Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow by Y. Liu, S. L. Diamond

“…Since TLR signaling can activate nuclear factor-kappaB (NF-κB), the IKK-inhibitor (IKK inhibitor VII) and NF-κB inhibitor (Bay 11-7082) were tested. …”
Get full text

Korean Version of the Confidence of Arm and Hand Movement Scale and Its Psychometric Properties by Hanna Kim, Yeajin Ham, Joon-Ho Shin

“…Bland–Altman plot analysis showed good agreement, indicating test-retest reliability. Moreover, K-CAHM showed good concurrent validity, demonstrated by its correlation with three domains of the International Classification of Functioning, Disability and Health: Fugl-Meyer assessment, the Jebsen-Taylor Hand Function Test, personal hygiene and bathing in the modified Barthel Index, and hand and stroke recovery domain in the Stroke Impact Scale. …”
Get full text

Micro-3D sculptured metastructures with deep trenches for sub-10 μm resolution by Anıl Çağrı Atak, Emre Ünal, Hilmi Volkan Demir

“…Using the numerical solutions, we custom-tailored these metastructure resonators to fall within a specific resonance frequency range of 4-6 GHz while undertaking comparative analyses regarding overall footprint, quality factor, and resonance frequency shift as a function of their cross-sectional aspect ratio. …”
Get full text

Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice. by Florence Njau, Nelli Shushakova, Heiko Schenk, Vera Christine Wulfmeyer, Robin Bollin, Jan Menne, Hermann Haller

“…Preliminary evidence suggests that CaD interferes with HS binding sites of fibroblast growth factor. We therefore tested the hypotheses that (1) CaD inhibits VEGF signaling in endothelial cells, (2) that this effect is mediated via interference between CaD and HS, and (3) that CaD ameliorates diabetic nephropathy in a streptozotocin-induced diabetic mouse model by VEGF inhibition. …”
Get full text

Polyester/Kota Stone Dust Composite: A Comprehensive Investigation of Mechanical and Sliding Wear Properties by Rakesh Singh, Vinay Chandra Jha

“…It is observed that the Kota stone dust loading is the utmost significant factor, whereas normal load is the least significant factor that administrates the sliding wear rate. …”
Get full text

Reliability and validity of mental health measurement of young people in a Chinese urban context. by Jing Zhou, Timo Toikko

“…Utilizing a sample of 3,279 participants aged 14-35 years, the study employed rigorous statistical analyses, including Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and tests for convergent, discriminant, and concurrent validity, to evaluate the scale's psychometric properties. …”
Get full text

Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients by Jian Bin Li, Peng Cheng Liu, Liming Chen, Rui Wu

“…At baseline, comprehensive assessments including complete blood count, liver and kidney function tests, blood glucose levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-citrullinated protein antibody (ACPA), as well as counts of swollen and tender joints, Health Assessment Questionnaire (HAQ) score, pain visual analogue scale (VAS) scores, and DAS28-CRP scores were conducted. …”
Get full text

Preventing and approaching crises for frail community-dwelling patients through innovative care (PRACTIC): study protocol for a process evaluation of a complex intervention in home... by Ellen Thea Gjelseth Dalbak, Anette Væringstad, Bjørn Lichtwarck, Janne Myhre, Daniela Holle, Sverre Bergh, Øyvind Kirkevold

Get full text

Dextrose prolotherapy at varying concentrations ameliorates tendon injury via IGF-2R: an integrated study of Mendelian randomization and an animal model by Lina Zhou, Hui Liang, Yulin Chen, Kai Hu, Xixia Liu

“…Among the tested concentrations, 25% hypertonic glucose yielded the best therapeutic outcomes.…”
Get full text

Principles of effective out-patient diagnostics of diffuse liver diseases by Komova A. G., M. V. Mayevskaya, V. T. Ivashkin

“…Results. Abnormal liver functional tests were revealed in 30,6% of industrial city inhabitants — in 1461 of 4768 cases (232 patients were excluded from the study due to partial data loss), significantly more frequently in men in comparison to women, i.e. 49,7 and 25,5% respectively (p<0,001). …”
Get full text

Genomic and proteomic characterization of four novel Schitoviridae family phages targeting uropathogenic Escherichia coli strain by Hira Niaz, Mikael Skurnik, Fazal Adnan

