Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

“…Statistical Analysis Used: Student’s t-test and Fisher’s exact test were used to compare clinical parameters and frequency differences amongst PCOS patients with and without variants. …”
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Pediatric health-related quality of life: a structural equation modeling approach. by Ester Villalonga-Olives, Ichiro Kawachi, Josué Almansa, Claudia Witte, Benjamin Lange, Christiane Kiese-Himmel, Nicole von Steinbüchel

“…<h4>Methods</h4>The contributory factors to Health Related Quality of Life that we included were symptom status (presence of chronic disease or hospitalizations), functional status (developmental status), developmental aspects of the individual (social-emotional) behavior, and characteristics of the social environment (socioeconomic status and area of education). …”
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ENVIRONMENTAL ACCOUNTING AND CORPORATE SOCIAL RESPONSIBILITY AS CATALYSTS FOR SUSTAINABLE NATIONAL DEVELOPMENT IN NIGERIA: AN EMPIRICAL ANALYSIS by Emmanuel Temitope Adedoyin, Peters Ade Sanni, Ibrahim T. Lawal, Mohammed Nezifi Ibrahim

“…Specifically, correlation analysis, multiple linear regression, vector autoregression (VAR), Granger causality tests, and impulse response functions were employed to explore both static and dynamic relationships among the variables. …”
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A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture by Dennis Kläge, Elisabeth Müller, Jörg S. Hartig

“…We were able to identify functional structures suited for aptazyme design and generated highly efficient hammerhead ribozyme variants originating from the human genome. …”
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Nonalcoholic Steatohepatitis in a Patient with Ataxia-Telangiectasia by Trinidad Caballero, Mercedes Caba-Molina, Javier Salmerón, Mercedes Gómez-Morales

“…A-T patients have inactivation of ataxia-telangiectasia-mutated (ATM) protein, which controls DNA double-strand break repair and is involved in oxidative stress response, among other functions; dysfunctional control of reactive oxygen species may be responsible for many of the clinical manifestations of this disease. …”
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Reliability and validity of the Mentalization Questionnaire in a potentially depressed group of Chinese college students by Xin Huang, Zemin Zhou, Guang Yang, Jiao Liu, Xuan Li, Xuemei Li

“…Concurrent validity was examined using the 8-item Reflective Functioning Questionnaire (RFQ-8). To assess test-retest reliability, 85 participants were randomly selected for retesting one week after initial administration.ResultsThe MZQ revealed a 3-factor structural model, and confirmatory factor analysis showed satisfactory fit indices for all three structures (χ²/df = 3.69, NFI = 0.83, CFI = 0.87, GFI = 0.92, IFI = 0.87, TLI = 0.83, RMSEA = 0.078). …”
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Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis by Elizabeth C. Okafor, Katherine H. Hullsiek, Darlisha A. Williams, James E. Scriven, Joshua Rhein, Henry W. Nabeta, Abdu K. Musubire, Radha Rajasingham, Conrad Muzoora, Charlotte Schutz, Graeme Meintjes, David B. Meya, David R. Boulware

“…Results. Of the 21 analytes tested at baseline, there was no correlation detected between nearly all analytes. …”
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Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction by Jing Wen, Cui Wang, Li-yun Song, Yin-ying Wang, Peng-tao Liang, Wen-lin Pang, Wen Yin, Qiang Zhang, Wei-tian Zhao, Xue-ping Sun, Jin-yuan Yan, Zhong-shan Yang

“…Potential pharmacologic targets were predicted via network pharmacology. Finally, tests including immunohistochemistry, reverse transcription-quantitative polymerase chain reaction, and western blotting were used to evaluate the relative expression levels of collagen, transforming growth factor β, α-smooth muscle actin, hydroxyproline, and ferroptosis-related genes (GPX4, SLC7A11, ACSL4, and PTGS2) and candidates involved in the mediation of pathways associated with ferroptosis (Hif-1α and EGFR). …”
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Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats by Arijana Demaili, Anna Portugalov, Anna Portugalov, Mouna Maroun, Mouna Maroun, Irit Akirav, Irit Akirav, Katharina Braun, Katharina Braun, Jörg Bock, Jörg Bock, Jörg Bock

