadimi, Penghua Shi, Hongming Xu

“…The model was trained using experimental data from diesel injector spray tests, and its accuracy was evaluated through parametric sensitivity analysis, examining the influence of various input factors. …”
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Early Life Cognitive Abilities and Body Weight: Cross-Sectional Study of the Association of Inhibitory Control, Cognitive Flexibility, and Sustained Attention with BMI Percentiles... by Tamara Wirt, Anja Schreiber, Dorothea Kesztyüs, Jürgen M. Steinacker

“…The findings suggest that especially cognitive abilities known as executive functions (inhibitory control and cognitive flexibility) are associated with children’s body weight. …”
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Sliding Mode Backstepping Control of Excavator Bucket Trajectory Synovial in Particle Swarm Optimization Algorithm and Neural Network Disturbance Observer by Xiangfei Tao, Kailei Liu, Jing Yang, Yu Chen, Jiayuan Chen, Haoran Zhu

“…As a representative of multi-functional engineering machinery, the excavator is irreplaceable in the field of engineering construction. …”
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Establishment and molecular characterization of novel luminal A and luminal B canine mammary cancer cell lines for comparative oncology by Juthathip Jurutha, Yanika Piyasanti, Kornkanok Sritabtim, Suparat Chaipipat, Kannika Siripattarapravat, Sukumal Prukudom, Usuma Jermnak, Rungthiwa Sinsiri, Kakanang Wongsuppabut, Charuwan Wongsali, Nutawan Niyatiwatchanchai, Wijit Sutthiprapa, Napachanok Swainson, Wachiraphan Supsavhad

“…Despite the availability of various CMC cell lines, most represent triple-negative or epidermal growth factor receptor 2 (ErbB2)-enriched subtypes, which limit research on hormone receptor-positive cancers. …”
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Unraveling the frequency of intestinal constipation in woman with urinary incontinence: a descriptive observational study by Bruna Isadora Thomé, Karoleen Oswald Scharan, Gisela Maria Assis, Auristela Duarte de Lima Moser

“…Comparisons between women with and without constipation involved χ2, Fisher's Exact, Student's t-test, Mann-Whitney U, and univariate logistic regression was performed to assess the association between sociodemographic/personal factors and the risk factor constipation. …”
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease. by IBC 50K CAD Consortium

“…Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. …”
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Examining the Effect of Earplugs, Eye Mask, and Earplugs + Eye Mask on the Sleep Quality in Intensive Care Patients: a Randomised Controlled Trial by Aysun Kazak Saltı, Hasret Topalı, Erdoğan Yolbaş, Sevilay Hintistan

“…Objective: Quality sleep, which plays an important role in the physical, cognitive, immunological, and psychosocial functions of patients, is imperative, especially for patients hospitalised in intensive care units (ICU) to recover from their critical illnesses. …”
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