“…In addition, no genes encoding virulence factors, antibiotic resistance or lysogeny factors were identified. …”
Get full text

Contribution and significance of Heidelberg retinal tomography II in diagnostics of ocular hypertension and its conversion into primary open-angle glaucoma by Marković Vujica, Kontić Đorđe, Hentova-Senćanić Paraskeva, Božić Marija, Marjanović Ivan, Krstić Vera, Kovačević Dragana

“…Also, when the results of the functional tests remain unchanged, that confirms the conversion of ocular hypertension into glaucoma. …”
Get full text

Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure. by Emília Ilona Gaál, Perttu Salo, Kati Kristiansson, Karola Rehnström, Johannes Kettunen, Antti-Pekka Sarin, Mika Niemelä, Antti Jula, Olli T Raitakari, Terho Lehtimäki, Johan G Eriksson, Elisabeth Widen, Murat Günel, Mitja Kurki, Mikael von und Zu Fraunberg, Juha E Jääskeläinen, Juha Hernesniemi, Marjo-Riitta Järvelin, Anneli Pouta, International Consortium for Blood Pressure Genome-Wide Association Studies, Christopher Newton-Cheh, Veikko Salomaa, Aarno Palotie, Markus Perola

“…Studying the genetics of risk factors predisposing to disease is an attractive approach to identify targets for functional studies. …”
Get full text

Intestinal Permeability: The Basics by Ingvar Bjarnason, Andrew Macpherson, Ian S Menzies

“…The authors review some of the more fundamental principles underlying the noninvasive assessment of intestinal permeability in humans, the choice of test markers and their analyses, and the practical aspects of test dose composition and how these can be changed to allow the specific assessment of regional permeability changes and other intestinal functions. …”
Get full text

Barriers to and facilitators of clinician acceptance and use of artificial intelligence in healthcare settings: a scoping review by Alex Federman, Yufei Wang, Jalayne J Arias, Catherine E A Scipion, Margaret A Manchester

“…Overall, drivers of clinician AI acceptance and use were ambivalent, functioning as either barriers or facilitators depending on context. …”
Get full text

Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Secondary: evaluate the impact of pramipexole on mood and anxiety, psychosocial function, cost-effectiveness, and safety and tolerability over 48 weeks. …”
Get full text

Assessing the validity and reliability of the Indonesian version of Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Scale v1.2 by Vitriana Biben, Farida Arisanti, Efi Fitriana, Erika Maklun, Vindy Margaretha Miguna, Nabilla Fikria Alviani

“…Content validity was tested by five experts using the Scale-Content Validity Index (S-CVI), and structural validity was evaluated through Confirmatory Factor Analysis (CFA). …”
Get full text

Design and Optimization of a Cross-Beam Force Transducer for a Stationary Dynamometer for Measuring Milling Cutting Force by Muhammad Rizal, Jaharah A. Ghani, Husni Usman, Muhammad Dirhamsyah, Amir Zaki Mubarak

“…The response surface method (RSM) estimates a desired second-order polynomial function for three geometric parameters based on sensitivity, interference error, safety factor, and stiffness. …”
Get full text

Finite Element Simulation and Optimization of Reaming Process by YUE Caixu, HU Desheng, ZHANG Anshan, LIU Xianli, LIU Zhibo, CHEN Zhitao

“…Firstly, the secondary development of blade and workpiece geometric parameter modeling is carried out through Python language; secondly, single factor experiment method is used to analyze the influence trend of different blade geometric parameters on cutting force and cutting temperature; finally, the orthogonal experiment method and response surface method are combined to establish a function with cutting force and cutting temperature as the objective is obtained, and the optimal solution of insert geometric parameters is obtained through the Fmincon optimization model. …”
Get full text

Identifying chronic obstructive pulmonary disease subtypes using multi-trait geneticsResearch in context by Andrey Ziyatdinov, Brian D. Hobbs, Samir Kanaan-Izquierdo, Matthew Moll, Phuwanat Sakornsakolpat, Nick Shrine, Jing Chen, Kijoung Song, Russell P. Bowler, Peter J. Castaldi, Martin D. Tobin, Peter Kraft, Edwin K. Silverman, Hanna Julienne, Michael H. Cho, Hugues Aschard

“…Methods: We clustered genome-wide association studies of COPD, lung function, and asthma and phenotypes from the UK Biobank using non-negative matrix factorization. …”
Get full text