“…Several studies in both animal models and in humans have provided substantial evidence that early life stress (ELS) induces long-term changes in behavior and brain function, making it a significant risk factor in the aetiology of various mental disorders, including anxiety and depression. …”
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Exome sequencing in an admixed isolated population indicates NFXL1 variants confer a risk for specific language impairment. by Pía Villanueva, Ron Nudel, Alexander Hoischen, María Angélica Fernández, Nuala H Simpson, Christian Gilissen, Rose H Reader, Lillian Jara, María Magdalena Echeverry, Clyde Francks, Gillian Baird, Gina Conti-Ramsden, Anne O'Hare, Patrick F Bolton, Elizabeth R Hennessy, SLI Consortium, Hernán Palomino, Luis Carvajal-Carmona, Joris A Veltman, Jean-Baptiste Cazier, Zulema De Barbieri, Simon E Fisher, Dianne F Newbury

“…We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 × 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. …”
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Radioactive Iodine and Krypton Control for Nuclear Fuel Reprocessing Facilities by Nick R. Soelberg, Troy G. Garn, Mitchell R. Greenhalgh, Jack D. Law, Robert Jubin, Denis M. Strachan, Praveen K. Thallapally

“…Iodine decontamination factors as high as 105, iodine loading capacities, and other adsorption parameters including adsorption rates have been demonstrated under some conditions for both silver zeolite (AgZ) and Ag-functionalized aerogel. …”
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Batch Adsorption of Orange II Dye on a New Green Hydrogel—Study on Working Parameters and Process Enhancement by Andrei-Ionuț Simion, Cristina-Gabriela Grigoraș, Lidia Favier

“…The analyses of its morphological structure and functional groups by scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) showed the successful entrapping of the CS in the SA polymeric matrix. …”
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The influence of fitness mobile apps on workout behavior intention among Chinese young adults. by Mengyu Li, Shujie Wang, Abdul Rahim Ahmed Soliman Darweesh

“…Finally, the moderation test showed that belief moderated the assignations between the independent factors and workout behavior intentions. …”
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TRANSPORT SYSTEM OF THE DIGITAL SOCIETY: PROBLEMS AND SOLUTIONS by T. A. Rudakova, O. Yu. Rudakova

“…However, as practice shows, during this period new conditions for the functioning of the industry arise (the emergence of new modes of transport or their modification) and elements of the transport system undergo changes. …”
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The associations between current and anticipatory weight-related shame and flourishing in adolescent girls in sport by Kristen M. Lucibello, Tara Zeitoun, David M. Brown, Eva Pila, Catherine M. Sabiston

“…., positive mental health reflecting positive social relationships and sense of purpose and optimism) is important for experiencing growth, resilience, and functioning – especially in sport. Factors that may limit or potentiate the experience of flourishing in sport need to be understood. …”
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Autonomous Vehicle Acceptance in China: TAM-Based Comparison of Civilian and Military Contexts by Dan Wan, Ling Peng

“…Data analysis was conducted through reliability and validity tests, correlation analysis, and Structural Equation Modeling (SEM). …”
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PEDAGOGICAL ASSISTANCE IN HIGH SCHOOL STUDENTS’ PROFESSIONAL SELF–DETERMINATION by V. N. Kormakova, E. N. Musaelian, D. I. Ruziyeva

“…There has been developed a scientific concept of pedagogical assistance in self-determination of high school students in the field of trade occupations, which includes the structure, functions, laws and principles, factors, pedagogical conditions and a mechanism to ensure the effectiveness of the selfdetermination process; technological and reflexive foundations of this process.Practical significance. …”
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Oral Administration of 4-Hydroxy-3-Methoxycinnamaldehyde Attenuates Atopic Dermatitis by Inhibiting T Cell and Keratinocyte Activation. by Hyun-Su Lee, Eun-Ju Choi, Heeri Choi, Kyung-Sik Lee, Hye-Ran Kim, Bo-Ra Na, Min-Sung Kwon, Gil-Saeng Jeong, Hyun Gyu Choi, Eun Young Choi, Chang-Duk Jun

“…Collectively, these findings suggest that 4H3MC ameliorates AD symptoms by modulating the functions of effector T cells and keratinocytes.…”
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The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families by Rongling Wu, Claudia Gragnoli

“…MC3R and MC4R were previously reported in PCOS. However, functional studies are needed to validate these results.…”
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Buffering the Impact of Loneliness on Academic Stress: The Moderating Power of Self-Compassion by Devie Yundianto, Zuniyanti Khoiriyah, Anna Armeini Rangkuti, Muhammad Khatami, Uzma Azam

“…These findings demonstrate that self-compassion functions as an emotional coping resource capable of reducing stress associated with social isolation. …”
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